Yi Du

Beijing Friendship Hospital

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Jianfeng He

Foshan Hospital of TCM

Wenjing Luo

Anhui Normal University

Qiuming Hu

Capital Medical University

Chen Guang-sheng

Guangsheng Chen

Beijing Jiaotong University

Bo Liu

Chongqing Medical University

Dongmei Wang

University of Chinese Academy of Sciences

Min Kyu Han

Shanghai University of Traditional Chinese Medicine

Qiu-Shui Huang

First Affiliated Hospital of GuangXi Medical University

Chao Gao

Jiangsu Province Hospital

Cooperative Institutions

Capital Medical University

Guangxi Medical University

First Affiliated Hospital of GuangXi Medical University

The People's Hospital of Guangxi Zhuang Autonomous Region

Beijing Friendship Hospital

Huazhong University of Science and Technology

Shandong First Medical University

Chinese Academy of Agricultural Sciences

University of Chinese Academy of Sciences

Chengdu University of Traditional Chinese Medicine

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Effect of Continuous Ultrasonic Phacoemulsification with Anterior Chamber Maintainer on Corneal Endothelial Damage in Hard Nuclear Cataract

European Journal of Ophthalmology (2014)

Chen Guang-sheng Dongmei Wang Yi Du Hongbo Huang

To study the effects of continuous ultrasonic phacoemulsification performed with and without an anterior chamber maintainer (ACM) on corneal endothelial damage in patients with hard nuclear cataract.Sixty eyes in 60 patients with hard nuclear cataract (grade IV), one lesion per eye, were randomly allocated into 2 groups: continuous ultrasonic phacoemulsification with (group A) or without (group B) ACM. The intraoperative accumulated energy complex parameter (AECP), frequency of shallow anterior chamber, and postoperative corneal incision edema, corneal endothelial cell counts, and visual recovery were compared between the groups.The intraoperative AECP, postoperative corneal incision edema, and postoperative visual recovery showed no significant differences between the groups (p>0.05). At 1 month postoperatively, the corneal endothelial cell loss rate and hexagonal cell percentage (postoperative compared to preoperative) in groups A and B were 0.117 ± 0.12 and 9.97 ± 9.52% and 0.15 ± 0.73 and 8.5 ± 4.60%, respectively, with no significant difference noted (p>0.05). The endothelial cell mutation rate was significantly lower in group A than in group B at 6.41 ± 6.78% and 28.27 ± 27.95%, respectively (p<0.05). The frequency of intraoperative shallow anterior chamber was significantly lower in group A than in group B (2 vs 17 times, p<0.05).Continuous ultrasonic phacoemulsification with ACM is a safe, effective, simple, and easy method to treat hard nuclear cataract and causes minimal damage to corneal endothelial cells. It is an ideal surgical option and is worth popularizing.

10.5301/ejo.5000537

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Clinical differences between young and older patients with optic neuritis

Annals of Eye Science (2017)

Wenjing Luo Qiu-Shui Huang Jianfeng He Min Kyu Han Bo Liu

Background: To compare clinical features in young (18–44 years) and older patients (>44 years) with optic neuritis (ON). Methods: This is a retrospective case series study. One hundred thirty-three young cases and 51 older cases diagnosed with ON were reviewed. Results: The older patients had lower proportion of disc swelling (37.3% vs. 57.1%, P=0.016), but higher proportion of brain plaques (21.6% vs. 7.5%, P=0.007) compared with the young patients. The proportion of patients suffered from hypertension or hyperglycemia was nearly 6 times higher in the older patients than in the young patients (29.4% vs. 5.3%, P<0.001). There were no significant differences in other clinical parameters [including gender, eye pain, clinical evidence of multiple sclerosis and best corrected visual acuity (BCVA)] between the older and young patients. Conclusions: There are some distinct differences between young patients (18–44 years) and older patients (>44 years). Physicians should pay attention to the side effects of corticosteroids in elderly patients in clinical practice, although they are generally safe.

