Journal Article Plasma concentrations of sulfadoxine-pyrimethamine, mefloqine and its main metabolite after regular malaria prophylaxis for two years Get access Urban Hellgren, Urban Hellgren 1Department of Infectious Diseases, Karolinska Institute, Roslagstull Hospital, Box 5651, S-114 89 Stockholm, Sweden Search for other works by this author on: Oxford Academic PubMed Google Scholar Victor Hugo Angel, Victor Hugo Angel 2Project Basse-Naval, Bahia Malaga, Buenaventura, Colombia Search for other works by this author on: Oxford Academic PubMed Google Scholar Yngve Bergqvist, Yngve Bergqvist 3Department of Clinical Chemistry, Falun Central Hospital, Falun, Sweden Search for other works by this author on: Oxford Academic PubMed Google Scholar José Segundo Forero-Gomez, José Segundo Forero-Gomez 4Ministry of Health, Campanas Directas SEM, Bogota, Colombia Search for other works by this author on: Oxford Academic PubMed Google Scholar Lars Rombo Lars Rombo 1Department of Infectious Diseases, Karolinska Institute, Roslagstull Hospital, Box 5651, S-114 89 Stockholm, Sweden Search for other works by this author on: Oxford Academic PubMed Google Scholar Transactions of The Royal Society of Tropical Medicine and Hygiene, Volume 85, Issue 3, May-June, Pages 356–357, https://doi.org/10.1016/0035-9203(91)90287-9 Published: 01 June 1991 Article history Received: 03 January 1991 Accepted: 22 January 1991 Published: 01 June 1991
The plasma concentrations of sulfadoxine, pyrimethamine, mefloquine and its major metabolite were determined in 18 healthy male volunteers who had regularly taken either 500 mg of sulfadoxine and 25 mg of pyrimethamine (Fansidar) weekly or 250 mg mefloquine regularly every 14 d during 6 months for malaria prophylaxis. The mean trough concentrations of sulfadoxine, pyrimethamine and mefloquine were 194, 0.28 and 1.48 mumol/litre and the mean half lives were 7.7, 4.2 and 25 d respectively. The variation in area under the curve for the 3 drugs was only 2-3 fold. The findings do not indicate that drug accumulation or induction of metabolism occurred during long-term usage.
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