Hacer Yapıcıoğlu-Yıldızdaş

Cukurova University

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Lena Hellström‐Westas

Uppsala University

Floris Groenendaal

University Medical Center Utrecht

Erdal Taşkın

Fırat University

Neil Marlow

University College London

Ola Didrik Saugstad

University of Oslo

Achim Plum

Epigenomics (Germany)

Peter Bartmann

University Hospital Bonn

Manon J.N.L. Benders

University Medical Center Utrecht

Axel R. Franz

Friedrich Schiller University Jena

Ron Meyer

University Children's Hospital Tübingen

Cooperative Institutions

University of Toronto

KU Leuven

Hospital for Sick Children

British Columbia Children's Hospital

Mount Sinai Hospital

SickKids Foundation

Europe Hospitals

University Children's Hospital Tübingen

Brigham and Women's Hospital

University of Calgary

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Ungünstige langfristige Entwicklung auch nach moderater perinataler Azidose und milder hypoxisch-ischämischer Enzephalopathie – betroffene Kinder könnten von neuroprotektiven Interventionen und systematischer Weiterbetreuung profitieren

Zeitschrift für Geburtshilfe und Neonatologie (2023)

Axel R. Franz J Kittel Tobias Geis Britta Hüning Sebastian Prager

Hintergrund Therapeutische Hypothermie (TH) ist die einzige evidenzbasierte neuroprotektive Therapieoption bei hypoxisch-ischämischer Enzephalopathie (HIE) und sollte möglichst rasch nach Geburt begonnen werden. Betroffene Kinder müssen daher sicher und frühzeitig identifiziert werden. Die gegenwärtig verfügbaren klinischen Instrumente sind hierfür unzureichend.

10.1055/s-0043-1769207

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Two newborn babies with generalized arterial calcification of infancy, two new mutations

The Turkish Journal of Pediatrics (2016)

Hacer Yapıcıoğlu-Yıldızdaş Nazan Özbarlas Sevcan Erdem Mehmet Bertan Yılmaz Ferda Özlü

Idiopathic generalized arterial calcification of infancy-1 (GACI-1) is a rare and potentially lethal disease characterized by diffuse calcification of large and medium-sized arteries such as aorta, renal, pulmonary, cerebral and mesenteric arteries. Here we report two new mutations in two newborn babies with GACI-1 treated with bisphosphonates, and their progress in the first year of life.

Abdominal aorta

Mesenteric arteries

10.24953/turkjped.2016.04.013

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Proceedings of the 14th International Newborn Brain Conference: Other forms of brain monitoring, such as NIRS, fMRI, biochemical, etc.

Journal of Neonatal-Perinatal Medicine (2023)

Sanoj Karayil Mohammad Ali Talal Altamimi Kim V. Annink Peter Bartmann Nina Beato

10.3233/npm-239004

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Proceedings of the 13th International Newborn Brain Conference: Neuroprotection strategies in the neonate

Journal of Neonatal-Perinatal Medicine (2022)

Ayman Abou Mehrem Essa Al Awad Kim Anninck Stephanie H. Au‐Young Nesil Aydinol

BACKGROUND: Hypoxic-ischemic (HI) brain injury is one of the most common neurological problems observed in infants.Hypothermia is the only approved therapy for neonatal HI encephalopathy.This therapy is only partially protective, cannot be used in preterm infants, and has a narrow therapeutic window after birth.Therefore, additional adjunctive therapies are urgently required.IAIPs are naturally plasma-derived proteins.We have previously shown that IAIP alone reduces cortical neuronal cell death, improves behavior outcomes, and attenuates brain volume loss in neonatal HI rats (

10.3233/npm-229003

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RAPID FLUID ADMINISTRATION AND THE INCIDENCE OF HYPOTENSION INDUCED BY SPINAL ANESTHESIA AND EPHEDRINE REQUIREMENT: THE EFFECT OF CRYSTALLOID VERSUS COLLOID COLOADING.

