Misao Yoneda

Suzuka University of Medical Science

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The SHAP-HA complex in sera from patients with rheumatoid arthritis and osteoarthritis.

PubMed (1999)

Daihei Kida Misao Yoneda S Miyaura Tomohiro Ishimaru Yuko Yoshida

To investigate serum derived hyaluronan (HA) associated protein-hyaluronan (SHAP-HA) complex in sera from patients with rheumatoid arthritis (RA) and osteoarthritis (OA) and determine levels of the complex in comparison with those of hyaluronan (HA), in order to assess the role of the complex as an indicator of joint inflammation.ELISA and HA binding assays were used for quantitation of the SHAP-HA complex and HA levels in serum samples from 142 patients (114 with RA, 28 with OA) and 31 healthy controls. Clinical evaluations were also performed.In some RA sera, SHAP-HA complex levels were extremely high compared to control levels, but in OA sera no marked increase was observed compared to controls. This was also the case with the HA levels compared between RA and OA sera. However, in RA the levels of the SHAP-HA complex appear to be more related to clinical variables than are levels of HA, and the most significant correlations between levels of SHAP-HA complex and HA were found in the RA group.Quantitation of the SHAP-HA complex in sera may be useful as a joint marker that directly correlates to the degree of joint inflammation in RA, and offers new insight into the pathogenesis of arthritis. It may also serve as an independent criterion in the subsequent classification of RA and OA.

Pathogenesis

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Citations (56)

A case of duodenal carcinoid tumor diagnosed by endoscopic ultrasonography with guided fine-needle aspiration (EUS-FNA)

The Journal of the Japanese Society of Clinical Cytology (2009)

Misao Yoneda Yuji Kozuka Hiroshi Imai Akiko SHIBAHARA Mika Kitayama

背景 : 十二指腸・膵頭部領域にカルチノイド腫瘍が認められることは比較的まれである. Endoscopic ultrasound guided fine needle aspiration (以下 EUS-FNA) 時の Diff-Quik 染色が診断に有用であったカルチノイド腫瘍を経験したので報告する.症例 : 60 歳代, 男性. 悪心, 嘔吐を主訴とし腹部超音波検査において十二指腸粘膜下・膵頭部領域に約 18 mm の円形腫瘤を認めた. 2 回の上部消化管の内視鏡検査では異常を指摘されなかった. EUS-FNA 時における Diff-Quik 染色の細胞所見では, クロマチンの増量したごましお状の核, ロゼット形成, 2 核・3 核細胞が認められ, カルチノイド腫瘍の疑いとされた. Pap 染色においても同様の所見であった. セルブロックでは, 異型細胞に核内封入体を認め, 免疫染色で CD56 陽性, synaptophysin 陽性となりカルチノイド腫瘍と確定診断した. 血中腫瘍マーカー, 内分泌ホルモンの上昇は認めなかった. 摘出標本では, 胞巣状配列を示し, 脈管浸潤, リンパ節転移, 核内封入体が認められた. 免疫染色では, セルブロックと同様に CD56 陽性, synaptophysin 陽性であった.結論 : EUS-FNA 時における Diff-Quik 染色の迅速診断は, カルチノイド腫瘍の細胞診断に有用と考えられた.

Endoscopic Ultrasound

Endoscopic ultrasonography

Synaptophysin

10.5795/jjscc.48.285

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Citations (0)

Serum ferritin and liver iron status do not correlate with severity of hepatitis C type 1b

Gastroenterology (1995)

Takafumi Kato Misao Yoneda K. Nakamura Atsushi Kimura K. Tamori

10.1016/0016-5085(95)28683-7

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Human Equilibrative Nucleoside Transporter 1 Expression in Endoscopic Ultrasonography-Guided Fine-Needle Aspiration Biopsy Samples Is a Strong Predictor of Clinical Response and Survival in the Patients With Pancreatic Ductal Adenocarcinoma Undergoing Gemcitabine-Based Chemoradiotherapy

Pancreas (2016)

Reiko Yamada Shugo Mizuno Katsunori Uchida Misao Yoneda Kazuki Kanayama

This study aimed to clarify whether pretreatment human equilibrative nucleoside transporter (hENT1) expressions in endoscopic ultrasonography-guided fine-needle aspiration biopsy (EUS-FNAB) specimens obtained from resectable, borderline resectable, and locally advanced unresectable pancreatic ductal adenocarcinoma (PDAC) are concordant with those in the resected specimen after gemcitabine-based chemoradiotherapy (Gem-CRT) and to validate the utility of hENT1 expression using EUS-FNAB samples as a prognostic marker.We evaluated the relationship between hENT1 expressions assessed by immunohistochemical staining and clinical outcomes in 51 of 76 patients with PDAC who were diagnosed by EUS-FNAB and received preoperative Gem-CRT.The concordance rate of hENT1 expressions was 89.2% (K = 0.681). Median survival time (month) in the 51 whole patients and 37 patients with resection was significantly longer in hENT1 positive than in hENT1 negative: 25.0 and 30.0 versus 9.0 and 9.0, respectively. A multivariate analysis confirmed that hENT1 expression was an independent prognostic factor in both whole patients and those with resection. Regardless of T3 and T4, hENT1-positive patients with resection had significantly better prognosis than hENT1-negative patients, whose prognosis was similar to those without resection.The assessment of hENT1 expression using EUS-FNAB samples before Gem-CRT provides important information on patients with PDAC who can benefit from curative-intent resection.

