Ishani Deshmukh

Employees State Insurance Post Graduate Institute of Medical Sciences and Research

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Mahismita Patro

All India Institute of Medical Sciences Bhubaneswar

Shweta Anand

Vellore Institute of Technology University

Sameer Vaidya

Employees State Insurance Post Graduate Institute of Medical Sciences and Research

Dipti Gothi

Employees State Insurance Post Graduate Institute of Medical Sciences and Research

Dipti Gothi

Employees State Insurance Post Graduate Institute of Medical Sciences and Research

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Employees State Insurance Post Graduate Institute of Medical Sciences and Research

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ESIC Hospital

Institute of Medical Sciences

ESI - Post Graduate Institute of Medical Science and Research

Employees' State Insurance Model Hospital

All India Institute of Medical Sciences

Era's Lucknow Medical College and Hospital

Topiwala National Medical College & BYL Nair Charitable Hospital

Vellore Institute of Technology University

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Screening Parameters for COPD-OSA Overlap Syndrome in COPD Patients: Indian Perspective

The Indian Journal of Chest Diseases and Allied Sciences (2023)

Dipti Gothi Mahismita Patro Sameer Vaidya Ishani Deshmukh

Introduction:As Indian patients have different predisposing morphological characteristics, we undertook this study to evaluate the clinical profile of overlap syndrome and compare them with COPD patients to find out the screening tools for obstructive sleep apnea (OSA) in Indian chronic obstructive pulmonary disease (COPD) patients. Aims and objectives:• To study the clinical profile of patients with overlap syndrome.• To compare them with COPD patients.• To develop screening tools for overlap syndrome in COPD. Materials and methods:A prospective case-control study was carried out in a tertiary care center.Overnight pulse oximetry was carried out for all COPD patients.Those having snoring or saw-tooth pattern on overnight oximetry were subjected to level 1 polysomnography.About 30 patients of overlap syndrome were compared with 65 COPD patients.Results: The mean age in overlap syndrome group (56.9 ± 6.86 years) was significantly lower (p < 0.01).The daytime PaO 2 and lowest nocturnal saturation were significantly lower in overlap group.PaCO 2 and forced expiratory volume at 1 second (FEV1) were significantly higher.For diagnosing overlap syndrome, the positive and the negative predictive values of snoring were 84.42 and 100%; of body mass index (BMI) ≥25 kg/m 2 were 86.67 and 98.88%; and of excessive daytime sleepiness were 37.57 and 97.86%, respectively.Conclusion: Absence of snoring and BMI <25 kg/m 2 virtually rules out overlap syndrome.The EDS has a high false-positive rate for predicting OSA.Patients having overlap syndrome have poor daytime and nocturnal oxygenation despite good lung functions.

Overlap syndrome

10.5005/jp-journals-11007-0058

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An interesting case of whitish pleural effusion: think beyond the obvious

Breathe (2022)

Shweta Anand Dipti Gothi Mahismita Patro Ishani Deshmukh

A whitish pleural fluid calls for further biochemical and microbiological investigations beyond routine pleural fluid analysis as it decides the aetiology and management.https://bit.ly/3GwGpzS

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Etiology

10.1183/20734735.0214-2021

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A follow-up study of post infectious obliterative bronchiolitis in adults and comparative analysis with chronic obstructive pulmonary disease

Lung India (2021)

Dipti Gothi Shweta Anand Mahismita Patro Sameer Vaidya Ishani Deshmukh

Objectives: The objective is (1) To evaluate the change in forced expiratory volume in one second (FEV 1 ), forced vital capacity (FVC), dyspnea grading, body mass index, and oxygen saturation (SpO 2 ) in adults with postinfectious obliterative bronchiolitis (PIOB) over a period of time (2) To evaluate the same parameters in chronic obstructive pulmonary disease (COPD) patients and compare with PIOB. Materials and Methods: It was a retrospective observational study involving appropriately managed patients of PIOB and COPD with minimum 3 years of follow-up. Out of a total of 106 patients who followed up from January 2019 to December 2019 and had a follow-up data of more than 3 years, 61 (31 COPD and 30 PIOB) patients were included in the final analysis after applying the inclusion and exclusion criteria. Results: The baseline FEV 1 and FVC was significantly worse in PIOB group compared to COPD group. In PIOB group, there was nonsignificant increment in both the parameters (FVC by 18.79 ml and FEV 1 by 12.2 ml per year). There was a significant decline in FVC and FEV 1 in the COPD group by 106.8 ml and 63.25 ml per year, respectively. There was a significant difference between PIOB and COPD for the yearly change in FVC and FEV 1 ( P value being 0.000083 and 0.000033, respectively). In PIOB group, there was increment in modified Medical Research Council (mMRC) score and nonsignificant change in SpO 2 whereas the SpO 2 and mMRC score had a yearly decline in the COPD group. Conclusion: The PIOB is characterized by a nonsignificant increase in lung function whereas COPD shows a significant progressive decline.

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Subgroup analysis

10.4103/lungindia.lungindia_95_21

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