Luiz Max Carvalho

Fundação Getulio Vargas

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Flávio Codeço Coelho

Fundação Getulio Vargas

Leonardo Soares Bastos

Fundação Oswaldo Cruz

Andrew Rambaut

University of Edinburgh

Daniel Antunes Maciel Villela

Fundação Oswaldo Cruz

Marcelo Ferreira da Costa Gomes

Fundação Oswaldo Cruz

Raquel Martins Lana

Barcelona Supercomputing Center

Antônio Guilherme Pacheco

Fundação Oswaldo Cruz

Cláudia Torres Codeço

Fundação Oswaldo Cruz

Philippe Lemey

Rega Institute for Medical Research

Gytis Dudas

Vilnius University

Cooperative Institutions

University College London

305

University College London Hospitals NHS Foundation Trust

283

National Hospital for Neurology and Neurosurgery

277

The Francis Crick Institute

197

Fundação Oswaldo Cruz

Imperial College London

University of Oxford

Universidade de São Paulo

Universidade Federal do Rio de Janeiro

University of Cambridge

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

Phylogeography of foot-and-mouth disease virus serotype O in Ecuador

Infection Genetics and Evolution (2012)

Luiz Max Carvalho Leonardo Bacelar Lima Santos Nuno R. Faria Waldemir de Castro Silveira

10.1016/j.meegid.2012.08.016

Cite

Citations (12)

Zika is not a reason for missing the Olympic Games in Rio de Janeiro: response to the open letter of Dr Attaran and colleagues to Dr Margaret Chan, Director - General, WHO, on the Zika threat to the Olympic and Paralympic Games

Memórias do Instituto Oswaldo Cruz (2016)

Cláudia Torres Codeço Daniel Antunes Maciel Villela Marcelo Ferreira da Costa Gomes Leonardo Soares Bastos Oswaldo G. Cruz

Attaran and colleagues in an open letter to WHO expressed their concern about the upcoming Olympic and Paralympic Games in Rio de Janeiro and the threat posed by the Zika epidemic (Attaran 2016). We agree that Zika virus is of great public health concern and much remains to be known about this disease. Care should be taken to reduce the risk of infection, especially to pregnant women. However, we argue that this is not sufficient reason for changing the original plans for the Games, in particular because of the time of the year when they will take place. The present article outlines several scientific results related to Zika and mosquito-borne infectious diseases dynamics that we believe ratify the current position of WHO in not endorsing the postponing or relocation of the 2016 Olympic and Paralympic Games (WHO 2016).

Zika Virus

Relocation

Position (finance)

10.1590/0074-02760160003

Cite

Citations (19)

Virus genomes reveal the factors that spread and sustained the West African Ebola epidemic

bioRxiv (Cold Spring Harbor Laboratory) (2016)

Gytis Dudas Luiz Max Carvalho Trevor Bedford Andrew J. Tatem Guy Baele

Summary The 2013-2016 epidemic of Ebola virus disease in West Africa was of unprecedented magnitude, duration and impact. Extensive collaborative sequencing projects have produced a large collection of over 1600 Ebola virus genomes, representing over 5% of known cases, unmatched for any single human epidemic. In this comprehensive analysis of this entire dataset, we reconstruct in detail the history of migration, proliferation and decline of Ebola virus throughout the region. We test the association of geography, climate, administrative boundaries, demography and culture with viral movement among 56 administrative regions. Our results show that during the outbreak viral lineages moved according to a classic ‘gravity’ model, with more intense migration between larger and more proximate population centers. Notably, we find that despite a strong attenuation of international dispersal after border closures, localized cross-border transmission beforehand had already set the seeds for an international epidemic, rendering these measures relatively ineffective in curbing the epidemic. We use this empirical evidence to address why the epidemic did not spread into neighboring countries, showing that although these regions were susceptible to developing significant outbreaks, they were also at lower risk of viral introductions. Finally, viral genome sequence data uniquely reveals this large epidemic to be a heterogeneous and spatially dissociated collection of transmission clusters of varying size, duration and connectivity. These insights will help inform approaches to intervention in such epidemics in the future.