Optic neuritis

10.21037/aes.2017.10.01

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Comparison of intravitreal bevacizumab and ranibizumab used for myopic choroidal neovascularization

Medicine (2019)

Qiuming Hu Haoyu Li Yi Du Jianfeng He

To evaluate the effect of intravitreal bevacizumab (IVB) and ranibizumab (IVR) for the treatment of choroidal neovascularization (CNV) secondary to pathologic myopia (PM) by meta-analysis.Pertinent publications of randomized controlled trials (RCTs) were identified through systemic searches of PubMed, EMBASE, Web of science, Cochrane Library, clinicaltrials.gov, CNKI, CQVIP, and Wanfang database. All comparative studies of IVB or IVR as treatment for CNV secondary to pathologic myopia were included. Meta-analysis of these RCTs was performed using Review Manager 5.3 software. The χ test and I values were used to analyze heterogeneity. Measurements included best-corrected visual acuity (BCVA) and central foveal thickness (CFT).A total of 3 randomized controlled clinical trials involving 158 eyes were included, 81 eyes in IVB group and 77 eyes in IVR group. Compared with baseline, at 1, 3, 6, and 12 months after IVB or IVR treatment, BCVA was significantly increased. Change of BCVA at 1, 3, 6, and 12 months did not vary significantly between IVB and IVR group (1 month: Z = 0.30, 95% CI = -0.08 to 0.11, P = .76; 3 months: Z = 0.36, 95% CI = -0.10 to 0.15, P = .72; 6 months: Z = 0.17, 95% CI = -0.10 to 0.12, P = .86; 12 months: Z = 0.64, 95% CI = -0.15 to 0.08, P = .52).Both IVR and IVB can significantly improve BCVA of eyes with mCNV, but there was no significant difference between the 2 therapies on the treatment of mCNV.

10.1097/md.0000000000014905

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TEAS treatment improves gastrointestinal function after abdominal surgery: study protocol for a prospective randomized controlled trial

Research Square (Research Square) (2020)

Yafan Bai Chao Gao Wenjing Li Yi Du Li‐Xin An

Abstract Background : Postoperative gastrointestinal (GI) dysfunction (PGD) is a common problem after abdominal surgery. PGD can increase the length of hospital stay and the economic burden and may even lead to some serious complications. Acupuncture and moxibustion are alternative therapies recommended for PGD. However, the effect of preventive application of acupuncture or transcutaneous electrical acupuncture stimulation (TEAS) is still uncertain. The purpose of this study is to investigate the efficacy of the continuous application of TEAS on GI function recovery in patients after abdominal surgery. At the same time, we will try to confirm the mechanism of TEAS through the brain-gut axis.Methods/design : This study is a prospective, single-center, two-arm, randomized controlled trial that will be performed in a general hospital. In total, 280 patients scheduled for gastric or colorectal cancer surgery will be stratified into two groups. The experimental group will receive TEAS stimulation at Hegu (L14) and Neiguan (PC6), Zusanli (ST36), and Shangjuxu (ST37) once a day for 30 min during and after surgery until GI function recovery. The sham group will receive pseudo-TEAS at sham acupoints. The primary outcome will be the recovery time of postoperative bowel sounds, flatus, bowel movements and the changes in perioperative brain-intestinal peptides. The secondary outcome will be postoperative pain, perioperative complications, and hospitalization duration.Discussion : The results of this study will demonstrate that continuous preventive application of TEAS can improve the GI function recovery in patients undergoing abdominal surgery and that this effect may act through brain-gut peptides.Trial registration: Chinese Clinical Trial Registry, ID: ChiCTR1900023263, Registered on 11 May 2019,http://www.chictr.org.cn

Zusanli

Gastrointestinal function

Moxibustion

Colorectal Surgery

10.21203/rs.3.rs-19311/v1

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Oral versus intravenous steroid therapy for relapses in patients with multiple sclerosis: an updated meta-analysis of six randomized controlled trials

Medical Express (2017)

