Introduction. Diabetes mellitus as the most prevalent metabolic disease is a multifactorial disease which is influenced by environmental and genetic factors. In this systematic review, we assessed the association between genetic variants and diabetes/its complications in studies with Iranian populations. Methods. Google Scholar, PubMed, Scopus, and Persian web databases were systematically searched up to January 2014. The search terms were “gene,” “polymorphism,” “diabetes,” and “diabetic complications”; nephropathy, retinopathy, neuropathy, foot ulcer, and CAD (coronary artery diseases); and Persian equivalents. Animal studies, letters to editor, and in vitro studies were excluded. Results. Out of overall 3029 eligible articles, 88 articles were included. We found significant association between CTLA-4, IL-18, VDR, TAP2, IL-12, and CD4 genes and T1DM, HNF α and MODY, haptoglobin, paraoxonase, leptin, TCF7L2, calreticulin, ER α , PPAR- γ 2, CXCL5, calpain-10, IRS-1 and 2, GSTM1, KCNJ11, eNOS, VDR, INSR, ACE, apoA-I, apo E, adiponectin, PTPN1, CETP, AT1R, resistin, MMP-3, BChE K, AT2R, SUMO4, IL-10, VEGF, MTHFR, and GSTM1 with T2DM or its complications. Discussion. We found some controversial results due to heterogeneity in ethnicity and genetic background. We thought genome wide association studies on large number of samples will be helpful in identifying diabetes susceptible genes as an alternative to studying individual candidate genes in Iranian populations.

Candidate gene

Genome-wide Association Study

Genetic Association

TCF7L2

Resistin

10.1155/2015/585917

Cite

Citations (54)

Quality of reporting of randomized controlled trials of herbal medicines conducted in metabolic disorders in Middle East countries: A systematic review

Complementary Therapies in Medicine (2018)

Ozra Tabatabaei‐Malazy Zhaleh Shadman Hanieh‐Sadat Ejtahed Rasha Atlasi Mohammad Abdollahi

10.1016/j.ctim.2018.04.004

Cite

Citations (14)

Blood Pressure Control Among Diabetic Patients in the Eastern Mediterranean Region: A Systematic Review and Meta-Analysis

Current Diabetes Reviews (2024)

Amir Hossein Behnoush Sepehr Khosravi Fatemeh Ziamanesh Rasha Atlasi Ali Sheidaei

The control of blood pressure (BP) is a challenge in diabetic patients and is associated with adverse outcomes of diabetes. In this systematic review and metaanalysis, we investigated the BP control rate among hypertensive diabetic patients in the Eastern Mediterranean Region (EMR) countries.

Subgroup analysis

10.2174/0115733998327293240729080250

Cite

Citations (0)

Effect of adiponectin gene polymorphisms on waist circumference in patients with diabetes

Journal of Diabetes & Metabolic Disorders (2012)

Shirin Hasani‐Ranjbar Mahsa M. Amoli Ozra Tabatabaei‐Malazy Yalda Rumi Javad Tavakkoly‐Bazzaz

Abstract Background Plasma levels of adiponectin which is secreted from adipose tissue are associated with various parameters of metabolic syndrome. This effect seems to be a result of interactions between genetic and environmental factors including central obesity. The present study was carried out to investigate the possibility of relation between single nucleotide polymorphisms of adiponectin gene (+45 T/G and −11391 G/A) and waist circumferences (WC) in patients with type 2 diabetes. Methods This cross-sectional study was conducted on n = 238 diabetic patients selected as cases and n = 159 as healthy control who were recruited from Rafsanjan city in south – east of Iran. The possible association of +45 T/G and –11391 G/A adiponectin gene polymorphisms with WC according to age and sex was evaluated. Results There was no significant difference in distribution of frequencies of +45 T/G and –11391 G/A adiponectin gene polymorphisms in each group. We only found a significant association between –11391 G/A adiponectin gene polymorphism with WC in diabetic group (p = 0.021). This association was remained significant after adjustment in multivariate regression model (p = 0.019, OR: 0.244, 95%CI: 0.075-0.791) and also this effect was independent of sex and age. Conclusion We found higher abdominal obesity in GA or AA carriers of adiponectin – 11391 G/A genotype in type 2 diabetes patients independent of age and sex.

Abdominal obesity

10.1186/2251-6581-11-14

Cite

Citations (14)

Gender-specific differences in the association of adiponectin gene polymorphisms with body mass index.

PubMed (2010)

Ozra Tabatabaei‐Malazy Shirin Hasani‐Ranjbar Mahsa M. Amoli Ramin Heshmat Mohammadali Sajadi

Adiponectin gene polymorphisms are associated with obesity, metabolic syndrome and type 2 diabetes (T2D). The study evaluated possible associations of +45T/G and -11391G/A adiponectin gene polymorphisms with body mass index (BMI), waist circumferences (WC), and blood pressure in diabetic and non-diabetic Iranians.This cross-sectional study involved two groups of subjects: 243 diabetic patients and 173 non-diabetic subjects recruited from Rafsanjan city in the south-east of Iran.No significant association was found between +45T/G and -11391G/A adiponectin gene polymorphisms and systolic or diastolic blood pressure. However, male carriers of the TT genotype of +45T/G had a significantly higher mean BMI than male GG homozygotes (p = 0.018). Also, male carriers of the GG genotype of -11391G/A had significantly higher mean BMI than male GA or AA homozygotes (p = 0.041). Female carriers of the GG genotype of -11391G/A had significantly higher mean WC than female GA or AA homozygotes (p = 0.038).We observed a significantly higher BMI in women, and GA or AA carriers of -11391G/A polymorphism. Also, there was a significantly lower WC in females and GG carriers of +45T/G. These results point to a gender-specific impact of the studied genotypes on BMI and WC.

10.1900/rds.2010.7.241

Cite

Citations (37)

The national trend of the burden of Chronic Kidney Disease (CKD) in Iran from 1990 to 2019

Journal of Diabetes & Metabolic Disorders (2023)

Patricia Khashayar Yeganeh Sharifnejad Tehrani Ozra Tabatabaei‐Malazy Pouria Khashayar Sahar Saeedi Moghaddam

10.1007/s40200-023-01298-y

Cite

Citations (1)

Unraveling the link between insulin resistance and Non-alcoholic fatty liver disease (or metabolic dysfunction-associated steatotic liver disease): A Narrative Review

Journal of Diabetes & Metabolic Disorders (2023)

Fateme Ziamanesh Mehdi Mohammadi Sholeh Ebrahimpour Ozra Tabatabaei‐Malazy Asieh Mosallanejad