Mohsen Taghizadeh

Kashan University of Medical Sciences

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Zatollah Asemi

Kashan University of Medical Sciences

Mohammad Reza Memarzadeh

Isfahan University of Medical Sciences

Mehri Jamilian

Arak University of Medical Sciences

Fereshteh Bahmani

Kashan University of Medical Sciences

Sadegh Jafarnejad

Kashan University of Medical Sciences

Esmat Aghadavod

Kashan University of Medical Sciences

Sayyed Alireza Talaei

Kashan University of Medical Sciences

Omid Reza Tamtaji

Tehran University of Medical Sciences

Hossein Akbari

Kashan University of Medical Sciences

Mansooreh Samimi

Kashan University of Medical Sciences

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Kashan University of Medical Sciences

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Tehran University of Medical Sciences

108

New York University Press

Cambridge University Press

Shahid Beheshti University of Medical Sciences

Iran University of Medical Sciences

University of Tehran

Isfahan University of Medical Sciences

Mashhad University of Medical Sciences

Shiraz University of Medical Sciences

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The antidepressant effect of combined extracts of Hypericum perforatum and Echium amoenum supplementation in patients with depression symptoms: A randomized clinical trial.

PubMed (2023)

Akram Sadeghi Fatemeh Ghorayshi H. Baghshahi Hossein Akbari Mohammad Reza Memarzadeh

Echium amoenum and Hypericum perforatum dried flowers have been used for therapy of mental disorders in Iranian traditional medicine. In this study, we assessed the efficacy of the E. amoenum and H. perforatum extracts in patients with mild to moderate depression.In an 8-week double-blind, parallel-group trial, 51 patients randomly consumed 20 mg of fluoxetine or 350 mg of herbal medicine twice daily. The Hamilton Rating Scale for Depression (HAM-D) was used to assess depression severity in patients at weeks 0, 4, and 8.According to the Hamilton score, there were no significant differences between the fluoxetine- and herbal medicine-treated groups after 4 and 8 weeks (p>0.05). Dry mouth was the only reported side effect which was significantly lower in the herbal group (p<0.05) in weeks 2 and 4.E. amoenum and H. perforatum have anti-depressant properties similar to fluoxetine and they can be used to treat depression as an alternative to fluoxetine.

Depression

Hypericum

10.22038/ajp.2023.21707

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Citations (4)

The Wound Healing Effects of Herbal Cream Containing Oliveria Decumbens and Pelargonium Graveolens Essential Oils in Diabetic Foot Ulcer Model.

PubMed (2018)

Mohaddese Mahboubi Mohsen Taghizadeh Tahereh Khamechian Omid Reza Tamtaji R. Mokhtari

The number of diabetic patients in adult population is increasing. All this population are at risk of developing diabetic foot ulcers (DFUs) that are associated with unwanted ailments and high mortality. In spite of current therapies for DFUs, further therapies are needed to help the patients.The efficacy of herbal cream containing Pelargonium graveolens and Oliveria decombens essential oils was evaluated topically for treatment of DFUs in rat animal model in comparison with two other herbal formulas containing each essential oil alone, placebo (the basic formula without active ingredients) and normal saline as control groups. After anesthesia of diabetic rats (n=75) induced by streptozotocin (STZ), diabetic wounds were visible on the hind dorsal surface of the foot. The treatments were initiated on Day 1 and repeated 3 times a day for thirteen consecutive days. On day 1, 3, 5, 8 and 13, the wound sizes were determined and assessed histologically.Three herbal formulations reduced the size of wounds in rats with DFUs, while the cream containing combined herbals of O. decumbens and P. graveolens essential oils had the highest tissue repair in DFU rat models.Due to better wound healing effects of combined herbal cream containing O. decumbens and P. graveolens essential oils, it can be recommended in treatment of DFUs.

Diabetic foot ulcer

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Flaxseed Oil Supplementation Improve Gene Expression Levels of PPAR‐γ, LP(a), IL‐1 and TNF‐α in Type 2 Diabetic Patients with Coronary Heart Disease

Lipids (2017)

