Lillian G. Matthews

Murdoch Children's Research Institute

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Peter J. Anderson

Murdoch Children's Research Institute

Deanne K. Thompson

Murdoch Children's Research Institute

Lex W. Doyle

University of Melbourne

Jeanie L.Y. Cheong

University of Melbourne

Terrie E. Inder

Children's Hospital of Orange County

Claire E. Kelly

Murdoch Children's Research Institute

Bonnie Alexander

Murdoch Children's Research Institute

Marc L. Seal

Murdoch Children's Research Institute

Alicia J. Spittle

University of Melbourne

Richard Beare

Monash University

Cooperative Institutions

Health and Human Development (2HD) Research Network

RELX Group (United States)

Murdoch Children's Research Institute

Royal Children's Hospital

University of Melbourne

Brigham and Women's Hospital

Harvard University

Washington University in St. Louis

Monash University

Research Network (United States)

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

Table of Contents

The Journal of Pediatrics (2019)

James Gaensbauer James Todd Joseph A. Grubenhoff Danielle E. Soranno Mary T. Caserta

Table (database)

10.1016/s0022-3476(19)31238-7

Cite

Citations (0)

Desikan-Killiany-Tourville Atlas Compatible Version of M-CRIB Neonatal Parcellated Whole Brain Atlas: The M-CRIB 2.0

bioRxiv (Cold Spring Harbor Laboratory) (2018)

Bonnie Alexander Wai Yen Loh Lillian G. Matthews Andrea L. Murray Chris Adamson

Abstract Our recently published M-CRIB atlas comprises 100 neonatal brain regions including 68 compatible with the widely-used Desikan-Killiany adult cortical atlas. A successor to the Desikan-Killiany atlas is the Desikan-Killiany-Tourville atlas, in which some regions with unclear boundaries were removed, and many existing boundaries were revised to conform to clearer landmarks in sulcal fundi. Our first aim here was to modify cortical M-CRIB regions to comply with the Desikan-Killiany-Tourville protocol, in order to offer: a) compatibility with this adult cortical atlas, b) greater labelling accuracy due to clearer landmarks, and c) optimisation of cortical regions for integration with surface-based infant parcellation pipelines. Secondly, we aimed to update subcortical regions in order to offer greater compatibility with subcortical segmentations produced in FreeSurfer. Data utilized were the T2-weighted MRI scans in our M-CRIB atlas, for ten healthy neonates (postmenstrual age at MRI 40-43 weeks, 4 female), and corresponding parcellated images. Edits were performed on the parcellated images in volume space using ITK-SNAP. Cortical updates included deletion of frontal and temporal poles and ‘Banks STS’, and modification of boundaries of many other regions. Changes to subcortical regions included the addition of ‘ventral diencephalon’, and deletion of ‘subcortical matter’ labels. A detailed updated parcellation protocol was produced. The resulting whole-brain M-CRIB 2.0 atlas comprises 94 regions altogether. This atlas provides comparability with adult Desikan-Killiany-Tourville-labelled cortical data and FreeSurfer-labelled subcortical data, and is more readily adaptable for incorporation into surface-based neonatal parcellation pipelines. As such, it offers the ability to help facilitate a broad range of investigations into brain structure and function both at the neonatal time point and developmentally across the lifespan.

10.1101/409045

Cite

Citations (2)

Associations of Macronutrient Intake Determined by Point-of-Care Human Milk Analysis with Brain Development among very Preterm Infants

Children (2022)

Katherine Bell Sara Cherkerzian Kaitlin Drouin Lillian G. Matthews Terrie E. Inder

Point-of-care human milk analysis is now feasible in the neonatal intensive care unit (NICU) and allows accurate measurement of macronutrient delivery. Higher macronutrient intakes over this period may promote brain growth and development. In a prospective, observational study of 55 infants born at <32 weeks’ gestation, we used a mid-infrared spectroscopy-based human milk analyzer to measure the macronutrient content in repeated samples of human milk over the NICU hospitalization. We calculated daily nutrient intakes from unfortified milk and assigned infants to quintiles based on median intakes over the hospitalization. Infants underwent brain magnetic resonance imaging at term equivalent age to quantify total and regional brain volumes and fractional anisotropy of white matter tracts. Infants in the highest quintile of energy intake from milk, as compared with the lower four quintiles, had larger total brain volume (31 cc, 95% confidence interval [CI]: 5, 56), cortical gray matter (15 cc, 95%CI: 1, 30), and white matter volume (23 cc, 95%CI: 12, 33). Higher protein intake was associated with larger total brain (36 cc, 95%CI: 7, 65), cortical gray matter (22 cc, 95%CI: 6, 38) and deep gray matter (1 cc, 95%CI: 0.1, 3) volumes. These findings suggest innovative strategies to close nutrient delivery gaps in the NICU may promote brain growth for preterm infants.