Wenjing Luo Min Han Chunying Wei Bo Liu Yi Du

PROPOSITO: Avaliar de forma sistematica se esteroides orais podem ser utilizados com a mesma eficacia e seguranca em comparacao com o regime intravenoso para o tratamento de recaidas da esclerose multipla (MS). METODO: Foram pesquisados Medline, Embase e Cochrane Library e sistematicamente revistos artigos comparando resultados de esteroides orais versus intravenosos para recaidas agudas em pacientes com diagnostico de esclerose multipla clinicamente definida. RESULTADOS: Seis artigos com 414 participantes no total foram analisados. Cinco dos estudos incluidos relataram a proporcao de doentes com melhoria atraves de Expanded Disability Status Scale depois de receber um ou outro tratamento: metilprednisolona oral ou intravenosa por quatro semanas. Os resultados combinados mostraram que nao houve diferenca estatisticamente significativa (OR 0,96; 95% 101 0,60, 1,54 ; p = 0,86). Tres estudos mostraram os resultados detalhados de eventos adversos, indicando que os dois tratamentos parecem ser igualmente seguros. Dois ensaios revelaram que nao havia nenhuma diferenca significativa no aumento de atividade de gadolinio via imagens por ressonância magnetica. Um estudo mostrou que a area media sob as curvas de concentracao-tempo (AUC) as 24 horas e 48 horas nao diferiram entre os grupos. CONCLUSAO: Nao foram encontradas diferencas significativas em termos de clinicos (beneficios e eventos adversos) ou nos resultados radiologicos e farmacologicos em pacientes pos-esteroides por via oral ou intravenosa no tratamento de varias recaidas de esclerose. Nossa metanalise fornece evidencias de que a terapia com esteroides por via oral nao e inferior a terapia com esteroides por via intravenosa. Assim, a administracao oral pode ser um substituto favoravel para medicacao intravenosa de recidivas da esclerose multipla.

10.5935/medicalexpress.2017.02.01

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Correlation between Sunset Glow Fundus and Initial Dosage of Corticosteroid in Patients with Vogt-Koyanagi-Harada Disease

American Journal of Ophthalmology (2009)

Yuqiang Guo Yi Du Jianfeng He

Vogt–Koyanagi–Harada disease

Choroid

Fundus (uterus)

Univariate analysis

10.1016/j.ajo.2009.02.005

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Transepithelial photorefractive keratectomy mode using SCHWIND-ESIRIS excimer laser: initial clinical results.

PubMed (2012)

Dongmei Wang Yi Du Guangsheng Chen Liu-Song Tang Jianfeng He

To evaluate postoperative pain, uncorrected visual acuity (UCVA), and cornea haze value after transepithelial photorefractive keratectomy (T-PRK) performed with aspherical ablation profile using SCHWIND ESIRIS excimer laser.Retrospective case series. Fifty-nice eyes (32 patients) with myopia associated with or without astigmatism underwent phototherapeutic keratectomy (PTK) followed by photorefractive keratectomy (PRK) which performed by Optimized Refractive Keratecomy (ORK)-CAM software based on aspherical ablation profile using SCHWIND ESIRIS excimer laser. Postoperative pain scale was measured on a questionnaire through five levels. Haze was graded by five grades, and UCVA, manifest refraction spherical equivalent (MRSE) were analyzed.Mean pain level was (1.37±0.613) (range: 1 to 3), the mean time picking out the soft contact lens was (6.22±1.73) days, at 3 months, UCVA was 1.0 for 40 eyes (67.8%), 0.5 for all eyes (100.0%). The UCVA was significantly less than the preoperative best spectacle corrected visual acuity (BSCVA) (t=-2.84, P=0.006), haze value was (0.27±0.25), no patients had a haze grade up to 2. Mean MRSE was (0.76±0.96) diopter(D) by 3 months.The outcomes from this study show that using the SCHWIND ESIRIS aspherical ablation profile for transepithelial PRK has a good visual result. The primary advantage is related to a spherical ablation profile, automatically considers the ablation volume of the stroma and the accurate and smooth removal of the epithelium with PTK. Additional studies are needed to determine long-term outcomes.

Phototherapeutic keratectomy

Excimer

10.3980/j.issn.2222-3959.2012.03.16

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Citations (23)