Jona Ruben Iffland

University of Giessen

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Christoph Mulert

University of Giessen

Bernd Hanewald

University of Giessen

Gebhard Sammer

University of Giessen

B. Gallhofer

University of Giessen

Denise Elfriede Liesa Lockhofen

University of Giessen

Gregor Leicht

Universität Hamburg

Benjamin Straube

Philipps University of Marburg

Winfried Rief

Philipps University of Marburg

Katrin Leinweber

Philipps University of Marburg

Marcel Linka

University of Giessen

Cooperative Institutions

University of Giessen

Philipps University of Marburg

Brain (Germany)

Giessen School of Theology

Universität Hamburg

Bielefeld University

University Medical Center Hamburg-Eppendorf

Universitätsklinikum Gießen und Marburg

Central Institute of Mental Health

Center for Psychobiology and Behavioral Medicine

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Functional connectivity in a monetary and social incentive delay task in medicated patients with schizophrenia

Frontiers in Psychiatry (2023)

Bernd Hanewald Denise Elfriede Liesa Lockhofen Gebhard Sammer Markus Stingl B. Gallhofer

Numerous studies indicate impaired reward-related learning in individuals with schizophrenia, with various factors such as illness duration, medication, disease severity, and level of analysis (behavioral or neurophysiological data) potentially confounding the results. Patients with schizophrenia who are treated with second-generation antipsychotics have been found to have a less affected reward system. However, this finding does not explain the neural dysfunctions observed in previous studies. This study aimed to address the open question of whether the less impaired reward-related behavior is associated with unimpaired task-related functional connectivity or altered task-related functional connectivity.

Reward system

10.3389/fpsyt.2023.1200860

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Top-down modulation of dichotic listening affects interhemispheric connectivity: an electroencephalography study

Frontiers in Neuroscience (2024)

Osama Elyamany Jona Ruben Iffland Denise Elfriede Liesa Lockhofen Saskia Steinmann Gregor Leicht

Dichotic listening (DL) has been extensively used as a task to investigate auditory processing and hemispheric lateralisation in humans. According to the "callosal relay model," the typical finding of a right ear advantage (REA) occurs because the information coming from the right ear has direct access to the left dominant hemisphere while the information coming from the left ear has to cross via the corpus callosum. The underlying neuroanatomical correlates and neurophysiological mechanisms have been described using diffusion tensor imaging (DTI) and lagged phase synchronization (LPS) of the interhemispheric auditory pathway. During the non-forced condition of DL, functional connectivity (LPS) of interhemispheric gamma-band coupling has been described as a relevant mechanism related to auditory perception in DL. In this study, we aimed to extend the previous results by exploring the effects of top-down modulation of DL (forced-attention condition) on interhemispheric gamma-band LPS.

Dichotic listening

Modulation (music)

10.3389/fnins.2024.1424746

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Study protocol TransTAM: Transdiagnostic research into emotional disorders and cognitive-behavioral therapy of the adaptive mind

BMC Psychiatry (2024)

Andrea Hermann Christoph Benke Carlo Blecker Benjamin de Haas Yifei He

Behavioral therapy

Depression

10.1186/s12888-024-06108-0

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S-Citalopram in neuroendocrine challenge-tests: Serotonergic responsivity in healthy male and female human participants

Psychoneuroendocrinology (2006)

Yvonne Kuepper Sandra Bausch Jona Ruben Iffland Martin Reuter Juergen Hennig

Citalopram

Serotonin reuptake inhibitor

Crossover study

10.1016/j.psyneuen.2006.09.001

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Citations (7)

Validation of the German Version of the Social Functioning Scale (SFS) for Schizophrenia

PLoS ONE (2015)

Jona Ruben Iffland Denise Elfriede Liesa Lockhofen Harald Gruppe B. Gallhofer Gebhard Sammer