Brain Development

Human brain

10.3390/children9070969

Cite

Citations (8)

Desikan-Killiany-Tourville Atlas Compatible Version of M-CRIB Neonatal Parcellated Whole Brain Atlas: The M-CRIB 2.0

Frontiers in Neuroscience (2019)

Bonnie Alexander Wai Yen Loh Lillian G. Matthews Andrea L. Murray Chris Adamson

Our recently published M-CRIB atlas comprises 100 neonatal brain regions including 68 compatible with the widely-used Desikan-Killiany adult cortical atlas. A successor to the Desikan-Killiany atlas is the Desikan-Killiany-Tourville atlas, in which some regions with unclear boundaries were removed, and many existing boundaries were revised to conform to clearer landmarks in sulcal fundi. Our first aim here was to modify cortical M-CRIB regions to comply with the Desikan-Killiany-Tourville protocol, in order to offer: (a) compatibility with this adult cortical atlas, (b) greater labeling accuracy due to clearer landmarks, and (c) optimisation of cortical regions for integration with surface-based infant parcellation pipelines. Secondly, we aimed to update subcortical regions in order to offer greater compatibility with subcortical segmentations produced in FreeSurfer. Data utilized were the T2-weighted MRI scans in our M-CRIB atlas, for 10 healthy neonates (post-menstrual age at MRI 40-43 weeks, four female), and corresponding parcellated images. Edits were performed on the parcellated images in volume space using ITK-SNAP. Cortical updates included deletion of frontal and temporal poles and 'Banks STS,' and modification of boundaries of many other regions. Changes to subcortical regions included the addition of 'ventral diencephalon,' and deletion of 'subcortical matter' labels. A detailed updated parcellation protocol was produced. The resulting whole-brain M-CRIB 2.0 atlas comprises 94 regions altogether. This atlas provides comparability with adult Desikan-Killiany-Tourville-labeled cortical data and FreeSurfer-labeed subcortical data, and is more readily adaptable for incorporation into surface-based neonatal parcellation pipelines. As such, it offers the ability to help facilitate a broad range of investigations into brain structure and function both at the neonatal time point and developmentally across the lifespan.

10.3389/fnins.2019.00034

Cite

Citations (44)

Longitudinal Preterm Cerebellar Volume: Perinatal and Neurodevelopmental Outcome Associations

The Cerebellum (2018)

Lillian G. Matthews Terrie E. Inder Leona Pascoe Kush Kapur K. J. Lee

Longitudinal Study

10.1007/s12311-018-0946-1

Cite

Citations (48)

A Novel Approach to Assess the Impact of Disease in Patients with SCN8A-Related Developmental and Epileptic Encephalopathy (P3-9.008)

Neurology (2023)

Kelley Dalby Ted Snyder Lillian G. Matthews Michael Oldham Steven Petrou

Objective:

Clinical data generated using Invitae's Ciitizen patient-consented, real-world data platform were used to explore disease burden in SCN8A-DEE.

Background:

SCN8A-related DEE is a rare disease associated with pathogenic variants in the SCN8A gene encoding the voltage-gated sodium channel alpha subunit Na_v1.6. Due to significant phenotypic heterogeneity, comprehensive understanding of disease impact and progression is limited.

Design/Methods:

Real-world clinical data were extracted from patients with an SCN8A variant using the Ciitizen platform, which employs a proprietary approach combining machine learning and expert human review to streamline generation of research-grade data from unstructured health records spanning ~10 years. Extracted data including seizure history, comorbidities, and therapeutic interventions were analyzed.

Results:

79 patients were enrolled and contributed data for analyses. Mean patient age was 8.2 years (1–23), with similar percentages of males and females. Patients were categorized based on age at seizure onset; ≤6 months (75.6%) or >6 months (34.2%). A further group included patients without seizures (5%). Mean age at seizure onset was 70.4 days (1–175) for patients with early (≤6 months) seizures and 749.3 days (224–4409) for those with later (>6 months) seizures. While seizure frequency was variable, most patients continued to experience seizures over time. Procedural interventions and hospitalizations were high across the lifespan; nearly a third occurring in the first year of life. Mean number of medications prescribed over a patient's lifetime was 17.6 (3–44). Patients experienced multiple comorbidities; global developmental delay was the most common (81%), with sleep disorders, hypotonia, feeding difficulties and GERD reported in >50%.

