Heike Schmuths

Leibniz Institute of Plant Genetics and Crop Plant Research

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Matthias H. Hoffmann

Łukasiewicz Research Network - Wood Technology Institute

Michael J. Holdsworth

University of Nottingham

Frederica L. Theodoulou

Rothamsted Research

Steven Footitt

Boğaziçi University

Konrad Bachmann

Heidelberg University

Tara J. Holman

Biocenter Finland

Julietta Marquez

Hawaii Agriculture Research Center

Anne Medhurst

University of Nottingham

Jürgen Tomiuk

University of Tübingen

Reinhard Fritsch

Leibniz Institute of Plant Genetics and Crop Plant Research

Cooperative Institutions

University of Nottingham

Leibniz Institute of Plant Genetics and Crop Plant Research

Rothamsted Research

University of Leeds

Instituto Valenciano de Investigaciones Agrarias

Max Planck Society

Max Planck Institute of Molecular Plant Physiology

Leibniz Association

Leibniz Institute for Neurobiology

University of Potsdam

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

Evidence for a large-scale population structure of Arabidopsis thaliana from genome-wide single nucleotide polymorphism markers

Theoretical and Applied Genetics (2006)

Karl Schmid Ottó Törjék Rhonda C. Meyer Heike Schmuths Matthias H. Hoffmann

Linkage Disequilibrium

10.1007/s00122-006-0212-7

Cite

Citations (129)

Evolution by Reticulation: European Dogroses Originated by Multiple Hybridization Across the Genus Rosa

Journal of Heredity (2004)

Christiane M. Ritz Heike Schmuths Volker Wissemann

The European dogroses (Rosa sect. Caninae (DC.) Ser.) are characterized by a unique meiosis system ("canina-meiosis"), which controls the heterogamous development of tetraploid egg cells and haploid pollen grains resulting in a pentaploid somatic status. This permanent anorthoploidy is supposed to have originated by a hybridization event in the postglacial period. In this study we present molecular evidence by an analysis of nuclear ribosomal DNA data that dogroses are complex allopolyploids resulting from multiple hybridization events. As previously described, the nrITS-1 region does not undergo concerted evolution in dogroses. Thus, different ITS-1 sequences persist within single individuals. Secondary structure predictions do not point to the existence of pseudogenes within these ITS-1 types. Our data suggest that the pentaploid Caninae genome originated from different members of nondogroses and the now extinct Protocaninae.

Pseudogene

Concerted evolution

10.1093/jhered/esi011

Cite

Citations (120)

Analysis of molecular data of Arabidopsis thaliana (L.) Heynh. (Brassicaceae) with Geographical Information Systems (GIS)

Molecular Ecology (2003)

Matthias H. Hoffmann Änne Glass Jürgen Tomiuk Heike Schmuths Reinhard Fritsch

Abstract A Geographical Information System (GIS) is used to analyse allelic information of 13 sequenced loci of natural populations of Arabidopsis thaliana and to identify geographical structures. GIS provides tools for visualization and analysis of geographical population structures using molecular data. The geographical distribution of the number of variable positions in the alignments, the distribution of recombinant sequence blocks, and the distribution of a newly defined measure, the differentiation index, are studied. The differentiation index is introduced to measure the sequence divergence among individual plants sampled from various geographical localities. The numbers of variable positions and the differentiation index are also used for a metadata analysis covering about 26 kb of the genome. This analysis reveals, for the first time, differences in DNA sequence structures of geographically different populations of A. thaliana . The broadly defined west Mediterranean region consists of accessions with the highest numbers of polymorphic positions followed by the west European region. The GIS technology Kriging is used to define Arabidopsis specific diversity zones in Europe. The highest genetic variability is observed along the Atlantic coast from the western Iberian Peninsula to southern Great Britain, while lowest variability is found in central Europe.

Brassicaceae

10.1046/j.1365-294x.2003.01791.x

Cite

Citations (36)

The N-end rule pathway promotes seed germination and establishment through removal of ABA sensitivity in Arabidopsis

Proceedings of the National Academy of Sciences (2009)

Tara J. Holman Peter D. Jones Laurel Russell Anne Medhurst Susana Úbeda-Tomás

The N-end rule pathway targets protein degradation through the identity of the amino-terminal residue of specific protein substrates. Two components of this pathway in Arabidopsis thaliana , PROTEOLYSIS6 (PRT6) and arginyl-tRNA:protein arginyltransferase (ATE), were shown to regulate seed after-ripening, seedling sugar sensitivity, seedling lipid breakdown, and abscisic acid (ABA) sensitivity of germination. Sensitivity of prt6 mutant seeds to ABA inhibition of endosperm rupture reduced with after-ripening time, suggesting that seeds display a previously undescribed window of sensitivity to ABA. Reduced root growth of prt6 alleles and the ate1 ate2 double mutant was rescued by exogenous sucrose, and the breakdown of lipid bodies and seed-derived triacylglycerol was impaired in mutant seedlings, implicating the N-end rule pathway in control of seed oil mobilization. Epistasis analysis indicated that PRT6 control of germination and establishment, as exemplified by ABA and sugar sensitivity, as well as storage oil mobilization, occurs at least in part via transcription factors ABI3 and ABI5. The N-end rule pathway of protein turnover is therefore postulated to inactivate as-yet unidentified key component(s) of ABA signaling to influence the seed-to-seedling transition.

