Bo Qian

Chinese Academy of Sciences

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Hanmin Huang

University of Science and Technology of China

Chungu Xia

Lanzhou Institute of Chemical Physics

Hongli Bao

Fujian Institute of Research on the Structure of Matter

Yinjun Xie

Chinese Academy of Sciences

Lei Yang

Chengdu University

Shengmei Guo

Nanchang University

Pan Xie

Shaanxi University of Science and Technology

Hanmin Huang

Yong‐Min Liang

Lanzhou University

Qiming Zhu

Nanning Normal University

Cooperative Institutions

Chinese Academy of Sciences

Lanzhou Institute of Chemical Physics

University of Chinese Academy of Sciences

Fujian Institute of Research on the Structure of Matter

Lanzhou University

Lanzhou City University

University of Science and Technology of China

Fuzhou University

State Key Laboratory of Structural Chemistry

Zhejiang University

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Iron‐Catalyzed Decarboxylative Alkyl Etherification of Vinylarenes with Aliphatic Acids as the Alkyl Source

Angewandte Chemie (2017)

Wujun Jian Liang Ge Yihang Jiao Bo Qian Hongli Bao

Abstract Because of the lack of effective alkylating reagents, alkyl etherification of olefins with general alkyl groups has not been previously reported. In this work, a variety of alkyl diacyl peroxides and peresters generated from aliphatic acids have been found to enable the first iron‐catalyzed alkyl etherification of olefins with general alkyl groups. Primary, secondary and tertiary aliphatic acids are suitable for this reaction, delivering products with yields up to 97 %. Primary and secondary alcohols react well, affording products in up to 91 % yield.

Primary (astronomy)

Beta-Hydride elimination

10.1002/ange.201612365

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Citations (29)

CCDC 781008: Experimental Crystal Structure Determination

The Cambridge Structural Database (2010)

Bo Qian Shengmei Guo Jianping Shao Qiming Zhu Yang Lei

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

10.5517/ccv6ptj

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ChemInform Abstract: Palladium-Catalyzed Benzylic Addition of 2-Methyl Azaarenes to N-Sulfonyl Aldimines via C-H Bond Activation.

ChemInform (2010)

Bo Qian Shengmei Guo Jianping Shao Qiming Zhu Lei Yang

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

Aldimine

Sulfonyl

10.1002/chin.201031155

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CCDC 1834773: Experimental Crystal Structure Determination

The Cambridge Structural Database (2018)

Jiawen Li Bo Qian Hanmin Huang

Crystal (programming language)

10.5517/ccdc.csd.cc1zl771

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Synergic Extraction of Lanthanide Ions by Bis-(1′-Phenyl-3′-methyl-5′-Pyrazol one-4′-yl)Ethanedione and Phenanthroline

Chinese Journal of Applied Chemistry (1996)

Anyun Zhang Bo Qian Gailing Gao Jing Pei Zichun Wang

Phenanthroline

10.3724/j.issn.1000-0518.1996.3.9092

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Chiral Brønsted Acid Directed Iron‐Catalyzed Enantioselective Friedel–Crafts Alkylation of Indoles with β‐Aryl α′‐Hydroxy Enones

Chemistry - A European Journal (2009)

Lei Yang Qiming Zhu Shengmei Guo Bo Qian Chungu Xia

A cooperative catalytic system established by the combination of an iron salt and a chiral Brønsted acid has proven to be effective in the asymmetric Friedel-Crafts alkylation of indoles with beta-aryl alpha'-hydroxy enones. Good to excellent yields and enatioselectivities were observed for a variety of alpha'-hydroxy enones and indoles, particularly for the beta-aryl alpha'-hydroxy enones bearing an electron-withdrawing group at the para position of the phenyl ring (up to 90 % yield and 91 % ee). The proton of the chiral Brønsted acid, the Lewis acid activation site, as well as the inherent basic site for the hydrogen-bonding interaction of the Brønsted acid are responsible for the high catalytic activities and enantioselectivities of the title reaction. A possible reaction mechanism was proposed. The key catalytic species in the catalytic system, the phosphate salt of Fe(III), which was thought to be responsible for the high activity and good enantioselectivity, was then confirmed by ESIMS studies.

Friedel–Crafts reaction

Brønsted–Lowry acid–base theory

10.1002/chem.200902705

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Citations (86)

Stereoselective synthesis of trans β-lactams via palladium/N-heterocyclic carbene-catalyzed carbonylative [2+2] cycloaddition

Tetrahedron Letters (2012)

Pan Xie Bo Qian Hanmin Huang Chungu Xia

Carbonylation

Lactam

Cleavage (geology)

10.1016/j.tetlet.2012.01.073

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Citations (28)

CCDC 803584: Experimental Crystal Structure Determination

The Cambridge Structural Database (2011)

Yinjun Xie Yingwei Zhao Bo Qian Lei Yang Chungu Xia

10.5517/ccvz622

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ChemInform Abstract: Iron‐Catalyzed Alkenylation of Isochroman Acetals with Simple Alkenes.

ChemInform (2015)

Bo Qian Cuifang Qiao Yinjun Xie Hanmin Huang

Abstract Iron(III) p‐toluenesulfonate is found to be an efficient and inexpensive catalyst for the nucleophilic addition of alkenes to 1‐methoxyisochromans under redox‐neutral conditions.

10.1002/chin.201522185

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Iron-Catalyzed Carboamination of Olefins: Synthesis of Amines and Disubstituted β-Amino Acids

Journal of the American Chemical Society (2017)

Bo Qian Shaowei Chen Ting Wang Xinhao Zhang Hongli Bao

Intermolecular carboamination of olefins with general alkyl groups is an unsolved problem. Diastereoselective carboamination of acyclic olefins represents an additional challenge in intermolecular carboaminations. We have developed a general alkylamination of vinylarenes and the unprecedented diastereoselective anti-carboamination of unsaturated esters, generating amines and unnatural β-amino acids. This alkylamination is enabled by difunctional alkylating reagents and the iron catalyst. Alkyl diacyl peroxides, readily synthesized from aliphatic acids, serve as both alkylating reagents and internal oxidizing agents. A computational study suggests that addition of a nitrile to the carbocation is the diastereoselectivity-determining step, and hyperconjugation is proposed to account for the highly diastereoselective anti-carboamination.

Oxidizing agent

10.1021/jacs.7b06590

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Citations (144)