Conclusions:

This work represents a new generation of natural history study providing the most robust real-world dataset to date on disease burden and progression in SCN8A-DEE. Knowledge from this study is anticipated to accelerate drug development efforts by providing new insights into the broad, longitudinal impact of disease, therefore informing trial endpoints beyond seizure symptomatology. Disclosure: Kelley Dalby has received personal compensation for serving as an employee of Praxis Precision Medicines. Kelley Dalby has stock in Praxis Precision Medicines. Kelley Dalby has stock in RogCon. Mr. Snyder has received personal compensation for serving as an employee of Praxis Precision Medicines. Mr. Snyder has received stock or an ownership interest from Praxis Precision Medicines. Dr. G Matthews has received personal compensation in the range of $100,000-$499,999 for serving as a Consultant for Praxis Precision Medicines. Dr. G Matthews has stock in Praxis Precision Medicines. Dr. Oldham has received personal compensation for serving as an employee of Praxis Precision Medicines. Steven Petrou has received personal compensation in the range of $100,000-$499,999 for serving as a Consultant for Praxis Precision Medicines. Steven Petrou has stock in Praxis Precision Medicines. The institution of Steven Petrou has received research support from Praxis Precision Medicines. The institution of Steven Petrou has received research support from Medical Research Future Fund. Steven Petrou has received intellectual property interests from a discovery or technology relating to health care. Steven Petrou has received intellectual property interests from a discovery or technology relating to health care. Dr. Souza has received personal compensation for serving as an employee of Praxis Precision Medicines. Dr. Souza has stock in Praxis Precision Medicines.

10.1212/wnl.0000000000203072

Cite

Citations (0)

Tracking regional brain growth up to age 13 in children born term and very preterm

Nature Communications (2020)

Deanne K. Thompson Lillian G. Matthews Bonnie Alexander Katherine J. Lee Claire E. Kelly

Abstract Serial regional brain growth from the newborn period to adolescence has not been described. Here, we measured regional brain growth in 216 very preterm (VP) and 45 full-term (FT) children. Brain MRI was performed at term-equivalent age, 7 and 13 years in 82 regions. Brain volumes increased between term-equivalent and 7 years, with faster growth in the FT than VP group. Perinatal brain abnormality was associated with less increase in brain volume between term-equivalent and 7 years in the VP group. Between 7 and 13 years, volumes were relatively stable, with some subcortical and cortical regions increasing while others reduced. Notably, VP infants continued to lag, with overall brain size generally less than that of FT peers at 13 years. Parieto–frontal growth, mainly between 7 and 13 years in FT children, was associated with higher intelligence at 13 years. This study improves understanding of typical and atypical regional brain growth.

Brain Development

Abnormality

10.1038/s41467-020-14334-9

Cite

Citations (55)

White matter extension of the Melbourne Children's Regional Infant Brain atlas: M‐CRIB‐WM

Human Brain Mapping (2020)

Bonnie Alexander Joseph Yang Sarah Hui Wen Yao Michelle Hao Wu Jian Chen

Abstract Brain atlases providing standardised identification of neonatal brain regions are key in investigating neurological disorders of early childhood. Our previously developed Melbourne Children's Regional Infant Brain (M‐CRIB) and M‐CRIB 2.0 neonatal brain atlases provide standardised parcellation of 100 brain regions including cortical, subcortical, and cerebellar regions. The aim of this study was to extend M‐CRIB atlas coverage to include 54 white matter (WM) regions. Participants were 10 healthy term‐born neonates that were used to create the initial M‐CRIB atlas. WM regions were manually segmented based on T 2 images and co‐registered diffusion tensor imaging‐based, direction‐encoded colour maps. Our labelled regions imitate the Johns Hopkins University neonatal atlas, with minor anatomical modifications. All segmentations were reviewed and approved by a paediatric radiologist and a neurosurgery research fellow for anatomical accuracy. The resulting neonatal WM atlas comprises 54 WM regions: 24 paired regions, and six unpaired regions comprising five corpus callosum subdivisions, and one pontine crossing tract. Detailed protocols for manual WM parcellations are provided, and the M‐CRIB‐WM atlas is presented together with the existing M‐CRIB cortical, subcortical, and cerebellar parcellations in 10 individual neonatal MRI data sets. The novel M‐CRIB‐WM atlas, along with the M‐CRIB cortical and subcortical atlases, provide neonatal whole brain MRI coverage in the first multi‐subject manually parcellated neonatal atlas compatible with atlases commonly used at older time points. The M‐CRIB‐WM atlas is publicly available, providing a valuable tool that will help facilitate neuroimaging research into neonatal brain development in both healthy and diseased states.

Brain atlas

10.1002/hbm.24948

Cite

Citations (11)

Su1747 DIFFERENCES IN DEMOGRAPHICS, COMORBIDITIES, AND SYMPTOMATOLOGY AMONG PATIENTS REFERRED FOR GASTRIC EMPTYING SCINTIGRAPHY

Gastroenterology (2020)

Katherine Duffey Michelle Hannon Justin S. Robbins Lillian G. Matthews Jacqueline P. Chang

Demographics

10.1016/s0016-5085(20)32275-7

Cite

Citations (0)

A New MRI-Based Pediatric Subcortical Segmentation Technique (PSST)