Vojislav Jovanović

National University of Singapore

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Paul A. MacAry

National University of Singapore

Brendan P. Halloran

University of Alberta

Sophie Brouard

Inserm

Philip F. Halloran

University of Alberta

Jeffery M. Venner

University of Manitoba

Richard N. Fedorak

University of Alberta

T. Dujin

D.M. Kemeny

National University of Singapore

DŠ

D. Šuvakov

Kenneth G. C. Smith

Walter and Eliza Hall Institute of Medical Research

Cooperative Institutions

National University of Singapore

Inserm

Nantes Université

Centre Hospitalier Universitaire de Nantes

Institut de Transplantation Urologie en Nephrologie

Center for Research in Transplantation and Translational Immunology

University of Alberta

Centre d'Investigation Clinique de Nantes

National University Health System

Universidade Estadual Paulista (Unesp)

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[Amylase in the blood of patients with endemic podagra--contribution to the study of podagra].

PubMed (1960)

Vojislav Jovanović V. B. Atanackovic B Babic-Djivanovic

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Contents, Vol. 3, 1961

Annals of Nutrition and Metabolism (1961)

W. Halden E. Schauenstein M. Taufer H. Puchner J Parízková

10.1159/000174733

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Microarray Analysis of Crohnʼs Disease and Correlation With Traditional Clinical and Histologic Features

The American Journal of Gastroenterology (2015)

Vojislav Jovanović J. Chang Chelsea Morin Aducio Thiesen Richard N. Fedorak

Introduction: As a T cell-mediated disease of the gastrointestinal epithelium, Crohn's disease (CD) is likely to share pathogenic elements with other T cell-mediated inflammatory diseases. Recently we showed that ulcerative colitis (UC) manifested large-scale molecular disturbances that correlated with endoscopic and histologic features(IBD 20: 2353, 2014). We hypothesized that ileal CD would manifest similar disturbance. Methods: We studied 27 patients in 31 biopsies with ileal CD, characterizing the clinical, endoscopic and histological features and defined the mRNA phenotype using microarray analysis of ileal biopsies. We measured the expression of pathogenesis-based transcript sets (PBTs) previously published for ulcerative colitis representing effector T cells, macrophages, IFNG effects, and parenchymal injury-repair response and dedifferentiation (table 1). The molecular features were then correlated with conventional assessments including clinical features (modified Harvey Bradshaw index(HBI), simple endoscopic score for CD(SES-CD), c-reactive protein, albumin) and histologic features (lamina propria neutrophilic and lymphoplasmacytic infiltrate, crypt abscess, ulcers present and crypt architectural distortion). Results: CD ileal biopsies arranged by injury-repair score (IRRAT) manifested coordinate transcript changes with IFNG-induced transcripts (GRIT), macrophage transcripts (QCMAT), and injury-repair transcripts increasing while parenchymal transcripts (PT) decreased (figure 1). Lymphoplasmacytic infiltrate was significantly correlated with IRRAT (P=0.005) and negatively correlated with parenchymal transcript expression (P=0.01). Neutrophilic lamina propria infiltrate (p=0.03) and number of ulcers (p=0.03) also correlated with IRRAT. No significant correlation was seen between the molecular features and the HBI (P=0.5), SES-CD(P=0.8) or CRP (0.2).Figure 1Table 1: Pathogenesis-based transcript sets (PBTs)Conclusion: The molecular phenotype of CD manifests a large-scale coordinate disturbance similar to that in UC and other T cell-mediated diseases, reflecting changes in inflammatory cells and parenchymal elements and correlating with histologic assessment, especially the lymphoplasmacytic and neutrophilic lamina propria infiltrate, but not with the clinical and endoscopic features. This raises further questions about our clinical and endoscopic assessments of CD. Novel molecular systems for quantitating and staging the disease elements in the tissues in CD may add a significant new dimension to patient management beyond our current standards.