Ali Akbar Hashemzadeh Nikoo Nasoohi Fariba Raygan Esmat Aghadavod Elmira Akbari

This study was carried out to determine the effects of flaxseed oil administration on gene expression levels related to insulin, lipid and inflammation in overweight diabetic patients with coronary heart disease (CHD). This randomized double-blind, placebo-controlled trial was conducted among 60 diabetic patients with CHD. Subjects were randomly allocated into two groups to intake either 1000 mg n-3 fatty acid from flaxseed oil containing 400 mg α-Linolenic acid [ALA (18:3n-3)] (n = 30) or placebo (n = 30) twice a day for 12 weeks. Gene expression related to insulin, lipid and inflammation were quantified in peripheral blood mononuclear cells (PBMC) of diabetic patients with CHD with RT-PCR method. Results of RT-PCR demonstrated that after the 12-week intervention, compared with the placebo, flaxseed oil supplementation could up-regulate gene expression of peroxisome proliferator-activated receptor gamma (PPAR-γ) (P = 0.02) in PBMC of diabetic patients with CHD. In addition, compared with the placebo, taking flaxseed oil supplements down-regulated gene expression levels of lipoprotein(a) [LP(a)] (P = 0.001), interleukin-1 (IL-1) (P = 0.001) and tumor necrosis factor alpha (TNF-α) (P = 0.02) in PBMC of diabetic patients with CHD. We did not observe any significant effect of flaxseed oil supplementation on gene expression levels of low-density lipoprotein receptor (LDLR), IL-8 and transforming growth factor beta (TGF-β) in PBMC of diabetic patients with CHD. Overall, flaxseed oil supplementation for 12 weeks in diabetic patients with CHD significantly improved gene expression levels of PPAR-γ, LP(a), IL-1 and TNF-α, but did not influence LDLR, IL-8 and TGF-β.

Lipidology

10.1007/s11745-017-4295-5

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Citations (47)

The effects of selenium plus probiotics supplementation on glycemic status and serum lipoproteins in patients with gestational diabetes mellitus: A randomized, double-blind, placebo-controlled trial

Clinical Nutrition ESPEN (2022)

Elaheh Amirani Zatollah Asemi Mohsen Taghizadeh

Placebo-controlled study

10.1016/j.clnesp.2022.02.010

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Citations (16)

RETRACTED ARTICLE: Elevated blood pressure reduction after α-lipoic acid supplementation: a meta-analysis of randomized controlled trials

Journal of Human Hypertension (2019)

Virginia Boccardi Mohsen Taghizadeh Sina Amirjani Sadegh Jafarnejad

10.1038/s41371-019-0174-2

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Citations (3)

The Relationship between Soil Moisture and Lead on the Activity of Urease and Phosphatase Enzymes

Journal of Water and Soil Science (2020)

Akbar Forghani Amir Hossein Forghani Mohsen Taghizadeh Babak Rabiei

Soil enzyme

Lead (geology)

10.47176/jwss.24.1.3098

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The Effects of Flaxseed Oil Omega-3 Fatty Acids Supplementation on Metabolic Status of Patients with Polycystic Ovary Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial

Experimental and Clinical Endocrinology & Diabetes (2017)

Golara Mirmasoumi Mohammad Fazilati Fatemeh Foroozanfard Zahra Vahedpoor Samaneh Mahmoodi

Abstract Objective This study was conducted to evaluate the effects of flaxseed oil omega-3 fatty acids supplementation on metabolic status of patients with polycystic ovary syndrome (PCOS). Methods This randomized double-blind, placebo-controlled trial was conducted on 60 women with PCOS according to the Rotterdam criteria aged 18–40 years old. Participants were randomly assigned into two groups to receive either 1,000 mg flaxseed oil omega-3 fatty acids (n=30) or placebo (n=30) twice a day for 12 weeks. Metabolic, endocrine, inflammatory factors were quantified at baseline and after the 12-week intervention. Results After the 12-week intervention, compared to the placebo, flaxseed oil omega-3 supplementation significantly decreased insulin values (−2.6±7.7 vs.+1.3±3.9 µIU/mL, P=0.01), homeostasis model of assessment-estimated insulin resistance (−0.7±1.7 vs.+0.3±0.9, P=0.01), mF-G scores (−1.2±1.7 vs. -0.1±0.4, P=0.001), and increased quantitative insulin sensitivity check index (+0.01±0.02 vs. −0.01±0.02, P=0.01). In addition, supplementation with flaxseed oil omega-3 resulted in significant decreases in serum triglycerides (−5.1±20.9 vs.+9.7±26.1 mg/dL, P=0.01), VLDL-cholesterol (−1.0±4.2 vs.+1.9±5.2 mg/dL, P=0.01) and high-sensitivity C-reactive protein (hs-CRP) (−1.6±3.1 vs.+0.2±1.5 mg/L, P=0.004) compared to the placebo. We did not see any significant effect of flaxseed oil omega-3 supplementation on hormonal and other lipid profiles, and plasma nitric oxide levels. Conclusions Overall, flaxseed oil omega-3 supplementation for 12 weeks in women with PCOS had beneficial effects on insulin metabolism, mF-G scores, serum triglycerides, VLDL-cholesterol and hs-CRP levels, but did not affect hormonal and other lipid profiles, and plasma nitric oxide levels.

