Mercedes Heras

Hospital Universitari Sant Joan de Reus

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L. Masana

Institut d'Investigació Sanitària Pere Virgili

Josefa Girona

Institut d'Investigació Sanitària Pere Virgili

Núria Plana

Universidad Rovira i Virgili

Raimón Ferré

Mayo Clinic

Anna Cabré

University of Pennsylvania

Daiana Ibarretxe

Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas

Xavier Correig

Universidad Rovira i Virgili

Núria Amigó

Universidad Rovira i Virgili

Josep Ribalta

Universidad Rovira i Virgili

Jordi Merino

Novo Nordisk Foundation

Cooperative Institutions

Universidad Rovira i Virgili

117

Institut d'Investigació Sanitària Pere Virgili

108

Hospital Universitari Sant Joan de Reus

Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas

Instituto de Salud Carlos III

Centro de Investigación Biomédica en Red

Universitat de Barcelona

Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition

Consorci Institut D'Investigacions Biomediques August Pi I Sunyer

Hospital Clínic de Barcelona

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Journal of Vascular Research (2012)

Yanna Dantas Rattmann Eric Anselm Jong-Hun Kim S. Dal-Ros Cyril Auger

10.1159/000339548

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Citations (0)

Front & Back Matter

Journal of Vascular Research (2012)

Yanna Dantas Rattmann Eric Anselm Jong‐Hun Kim S. Dal-Ros Cyril Auger

10.1159/000341325

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Low-carbohydrate, high-protein, high-fat diet alters small peripheral artery reactivity in metabolic syndrome patients

Clínica e Investigación en Arteriosclerosis (2013)

Jordi Merino Richard Kones Raimón Ferré Núria Plana Josefa Girona

Quartile

10.1016/j.arteri.2013.11.004

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Citations (9)

Lipoprotein hydrophobic core lipids are partially extruded to surface in smaller HDL: “Herniated” HDL, a common feature in diabetes

Scientific Reports (2016)

Núria Amigó Roger Mallol Mercedes Heras Sergio Martínez‐Hervás Francisco Blanco‐Vaca

Abstract Recent studies have shown that pharmacological increases in HDL cholesterol concentrations do not necessarily translate into clinical benefits for patients, raising concerns about its predictive value for cardiovascular events. Here we hypothesize that the size-modulated lipid distribution within HDL particles is compromised in metabolic disorders that have abnormal HDL particle sizes, such as type 2 diabetes mellitus (DM2). By using NMR spectroscopy combined with a biochemical volumetric model we determined the size and spatial lipid distribution of HDL subclasses in a cohort of 26 controls and 29 DM2 patients before and after two drug treatments, one with niacin plus laropiprant and another with fenofibrate as an add-on to simvastatin. We further characterized the HDL surface properties using atomic force microscopy and fluorescent probes to show an abnormal lipid distribution within smaller HDL particles, a subclass particularly enriched in the DM2 patients. The reduction in the size, force cholesterol esters and triglycerides to emerge from the HDL core to the surface, making the outer surface of HDL more hydrophobic. Interestingly, pharmacological interventions had no effect on this undesired configuration, which may explain the lack of clinical benefits in DM2 subjects.

Fenofibrate

Niacin

10.1038/srep19249

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Citations (31)

Efficacy and Safety of Fosfomycin Plus Imipenem as Rescue Therapy for Complicated Bacteremia and Endocarditis Due to Methicillin-Resistant Staphylococcus aureus: A Multicenter Clinical Trial

Clinical Infectious Diseases (2014)

Ana del Río Lechuga Oriol Gasch Asunción Moreno Carmen Peña Jordi Cuquet

Background. There is an urgent need for alternative rescue therapies in invasive infections caused by methicillin-resistant Staphylococcus aureus (MRSA). We assessed the clinical efficacy and safety of the combination of fosfomycin and imipenem as rescue therapy for MRSA infective endocarditis and complicated bacteremia.

Fosfomycin

Bacteremia

Daptomycin

Combination therapy

Infective Endocarditis

10.1093/cid/ciu580

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Citations (79)

Unsaturated fatty acids and their oxidation products stimulate CD36 expression in human macrophages

Clínica e Investigación en Arteriosclerosis (2003)

Joan-Carles Vallvé K. Uliaque Josefa Girona Anna Cabré Josep Ribalta

CD36