Pandemic

10.1101/071779

Cite

Citations (7)

Comment on “Mutation rate and genotype variation of Ebola virus from Mali case sequences”

Science (2016)

Andrew Rambaut Gytis Dudas Luiz Max Carvalho Daniel J. Park Nathan L. Yozwiak

Hoenen et al . (Reports, 3 April 2015, p. 117; published online 26 March) suggested that the Ebola virus Makona responsible for the West African epidemic evolved more slowly than previously reported. We show that this was based on corrupted data. An erratum provided a rate compatible with the initial and later, more precise, estimates but did not correctly state the nature of the error.

Variation (astronomy)

10.1126/science.aaf3823

Cite

Citations (7)

Virus genomes reveal factors that spread and sustained the Ebola epidemic

Nature (2017)

Gytis Dudas Luiz Max Carvalho Trevor Bedford Andrew J. Tatem Guy Baele

Pandemic

Ebolavirus

10.1038/nature22040

Cite

Citations (412)

Higher incidence of Zika in adult women than adult men in Rio de Janeiro suggests a significant contribution of sexual transmission from men to women

International Journal of Infectious Diseases (2016)

Flávio Codeço Coelho Betina Durovni Valéria Saraceni Cristina Lemos Cláudia Torres Codeço

Zika Virus

Sexual transmission

10.1016/j.ijid.2016.08.023

Cite

Citations (144)

RECAÍDA ATÍPICA DE MIELOMA MÚLTIPLO ASSOCIADA AO USO DE TOCILIZUMABE PARA COVID -19

Hematology Transfusion and Cell Therapy (2020)

Juliana Fraga Soares Bombonatti Luiz Max Carvalho Silvia R. Loss M.M. Langhi Abdulfeta Abdo

2019-20 coronavirus outbreak

10.1016/j.htct.2020.10.458

Cite

Citations (1)

Persistent high mortality rates for Diabetes Mellitus and Hypertension after excluding deaths associated with COVID-19 in Brazil, 2020–2022

PLOS Global Public Health (2024)

Rodrigo Moreira Leonardo Soares Bastos Luiz Max Carvalho Laís Picinini Freitas Antônio Guilherme Pacheco

Introduction The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) posed a significant public health challenge globally, with Brazil being no exception. Excess mortality during this period reached alarming levels. Cardiovascular diseases (CVD), Systemic Hypertension (HTN), and Diabetes Mellitus (DM) were associated with increased mortality. However, the specific impact of DM and HTN on mortality during the pandemic remains poorly understood. Methods This study analyzed mortality data from Brazil’s mortality system, covering the period from 2015 to 2022. Data included all causes of death as listed on death certificates, categorized by International Classification of Diseases 10th edition (ICD-10) codes. Population data were obtained from the Brazilian Census. Mortality ratios (MRs) were calculated by comparing death rates in 2020, 2021, and 2022 to the average rates from 2015 to 2019. Adjusted MRs were calculated using Poisson models. Results Between 2015 and 2022, Brazil recorded a total of 11,423,288 deaths. Death rates remained relatively stable until 2019 but experienced a sharp increase in 2020 and 2021. In 2022, although a decrease was observed, it did not return to pre-pandemic levels. This trend persisted even when analyzing records mentioning DM, HTN, or CVD. Excluding death certificates mentioning COVID-19 codes, the trends still showed increases from 2020 through 2022, though less pronounced. Conclusion This study highlights the persistent high mortality rates for DM and HTN in Brazil during the years 2020–2022, even after excluding deaths associated with COVID-19. These findings emphasize the need for continued attention to managing and preventing DM and HTN as part of public health strategies, both during and beyond the COVID-19 pandemic. There are complex interactions between these conditions and the pandemic’s impact on mortality rates.