PubMed (2015)

H. Ünlügenç Mediha Türktan Cüneyt Evrüke Murat Gündüz Refik Burgut

Spinal anesthesia for caesarean delivery is often associated with hypotension. This study was conducted to evaluate the effects of rapid crystalloid (Lactated Ringer's solution; LRS) or colloid (hydroxyethyl starch; HES) cohydration with a second intravenous access line on the incidence of hypotension and ephedrine requirement during spinal anesthesia for cesarean section.We studied 90 women with uncomplicated pregnancies undergoing elective cesarean section under spinal anesthesia. Intravenous access was established in all patients with two peripheral intravenous lines, the first being used for the baseline volume infusion. Immediately after induction of spinal anesthesia, LRS (Group L) or HES (Group C) infusions were started at the maximal possible rate via the second line in groups L and C respectively. In the third group (Group E), patients received lactated Ringer's solution at a 'keep vein open' rate to maintain the double-blind nature. The incidence of hypotension, ephedrine requirements, total amount of volume and side effects were recorded.The incidence of hypotension was significantly greater in group E than in groups L and C, and greater in group L than in group C (p < 0.03 and p < 0.01 respectively ). The total dose of ephedrine used to treat hypotension was significantly less in groups L and C than in group E (p < 0.001 and p < 0.001 respectively). Groups L and C received similar infusion volumes and doses of ephedrine.Giving either LR or HES coloading via a second IV line caused less hypotension and required less use of ephedrine compared to no coloading. There were no maternal or neonatal side effects.

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Twin reversed arterial perfusion syndrome in a monochorionic monoamniotic twin pregnancy

The Turkish Journal of Pediatrics (2017)

Hacer Yapıcıoğlu-Yıldızdaş Ümit Ece Mete Sucu Gülseren Bilen Yurdakul Hüseyin Şimşek

Twin reversed arterial perfusion syndrome is mostly seen in monochorionic diamniotic twin pregnancies with an estimated incidence of 1/9500-11000 pregnancies. One of the twins is acardiac with various abnormalities especially with upper part of the body, and mortality is 100%. The other twin functions as a pump twin and mostly has polyhydramnios and heart failure; and mortality rate is high due to prematurity and heart failure. Herein we report a TRAP syndrome and the prognosis of pump twin who was born at 30 weeks gestational age.

Polyhydramnios

Arterial perfusion

Perinatal mortality

10.24953/turkjped.2017.06.020

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Die AAMBI-Studie (Asphyxia Associated Metabolite Biomarker Investigation): Ergebnisse im Neugeborenenalter und mit 22–42 Monaten

Zeitschrift für Geburtshilfe und Neonatologie (2022)

R A Franz Hacer Yapıcıoğlu-Yıldızdaş Erdal Taşkın Aysenur Yaman Yalçın Çelik

Einleitung Klassische Parameter (pH, BE, APGAR- und Thompson-Score) sowie klinische Zeichen sind im Allgemeinen zu ungenau, um Neugeborene (NG) frühzeitig zu erkennen, die von einer neuroprotektiven Therapie profitieren könnten. Die AAMBI Studie dient der Identifikation von Metaboliten als Biomarker für eine hypoxisch-ischämische Enzephalopathie (HIE), um diese diagnostische Lücke zu schließen.

10.1055/s-0042-1748605

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Asphyxia Associated Metabolite Biomarker Investigation (AAMBI). Ergebnisse im Neugeborenenalter und mit 22-42 Monaten

Zeitschrift für Geburtshilfe und Neonatologie (2021)

Axel R. Franz Hacer Yapıcıoğlu-Yıldızdaş Erdal Taşkın Akan Yaman Yalçın Çelik

Einleitung Eine Hypothermiebehandlung (tHT) kann Folgeschäden einer perinatalen hypoxisch-ischämischen Enzephalopathie (HIE) reduzieren. Pharmakologische Therapien zur Neuroprotektion befinden sich in Erprobung. Die frühe Identifikation von Kindern, die von einer neuroprotektiven Behandlung profitieren, basierend auf klinischen Zeichen, pH, Basendefizit und APGAR-Score ist nicht ausreichend zuverlässig. Die AAMBI Studie dient der Identifikation von Metaboliten als Biomarker für eine HIE, um diese diagnostische Lücke zu schließen.

10.1055/s-0041-1739716

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