Daniela Pereira Alves

Universidade Federal de Minas Gerais

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Igor Dimitri Gama Duarte

Universidade Federal de Minas Gerais

Patrícia Gonçalves da Motta

Universidade Federal de Minas Gerais

Andréa C. Perez

Universidade Federal de Minas Gerais

Li Weigang

Universidade de Brasília

Janetti N. Francischi

Universidade Federal de Minas Gerais

Bruna Luiza Emerich

Universidade Federal de Minas Gerais

Karine Santos Gonçalves

Maria Elena de Lima

Grupo Santa Casa de Belo Horizonte

Michael Richardson

Ezequiel Dias Foundation

Cinthia F. Pacheco

Universidade Federal de Minas Gerais

Cooperative Institutions

Universidade Federal de Minas Gerais

Novo Nordisk (Denmark)

Chinese Academy of Sciences

University of Brescia

Universidade Federal dos Vales do Jequitinhonha e Mucuri

Centre National de la Recherche Scientifique

Ezequiel Dias Foundation

Charles University

Sichuan University

Universidade Estadual de Montes Claros

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

Diclofenac-induced peripheral antinociception is associated with ATP-sensitive K+ channels activation

Life Sciences (2004)

Daniela Pereira Alves Maria A.F Tatsuo Rômulo Leite Igor Dimitri Gama Duarte

Channel blocker

Diclofenac

Potassium channel blocker

Apamin

Tetraethylammonium

Tolbutamide

10.1016/j.lfs.2003.10.012

Cite

Citations (95)

Additive antinociceptive effect of the combination of diazoxide, an activator of ATP-sensitive K+ channels, and sodium nitroprusside and dibutyryl-cGMP

European Journal of Pharmacology (2004)

Daniela Pereira Alves Adriana C. Soares Janetti N. Francischi Maria S.A. Castro Andréa C. Perez

Diazoxide

Sodium nitroprusside

10.1016/j.ejphar.2004.02.022

Cite

Citations (51)

A utilização da fitoterapia e plantas medicinais como prática terapêutica pela visão de estudantes de enfermagem

Conexão Ciência (Online) (2019)

Marcos Luciano Pimenta Pinheiro Daniela Pereira Alves Eva Jéssica de Jesus Silva Maronne Quadros Antunes Eurislene Antunes Damasceno

Introdução: O saber popular e o conhecimento empírico há muito vêm demonstrando os efeitos benéficos proporcionados pelo uso de plantas como terapia complementar ou alternativa. Objetivo: Este estudo teve como objetivo avaliar o conhecimento e o uso de plantas medicinais e fitoterápicos como prática terapêutica por acadêmicos de enfermagem. Metodologia: Trata-se de um estudo transversal, de caráter quantitativo, composto por uma mostra de 90 acadêmicos de enfermagem, utilizando um questionário semiestruturado adaptado para a coleta de dados. Resultados: Nenhum entrevistado conhecia a diferença de conceito entre fitoterápico e planta medicinal e 67% destes, afirmaram saber pouco sobre o assunto, mas a totalidade dos entrevistados afirmou que já utilizaram plantas medicinais pelo menos uma vez, principalmente na forma de chá. Conclusão: Conclui-se que há uma lacuna no aprendizado dos acadêmicos de enfermagem sobre o conhecimento da fitoterapia e das plantas medicinais. A inserção de uma disciplina com esta temática poderá contribuir para a solução deste problema, melhorando o conhecimento na área.

10.24862/cco.v14i3.952

Cite

Citations (1)

Antinociceptive effect of PnTx4(5-5), a peptide from Phoneutria nigriventer spider venom, in rat models and the involvement of glutamatergic system

The Journal of venomous animals and toxins including tropical diseases (2019)

Camila Franco Batista Oliveira Daniela Pereira Alves Bruna Luiza Emerich Suely G. Figueiredo Marta do Nascimento Cordeiro

The venom of Phoneutria nigriventer spider is a source of numerous bioactive substances, including some toxins active in insects. An example is PnTx4(5-5) that shows a high insecticidal activity and no apparent toxicity to mice, although it inhibited NMDA-evoked currents in rat hippocampal neurons. In this work the analgesic activity of PnTx4(5-5) (renamed Γ-ctenitoxin-Pn1a) was investigated.The antinociceptive activity was evaluated using the paw pressure test in rats, after hyperalgesia induction with intraplantar injection of carrageenan or prostaglandin E2 (PGE2).PnTx4(5-5), subcutaneously injected, was able to reduce the hyperalgesia induced by PGE2 in rat paw, demonstrating a systemic effect. PnTx4(5-5) administered in the plantar surface of the paw caused a peripheral and dose-dependent antinociceptive effect on hyperalgesia induced by carrageenan or PGE2. The hyperalgesic effect observed in these two pain models was completely reversed with 5 µg of PnTx4(5-5). Intraplantar administration of L-glutamate induced hyperalgesic effect that was significantly reverted by 5 μg of PnTx4(5-5) injection in rat paw.The antinociceptive effect for PnTx4(5-5) was demonstrated against different rat pain models, i.e. induced by PGE2, carrageenan or glutamate. We suggest that the antinociceptive effect of PnTx4(5-5) may be related to an inhibitory activity on the glutamatergic system.