Lamina propria

Pathogenesis

10.14309/00000434-201510001-01924

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Anti-lipid response in Systemic Lupus Erythematosus (44.4)

The Journal of Immunology (2011)

Vojislav Jovanović Amanda Ng Ai Poh Eliza Ho Xin Pei Yan Ting Lim Nurhuda Abdul Aziz

Abstract Systemic Lupus Erythematosus (SLE) is a chronic, multisystem, autoimmune disorder with a broad range of clinical presentations. One of the main factors, proposed to contribute to the development of clinical manifestations of SLE is accumulation and impaired clearance of immune complexes. The aim of the present study was to investigate lipid and anti-lipid antibody profiles in SLE patients’ plasma using ELISA and gas chromatography-mass spectrometry (GC-MS). The SLE cohort employed in this study is composed of 24 subjects and disease monitoring was undertaken with serial BILAG disease scoring. The blood was collected at three time points: at the moment of flare; and 3-months/12-months after treatment had started. For oxysterols (7α-hydroxycholesterol, 7β-hydroxycholesterol, 7-ketocholesterol) we report a trend where lipid levels and corresponding anti-lipid IgG concentrations are significantly reduced during the course of treatment. For phospholipids (oxidized phosphatidylcholine, cardiolipin) we also show high levels of anti-lipid IgG during flare or active disease. Using GC-MS and ELISA we have confirmed an association of high lipid levels and high anti-lipid IgG level with disease flare in comparison to 12 months after the commencement of treatment. We propose that auto anti-lipid IgGs should now be considered a component of the accumulated immune complexes in SLE and thus may contribute to disease pathogenesis.

Pathogenesis

Lipid Profile

10.4049/jimmunol.186.supp.44.4

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Reﬂexiones sobre la educación en Iberoamérica

Maria Fernanda Celli de Oliveira Luci Regina Muzzeti Luz Amparo Abril Amaya Leidi Otilia Bareño Silva Raúl Pizarro Sánchez

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Methods and therapeuticals to control Varroa Jacobsoni in large apieries: Effects of Amitrase-based therapeuticals

T. Dujin Vojislav Jovanović Miloje Savic D. Šuvakov

Varroa jacobsoni

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Effect of Galofak SP-125 and Tylan premix applied in the nutrition of fattening pigs.

Snežana Živković A. Kutuzov Vojislav Jovanović

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Transplant tolerance is associated with reduced expression of cystathionine-γ-lyase that controls IL-12 production by dendritic cells and TH-1 immune responses

Blood (2012)

Romain Vuillefroy de Silly Flora Coulon Nicolas Poirier Vojislav Jovanović Sophie Brouard

Cystathionine gamma-lyase

10.1182/blood-2011-04-350546

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AKT1 leader gene and downstream targets are involved in a rat model of kidney allograft tolerance

Journal of Cellular Biochemistry (2010)

Vojislav Jovanović Luca Giacomelli Victor Sivozhelezov Nicolas Degauque David Lair

Abstract Tolerance is the so‐called “Holy Grail” of transplantation but achieving this state is proving a major challenge, particularly in the clinical settings. This tolerance state can be induced in rodent models using a variety of maneuvers. This phenomenon is classically characterized by donor specificity (recipients accept a secondary donor‐specific allograft but reject third‐party allograft) as well as by the absence of chronic rejection lesion. We previously showed that administration and anti‐donor anti‐class II serum on the day of transplantation induce tolerance to a kidney allograft in the LEW‐1W to LEW‐1A strain combination. In this study, we used DNA microarrays to compare gene patterns involved in anti‐donor anti‐class II tolerated or untreated syngeneic kidney transplants in this strain combination. Statistical and non‐statistical analyses were combined with ab initio analysis, using the recently developed leader gene approach, to shed new light on this phenomenon. Theoretical and experimental results suggest that tolerance and rejection outcome may be in large part determined by low expression variations of some genes, which can form a core gene network around specific genes such as Rac1, NFKB1, RelA, AKT1, IKBKB, BCL2, BCLX, and CHUK. Through this model, we showed that AKT1 gene, WNT pathway and NO synthesis are strictly connected to each other and may play an important role in kidney tolerance and rejection processes, with AKT1 gene being the center of this complex network of interactions. J. Cell. Biochem. 111: 709–719, 2010. © 2010 Wiley‐Liss, Inc.

10.1002/jcb.22757

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Studies on methods and therapeutic agents used to control Varroa jacobsoni in large apiaries. II. Results of a three-year study on the effect of amitraz-based preparations.

Veterinarski glasnik (1990)

T. Dujin Vojislav Jovanović Miloje Savic D. Šuvakov

Amitraz

Apiary

Varroa jacobsoni

Varroa sensitive hygiene

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