Marius Găzdac

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Annamária Pakucs

Universitatea de Medicină, Farmacie, Științe și Tehnologie „George Emil Palade” din Târgu Mureș

Erzsébet Lázár

Universitatea de Medicină, Farmacie, Științe și Tehnologie „George Emil Palade” din Târgu Mureș

C. Tudor

Ovidius University

Judit-Beáta Köpeczi

Enikő Kakucs

Clinical Emergency Hospital Bucharest

Eszter Mild

Universitatea de Medicină, Farmacie, Științe și Tehnologie „George Emil Palade” din Târgu Mureș

István Benedek

Babeș-Bolyai University

István Benedek

Spitalul Clinic Judetean de Urgenta Târgu Mureş

JÁ

János Ács

Universitatea de Medicină, Farmacie, Științe și Tehnologie „George Emil Palade” din Târgu Mureș

Szende Jakab

Universitatea de Medicină, Farmacie, Științe și Tehnologie „George Emil Palade” din Târgu Mureș

Cooperative Institutions

Universitatea de Medicină, Farmacie, Științe și Tehnologie „George Emil Palade” din Târgu Mureș

Spitalul Clinic Judetean Mures

Clinical Emergency Hospital Bucharest

Spitalul Clinic Judetean de Urgenta Târgu Mureş

Ovidius University

Emergency University

Amita Health St. Mary's Hospital

Novem (Netherlands)

TU Wien

Babeș-Bolyai University

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Stem Cell Mobilization and Harvesting Failure in Case of Heavily Pretreated Patients

Journal of Interdisciplinary Medicine (2017)

Eszter Mild Erzsébet Lázár Judit-Beáta Köpeczi Enikő Kakucs Marius Găzdac

Abstract Background: High-dose chemotherapy and autologous stem cell transplantation have become a standard curative treatment in various hematologic malignancies. Many factors can affect the success of mobilization and hematopoietic stem cell harvesting. Aim: The aim of this study was to analyze factors that lead to mobilization failure. Material and Methods: We conducted a retrospective study on 19 patients with failure of stem cell harvesting. All patients were administered high doses of GCS-F (filgrastim, 15 μg/kg/day) and 0.24 mg/kg of plerixafor on day +5 or +10 of harvesting. Results: The median age of the study population was 51 years (range 35–67) and 52.6% (n = 10) were males. The study group included 4 (21%) subjects with multiple myeloma, 6 (31.5%) with Hodgkin lymphoma, 8 cases (42.1%) with non-Hodgkin lymphoma and 1 patient with chronic lymphocytic leukemia. Each patient received 2.78 (range 1–5) lines of chemotherapy, administered in 11.57 (range 2 to over 20) cycles of treatment. Conclusion: In hematologic malignancies it is very important to collect stem cells in time, in order to reduce mobilization failure. As we have shown in our studied cases, multiple lines of polychemotherapy with or without radiotherapy lead to mobilization failure.

Plerixafor

Mobilization

Autologous stem-cell transplantation

10.1515/jim-2017-0100

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Post Autologous Stem Cell Transplantation Complication Management in Case of Malignant Lymphoma Patients

Journal of Interdisciplinary Medicine (2017)

Annamária Pakucs Erzsébet Lázár Judit Beáta Köpeczi Enikő Kakucs István Benedek

Abstract Introduction: Autologous hematopoietic stem cell transplantation (ASCT) represents a standard therapy in the management of hematologic malignancies such as malignant lymphomas and has used for approximately three decades. The aim of this study was to determine the occurring post-ASCT complications and their impact on the patients’ recovery for a better management. Material and methods: An observational retrospective study was performed during a five-year period between 2012 and 2017, involving 58 classical Hodgkin lymphoma and 36 non-Hodgkin lymphoma patients, who underwent ASCT in the Bone Marrow Transplantation Unit of Tîrgu Mureş. The main analyzed complications were: infections, bleeding, hydroelectrolytic disorders, and hypoalbuminemia. Results: After data analysis we found that 17 patients (18%) presented microbiologically confirmed infection, 10 patients (11%) presented clinically non-significant bleeding, 39 patients (42%) presented electrolyte disorders, and 33 patients (36%) presented hypoalbuminemia, obtaining a positive correlation between the rate of adverse events after ASCT with age (r = 0.9914, p = 0.0009) and the average hospitalization period (r = 1, p <0.00001). Conclusions: The identification of adverse events and their correlation with the patients’ clinical outcome can lead to better patient management and a faster recovery after ASCT.

Hypoalbuminemia

Autologous stem-cell transplantation

10.1515/jim-2017-0098

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Double Autologous Stem Cell Transplantation in a Case of Non-secretory Multiple Myeloma

Journal of Interdisciplinary Medicine (2016)

Erzsébet Lázár Marius Găzdac Szende Jakab István Benedek Judit-Beáta Köpeczi

Abstract Multiple myeloma represents a challenge for hematologists because it has become more frequent at a young age in recent years. This is why autologous stem cell transplantation is included in the standard treatment of myeloma patients. We present the case of a 39-year-old patient who was diagnosed with non-secretory myeloma with double autologous transplantation and underwent neurosurgery for spinal cord compression caused by a plasmocytoma at D5 level. We present the evolution and complexity of this very difficult case.

Autologous stem-cell transplantation

Spinal cord compression

10.1515/jim-2016-0058

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