M. Grimaldi

Southern Research Institute

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Gennaro Schettini

Virginia Tech

Olimpia Meucci

Drexel University

Tullio Florio

University of Genoa

E. Landolfi

Detroit Medical Center

C. Ventra

University of Pavia

Antonella Scorziello

University of Naples Federico II

A Marino

Universidad Independiente

William Bourguet

Centre de Biologie Structurale

V. Delfosse

Centre de Biologie Structurale

G Magri

Policlinico S.Orsola-Malpighi

Cooperative Institutions

University of Naples Federico II

National Institutes of Health

Federico II University Hospital

Istituti di Ricovero e Cura a Carattere Scientifico

Istituto Nazionale di Fisica Nucleare, Sezione di Napoli

University of Campania "Luigi Vanvitelli"

Southern Research Institute

National Center for Advancing Translational Sciences

National Research Council

Institute for Experimental Endocrinology and Oncology

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Fipexide improvement of cognitive functions in rat: Behavioural and neurochemical studies

Pharmacological Research (1990)

A Marino Tullio Florio Olimpia Meucci E. Landolfi M. Grimaldi

Neurochemical

Sulpiride

10.1016/1043-6618(90)90714-o

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Citations (6)

Crystal structure of hERa-LBD (Y537S) in complex with butylparaben

V. Delfosse M. Grimaldi William Bourguet

Crystal (programming language)

10.2210/pdb4mg9/pdb

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Citations (0)

Case Control Study on Nutritional Risk Factors in Celiac Disease

Journal of Pediatric Gastroenterology and Nutrition (1988)

L. Greco Salvatore Auricchio M Mayer M. Grimaldi

This study explored whether risk or protective nutritional factors have a role in childhood celiac disease. The effect of bottle feeding and early introduction of gluten to the diet was evaluated in a case control study. For each case, about 10 controls were recruited: sample size was determined as required for the evaluation of the study hypothesis. Patients were significantly less breast fed than were controls. Bottle-fed children had an earlier introduction of gluten to the diet than did controls, but when early gluten introduction was analyzed across strata of breast-fed or bottle-fed children, no risk was attributed to it. Bottle feeding appeared to be a significant risk factor in children who received gluten early as well as in those who received gluten later. Breast-feeding rates for patients and controls were equal at birth, but lower for patients by the age of 1 month: from then onward, there was a constant difference between patients and controls regarding the percentage still at breast. Interruption of breast feeding was a risk factor in celiac disease, but early gluten introduction did not appear to be a similar risk factor in the present study.

10.1097/00005176-198805000-00013

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Citations (111)

Thrombin mutants with altered enzymatic activity have an impaired mitogenic effect on mouse fibroblasts and are inefficient modulators of stellation of rat cortical astrocytes

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research (1999)

Rosaria Arcone Maria Gabriella Pagliuca Alberto Chinali M. Grimaldi Gennaro Schettini

Thrombin receptor

10.1016/s0167-4889(99)00086-5

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Citations (8)

Neuroprotective Antioxidants from Marijuana^a

Annals of the New York Academy of Sciences (2000)

Aidan J. Hampson M. Grimaldi M. LOLIC David A. Wink Robert Rosenthal

Cannabidiol and other cannabinoids were examined as neuroprotectants in rat cortical neuron cultures exposed to toxic levels of the neurotransmitter, glutamate. The psychotropic cannabinoid receptor agonist delta 9-tetrahydrocannabinol (THC) and cannabidiol, (a non-psychoactive constituent of marijuana), both reduced NMDA, AMPA and kainate receptor mediated neurotoxicities. Neuroprotection was not affected by cannabinoid receptor antagonist, indicating a (cannabinoid) receptor-independent mechanism of action. Glutamate toxicity can be reduced by antioxidants. Using cyclic voltametry and a fenton reaction based system, it was demonstrated that Cannabidiol, THC and other cannabinoids are potent antioxidants. As evidence that cannabinoids can act as an antioxidants in neuronal cultures, cannabidiol was demonstrated to reduce hydroperoxide toxicity in neurons. In a head to head trial of the abilities of various antioxidants to prevent glutamate toxicity, cannabidiol was superior to both alpha-tocopherol and ascorbate in protective capacity. Recent preliminary studies in a rat model of focal cerebral ischemia suggest that cannabidiol may be at least as effective in vivo as seen in these in vitro studies.

10.1111/j.1749-6632.2000.tb06193.x

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Citations (197)

A C-terminal alpha-helix plus basic region motif is the major structural determinant of p53 tetramerization.