2019-20 coronavirus outbreak

Pandemic

10.1371/journal.pgph.0002576

Cite

Citations (2)

Persistent High Mortality Rates for Diabetes Mellitus and Hypertension after Excluding Deaths Associated with COVID-19 in Brazil, 2020-2022

Rodrigo Carvalho Moreira Leonardo Soares Bastos Luiz Max Carvalho Laís Picinini Freitas Antônio Guilherme Pacheco

Background: The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) posed a significant public health challenge globally, with Brazil being no exception. Excess mortality during this period reached alarming levels. Cardiovascular diseases (CVD), Systemic Hypertension (HTN), and Diabetes Mellitus (DM) were associated with increased mortality. However, the specific impact of DM and HTN on mortality during the pandemic remains poorly understood.Methods: This study analyzed mortality data from Brazil's mortality system, covering the period from 2015 to 2022. Data included all causes of death as listed on death certificates, categorized by International Classification of Diseases 10th edition (ICD-10) codes. Population data were obtained from the Brazilian Census. Mortality ratios (MRs) were calculated by comparing death rates in 2020, 2021, and 2022 to the average rates from 2015 to 2019. Adjusted MRs were calculated using Poisson models.Results: Between 2015 and 2022, Brazil recorded a total of 11,423,288 deaths. Death rates remained relatively stable until 2019 but experienced a sharp increase in 2020 and 2021. In 2022, although a decrease was observed, it did not return to pre-pandemic levels. This trend persisted even when analyzing records mentioning DM, HTN, or CVD. Excluding death certificates mentioning COVID-19 codes, the trends still showed increases from 2020 through 2022, though less pronounced.Conclusion: This study highlights the persistent high mortality rates for DM and HTN in Brazil during the years 2020-2022, even after excluding deaths associated with COVID-19. These findings emphasize the need for continued attention to managing and preventing DM and HTN as part of public health strategies, both during and beyond the COVID-19 pandemic. There are complex interactions between these conditions and the pandemic's impact on mortality rates.Funding: This work has been partially funded by Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) and Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ).Declaration of Interest: The authors declare no conflicts of interest.

2019-20 coronavirus outbreak

10.2139/ssrn.4570476

Cite

Citations (0)

Avaliação do desenho da vigilância sentinela de síndrome gripal no Brasil

Cadernos de Saúde Pública (2024)

Laís Picinini Freitas Cláudia Torres Codeço Leonardo Soares Bastos Daniel Antunes Maciel Villela Oswaldo Gonçalves Cruz

Resumo: A vigilância sentinela de síndrome gripal atua no Brasil identificando os vírus respiratórios de importância para a saúde pública circulantes no país, e começou a ser implementada em 2000. Recentemente, a pandemia de COVID-19 reforçou a importância da detecção precoce de novos vírus em circulação no território brasileiro. Assim, se faz oportuna uma análise do desenho da vigilância sentinela de síndrome gripal. Para tal, simulamos uma rede sentinela, identificando os municípios que fariam parte da rede segundo os critérios definidos no desenho da vigilância sentinela de síndrome gripal, e, a partir dos dados de casos testados de síndrome respiratória aguda grave (SRAG) de 2014 a 2019, sorteamos amostras para cada município sentinela por semana epidemiológica. O sorteio foi repetido mil vezes, obtendo-se a mediana e intervalo quantílico de 95% (IQ95%) da positividade para cada vírus por Unidade Federativa e semana epidemiológica. Segundo os critérios do desenho da vigilância sentinela de síndrome gripal, unidades sentinelas estariam em 64 municípios, distribuídas principalmente em capitais e suas zonas metropolitanas, o que preconizou 690 amostras semanais. O desenho apresentou boa sensibilidade (total de 91,65%, considerando o IQ95%) para a detecção qualitativa dos vírus respiratórios, mesmo os de baixa circulação. Porém, houve importante incerteza na estimativa quantitativa de positividade, chegando a, pelo menos, 20% em 11,34% das estimativas. Os resultados aqui apresentados visam auxiliar a avaliação e a atualização do desenho da rede sentinela. Estratégias para reduzir a incerteza nas estimativas de positividade precisam ser avaliadas, assim como a necessidade de maior cobertura espacial.

10.1590/0102-311xpt028823

Cite

Citations (0)