Carrageenan

10.1590/1678-9199-jvatitd-2019-0022

Cite

Citations (19)

Involvement of ATP-sensitive K+ channels in the peripheral antinociceptive effect induced by dipyrone

European Journal of Pharmacology (2002)

Daniela Pereira Alves Igor Dimitri Gama Duarte

Channel blocker

Tolbutamide

Tetraethylammonium

4-Aminopyridine

10.1016/s0014-2999(02)01412-7

Cite

Citations (129)

Modulation of Peripheral Inflammatory Pain Thresholds by M1 and Nicotinic Receptor Antagonists

Pharmacology (2011)

Patrícia Gonçalves da Motta Andréa C. Perez Daniela Pereira Alves Igor Dimitri Gama Duarte

The study used the paw withdrawal test to investigate the role of the cholinergic system on the modulation of inflammatory pain induced by carrageenan (Cg) at the peripheral level, through activation of muscarinic and nicotinic receptors. Intraplantar administration of the specific M1 receptor antagonist telenzepine (TEL; 6, 12 and 24 µg/paw) caused a dose-dependent reduction in the nociceptive threshold induced by Cg (125 µg/paw). This effect was not observed with increasing doses (4, 10 and 40 µg) of other specific receptor antagonists: M2 (dimethindene), M3 (4-DAMP) and M4 (tropicamide). The nicotinic antagonist mecamylamine (MEC; 25, 50 and 100 µg/paw) also caused a dose-dependent reduction in the nociceptive threshold induced by Cg (125 µg). To exclude a non-local effect, Cg (125 µg) was injected into both hind paws, while TEL (12 µg) and MEC (50 µg) were administered only in the right paw. At these doses, the muscarinic antagonists increased inflammatory pain only in the treated right paw, suggesting a peripheral effect. In the presence of prostaglandin E2 (1 µg/paw), TEL (12 µg) and MEC (50 µg) did not reduce the nociceptive threshold, suggesting that this hyperalgesic agent does not induce the release of endogenous acetylcholine. These data suggest that muscarinic M1 and nicotinic receptors participate in the modulation of endogenous cholinergic inflammatory pain at the peripheral level.

Mecamylamine

Muscarinic antagonist

Nicotinic Antagonist

10.1159/000333791

Cite

Citations (6)

Antinociceptive effect of PnTx4(5-5), a peptide from Phoneutria nigriventer spider venom, in rat models and the involvement of glutamatergic system

Figshare (2019)

Camila Franco Batista Oliveira Daniela Pereira Alves Bruna Luiza Emerich Suely G. Figueiredo Marta do Nascimento Cordeiro

ABSTRACT Background: The venom of Phoneutria nigriventer spider is a source of numerous bioactive substances, including some toxins active in insects. An example is PnTx4(5-5) that shows a high insecticidal activity and no apparent toxicity to mice, although it inhibited NMDA-evoked currents in rat hippocampal neurons. In this work the analgesic activity of PnTx4(5-5) (renamed Γ-ctenitoxin-Pn1a) was investigated. Methods: The antinociceptive activity was evaluated using the paw pressure test in rats, after hyperalgesia induction with intraplantar injection of carrageenan or prostaglandin E2 (PGE2). Results: PnTx4(5-5), subcutaneously injected, was able to reduce the hyperalgesia induced by PGE2 in rat paw, demonstrating a systemic effect. PnTx4(5-5) administered in the plantar surface of the paw caused a peripheral and dose-dependent antinociceptive effect on hyperalgesia induced by carrageenan or PGE2. The hyperalgesic effect observed in these two pain models was completely reversed with 5 µg of PnTx4(5-5). Intraplantar administration of L-glutamate induced hyperalgesic effect that was significantly reverted by 5 μg of PnTx4(5-5) injection in rat paw. Conclusion: The antinociceptive effect for PnTx4(5-5) was demonstrated against different rat pain models, i.e. induced by PGE2, carrageenan or glutamate. We suggest that the antinociceptive effect of PnTx4(5-5) may be related to an inhibitory activity on the glutamatergic system.

10.6084/m9.figshare.9599480

Cite

Citations (0)

Inflammation Mobilizes Local Resources to Control Hyperalgesia: The Role of Endogenous Opioid Peptides

Pharmacology (2012)

Daniela Pereira Alves Patrícia Gonçalves da Motta Patrícia Paiva Lima Celso Martins Queiroz‐Junior Marcelo Vidigal Caliari

The aim of the present study was to investigate the mechanisms underlying the endogenous control of nociception at a peripheral level during inflammation. Using a pharmacological approach and the rat paw pressure test, we assessed the effect of an intraplantar injection of naloxone, an opioid receptor antagonist, and bestatin, an aminopeptidase inhibitor, on hyperalgesia induced by carrageenan, which mimics an inflammatory process, or prostaglandin E2 (PGE2), which directly sensitizes nociceptors. Naloxone induced a significant and dose-dependent (25, 50 or 100 µg) increase in carrageenan-induced hyperalgesia, but not PGE2-induced hyperalgesia. Bestatin (400 µg/paw) significantly counteracted carrageenan-induced hyperalgesia, inducing an increase in the nociceptive threshold compared to control, but it did not modify hyperalgesia induced by PGE2 injection into the rat paw. Positive β-endorphin immunoreactivity was increased in paw inflammation induced by carrageenan in comparison with the control group. However, PGE2 did not significantly alter the immunostained area. These results provide evidence for activation of the endogenous opioidergic system during inflammation and indicate that this system regulates hyperalgesia through a negative feedback mechanism, modulating it at a peripheral level.

Opioidergic

Carrageenan

Endogenous opioid

Nociceptor

10.1159/000335095

Cite

Citations (16)

NO/cGMP production is important for the endogenous peripheral control of hyperalgesia during inflammation

Nitric Oxide (2012)

Daniela Pereira Alves Patrícia Gonçalves da Motta Thiago Roberto Lima Romero André Klein Igor Dimitri Gama Duarte

Zaprinast

Carrageenan