JaeWoong Won

Chonnam National University

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Wonbong Lim

Chonnam National University

Sang Mi Jeon

Chonnam National University

Ji‐Sun Kim

Rutgers New Jersey Medical School

Okjoon Kim

Chonnam National University

Sandeep Karna

Ajou University

Yoo Duk Choi

Chonnam National University Hospital

Seo Yeon Kim

Yonsei University

SangWoo Kim

University of Oxford

Hongran Choi

Chonnam National University

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Chonnam National University

Korea Institute of Brain Science

Chonnam National University Hospital

Chosun University

Ajou University

Konkuk University

Chosun University Hospital

Orthopaedic Research

Indiana University School of Medicine

Gwangju University

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Modulation of Lipopolysaccharide‐Induced NF‐κB Signaling Pathway by 635 nm Irradiation via Heat Shock Protein 27 in Human Gingival Fibroblast Cells

Photochemistry and Photobiology (2012)

Wonbong Lim Ji‐Sun Kim SangWoo Kim Sandeep Karna JaeWoong Won

Abstract Heat shock protein‐27 ( HSP 27) is a member of the small HSP family which has been linked to the nuclear factor‐kappa B ( NF ‐ κB ) signaling pathway regulating inflammatory responses. Clinical reports have suggested that low‐level light therapy/laser irradiation ( LLLT ) could be an effective alternative treatment to relieve inflammation during bacterial infection associated with periodontal disease. However, it remains unclear how light irradiation can modulate the NF ‐ κB signaling pathway. We examined whether or not 635 nm irradiation could lead to a modulation of the NF ‐ kB signaling pathway in HSP 27‐silenced cells and analyzed the functional cross‐talk between these factors in NF ‐ κB activation. The results showed that 635 nm irradiation led to a decrease in the HSP 27 phosphorylation, reactive oxygen species ( ROS ) generation, I‐κB kinase ( IKK )/inhibitor of κB ( IκB )/ NF ‐ κB phosphorylation, NF ‐ κB p65 translocation and a subsequent decrease in the COX ‐1/2 expression and prostaglandin ( PGE 2 ) release in lipopolysaccharide( LPS )‐induced human gingival fibroblast cells ( hGFs ). However, in HSP 27‐silenced hGFs , no obvious changes were observed in ROS generation, IKK / IκB / NF ‐ κB phosphorylation, NF ‐ κB p65 translocation, nor in COX ‐1/2 expression, or PGE 2 release. This could be a mechanism by which 635 nm irradiation modulates LPS ‐induced NF ‐ κB signaling pathway via HSP 27 in inflammation. Thus, HSP 27 may play a role in regulating the anti‐inflammatory response of LLLT .

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10.1111/j.1751-1097.2012.01225.x

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