Daniele Rovai

Istituto di Fisiologia Clinica

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Antonio LʼAbbate

Istituto di Fisiologia Clinica

A. Distante

Agostino Gemelli University Polyclinic

Carlo Palombo

University of Pisa

Massimo Lombardi

IRCCS Policlinico San Donato

E Moscarelli

Eli Lilly (United States)

Danilo Neglia

Fondazione Toscana Gabriele Monasterio

M.A. Morales

Universidad Nacional Autónoma de México

Alessandro Pingitore

Istituto di Fisiologia Clinica

Paolo Marzullo

IRCCS Istituto Auxologico Italiano

Gianluca Di Bella

University of Messina

Cooperative Institutions

Istituto di Fisiologia Clinica

170

University of Pisa

129

National Research Council

Fondazione Toscana Gabriele Monasterio

Foundation of Cardiac Surgery Development

Regione Toscana

Azienda Ospedaliera Universitaria Pisana

Society of Interventional Radiology

Czech Academy of Sciences, Institute of Physiology

Scuola Superiore Sant'Anna

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A non-invasive approach to detect transient changes due to acute myocardial ischemia in man: role of M-mode and two-dimensional echocardiography

A. Distante Daniele Rovai Eugenio Picano Carlo Palombo E Moscarelli

Transient (computer programming)

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Quantitative aspects in myocardial contrast echocardiography

European Heart Journal (1995)

Daniele Rovai E.M. Ferdeghini A. Mazzarisi Marco Paterni Valter Lubrano

Journal Article Quantitative aspects in myocardial contrast echocardiography Get access D. Rovai, D. Rovai C.N.R., Clinical Physiology InstitutePisa, Italy Correspondence: Daniele Rovai, MD. C.N.R., Clinical Physiology Institute, Via Savi 8, I-56100, Pisa, Italy Search for other works by this author on: Oxford Academic PubMed Google Scholar E. M. Ferdeghini, E. M. Ferdeghini C.N.R., Clinical Physiology InstitutePisa, Italy Search for other works by this author on: Oxford Academic PubMed Google Scholar A. Mazzarisi, A. Mazzarisi C.N.R., Clinical Physiology InstitutePisa, Italy Search for other works by this author on: Oxford Academic PubMed Google Scholar M. Paterni, M. Paterni C.N.R., Clinical Physiology InstitutePisa, Italy Search for other works by this author on: Oxford Academic PubMed Google Scholar V. Lubrano, V. Lubrano C.N.R., Clinical Physiology InstitutePisa, Italy Search for other works by this author on: Oxford Academic PubMed Google Scholar C. Vassalle, C. Vassalle C.N.R., Clinical Physiology InstitutePisa, Italy Search for other works by this author on: Oxford Academic PubMed Google Scholar L. Serasini, L. Serasini C.N.R., Clinical Physiology InstitutePisa, Italy Search for other works by this author on: Oxford Academic PubMed Google Scholar A. L'Abbate A. L'Abbate C.N.R., Clinical Physiology InstitutePisa, Italy Search for other works by this author on: Oxford Academic PubMed Google Scholar European Heart Journal, Volume 16, Issue suppl_J, October 1995, Pages 42–45, https://doi.org/10.1093/eurheartj/16.suppl_J.42 Published: 01 October 1995

Coronary circulation

Coronary vessel

Cardiac cycle

10.1093/eurheartj/16.suppl_j.42

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Citations (9)

6.19

Journal of Nuclear Cardiology (2007)

Alessia Gimelli Paolo Marzullo Antonio L’Abbate Daniele Rovai

Gated SPECT

Thallium

Technetium (99mTc) sestamibi

Emission computed tomography

10.1016/j.nuclcard.2006.12.172

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In vivo imaging of myocardial perfusion by contrast echocardiography.

PubMed (1989)

Daniele Rovai Antonio L’Abbate

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[Diagnosis of transient acute myocardial ischemia in man by M-mode echocardiography (author's transl)].

