M. Yu. Kuznetsova

Research Institute of Agriculture of Crimea

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ДВ

Д. В. Прохоров

V.I. Vernadsky Crimean Federal University

ОА

О. А. Притуло

V.I. Vernadsky Crimean Federal University

ОS

О. Savchuk

Taras Shevchenko National University of Kyiv

Tetiana Halenova

Taras Shevchenko National University of Kyiv

ЛІ

Л. І. Остапченко

Taras Shevchenko National University of Kyiv

M. B. Ispiryan

Research Institute of Agriculture of Crimea

Yu. V. Sherengovskaya

V.I. Vernadsky Crimean Federal University

N E Karakursakov

Research Institute of Agriculture of Crimea

Olha Sokolova

National Academy of Medical Sciences of Ukraine

L N Gumenyuk

Research Institute of Agriculture of Crimea

Cooperative Institutions

V.I. Vernadsky Crimean Federal University

Research Institute of Agriculture of Crimea

Taras Shevchenko National University of Kyiv

Bogomolets National Medical University

National Pirogov Memorial Medical University, Vinnytsya

Odessa National Medical University

International Iberian Nanotechnology Laboratory

Pirogov Russian National Research Medical University

Kyiv National University of Technologies and Design

CPCL Polytechnic College

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Pelotherapy and pelotherapy combined with intravenous laser blood irradiation at the sanatorium-resort stage of treatment of patients with psoriasis vulgaris

Problems of Balneology Physiotherapy and Exercise Therapy (2024)

L N Gumenyuk M. Yu. Kuznetsova M. B. Ispiryan U I Basnaev N E Karakursakov

Search of new rational ways to increase the effectiveness of treatment and rehabilitation measures for patients with psoriasis vulgaris continues to be one of the urgent problems in modern clinical dermatology.

Blood irradiation therapy

10.17116/kurort202410102124

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Monitoring the epidemiological indicators of the incidence of cutaneous melanoma and the possibility of enhancing the effectiveness of its early diagnosis in the Republic of Crimea

P A Herzen Journal of Oncology (2016)

О. А. Притуло Д. В. Прохоров M. Yu. Kuznetsova

10.17116/onkolog20165440-43

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Complex application of cosmetics products of the line A “Skinormil” in the care of the skin of patients with acne

Vestnik dermatologii i venerologii (2019)

Galina A. Vintserskaya M. V. Ngema Д. В. Прохоров M. Yu. Kuznetsova Yu. V. Sherengovskaya

The article outlines the questions of pathogenesis of acne as well as clinical trial data, which indicate that the skin of patients with acne needs comprehensive care with therapeutic cosmetics. Long term use of medical cosmetics has a positive effect on the course of acne disease. The basis of the study is the use of cosmetics line A “Skinormil” including the patented complex Citobiol lRIS, zinc sulfate and vitamin A. Seventy-four patients with acne of the first, second and third severity were monitored and it was recommended them a comprehensive skin care with medical cosmetics. According to the analysis of the clinical picture, it was concluded that on the background of proper care, there is a positive dynamics in the course of acne.

Skin care

Keratolytic

Medical care

10.25208/0042-4609-2019-95-2-81-86

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Influence of natural factors Saki lake combined with “Berlition® 600” (Thioctic acidi) on immunoregulatory processes taking into account morphological changes of skin in patients with plaque psoriasis

DOAJ (DOAJ: Directory of Open Access Journals) (2017)

M. Yu. Kuznetsova О. А. Притуло Д. В. Прохоров

10.25208/0042-4609-2016-0-1-55-62

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Vestnik dermatologii i venerologii (2016)

