Mehrnoosh Hasan Shahriari

Amirkabir University of Technology

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Majid Abdouss

Amirkabir University of Technology

Shafiq Ahmad Kahdestani

Herat University

Tajuddin Hafizi

Amirkabir University of Technology

Afra Hadjizadeh

Amirkabir University of Technology

Mohammad Atai

Iran Polymer and Petrochemical Institute

Malihe Ekrami

Shahid Beheshti University of Medical Sciences

Farnaz Kouhestani

Tehran University of Medical Sciences

Farzad Yousefi

Kateb University

Maryam Rezia Rad

Shahid Beheshti University of Medical Sciences

Vahid Heidary

Iranian Research Organization for Science and Technology

Cooperative Institutions

Shahid Beheshti University of Medical Sciences

Amirkabir University of Technology

Iran Polymer and Petrochemical Institute

Baqiyatallah University of Medical Sciences

Pasteur Institute of Iran

Tarbiat Modares University

University of Tehran

Tehran University of Medical Sciences

Shahid Beheshti University

National Institute of Genetic Engineering and Biotechnology

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Synthesis And Characterization of Vancomycin-Loaded Chitosan Nanoparticles For Drug Delivery

Research Square (Research Square) (2021)

Tajuddin Hafizi Mehrnoosh Hasan Shahriari Majid Abdouss Shafiq Ahmad Kahdestani

Abstract Chitosan is a linear polysaccharide with and prominent physicochemical and biological properties such as biocompatibility, biodegradability, nontoxicity, non-immunogenicity, bioadhesion, antibacterial, antifungal and hemostatic activity. Due to these properties, it has found many applications in cosmetic, textile, and food industries; agriculture; biotechnology; pharmaceutical industry and medicine; specially in biomedical applications. The special chemical structure of chitosan allows some specific modifications and by reducing the size of chitosan particles to Nano size, it becomes an excellent drug nanocarrier. Vancomycin is a typical antibiotic used for bacterial infections caused by geram positive bacteria. In this work, chitosan nanoparticles (CSNPs) were prepared via ionotropic gelation using tripolyphosphate (TPP) as crosslinker. The effect of chitosan and TPP concentration on the size of chitosan nanoparticles was studied and CS:TPP ratio of 1:1 with average size of nanoparticle about 100 nm were selected. The prepared samples were characterized using DLS, FTIR, TGA, DSC, and SEM techniques. The results confirmed that vancomycin has been loaded successfully on chitosan nanoparticles and there was not any interaction between vancomycin and chitosan. Also, it is observed that 40% of vancomycin is released burstly in the first 9 h and after that the drug release is continued gradually to receive 90% at 100 h.

Biocompatibility

Nanocarriers

10.21203/rs.3.rs-597221/v1

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Synthesis and characterization of vancomycin-loaded chitosan nanoparticles for drug delivery

Polymer Bulletin (2022)

Tajuddin Hafizi Mehrnoosh Hasan Shahriari Majid Abdouss Shafiq Ahmad Kahdestani

Biocompatibility

Nanocarriers

10.1007/s00289-022-04237-8

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Citations (17)

Purmorphamine increased adhesion, proliferation and expression of osteoblast phenotype markers of human dental pulp stem cells cultured on beta-tricalcium phosphate

Biomedicine & Pharmacotherapy (2016)

Maryam Rezia Rad Moein Khojaste Mehrnoosh Hasan Shahriari Saeed Asgary Arash Khojasteh

Osteopontin

10.1016/j.biopha.2016.05.016

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Citations (14)

The effect of molecular weight and content of PEG on in vitro drug release of electrospun curcumin loaded PLA/PEG nanofibers

Journal of Drug Delivery Science and Technology (2020)

Leila Moradkhannejhad Majid Abdouss Nasser Nikfarjam Mehrnoosh Hasan Shahriari Vahid Heidary

Electrospinning

10.1016/j.jddst.2020.101554

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Citations (83)

Copper Nanoparticles Reduce Expression of Key Virulence Genes in Vaginal Candida albicans Infection: Implications for Novel Antifungal Therapies

Deleted Journal (2024)

Mahmoud Hassan Shahryari Roudabeh Behzadi Mehrnoosh Hasan Shahriari

10.61186/jommid.12.1.35

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Preparation and characterization of eugenol-loaded oligochitosan nanoparticles through sol–gel and emulsion/sol–gel methods

Polymer Bulletin (2017)

Mehrnoosh Hasan Shahriari Mohammad Atai Mojgan Zandi Parvin Shokrollahi Laleh Solhi

Particle (ecology)