10.1055/s-0043-119751

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Citations (51)

Prevention and therapy of 1,2-dimethyl hydrazine induced colon carcinogenesis by Ferula assafoetida hydroalcoholic extract / 1,2-dimetilhidrazin ile indüklenmiş kalın bağırsak kanserlerinin Ferula assa-foetida ekstraktı kullanılarak önlenmesi ve tedavisi

Turkish Journal of Biochemistry (2015)

Fatemeh Torabi Abolfazl Dadkhah Faezeh Fatemi Salome Dini Mohsen Taghizadeh

Abstract Objective: In this study, we have evaluated the chemopreventive and chemotherapeutic effects of Ferula assa-foetida hydroalcoholic extract in 1, 2-dimethyl hydrazine (DMH) induced colon carcinogenesis. Methods: Male Wistar rats were divided into 6 groups: a negative control group without DMH; control group with injected DMH (20 mg/Kg b.w) and four groups receiving DMH +F. assa- foetida extract (6.25 and 12.5 mg/Kg b.w) as chemopreventive and chemotherapeutic groups. The effects of the extracts were assessed by estimating the hepatic oxidative stress/antioxidant parameters such as malondialdehyde, glutathione and ferric reducing ability of plasma (MDA, GSH, FRAP) and the detoxification enzymes; glutathione S-transferase and Cytochrome P 450 (GST and CYP 450 ). Moreover, the colonic β-catenin protein was examined in colon tissues followed by the histopathological analysis. Results: The results showed that the F. assa-foetida extracts markedly reversed the increased levels of CYP 450 , FRAP and β-catenin and also modulated the reduction of GST (activities and protein) and GSH levels. Histological observations of liver tissue correlated with the above biochemical findings indicating the decrease in the aberrant crypt foci (ACF) formations in the extract treated groups. Conclusion: The achieved results suggested the beneficial effect of the extracts on DMH metabolic processes in the colon indicating its chemopreventive and chemotherapeutic effects on colon carcinogenesis induced by DMH.

Malondialdehyde

10.1515/tjb-2015-0022

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Citations (4)

The effect of tablet containing Boswellia serrata and Melisa officinalis extract on older adults' memory: A randomized controlled trial

Archives of Gerontology and Geriatrics (2017)

Mohsen Taghizadeh Farzaneh Maghaminejad Mohammad Aghajani Malihe Rahmani Mohaddese Mahboubi

Wechsler Memory Scale

10.1016/j.archger.2017.12.008

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Citations (22)

The Effect of Omega-3 Fatty Acids, EPA, and/or DHA on Male Infertility: A Systematic Review and Meta-analysis

Journal of Dietary Supplements (2018)

Banafshe Hosseini Mahdieh Nourmohamadi Shima Hajipour Mohsen Taghizadeh Zatollah Asemi

The objective was to evaluate the effect of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) on sperm parameters including total sperm concentration, sperm motility, sperm DHA, and seminal plasma DHA concentration in infertile men. The literature search was conducted in PubMed, Google Scholar, and Scopus from January 1, 1990 to December 20, 2017. The systematic review and meta-analysis were based on randomized controlled trials in infertile men with DHA or EPA treatments, either alone or in combination with other micronutrients. Three studies met the inclusion criteria: 147 patients in the intervention group and 143 patients in the control group. The analysis showed that omega-3 treatments significantly increased the sperm motility (RR 5.82, 95% CI [2.91, 8.72], p <. 0001, I2 = 76%) and seminal DHA concentration (RR 1.61, 95% CI [0.15, 3.07], p =. 03, I2 = 98%). Compared with the controls, the interventions did not affect the sperm concentration (RR 0.31, 95% CI [-8.13, 8.76], p =. 94, I2 = 95%) or sperm DHA (RR 0.50, 95% CI [-4.17, 5.16], p =. 83, I2 = 99%). The observed heterogeneity may be due to administration period and dosage of omega-3 fatty acids across the studies. Funnel plot shows no evidence of publication bias. This meta-analysis indicates that supplementing infertile men with omega-3 fatty acids resulted in a significant improvement in sperm motility and concentration of DHA in seminal plasma.

Semen Analysis

10.1080/19390211.2018.1431753

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Citations (68)