10.1073/pnas.0810280106

Cite

Citations (176)

Comparative Analysis of Growth, Genome Size, Chromosome Numbers and Phylogeny of Arabidopsis thaliana and Three Cooccurring Species of the Brassicaceae from Uzbekistan

Journal of Botany (2010)

Matthias H. Hoffmann Heike Schmuths Christina Koch Armin Meister Reinhard Fritsch

Contrary to literature data Arabidopsis thaliana was rarely observed in Middle Asia during a collection trip in 2001. Instead, three other Brassicaceae species were frequently found at places where A. thaliana was expected. To reveal reasons for this frequency pattern, we studied chromosome numbers, genome sizes, phylogenetic relationships, developmental rates, and reproductive success of A. thaliana, Olimarabidopsis pumila, Arabis montbretiana , and Arabis auriculata from Uzbekistan in two temperature treatments. There are little but partially significant differences between phenotypes. All studied species have very small genomes. The 1Cx-values of different genotypes within the sampled species are correlated with altitude. Developmental rates are also correlated with 1Cx-values. In our growth experiments, Arabidopsis had high seed sterility at higher temperature, which might be one reason for the rarity of A. thaliana in Middle Asia.

Brassicaceae

Genome size

10.1155/2010/504613

Cite

Citations (6)

Effects of Preconditioning and Temperature During Germination of 73 Natural Accessions of Arabidopsis thaliana

Annals of Botany (2006)

Heike Schmuths Konrad Bachmann Wilhelm Weber Ralf Horres Matthias H. Hoffmann

• Background and Aims Germination and establishment of seeds are complex traits affected by a wide range of internal and external influences. The effects of parental temperature preconditioning and temperature during germination on germination and establishment of Arabidopsis thaliana were examined.

Radicle

10.1093/aob/mcl012

Cite

Citations (84)

Geographic Distribution and Recombination of Genomic Fragments on the Short Arm of Chromosome 2 of Arabidopsis thaliana

Plant Biology (2004)

Heike Schmuths Matthias H. Hoffmann Konrad Bachmann

Range expansion from Pleistocene refugia and anthropogenic influences contribute to the present distribution pattern of Arabidopsis thaliana. We scored a genome-wide set of CAPSs and found two markers with an east-west geographic distribution across the Eurasian range of the species. Regions around the two SNPs were sequenced in 98 accessions, including newly collected plants from Middle Asia and Western Siberia. These regions correspond to a gene ( approximately 1500 bp) and a non-coding region ( approximately 500 bp) 300 kbp apart on chromosome 2. Nucleotide diversities, pi, of the two sequenced fragments were 0.0032 and 0.0130. The haplotypes of both sequences belonged to one of two groups: a rather uniform "Asian" and a more variable "European" haplotype group, on the basis of non-disjunct clusters of SNPs. Recombination between "Asian" and "European" haplotypes occurs where they meet. Especially in the "European" haplotype, many rare SNP variants representing independent mutations are scattered among the shared haplotype-specific SNPs. This agrees with previous suggestions of two large haplotype groups in A. thaliana and the post-glacial colonization of central Europe from the east and the west. A clear correlation between climatic factors and the haplotype distribution may reflect the dispersal history rather than local climate adaptation. The pattern of SNP variation within the contiguous sequences explains why only a minority of SNPs selected across the genome show evidence of this geographic pattern.

10.1055/s-2004-817837

Cite

Citations (21)

Native range genetic variation in Arabidopsis thaliana is strongly geographically structured and reflects Pleistocene glacial dynamics

Molecular Ecology (2007)

James B. Beck Heike Schmuths Barbara A. Schaal

Despite Arabidopsis thaliana's pre-eminence as a model organism, major questions remain regarding the geographic structure of its genetic variation due to the geographically incomplete sample set available for previous studies. Many of these questions are addressed here with an analysis of genome-wide variation at 10 loci in 475 individuals from 167 globally distributed populations, including many from critical but previously un-sampled regions. Rooted haplotype networks at three loci suggest that A. thaliana arose in the Caucasus region. Identification of large-scale metapopulations indicates clear east-west genetic structure, both within proposed Pleistocene refugia and post-Pleistocene colonized regions. The refugia themselves are genetically differentiated from one another and display elevated levels of within-population genetic diversity relative to recolonized areas. The timing of an inferred demographic expansion coincides with the Eemian interglacial (approximately 120,000 years ago). Taken together, these patterns are strongly suggestive of Pleistocene range dynamics. Spatial autocorrelation analyses indicate that isolation by distance is pervasive at all hierarchical levels, but that it is reduced in portions of Europe.

Metapopulation

Isolation by distance

10.1111/j.1365-294x.2007.03615.x

Cite

Citations (166)

Genome Size Variation among Accessions of Arabidopsis thaliana

Annals of Botany (2004)

Heike Schmuths

• Background and Aims Estimates of the amount of nuclear DNA of Arabidopsis thaliana, known to be among the lowest within angiosperms, vary considerably. This study aimed to determine genome size of a range of accessions from throughout the entire Eurasian range of the species.

Genome size

Nuclear DNA

10.1093/aob/mch037

Cite

Citations (131)

The N-end rule pathway promotes seed germination and establishment through removal of ABA sensitivity in Arabidopsis.

Andreas Bachmair Prabhavathi Talloji Tara J. Holman Peter D. Jones Laurel Russell

Source

Cite

Citations (4)