Angelo Michele Inchingolo

University of Bari Aldo Moro

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i-10 index

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Co-Authors

Francesco Inchingolo

University of Bari Aldo Moro

190

Gianna Dipalma

University of Bari Aldo Moro

182

Alessio Danilo Inchingolo

University of Bari Aldo Moro

169

Giuseppina Malcangi

University of Bari Aldo Moro

Andrea Palermo

University of Salento

Antonio Mancini

University of Bari Aldo Moro

Assunta Patano

University of Bari Aldo Moro

Ioana Roxana Bordea

Iuliu Hațieganu University of Medicine and Pharmacy

Antônio Scarano

University of Chieti-Pescara

Felice Lorusso

University of Chieti-Pescara

Cooperative Institutions

University of Bari Aldo Moro

197

University of Milan

University of Naples Federico II

University of Foggia

Sapienza University of Rome

University of Campania "Luigi Vanvitelli"

University of Chieti-Pescara

Istituti di Ricovero e Cura a Carattere Scientifico

Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico

Ospedale Pediatrico Giovanni XXIII

Author Statistics

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Paediatric dental trauma: insights from epidemiological studies and management recommendations

BMC Oral Health (2025)

Alessandra Laforgia Angelo Michele Inchingolo Francesco Inchingolo Roberta Sardano Irma Trilli

Abstract Dental trauma is common in all age groups, although, epidemiologically, it is more common in children with studies that indicate that 15% of preschoolers and 20–25% of school-age children experience it. These injuries, which frequently call for immediate attention, can affect the hard tissues and supporting components of the teeth, and, because dental damage in deciduous teeth occurs frequently and affects speech, nutrition, and oral development, it is particularly worrying. After searching three databases, Scopus, Web of Science (WoS), and PubMed, and removing duplicates, 3,630 articles were screened, and 12 publications were included in the qualitative analysis. Due to their busy lifestyles, children are particularly susceptible to oral trauma and in certain areas and lower socioeconomic groups, the incidence is higher. From little fractures in the enamel to serious dislocations and avulsions, injuries vary and must be treated promptly in order to avoid consequences and to prevent long-term issues. Furthermore, a conservative treatment strategy is recommended to preserve tooth vitality and prevent extractions. Reducing the occurrence of dental injuries requires the implementation of preventive measures including mouthguard use and educational campaigns. In summary, this review emphasizes the importance of early diagnosis, immediate management, and long-term care, by synthesizing existing knowledge on the prevalence, types, management, complications, and prevention of dental trauma in deciduous teeth. Finally, it’s important to underscore the need for continued research to refine treatment approaches.

Dental trauma

Mouthguard

Vitality

10.1186/s12903-024-05222-5

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Citations (0)

The Association Between Temporomandibular Disorders and Tinnitus: Evidence and Therapeutic Perspectives from a Systematic Review

Journal of Clinical Medicine (2025)

Gianna Dipalma Alessio Danilo Inchingolo Carmela Pezzolla Roberta Sardano Irma Trilli

Background/Objectives: Tinnitus, often described as a ringing in the ears, affects a significant portion of the population, varying in perception and severity. Methods: This systematic review investigates the correlation between tinnitus and temporomandibular joint disorders (TMDs) within a PRISMA-compliant framework, ensuring methodological transparency and rigor. Using databases, such as PubMed, Scopus, and Web of Science, we analyzed studies from the past decade to evaluate clinical and observational evidence. Results: A significant association between TMD and tinnitus was found, with somatosensory and neuroplastic mechanisms contributing to this relationship. Key therapeutic approaches identified include manual therapy and multidisciplinary treatments, demonstrating potential clinical efficacy. Conclusions: However, the available evidence remains inconsistent, emphasizing the need for further research with standardized methodologies to improve understanding and refine therapeutic strategies. This review provides a foundation for future studies aiming to enhance tinnitus management by addressing underlying TMD-related mechanisms.