M. Yu. Kuznetsova О. А. Притуло Д. В. Прохоров

Objective. To study the effect of peloids Saki Lake and brine, combined with the drug “Berlition® 600” on immunoregulatory processes based on morphological and functional changes of the skin in patients with plaque psoriasis. Materials and methods. The study involved 90 patients with plaque psoriasis mild to moderate severity. The study group included - 45 patients receiving therapeutic mud treatments, and the brine baths in conjunction with the “Berlition® 600” in the control group - 45 patients treated with mud baths and RPMA. All patients using flow cytometry laser defined subpopulations of T-lymphocytes. The concentration of Ig A, M and G in the blood was determined by mikroturbidimetricheskim with monospecific antisera; proinflammatory and anti-inflammatory cytokines (IL-1a, IL-2, IL-8, IL-10, TNF-α) was measured by enzyme-linked immunosorbent assay (ELISA). Immunohistochemistry Skin biopsy were studied with the definition of CD3+, CD4+, CD8+ T-lymphocytes. Results and discussion. Patients in both treatment groups revealed an imbalance of T and B-cell immunity to the reduction in the number of helper-inductor (CD4+) and cytotoxic (CD8+) subpopulations of T-L in peripheral blood and increase in CD3+, with a predominance of CD8+ in psoriatic infiltrate amid overproduction of cytokines. Procedures for medical mud and the brine baths in combination with the drug “Berlition® 600” has a marked immunomodulatory effect due normalitsatsiey of T-cell immunity and reduction of the balance of cytokine profile, “clinical cure” and “significant improvement” reached 45 (100%) patients, the index regression PASI- 96,7 ± 1,3% DLQI-86 ± 2,1%. Conclusions. Peloids, balneotherapy in Lake Saki in combination with the drug “Berlition® 600” has a high clinical efficacy due to immunomodulatory, antiproliferative and anti-inflammatory effects and can be recommended as a differentiated, immunomodulatory therapy in patients with plaque psoriasis mild to moderate severity.

Proinflammatory cytokine

Skin biopsy

10.25208/0042-4609-2016-92-1-55-62

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ISOLATION AND CHARACTERIZATION OF INSULIN RECEPTOR OF PLASMA MEMBRANES OF RAT LIVER CELLS AT MODEL OF TYPE 2 DIABETES

Biotechnologia Acta (2014)

Tetiana Halenova M. Yu. Kuznetsova О. Savchuk Л. І. Остапченко

Isolation

10.15407/biotech7.03.081

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Clinical efficacy and characteristics of immunological changes in patients with psoriasis following the combined use of sulfide peloids from Lake Saki

Russian Journal of Skin and Venereal Diseases (2020)

M. Yu. Kuznetsova О. А. Притуло I. A. Dovgan Olha Sokolova

BACKGROUND: Psoriasis is a common disease, and many of its forms are resistant to treatment. AIM: This study aimed to analyze the effects of complex treatment with Lake Saki sulfide peloids on the clinical and immunological parameters patients with psoriasis. MATERIALS AND METHODS: The study included 90 patients with steady-state psoriasis of mild or moderate severity (51 men and 39 women) aged 2365 (mean age 37.3 12.7) years, who received treatment at the N.I. Pirogov Saki Military Clinical Health Resort of the Russian Ministry of Defense. The control group consisted of 30 apparently healthy volunteers. RESULTS: Taking into account the clinical and immunological parameters of patients with mild and moderate psoriasis, we have developed a complex differentiated method of treatment using Lake Saki peloids and brine supplemented with an alpha-lipoic acid preparation. CONCLUSION: The presented complex method of peloid balneotherapy in combination with alpha-lipoic acid preparation intensifies the 14-day course of sanatorium-resort treatment, increases the duration of remission, and enhances the quality of life of patients with mild-to-moderate psoriasis.

Balneotherapy

Christian ministry

10.17816/dv48909

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Low molecular weight regulators of the intracellular insulin signal transduction as the method of correction of insulin resistance in the treatment of type 2 diabetes mellitus

Biochemistry (Moscow) Supplement Series B Biomedical Chemistry (2015)

Tetiana Halenova M. Yu. Kuznetsova О. Savchuk Л. І. Остапченко

10.1134/s1990750815020079

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Citations (1)