Endoscopic ultrasonography

10.1097/mpa.0000000000000597

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Citations (31)

膵EUS-FNAにおけるLiquid-based cytology(LBC法)の細胞学的検討

医学検査 (2013)

Misao Yoneda Kazuki Kanayama

Liquid-based cytology

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Basic research on countermeasures against barium sulfate aggregation using a gastric phantom

IFMBE proceedings (2017)

Kenyu Yamamoto Naoko Fujiwara Yoshihiro Takeda Rena Takakura Tetsushi Ishida

Tap water

Barium sulfate

Barium

10.1007/978-981-10-5122-7_169

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Citations (1)

Effects of Mycobacteria Major Secretion Protein, Ag85B, on Allergic Inflammation in the Lung

PLoS ONE (2014)

Yusuke Tsujimura Hiroyasu Inada Misao Yoneda Tomoyuki Fujita Keitaro Matsuo

Many epidemiological studies have suggested that the recent increase in prevalence and severity of allergic diseases such as asthma is inversely correlated with Mycobacterium bovis bacillus Calmette Guerin (BCG) vaccination. However, the underlying mechanisms by which mycobacterial components suppress allergic diseases are not yet fully understood. Here we showed the inhibitory mechanisms for development of allergic airway inflammation by using highly purified recombinant Ag85B (rAg85B), which is one of the major protein antigens secreted from M. tuberculosis. Ag85B is thought to be a single immunogenic protein that can elicit a strong Th1-type immune response in hosts infected with mycobacteria, including individuals vaccinated with BCG. Administration of rAg85B showed a strong inhibitory effect on the development of allergic airway inflammation with induction of Th1-response and IL-17and IL-22 production. Both cytokines induced by rAg85B were involved in the induction of Th17-related cytokine-production innate immune cells in the lung. Administration of neutralizing antibodies to IL-17 or IL-22 in rAg85B-treated mice revealed that IL-17 induced the infiltration of neutrophils in BAL fluid and that allergen-induced bronchial eosinophilia was inhibited by IL-22. Furthermore, enhancement of the expression of genes associated with tissue homeostasis and wound healing was observed in bronchial tissues after rAg85B administration in a Th17-related cytokine dependent manner. The results of this study provide evidence for the potential usefulness of rAg85B as a novel approach for anti-allergic effect and tissue repair other than the role as a conventional TB vaccine.

10.1371/journal.pone.0106807

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Citations (17)

Sorafenib and TRAIL have synergistic effect on hepatocellular carcinoma

International Journal of Oncology (2012)

Keiichiro Nojiri Kazushi Sugimoto Katsuya Shiraki Masahiko Tameda YUUJI INAGAKI

A multi-kinase inhibitor, sorafenib, was recently approved and is currently recommended for the treatment of advanced hepatocellular carcinoma (HCC). However, HCC treatment outcomes are still poor and necessitate improvement. Therefore, we investigated the influence of sorafenib in combination with each of cytotoxic chemotherapy agents, hypoxia or tumor necrosis factor (TNF)-related apoptosis‑inducing ligand (TRAIL), on cytotoxicity to determine which is the better adjuvant. Additive cytotoxicity of sorafenib to chemotherapy agents, hypoxia and TRAIL, to HCC cells was assessed using cell viability assay. Intracellular levels of anti-apoptotic proteins were determined using western blot analysis. Activation of Wnt/β-catenin signaling was assessed using a luciferase reporter gene assay. Sorafenib significantly and synergistically enhanced the cytotoxicity of TRAIL to HCC cells and 4',6-diamidino-2-phenylindole (DAPI) staining showed increased apoptosis among cells treated with sorafenib and TRAIL. This augmentation in cytotoxicity was derived from sorafenib-mediated downregulation of anti-apoptotic proteins. However, sorafenib did not enhance the cytotoxicity of chemotherapy agents (cisplatin, 5-FU or doxorubicin) or hypoxic treatment to HCC. Moreover, hypoxic treatment induced Wnt/β-catenin signaling activation. Our data showed that in combination TRAIL and sorafenib had a synergistic cytokilling effect on HCC cells and that this effect derived from sorafenib-mediated downregulation of anti-apoptotic proteins.

DAPI

Viability assay

10.3892/ijo.2012.1676

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Citations (15)

Characterization of liver fibrosis stage and regression in chronic hepatitis C infected patients after achieving sustained virologic response using direct-acting antivirals as demonstrated by elastography

Journal of Hepatology (2017)

Emmanuel Thomas Misao Yoneda S. Alawad E. Schiff

Transient elastography

10.1016/s0168-8278(17)30874-7

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Citations (0)

High level expression of STAG1/PMEPA1 in an androgen-independent prostate cancer PC3 subclone

Cellular & Molecular Biology Letters (2007)

Yoshifumi Hirokawa Akimitsu Takagi Katsunori Uchida Yuji Kozuka Misao Yoneda

Abstract In this paper, we describe the isolation and characterization of two PC3 subclones. One subclone, mr, showed an epithelial phenotype, the other, M1, showed a sarcomatous morphology. Transplanted into nude mice, mr developed tumors at a dramatically faster rate than M1. Comparing the two subclones, differentially expressed genes were identified, including E-cadherin, IL-8 and STAG1/PMEPA1. These genes were expressed at higher levels in mr than in M1.

10.2478/s11658-007-0009-y

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Citations (13)