10.3390/jcm14030881

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Diagnosis and Orthodontic Treatment of Obstructive Sleep Apnea Syndrome Children—A Systematic Review

Diagnostics (2024)

Kenan Ferati Arbëresha Bexheti‐Ferati Andrea Palermo Carmen Pezzolla Irma Trilli

Obstructive sleep apnea syndrome (OSAS) is a respiratory illness that is associated with recurrent episodes of either partial or full obstruction of the upper airways, or apnea, among other sleep disorders. This study aims to analyze, through a literature review, whether orthodontic treatment can be a good treatment strategy for this type of disorder. We performed a database search on Scopus, Web of Science, and Pubmed with the keywords OSA(S) and orthodontics to select the papers under evaluation. The criteria for inclusion were articles related to OSA(S) children undergoing an orthodontic treatment and clinical studies or case series, excluding systematic reviews, narrative reviews, meta-analyses, adult studies, animal models, and in vitro studies. The screening phase ended with the selection of 16 publications for this work. RME, or rapid maxillary expansion, turned out to be the preferred orthodontic treatment in cases of pediatric OSAS. The goal of this orthodontic procedure is to increase the hard palate’s transverse diameter by reopening the mid-palatal suture. Children with maxillary contraction and dental malocclusion typically undergo such a procedure and have excellent results. However, OSAS is a multifactorial disorder; it does not seem related to the morphology of the oral cavity, and therefore, it is not always possible to cope with this problem exclusively through orthodontic treatment.

Narrative review

Oral appliance

10.3390/diagnostics14030289

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Citations (7)

Guided Bone Regeneration: CGF and PRF Combined With Various Types of Scaffolds—A Systematic Review

International Journal of Dentistry (2024)

Francesco Inchingolo Angelo Michele Inchingolo G Latini Elisabetta de Ruvo Merigrazia Campanelli

Bone regeneration plays a pivotal role in modern oral surgery, particularly in facilitating successful implant-prosthetic rehabilitation. This systematic review explores the regenerative potential of growth factors, such as platelet-rich fibrin (PRF) and concentrated growth factors (CGFs), when combined with various types of scaffolds in bone augmentation procedures, including guided bone regeneration, split crest, sinus lift (SL), and alveolar ridge preservation.

10.1155/ijod/4990295

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Potential of Graphene-Functionalized Titanium Surfaces for Dental Implantology: Systematic Review

Coatings (2023)

Angelo Michele Inchingolo Giuseppina Malcangi Alessio Danilo Inchingolo Antonio Mancini Giulia Palmieri

Titanium is the most frequently employed material in implantology, because of its high degree of biocompatibility. The properties of materials are crucial for osteointegration; therefore, great effort from researchers has been devoted to improving the capabilities of titanium implant surfaces. In this context, graphene oxide represents a promising nanomaterial because of its exceptional physical and chemical qualities. Many authors in recent years have concentrated their research on the use of graphene in biomedical applications such as tissue engineering, antimicrobial materials, and implants. According to recent studies, graphene coatings may considerably increase osteogenic differentiation of bone marrow mesenchymal stem cells in vitro by the regulation of FAK/P38 signaling pathway, and can encourage the osteointegration of dental implants in vivo. However, further studies, especially on human subjects, are necessary to validate these potential applications. The aim of this work was to evaluate the effects of graphene on bone metabolism and the advantages of its use in implantology. A systematic review of literature was performed on PubMed, Web of Science and Scopus databases, and the articles investigating the role of graphene to functionalize dental implant surfaces and his interactions with the host tissue were analyzed.

Biocompatibility

10.3390/coatings13040725

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Citations (15)

Therapeutic Strategies of Primary Molar Infraocclusion: A Systematic Review

Children (2023)

Assunta Patano Angelo Michele Inchingolo Claudia Laudadio Daniela Azzollini Grazia Marinelli

Background: Infraocclusion of deciduous molars is a clinical disturbance that occurs during primary and mixed dentition and has some orthodontic implications. Infraoccluded teeth are believed to be potential sites of malocclusion, with a risk of tipping neighbouring teeth and losing space. This systematic review aims to analyse the management of primary molars infraocclusion and to provide updated guidelines. Methods: A literature search was performed using PubMed, Scopus, and Web of Science databases from 1 January 2017 to 28 November 2022. The inclusion criteria were: studies only on human subjects, open access studies, case reports, randomised trials, retrospective, observational studies, and English language. Results: A total of 372 publications were identified from the databases and a final number of nine studies were included in the review for qualitative analysis. Conclusion: Management of patients suffering from infraocclusion depends on the severity, age at diagnosis, and presence of succeeded premolars. Early diagnosis of infraoccluded primary elements is fundamental and cannot be postponed. Preservation of the primary molars may be a valid option with long-term stability if there is no or moderate primary molar infraocclusion, root resorption of less than half of the root, and no decay or restoration.

