The aim of this study was to evaluate the intact margin after surgery regarding common method with consideration of 4 mm safe margin. Fifty patients with basal cell carcinoma operated in Tabriz Sina hospital, were chosen randomly and pathological report of these patients after surgery was evaluated with consideration of presence of intact margin. In pathologic report before operation of these patients, Basal cell carcinoma was certified. Also, brief data of these patients history was studied from present cases. Forty eight of 50 (96%) patients had intact margin after surgery and just in two patients (4%), lesion was excised insufficiently and they had involved margin. With brief study of patients' history, most of them had advanced ages and the most common site of tumor presentation was head and neck. The most of these patients had exposure with so much sun light that was accounted an important etiology. With comparison of mentioned statistical results with other reports from other countries, this rate is considered in acceptable range and surgical method is done properly in this hospital and consideration of 4 mm of tumoral margin is enough.
Our case is an 8 years old boy in whom the skin change was found a week after birth. Initially the involvement was limited to limbs but gradually it involved whole body skin. The skin manifestations are composed of hyper and hypo pigmented patch whitin each other. Pathologic finding was compatible with dyschromatosis universals hereditharia. This disease is a rare pigmentary disorder which is characterized with irregular hyper and hypo pigmented macula and patch in a reticular pattern. Skin manifestation can be limited to limbs or can be diffuse in all body skin. The lesions begin mostly several weeks after birth until 6 year of age.
The cellular mechanisms responsible for initiating or limiting the tumors including skin types are of great importance. The p53 is a tumor-inhibiting gene which is believed to be defective in many malignant situations. Ki67 is a non-histonic protein which is mainly interfere with the proliferation and has many controlling effects during the cell cycle. Because of their importance in skin tumor cell growth, this study aimed at evaluating the p53 and Ki67 expression in skin epithelial tumors by immunohistochemical method.In a descriptive setting, 50 biopsy samples (30 basal cell carcinomas (BCCs), 10 squamous cell carcinomas (SCCs), 8 keratoacanthomas (KAs), and 2 trichoepitheliomas (TEs)) were immunohistochemically evaluated for p53 and Ki67 expression during a 14-month period. The incidence and expression rate of these two variables were separately reported in each group of samples.The expression rate of p53 was 67.77% for the BCCs, 50.20% for the SCCs, and null for the KAs. For both TEs, it was 50%. The expression rate of Ki67 was 57.33% for the BCCs, 47.70% for the SCCs, 37.5% for the KAs, and 0.0% for TEs. The incidence of P53+ cells was 100% and 90% in the BCC and SCC samples, respectively. The both TEs were positive in this regard. The incidence of Ki67+ cells was 100% for the BCC, SCC, and KA samples. The both TEs were negative in this regard.This study showed that the incidence rate of p53- and Ki67-positive cells is very high in skin malignant epithelial tumors. The expression rate of these two variables is comparable with reports in the literature. Further studies with large sample size are recommended to be carried out for KA and TE samples.
Background: Although many warts are treated with usual methods, resistant cases are common problems. Bleomycin is one of the drugs used for resistant cases. The aim of this study was to compare the effect of cryotherapy and intralesional bleomycin injection combination with cryotherapy in the treatment of resistant warts. Methods: Sixty patients with resistant warts were selected and randomly divided into two groups of 30 A and B patients. In each group, cryotherapy was performed three sessions during 0, third and, sixth weeks in case of visible lesions. In group B, in addition to cryotherapy in week 0, and in the presence of visible lesions during week 3, injections of intra-lesions of bleomycin 1 mg/ml were administered. Treatment outcomes and possible complications were evaluated during the third and sixth weeks. Results: The response to the treatment was defined as poor, moderate, and well by the physician, which was 16.7%, 53.3% and, 10% in group A after 3 weeks of treatment, respectively and was 16.7%, 50% and, 33.3% in group B, respectively. The response to the treatment after 6 weeks of treatment was 33.3%, 40%, and 26.7% in group A and was 6.7%, 40%, and 53.3% in group B, respectively. Conclusion: Combined treatment of cryotherapy and intralesional bleomycin injection is more effective than cryotherapy in the treatment of resistant warts.
Background: Dermatoscopy can be applied to diagnose pigmented skin lesions. The aim of the present study was to compare dermatoscopic and histopathologic results in basal cell carcinoma (BCC) and melanocytic nevus of theface. Materials and Methods: In an analytical-descriptive study, 61 patients suspected of BCC or melanocytic nevi of face were randomly selected. The skin lesions of patients were evaluated with dermatoscopic method from February 2012 to February 2014 and results were compared with pathological features of samples. Results: In this study, mean age of patients was $49.5{\pm}18.9$. Some 25 (41%) were men and 36 (59%) were women. In 27 cases (44.3%) there was diagnosis of melanocytic nevus, in 28 cases (45.9%) diagnosis of BCC, and in 3 cases (4.9%) there was mixed diagnosis. The relationship between patients' gender and dermatoscopic diagnosis of the patients was statistically significant (P=0.001). For BCC the sensitivity and specificity of dermatoscopic method were 100% and 97% respectively and for melanocytic nevi 96.4% and 97%. Conclusions: Dermatoscopic study not only can be helpful in improving clinical diagnosis while guiding missed malignant lesions to pathologic evaluations, but also could be useful in evaluating further suspicious or recurrent cases.
Introduction: Since the emergence of COVID-19 in late 2019, multiple concerns have been raised regarding the unknown nature of the disease, including dermatologic complications. In this study, we discussed dermatologic manifestations of patients with COVID-19 infection who visited our clinic. Methods: Eighty- six patients were involved based on our inclusion and exclusion criteria (50 female and 36 male). All patients with definite diagnosis of COVID-19 who were referred to our dermatologic clinic were enrolled in this cross-sectional study. Only lesions which occurred 1 week prior to or 3 months after first COVID-19 symptoms were included. The photographs of all lesions were independently reviewed by four experienced dermatologists and an infectious disease specialist to reach the objectives stated above. Qualitative data presented as frequency (%) and compared using chi-squared or Fisher’s exact test, and quantitative data presented as mean±SD or median (IQR) based on normality, with P value≤0.05 considered statistically significant. Results: Eighty- six patients were enrolled in the study (mean±SD age=36.95±17.78). Eighteen specific types of dermatologic complications were seen. The most common lesions included maculopapular rash and scalp hair loss. The only lesions with a statistically significant difference regarding COVID-19 symptom onset time were maculopapular rash, telogen effluvium, and papular urticaria. The only lesions with statistically significant difference regarding COVID-19 severity were maculopapular rash, telogen effluvium, and urticaria. Conclusion: Our study revealed that a wide range of skin lesions may occur in patients with COVID-19. We found a statistically significant relation between disease severity and certain dermatologic manifestations.
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