PubMed (1992)

H W Stürzbecher Ruth Brain Christine M. Addison K. Rudge Maido Remm

Source

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Citations (193)

Specific localization of the annexin II heterotetramer in brain lipid raft fractions and its changes in spatial learning

Journal of Neurochemistry (2004)

Weiqin Zhao David M. Waisman M. Grimaldi

Annexin-II (AII) is a Ca(2+)-dependent phospholipid-binding protein that is present in both intracellular and extracellular compartments. In the present study AII immunoreactivity was found in a subpopulation of neurons in specific brain regions, including the cerebral cortex and the surface of hippocampal pyramidal neurons from adult rats. AII from synaptic membranes was detected by immunoblotting as multiple species containing the monomer (AII36) and heterotetramer (AIIt). AIIt was resistant to beta-mercaptoethanol and dithiothreitol in sodium dodecyl sulfate-polyacrylamide gel electrophoresis, but was completely reduced to monomers (36 kDa) by two-dimensional electrophoresis. AIIt resided exclusively in the detergent-resistant lipid rafts concentrated in neuronal dendrites, and its recruitment to those structures was enhanced by antibody cross-link. AII abundantly distributed on the outer leaflet of neuronal membranes and between spaces of neurons appeared to be neuronal adhesive. The formation of AIIt required synthesis of sphingolipids and cholesterol, and its stability depended on Ca2+. Increases in neuronal activities such as depolarization and learning were shown to promote formation of AIIt. Our results suggest that, via a dynamic association with dendritic lipid rafts, AII may play a role in synaptic signal transduction and remodeling. This probably involves focal adhesion and interactions with actin that are associated with brain development and memory consolidation.

Lipid raft

Bleb (medicine)

Heterotetramer

Colocalization

10.1111/j.1471-4159.2004.02509.x

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Citations (31)

Maitotoxin‐Induced Intracellular Calcium Rise in PC 12 Cells: Involvement of Dihydropyridine‐Sensitive and ω‐Conotoxin‐Sensitive Calcium Channels and Phosphoinositide Breakdown

Journal of Neurochemistry (1992)

Olimpia Meucci M. Grimaldi Antonella Scorziello Stefano Govoni Stefania Bergamaschi

The biological activities of maitotoxin are strictly dependent on the extracellular calcium concentration and are always associated with an increase of the free cytosolic calcium level. We tested the effects of voltage-sensitive calcium channel blockers (nicardipine and omega-conotoxin) on maitotoxin-induced intracellular calcium increase, membrane depolarization, and inositol phosphate production in PC12 cells. Maitotoxin dose dependently increased the cytosolic calcium level, as measured by the fluorescent probe fura 2. This effect disappeared in a calcium-free medium; it was still observed in the absence of extracellular sodium and was enhanced by the dihydropyridine calcium agonist Bay K 8644. Nicardipine inhibited the effect of maitotoxin on intracellular calcium concentration in a dose-dependent manner. The maitotoxin-induced calcium rise was also reduced by pretreating cells with omega-conotoxin. Pretreatment of cells with maitotoxin did not modify 125I-omega-conotoxin and [3H]PN 200-110 binding to PC12 membranes. Nicardipine and omega-conotoxin inhibition of maitotoxin-evoked calcium increase was reduced by pertussis toxin pretreatment. Maitotoxin caused a substantial membrane depolarization of PC12 cells as assessed by the fluorescent dye bisoxonol. This effect was reduced by pretreating the cells with either nicardipine or omega-conotoxin and was almost completely abolished by the simultaneous pretreatment with both calcium antagonists. Maitotoxin stimulated inositol phosphate production in a dose-dependent manner. This effect was reduced by pretreating the cells with 1 microM nicardipine and was completely abolished in a calcium-free EGTA-containing medium. The findings on maitotoxin-induced cytosolic calcium rise and membrane depolarization suggest that maitotoxin exerts its action primarily through the activation of voltage-sensitive calcium channels, the increase of inositol phosphate production likely being an effect dependent on calcium influx. The ability of nicardipine and omega-conotoxin to inhibit the effect of maitotoxin on both calcium homeostasis and membrane potential suggests that L- and N-type calcium channel activation is responsible for the influx of calcium following exposure to maitotoxin, and not that a depolarization of unknown nature causes the opening of calcium channels.

Nicardipine

Fura-2

Calcium in biology

10.1111/j.1471-4159.1992.tb09422.x

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Citations (18)

Prion protein fragment 106–126-induces astroglial proliferation through the activation of l-type calcium channels

Pharmacological Research (1995)

Tullio Florio M. Grimaldi Antonella Scorziello Morena Fattore Mario Salmona

Fragment (logic)

10.1016/1043-6618(95)86763-5

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