10.3390/children10030582

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Citations (12)

Coronavirus (SARS-CoV-2) Pandemic: Future Challenges for Dental Practitioners

Microorganisms (2020)

Ioana Roxana Bordea Edit Xhajanka Sebastian Candrea Simion Bran Florin Onișor

In the context of the SARS-CoV-2 (Severe acute respiratory syndrome coronavirus 2) pandemic, the medical system has been subjected to many changes. Face-to-face treatments have been suspended for a period of time. After the lockdown, dentists have to be aware of the modalities to protect themselves and their patients in order not to get infected. Dental practitioners are potentially exposed to a high degree of contamination with SARS-CoV-2 while performing dental procedures that produce aerosols. It should also be noted that the airways, namely the oral cavity and nostrils, are the access pathways for SARS-CoV-2. In order to protect themselves and their patients, they have to use full personal protective equipment. Relevant data regarding this pandemic are under evaluation and are still under test. In this article, we made a synthesis about the way in which SARS-CoV-2 spreads, how to diagnose a novel corona virus infection, what the possible treatments are, and which protective personal equipment we can use to stop its spreading.

Pandemic

Personal Protective Equipment

Face shield

Coronavirus

Modalities

2019-20 coronavirus outbreak

10.3390/microorganisms8111704

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Citations (44)

Cannabidiol for Oral Health: A New Promising Therapeutical Tool in Dentistry

Luigi Bellocchio Assunta Patano Alessio Danilo Inchingolo Francesco Inchingolo Gianna Dipalma

The medical use of Cannabis has a very long history. Although many principles are present in cannabis, called cannabinoids, Δ9tetrahydrocannabinol (Δ9-THC), cannabidiol (CBD) and can-nabinol (CBN) are the three main cannabinoids most present and described. CBD itself is not re-sponsible for psychotropic effects of cannabis since does not produce the typical behavioral effects associated to the consumption of this drug. Cannabidiol (CBD) has recently gained growing at-tention in modern society and seems to be more and more explored in dentistry. Several subjective findings suggest some therapeutic effects of CBD, which are strongly supported by research evi-dence. However, there is a plethora of data regarding CBD’s mechanism of action and therapeutic potential, which are in many cases contradictory. We will first provide an overview of scientific evidence on the molecular mechanism of CBD’s action. Furthermore, we will map the recent de-velopments regarding possible oral benefits of CBD. In summary, we will highlight CBD’s prom-ising biological features for dentistry application, despite exiting patents suggest current the compositions for oral care as the main interest for industry.

10.20944/preprints202305.0360.v1

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Citations (3)

Root Resorption during Orthodontic Treatment with Clear Aligners vs. Fixed Appliances—A Systematic Review

Applied Sciences (2024)

Francesco Inchingolo Angelo Michele Inchingolo Giulia Palmieri Chiara Di Pede Grazia Garofoli

The external apical root resorption that occurs during orthodontic treatment was the focus of this study, using either fixed appliances (FA) or clear aligners (CA). Using the Boolean keywords “APICAL ROOT RESORPTION” and “CLEAR ALIGNERS”, the study searched PubMed, Scopus, and Web of Science, with a restriction to English-language publications. A total of 50 publications were found by the computerized search, but after eliminating duplicates, completing reviews, and determining eligibility, only 9 papers could be used in the study. In conclusion, apical root resorption (ARR) is a frequent consequence of orthodontic tooth movement that mainly affects the lower incisors, which may compromise the success of the procedure and the health of the patient’s teeth. Several variables, including the type of tooth, have an impact on the severity of ARR.

10.3390/app14020690

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Citations (3)

White Spots: Prevention in Orthodontics—Systematic Review of the Literature

International Journal of Environmental Research and Public Health (2023)

Assunta Patano Giuseppina Malcangi Roberta Sardano Antonio Mastrodonato Grazia Garofoli

Early-stage dental demineralization, called white spots (WS), get their name from the characteristic colour that enamel takes on due to the acid attack of salivary cariogenic bacteria. They are often associated with fixed orthodontic therapy (FOT) and, if left untreated, evolve into caries with repercussions on oral health and dental aesthetics. This review aims to identify the most effective prophylaxis strategies to prevent WS during FOT. The search for the reviewed studies was conducted on the Pubmed, Scopus, and Web of Science databases, selecting English-only articles published in the 5 years from January 2018 to January 2023. The keywords used were "WS" and "fixed orthodontic*", using "AND" as the Boolean operator. A total of 16 studies were included for qualitative analysis. Prevention begins with maintaining proper oral hygiene; fluoride in toothpaste, mouthwashes, gels, varnishes, and sealants can be added to prophylaxis and used regularly. Using a laser in combination with fluoride helps prevent the occurrence of WS and assists in the repair processes of initial lesions. Further studies are needed to establish international guidelines for preventing WS in orthodontically treated patients.

Toothpaste

10.3390/ijerph20085608

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Citations (11)