Deficits in social functioning are a core symptom of schizophrenia and an important criterion for evaluating the success of treatment. However, there is little agreement regarding its measurement. A common, often cited instrument for assessing self-reported social functioning is the Social Functioning Scale (SFS). The study aimed to investigate the reliability and validity of the German translation. 101 patients suffering from schizophrenia (SZ) and 101 matched controls (C) (60 male / 41 female, 35.8 years in both groups) completed the German version. In addition, demographic, clinical, and functional data were collected. Internal consistency was investigated calculating Cronbach’s alpha for SFS full scale (α: .81) and all subscales (α: .59-.88). Significant bivariate correlation coefficients were found between all subscales as well as between all subscales and full scale (p <.01). For the total sample, principal component analysis gave evidence to prefer a single-factor solution (eigenvalue ≥ 1) accounting for 48.5 % of the variance. For the subsamples, a two-component solution (SZ; 57.0 %) and a three-component solution (C; 65.6 %) fitted best, respectively. For SZ and C, significant associations were found between SFS and external criteria. The main factor “group” emerged as being significant. C showed higher values on both subscales and full scale. The sensitivity of the SFS was examined using discriminant analysis. 86.5% of the participants could be categorized correctly to their actual group. The German translation of the SFS turned out to be a reliable and valid questionnaire comparable to the original English version. This is in line with Spanish and Norwegian translations of the SFS. Concluding, the German version of the SFS is well suited to become a useful and practicable instrument for the assessment of social functioning in both clinical practice and research. It accomplishes commonly used external assessment scales.

Discriminant validity

10.1371/journal.pone.0121807

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Study Protocol TransTAM: Transdiagnostic Research into Emotional Disorders and Cognitive-Behavioral Therapy of the Adaptive Mind

Andrea Hermann Christoph Benke Carlo Blecker Benjamin de Haas Yifei He

Background: Emotional disorders such as depression and anxiety disorders share significant similarities in their etiology and treatment. In recent decades, these commonalities have been increasingly recognized in classification systems and treatment programs crossing diagnostic boundaries. Methods: To examine the prospective effects of different transdiagnostic markers on relevant treatment outcomes, we plan to track a minimum of N = 200 patients with emotional disorders during their routine course of cognitive behavioral therapy at two German outpatient clinics. We will collect a wide range of transdiagnostic markers, ranging from basic perceptual processes and self-report measures to complex behavioral and neurobiological indicators, before entering therapy. Symptoms and psychopathological processes will be recorded before entering therapy, between the 20th and 24th therapy session, and at the end of therapy. Discussion: Our results could help to identify transdiagnostic markers with high predictive power, but also provide deeper insights into which patient groups with which symptom clusters are less likely to benefit from therapy, and for what reasons.Keywords: Therapy response, therapy outcome prediction, naturalistic outpatient sample, neurobiological markers, transdiagnostic markers, transdiagnostic symptom dimensions, longitudinal study, cognitive behavioral therapy.

Behavioral therapy

Depression

10.31219/osf.io/zwrp8

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Anticipation of Social and Monetary Rewards in Schizophrenia

Journal of Psychiatry (2017)

Bernd Hanewald Franziska Behrens Harald Gruppe Gebhard Sammer B. Gallhofer

Numerous behavioural and neuroimaging studies have explored human cognitive processing of various rewards, such as food, monetary or social stimuli. Previous studies with patients suffering from schizophrenia (SZ) used incentive delay tasks with monetary rewards. Apart from slower reaction times in general in SZ, there were no differences in task performance between patients with schizophrenia and healthy controls (HC). Patients with schizophrenia have impaired social functioning and thus may have a disturbed sensitivity to social rewards. 54 schizophrenia patients and 54 matched healthy controls completed a reward paradigm (incentive delay task) with monetary (MID) and social stimuli (SID). Reaction times and hit rates were analysed using a three-way repeated measures ANOVA. Patients demonstrated increased reaction times in both, the MID and the SID tasks compared to health controls. Hit rates for healthy controls significantly increased in the MID task, however these results were not found in the SID task with increasing reward level. In both tasks SZ improved their performance as rewards increased. The present findings suggest that patients with SZ are capable to anticipate monetary or social rewards and use this anticipation to guide their behaviour. Extrapolated to social functioning, the capability to anticipate potential reward could be used in therapeutic interventions.