PubMed (1981)

A. Distante Daniele Rovai Carlo Palombo A Maseri Antonio LʼAbbate

Under basal conditions the echocardiographic findings in anginal patients (pts.) without previous myocardial infarction appears usually normal. Consequently, the usefulness of the ultrasounds evaluation in angina pectoris has been commonly considered poor and the utilization of this technique in coronary artery disease has been restricted to the detection of myocardial infarction in its acute phase or to its chronic mechanical alterations. The purpose of this study was to assess the possibility offered by M-mode echocardiography to detect changes caused by transient myocardial ischemia at rest in man, in view of the possible diagnostic application of this technique. The reported results were obtained from 25 ischemic attacks (13 spontaneous and 12 ergonovine induced) with ST segment elevation or pseudonormalization of a basally negative T wave at rest. The semiautomatic computerized analysis of echocardiograms continuously recorded during these attacks showed a reduction of motion and of systolic thickening, accompanied by a diastolic thinning of the wall involved by the ischemia. These changes occur very early: they appear few seconds before ECG changes and are accompanied by a reduction of contraction and relaxation dP/dt and precede the onset of chest pain; moreover, they are followed by an increase in left ventricular internal diameters. In conclusion M-mode echocardiography is a sensitive technique capable to detect transient myocardial ischemia in the course of spontaneous or induced angina with ST segment elevation or positivity of negative T wave. This approach could be helpful in the diagnostic evaluation of patients with atypical chest pain and/or aspecific ECG changes and it can be complementary to other non invasive techniques such dynamic ECG and nuclear cardiology techniques.

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Stress echocardiography and myocardial contrast echocardiography in viability assessment

European Heart Journal (1997)

A. Distante Daniele Rovai

Stress Echocardiography

Stress testing (software)

10.1093/oxfordjournals.eurheartj.a015335

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Citations (6)

Therapeutic effect of diagnostic ultrasound on enzymatic thrombolysis

Thrombosis and Haemostasis (2004)

Giuseppina Basta Cristiana Lupi Guido Lazzerini Piero Chiarelli Antonio LʼAbbate

Summary If delivered at elevated intensity, ultrasound potentiates enzymatic clot dissolution; however, an elevated acoustic intensity damages vascular wall and favors reocclusion. This study’s aim was to investigate whether exposure to high-frequency, lowintensity ultrasound generated by a diagnostic scanner enhances enzymatic thrombolysis, and if this effect differs in clots from blood of normal subjects and of patients with coronary artery disease (CAD). Venous blood samples were drawn from 10 healthy volunteers and from 10 CAD patients on chronic medical treatment, which also included aspirin. Each sample generated 2 radiolabelled clots, which were positioned in 2 in vitro models filled with human plasma recirculating at 37°. One clot was exposed to acetyl salicylic acid (60 μg/ml), tissue plasminogen activator (3 μg/ml) and heparin (1 IU/ml), while the other was exposed to the same medications plus ultrasound (2.5 MHz, mechanical index = 1.0) for 3 hours. Enzymatic thrombolysis was measured as solubilization of radiolabel. Normal subjects and patients did not significantly differ as to coagulation parameters, weight, volume and density of the clots, and fibrinolytic activity (p = 0.794). Ultrasound exposure did not influence thrombolysis in clots of normal subjects (p = 0.367), while it enhanced the dissolution of clots of CAD patients (p = 0.013). The enhancement was equal to 51% at 5 minutes, 32% at 15 minutes, 27% at 30 minutes, 20% at 1 hour and 19% at 3 hours (p < 0.05). Diagnostic ultrasound enhances enzymatic dissolution of clots generated from the blood of CAD patients, likely due to chronic treatment and in particular to aspirin.

T-plasminogen activator

Bolus (digestion)

10.1160/th03-11-0684

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Citations (31)

Left ventricular ejection fraction measurements: accuracy and prognostic implications in a large population of patients with known or suspected ischemic heart disease

The International Journal of Cardiovascular Imaging (2008)

Alessia Gimelli Patrizia Landi Paolo Marraccini Rosa Sicari Paolo Frumento

Gated SPECT

Unstable angina

10.1007/s10554-008-9317-1

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