Sakib K. Khalid

Shifa International Hospital

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Guadalupe García–Tsao

Yale University

Jeffrey S. Crippin

Washington University in St. Louis

Martha Shea

VA Connecticut Healthcare System

Jill A. Lane

Scripps Clinic

Abdul Wahab Yousafzai

Shifa International Hospital

Timothy A. Horwedel

Barnes-Jewish Hospital

Siddiq Anwar

Adaptive Dynamics (United States)

Michael Semyak

Jill Edwards

University of Leeds

Majesh Makan

Washington University in St. Louis

Cooperative Institutions

Washington University in St. Louis

Yale University

VA Connecticut Healthcare System

Connecticut Health Foundation

Yale New Haven Hospital

Barnes-Jewish Hospital

Pennsylvania State University

Saint Louis University

Johns Hopkins University

Johns Hopkins Medicine

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Worsening of Nose Bleeding Heralds High Cardiac Output State in Hereditary Hemorrhagic Telangiectasia

The American Journal of Medicine (2009)

Sakib K. Khalid James Pershbacher Majesh Makan Benico Barzilai Daniel M. Goodenberger

10.1016/j.amjmed.2009.01.037

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Citations (21)

Cholestatic Variants of Viral Disease and Alcohol

Humana Press eBooks (2008)

Sakib K. Khalid Jeffrey S. Crippin

Hepatitis of any etiology routinely presents with elevated transaminases. However, the presence of cholestasis should not necessarily rule out the presence of viral or alcoholic hepatitis. Hepatotropic viruses, such as hepatitis A, B, C, and E, can present with an elevated alkaline phosphatase and hyperbilirubinemia. Cytomegalovirus and Epstein-Barr virus infections may also present in this manner. Alcoholic hepatitis, often defined by an AST/ALT ratio of 2–3:1, can have cholestatic characteristics, as well. A careful clinical history, viral serologies, and, in some cases, a liver biopsy can clarify these disease states.

Viral Hepatitis

Alcoholic Hepatitis

Etiology

Cytomegalovirus

Liver disease

10.1007/978-1-59745-118-5_7

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Citations (5)

Comparison of hepatitis C (HCV) treatment patterns in patients with and without mental illness (MI) and/or substance abuse (SA)

Gastroenterology (2003)

Siwaporn Chainuvati Sakib K. Khalid Susan Kancir Martha Shea Jill Edwards

Hepatitis C

Substance abuse treatment

10.1016/s0016-5085(03)83945-8

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Citations (0)

Impaired 6 Minute Walk Distance Predicts Poor Graft Survival in Kidney Transplant Patients.

Transplantation (2014)

Siddiq Anwar Muhammad Aleem Ashraf Syed Rizvi Sakib K. Khalid Rowena Delos Santos

Background: Impaired physical performance as assessed by 6-minute walk distance (6MWD) has been shown to be associated with all-cause mortality in various chronic illnesses. In lung and liver transplantation there is significant relationship between baseline 6MWD and survival among patients who are on the wait-list which extends through transplantation.Methods: Patients who are unable to walk 1000 ft (˜1/10 of a mile) in 6-minutes are generally excluded as transplant candidates at our center. We compared renal transplant recipients (RTR) who were transplanted between 2002-10 with 6MWD less than 1000 feet (Group A) who had physical limitations precluding walking or other positive indicators leading to their listing to the rest of transplant cohort transplanted in the same time frame (Group B). Results: There were 39 patients in Group A, and they were older and more likely to be white and male compared to Group B. There was no difference in rates of deceased donor allograft rates in the two groups. The rate of graft loss and death at 1 year was similar between groups at year 1, however, in a univariate analysis (Cox proportional hazards) graft-loss at any time point, the hazard ratio (HR) for cumulative graft loss was 2.031 (95% CI 1.046-3.947). In the multivariate analysis including age, sex, and race, 6MWD <1000 was associated with a HR for graft loss of 2.160 (1.100-4.241).Table: No Caption available.Figure: No Caption available.Discussion: 6MWD is a practical and inexpensive test to measure functional status and has been validated as a predictor of morbidity/mortality in other solid organ transplant groups. In our series 6MWD <1000 ft appears to predict early graft loss in RTR, and > 1000 ft is a good predictor of long-term survival. Despite the fact that RTR with lower 6MWD likely had other positive prognostic indicators for graft survival, a low 6MWD was a strong predictor of graft loss.

10.1097/00007890-201407151-02143

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Citations (3)

POSTPARTUM PSYCHIATRIC DISORDERS - A NEGLECTED AREA IN PAKISTAN

Journal of Ayub Medical College Abbottabad (2024)

Abdul Wahab Yousafzai Sakib K. Khalid

Postpartum psychiatric disorders, from mild Postpartum Blues to severe Depression and Psychosis, represent an underrepresented crisis in Pakistan. Despite their impact on maternal and neonatal health, these conditions are often misdiagnosed and untreated. Contributing factors include weak familial support, sociocultural stigma, and lack of awareness, especially in underserved areas. The negligence towards new mothers highlights the gaps in maternal mental health care in Pakistan, where regulatory frameworks are still evolving. This editorial explores the crisis, critiques existing services, and provides recommendations to improve early identification and intervention, aiming to raise awareness and provide strong support for affected mothers.

Stigma

Social stigma

Depression

10.55519/jamc-03-13873

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Citations (0)

Use of Over-the-Counter Analgesics Is Not Associated With Acute Decompensation in Patients With Cirrhosis

Clinical Gastroenterology and Hepatology (2009)

Sakib K. Khalid Jill A. Lane Victor J. Navarro Guadalupe García–Tsao

Decompensation

Acetaminophen

10.1016/j.cgh.2009.04.015

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Citations (50)

Sexual dysfunction and treatment compliance among patients taking antipsychotic medications at psychiatry unit in Muhimbili National Hospital, Dar es salaam, Tanzania

Sakib K. Khalid

Dar es salaam

Source

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Hepatic Vascular Malformations in Hereditary Hemorrhagic Telangiectasia

Seminars in Liver Disease (2008)

Sakib K. Khalid Guadalupe García–Tsao

Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant vascular disorder that can involve the liver diffusely in the form of vascular malformations ranging from small telangiectases to discrete arteriovenous malformations. Anatomically, three different patterns of abnormal vascular communications can occur in liver: portal vein to hepatic vein (portovenous), hepatic artery to hepatic vein (arteriovenous) and hepatic artery to portal vein (arterioportal), with the most common being arteriovenous. Only 5 to 8% of patients with these vascular malformations are symptomatic. When symptomatic, patients present with high-output cardiac failure, biliary ischemia (which, when severe, can progress to biliary and hepatic necrosis and lead to acute liver failure), or portal hypertension. Other less common presentations include portosystemic encephalopathy and abdominal angina. Diagnosis is confirmed by Doppler ultrasonography or multidetector computed tomography. The hallmark findings are intrahepatic hypervascularization and an enlarged common hepatic artery. Focal nodular hyperplasia and nodular regenerative hyperplasia are common findings. Symptomatic patients are treated with intensive medical treatment aimed at the predominant clinical presentation. Patients who fail aggressive medical therapy and those with acute biliary/hepatic necrosis should be considered for liver transplantation.

Nodular regenerative hyperplasia

Common hepatic artery

Portal vein thrombosis

Telangiectases

10.1055/s-0028-1085093

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Citations (79)

Management of Hepatitis C in the Setting of Liver Transplantation

Clinics in Liver Disease (2006)

Sakib K. Khalid Jeffrey S. Crippin

10.1016/j.cld.2006.05.008

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Citations (4)