Alicia J. Kowaltowski

Research Field

Table (database)

10.1053/s0016-5085(06)01953-6

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Protein Disulfide Isomerase overexpression induces mitochondrial reorganization and a differentiated VSMC phenotype: role of mitofusin-2

Free Radical Biology and Medicine (2023)

João Wosniak Rafael F.G. Rodrigues Pâmela A. Kakimoto Camille C. Caldeira da Silva Fernanda Antunes

10.1016/j.freeradbiomed.2023.10.220

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Redox properties of the adenoside triphosphate‐sensitive K⁺ channel in brain mitochondria

Journal of Neuroscience Research (2008)

Maynara Fornazari Juliana G. de Paula Roger F. Castilho Alicia J. Kowaltowski

Brain mitochondrial ATP-sensitive K+ channel (mitoK(ATP)) opening by diazoxide protects against ischemic damage and excitotoxic cell death. Here we studied the redox properties of brain mitoK(ATP) . MitoK(ATP) activation during excitotoxicity in cultured cerebellar granule neurons prevented the accumulation of reactive oxygen species (ROS) and cell death. Furthermore, mitoK(ATP) activation in isolated brain mitochondria significantly prevented H2O2 release by these organelles but did not change Ca2+ accumulation capacity. Interestingly, the activity of mitoK(ATP) was highly dependent on redox state. The thiol reductant mercaptopropionylglycine prevented mitoK(ATP) activity, whereas exogenous ROS activated the channel. In addition, the use of mitochondrial substrates that led to higher levels of endogenous mitochondrial ROS release closely correlated with enhanced K+ transport activity through mitoK(ATP). Altogether, our results indicate that brain mitoK(ATP) is a redox-sensitive channel that controls mitochondrial ROS release.

Diazoxide

Excitotoxicity

Adenosine triphosphate

10.1002/jnr.21614

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Citations (52)

Modulation of mitochondrial activity in keratinocytes by uva and visible-light

Free Radical Biology and Medicine (2023)

Manuel Alejandro Herrera Lopez Camille C. Caldeira da Silva Alicia J. Kowaltowski Maurício da Silva Baptista

Modulation (music)

10.1016/j.freeradbiomed.2023.10.150

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Adiponectin Promotes Glucose-Sensitive Insulin Secretion and Prevents Beta-Cell Damage by Obesity

Free Radical Biology and Medicine (2022)

Ana Cláudia Munhoz Julian A. Serna Eliosa Vilas-Boas Camille C. Caldeira da Silva Tiago G. Santos

Paracentrotus lividus

Strongylocentrotus purpuratus

Pinctada fucata

10.1016/j.freeradbiomed.2022.10.146

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Where do we aspire to publish? A position paper on scientific communication in biochemistry and molecular biology

Brazilian Journal of Medical and Biological Research (2019)

Maurı́cio S. Baptista Maria Júlia Manso Alves Guilherme M. Arantes Hugo A. Armelin Ohára Augusto

The scientific publication landscape is changing quickly, with an enormous increase in options and models. Articles can be published in a complex variety of journals that differ in their presentation format (online-only or in-print), editorial organizations that maintain them (commercial and/or society-based), editorial handling (academic or professional editors), editorial board composition (academic or professional), payment options to cover editorial costs (open access or pay-to-read), indexation, visibility, branding, and other aspects. Additionally, online submissions of non-revised versions of manuscripts prior to seeking publication in a peer-reviewed journal (a practice known as pre-printing) are a growing trend in biological sciences. In this changing landscape, researchers in biochemistry and molecular biology must re-think their priorities in terms of scientific output dissemination. The evaluation processes and institutional funding for scientific publications should also be revised accordingly. This article presents the results of discussions within the Department of Biochemistry, University of São Paulo, on this subject.

Presentation (obstetrics)

Publication

Editorial board

Scientific Communication

Scholarly Communication

Visibility

10.1590/1414-431x20198935

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Citations (2)

Calorie restriction attenuates hypertrophy-induced redox imbalance and mitochondrial ATP-sensitive K+ channel repression

The Journal of Nutritional Biochemistry (2018)

Cícera Edna Barbosa David Aline Maria Brito Lucas Maria Thalyne Silva Araújo Beatriz Neves Coelho Juarez Braga Soares Neto