Ma Fei

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Lili Tang

Heilongjiang Provincial Academy of Agricultural Sciences

Mingsheng Feng

Research Institute of Petroleum Exploration and Development

Qizheng Yao

China Pharmaceutical University

Jing-Bo Shi

Northwest University

Ping Guo

Weatherford College

Ping Wang

Peking University

Lixun Jiang

Xingyuan Ma

Lanzhou University

Tianwen Wang

Jiangsu Maritime Institute

Lei Shi

National Institute on Drug Abuse

Cooperative Institutions

Northeast Agricultural University

Harbin Medical University

China Pharmaceutical University

Chinese Academy of Sciences

Shaanxi University of Science and Technology

Shanghai Jiao Tong University

Huazhong University of Science and Technology

Heilongjiang Provincial Academy of Agricultural Sciences

Guangxi University

Yantai University

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Efficient Preparation of an Anti-tumor Protein TmSm by Reversible Phase Transition of ELPs and Self-cleaving Function of Intein

Zhongguo shengwu gongcheng zazhi (2013)

Lei Shi Lili Tang Xingyuan Ma Tianwen Wang Ma Fei

Intein

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Design and Synthesis of Pterin Derivares as Nitric Oxide Synthase Inhibitors

Letters in Drug Design & Discovery (2009)

Ma Fei Ping Guo Lixun Jiang Mingsheng Feng Jing-Bo Shi

In this paper, we reported the design, and synthesis of a series of novel pterin derivates i.e. 8a∼f, 9a∼f and 10a∼d. Their inhibitory activity against inducible nitric oxide synthase (iNOS) was evaluated in vitro. It was demonstrated that 4-alkoxypterin derivatives with acylation of 2-amino group showed potent inhibitory activity against iNOS, especially 8c, 8f and 10c. Keywords: Pterin, Tetrahydrobiopterin, Synthesis, Nitric oxide synthase, Inhibitive activity, In vitro

Pterin

Biopterin

10.2174/157018009789353482

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Correlation Analysis of Some Physical Chemistry Properties among Genetic Codons and Amino Acids

Ma Fei

The origin and evolution of the genetic code is a most interesting yet challenging problem for understanding life phenomena. To reveal the internal relations of the physical chemistry properties among genetic codons and amino acids,some important characters of codons molecular weight (MW), water affinity, base force and π energy, and those of amino acids with molecular weight, pI value, relative distance,no substitution and synonymous codon number were investigated.The correlations in these properties were performed using statistical analysis method. The results indicated that there are close relationships not only between the four properties of genetic codons but also between the five properties of amino acids as well as between codon properties and corresponding amino acids ones. In addition, the 20 kinds of amino acid could be classified into four groups based on four properties of codons, which may reflect the veritably corresponding relationships between codons and amino acids to some extent. Finally, the meaning of the internal relations among genetic codons and amino acids characters was discussed. It is clear that comprehending these correlations could provide unique vantage for elucidating co-evolutionary mechanisms between genetic codons and amino acids.

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