10.1007/s00289-017-2196-7

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Citations (7)

Synthesis and Characterization of Ni-doped TiO2 Nanostructures as an Active Self-cleaning Cover on Floor-Tile Surface

Journal of Cluster Science (2017)

Mehrnoosh Hasan Shahriari Maryam Hosseini-Zori

Titanium Dioxide

10.1007/s10876-017-1216-y

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Citations (2)

Allogenic vs. synthetic granules for bone tissue engineering: an in vitro study

Progress in Biomaterials (2018)

Farnaz Kouhestani Farnaz Dehabadi Mehrnoosh Hasan Shahriari Saeed Reza Motamedian

The aim of this study was to compare human dental pulp stem cells' (DPSCs) attachment, proliferation and osteogenic differentiation on allogenic and synthetic biphasic bone granules. In this in vitro study, two types of bone granules were used: allograft [freeze-dried bone allograft (FDBA)] and biphasic granules [hydroxyapatite/beta-tricalcium phosphate (HA/β-TCP)]. By isolation of DPSCs, their attachment to bone granules was observed by scanning electron microscope (SEM) at day 1 and 7 of cultivation. Vital cells were measured by MTT assay at 1, 3, and 7 days of cell culture. Comparison of vital cells at different time points was considered as cell proliferation. Finally, differentiation of DPSCs was evaluated by measurement of alkaline phosphatase (ALP) activity 3, 7, 14, and 21 days after cell seeding in standard and osteogenic media. Data were analyzed using two-way ANOVA with a significant level of 0.05. Attachment of DPSCs on FDBA granules seemed relatively stronger. The number of cells (based on MTT values) and ALP activity of the cells cultured on both study groups increased between time points (p ≤ 0.001). FDBA granules had more cells compared to HA/β-TCP granules (p < 0.001). There was no significant difference between ALP activity of two study groups cultured in the standard medium (p = 0.347) and they were both higher than the control group (p < 0.05). In the osteogenic medium, FDBA group had significantly higher ALP activity compared to HA/β-TCP (p = 0.035) and control (p = 0.001) groups while there was no significant difference between ALP activity of HA/β-TCP and control groups (p = 0.645). In conclusion, current in vitro study revealed that FDBA granules have more potential in supporting DPSCs attachment and proliferation and inducing their ALP activity compared to HA/β-TCP granules. Therefore, FDBA could serve as a proper bone substitute material.

MTT assay

10.1007/s40204-018-0092-3

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Citations (9)

Loading of gentamicin onto poly lactic-co-glycolic acid and poly lactic-coglycolic acid/nano-hydroxyapatite composite microspheres.

Biomedical Research-tokyo (2016)

Hanieh Nojehdehian Malihe Ekrami Mehrnoosh Hasan Shahriari Reza Karimi‐Soflou Zahra Jaberi-Ansari

Background and aim: In dental treatments, use of antibiotic carriers can decrease microorganisms more efficiently. In this study, gentamicin (GEN) was loaded onto poly lactic-co-glycolic acid (PLGA) copolymers and PLGA-nano hydroxyapatite (nHA) composite microspheres for a controlled release. The amount of drug release was measured for 20 days. Materials and methods: In this in-vitro study, microspheres were prepared using the water/oil/ water technique and different concentration of GEN loaded onto PLGA copolymers and PLGA- nHA composite microspheres. Loaded microspheres were evaluated morphologically using scanning electron microscopy (SEM). The rate of drug release from the composite microspheres was measured in phosphate buffered saline (PBS) medium for a period of 20 days using UV spectrophotometry (330 nm). Data were analyzed using ANOVA. Also, a microbial culture was carried out of microspheres with the least amount of drug in the first and last day of drug release assessment. Results: SEM images showed that the microspheres had a smooth surface and the pattern of drug release from the PLGA copolymers and PLGA-nHA composite microspheres loaded with GEN was different in each group at different time points, but this difference only in the PLGA+0.02 GEN group was significant. There was a significant difference between this group and other groups in the amount of released drug at day 6. Also, the results of microbial culture of the group with 0.02 GEN showed the antibacterial effect of these microspheres in the last day of experiment. Conclusion: The release profiles observed in this study and the well-established biocompatibility of PLGA indicate that the composite microspheres used in this study are suitable for infection control purposes in dentistry.

PLGA

Glycolic acid

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Advances in self-healing hydrogels to repair tissue defects

Polymer Bulletin (2022)

Mehrnoosh Hasan Shahriari Afra Hadjizadeh Majid Abdouss

Tissue Repair

10.1007/s00289-022-04133-1

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Citations (7)