Anticipation (artificial intelligence)

10.4172/2378-5756.1000410

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Citations (11)

Improving cognitive deficits in schizophrenia

International Clinical Psychopharmacology (2011)

Jona Ruben Iffland Bernd Hanewald Miriam König Heather M. Gebhardt Morten Kaletsch

The 16th Biennial Winter Workshop in Psychoses, 30 January to 2 February 2011 Innsbruck, Austria: POSTER ABSTRACTS

10.1097/01.yic.0000405948.80414.64

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Childhood Maltreatment in Individuals With Schizophrenia Spectrum Disorders: The Impact of Cut-Off Scores on Prevalence Rates

Frontiers in Psychiatry (2021)

Angelina Weitkämper Michael Kellner Jona Ruben Iffland Martin Drießen Hanna Kley

Childhood maltreatment is a common phenomenon in various psychiatric disorders. Accordingly, patients with disorders from the schizophrenia spectrum (SSD) appear to have high prevalence rates of childhood maltreatment. However, the interpretation and comparability of prevalence rates is impeded by methodological weaknesses and differences such as measures and thresholds used in previous studies. Therefore, we aimed to provide and compare systematically captured data on prevalence rates of all common types of childhood maltreatment in patients with SSD using a standardized and well-established questionnaire and the most frequently used thresholds. The sample consisted of 48 patients with a primary diagnosis of SSD. 58.3–77.1% of the sample experienced at least one type of childhood maltreatment. Prevalence rates for physical abuse, physical neglect, and emotional abuse were dependent on the thresholds used, while equal rates were found for emotional neglect and sexual abuse. Physical neglect (46–67%), and emotional abuse (44–48%) were most commonly reported, followed by emotional neglect (38%), physical abuse (25–38%), and sexual abuse (25%). Additionally, high levels of peer victimization were reported by SSD patients. It appears that childhood maltreatment is a common phenomenon in SSD, even though methodological details, especially cut-off scores, have a substantial impact on the prevalence rates that are determined. Therefore, the methodology of studies should be closely examined when drawing conclusions from presented prevalence rates.

Psychological abuse

Physical abuse

Schizophrenia Spectrum

Prevalence

10.3389/fpsyt.2021.692492

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Theta transcranial alternating current stimulation over the prefrontal cortex enhances theta power and working memory performance

Frontiers in Psychiatry (2025)

Ranjan Debnath Osama Elyamany Jona Ruben Iffland Jonas Rauh Marina Siebert

Introduction Transcranial alternating current stimulation (tACS) is a promising tool for modulating brain oscillations. This study investigated whether 5 Hz tACS could modulate neural oscillations in the prefrontal cortex and how this modulation impacts performance in working memory (WM) tasks. Method In two sessions, 28 healthy participants received 5 Hz tACS or sham stimulation over the left dorsolateral prefrontal cortex (DLPFC) while performing tasks with high and low WM loads. Resting-state EEG was recorded before and after stimulations for 5 minutes. EEG power was measured at electrodes surrounding the stimulation site. Results The results showed that tACS significantly improved reaction time (RT) compared to sham stimulation. This effect was task-specific, as tACS improved RT for hit responses only in high WM load trials, with no impact on low-load trials. Moreover, tACS significantly increased EEG power at 5 Hz and in the theta band compared to pre-stimulation levels. Discussion These findings demonstrate that tACS applied over left DLPFC modulates post-stimulation brain oscillations at the stimulation sites – known as tACS after-effects. Furthermore, the results suggest that 5 Hz tACS enhances response speed by elevating task-related activity in the prefrontal cortex to an optimal level for task performance. Conclusion In summary, the findings highlight the potential of tACS as a technique for modulating specific brain oscillations, with implications for research and therapeutic interventions.

Transcranial Direct Current Stimulation

Brain stimulation

10.3389/fpsyt.2024.1493675

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