A.B. Frare

Universidade de Brasília

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K.K.V.O. Moura

Universidade São Francisco

C.L. Ribeiro Júnior

Pontifícia Universidade Católica de Goiás

S.R. Souza

Escola Bahiana de Medicina e Saúde Pública

Iasmim Ribeiro da Costa

Pontifícia Universidade Católica de Goiás

B.M. Bordin

Pontifícia Universidade Católica de Goiás

Kevin Alves Barreto

Universidade de Brasília

Sidney Alcântara Pereira

Brigham and Women's Hospital

A.M. Barbosa

Universidade Federal do Acre

Luiz Guilherme Grossi Porto

Universidade de Brasília

R.C.P.C. Silva

Pontifícia Universidade Católica de Goiás

Cooperative Institutions

Universidade de Brasília

Pontifícia Universidade Católica de Goiás

Fundação de Apoio a Pesquisa do Estado de Goiás

Hospital de Clínicas Universidade Federal do Paraná

Universidade Federal de Goiás

Instituto Federal de Goiás

Universidade Federal do Paraná

Universidade de São Paulo

Skidmore College

Governo do Distrito Federal

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AVALIAÇÃO DA COMPREENSÃO DAS ESTUDANTES DO INSTITUTO FEDERAL DE GOIÁS – CAMPUS FORMOSA SOBRE ENDOMETRIOSE

Nathalia Aguiar de Carvalho Gyovana Além Cáceres Nayra Yane Pereira Nascimento A.B. Frare

10.22533/at.ed.6072108105

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Castration Prevents The Decrease Of White Adipose Tissue Induced By Treadmill Interval Training In Mice

Medicine & Science in Sports & Exercise (2021)

Ana Beatriz da Silva Sousa A.B. Frare Guilherme Vieira Daniel R F Saint-Martin Kevin Alves Barreto

Testosterone (T) exerts anabolic actions in body composition and facilitates the metabolic effects of physical exercise in males. T also influences adipose tissue by activating lipolysis, whereas T deficiency is associated with fat mass increase. PURPOSE: To investigate the effect of castration on the mass of different deposits of adipose tissue in male mice submitted to a treadmill interval training (TIT). METHODS: 16 adult (5-6 months) C57BL/6 mice were divided in 2 groups, Sham (n = 8) and gonadectomized (GDX, n = 8). The GDX underwent bilateral orchiectomy while the Sham underwent just a surgical trauma. Then, half of the mice from each group were submitted to a TIT. The mice were subjected to 5-days of treadmill familiarization, at 25° inclination, for 5 min and a speed of 5 m/min. Next, three maximum effort tests were performed, which consisted of 5 min of warming-up at a speed of 6 m/min followed by incremental speed stages of 2 m/min every 2 min, repeated in 48-hour intervals to assess the better distance covered, and maximum speed reached (MSR). Then, the animals were submitted to 8 weeks of a TIT, consisting of an initial warm-up at 5 m/min during 5 min, then 10 bouts of 4 min interspersed with 2 min of active rest (5 m/min). The training starts with an intensity of 55-65% MSR, with an increase of 10% per week reaching the intensity range of 85-95%. After training, the animals were euthanized and the epididymal white adipose tissue (epiWAT), inguinal white adipose tissue (ingWAT) and brown adipose tissue (BAT) were collected and weighed. We compared adipose tissue mass between groups, using One-way ANOVA/Tukey (p ≤ 0.05). RESULTS: We observed a significant reduction in the mass of epiWAT and ingWAT relative to body weight of the Sham-training group, but not of the GDX training group compared with their respective untrained controls. CONCLUSION: This study demonstrates that castration prevents the reduction of visceral and subcutaneous WAT induced by TIT in male mice. Supported by FAP-DF

Interval training

Treadmill

Adult male

Orchiectomy

10.1249/01.mss.0000763552.85884.c9

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GSTM1 and GSTT1 polymorphisms in endometriosis in women from Goiás, Brazil

Genetics and Molecular Research (2013)

A.B. Frare A.M. Barbosa Iasmim Ribeiro da Costa S.R. Souza R.C.P.C. Silva

GSTM1 and GSTT1 polymorphisms in endometriosis GSTT1 polymorphisms to the proliferation of endometriosis were not statistically significant, but the analysis of pathology and the association of GSTM1 and GSTT1 gene polymorphisms with p53 codon 72 revealed statistical significance.

Etiology

Glutathione S-transferase

10.4238/2013.august.2.1

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Citations (11)

Polymorphism of the progesterone receptor gene associated with endometriosis in patients from Goiás, Brazil

Genetics and Molecular Research (2011)

Iasmim Ribeiro da Costa R.C.P.C. Silva A.B. Frare C.T.X. Silva B.M. Bordin

Polymorphism of the progesterone receptor gene conclude that there is a significant correlation between PROGINS polymorphism and endometriosis.

Ethidium bromide

Progesterone receptor

10.4238/vol10-3gmr913

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Citations (19)

Sex Differences On The Cardiorespiratory Fitness Response To Treadmill Interval Training In Mice

Medicine & Science in Sports & Exercise (2021)

Kevin Alves Barreto A.B. Frare Ana Beatriz S. Sousa Guilherme Rodrigues Vieira Daniel Martín

Sex steroid hormones are major effectors of the sexual dimorphism in mammals and are suposed to differently impact cardiometabolic responses to exercise training. Testosterone is related to the development of strength and muscle mass while estrogen is believed to associate with endurance capacity. Sex differences on cardiorespiratory fitness (CRF) response to interval training (IT) deserve further evaluation, specially in animal models. PURPOSE: To compare the CRF response to a treadmill interval training protocol in mice of both sexes. METHODS: 26 adult (3-4 months old) C57BL/6 mice were evaluated (14 fem / 12 males). Firstly, all animals were subjected to a 10-day treadmill familiarization step within 2 weeks, 5 days/week, at 25° inclination, having both session duration and speed progressively increased from 5 to 10 min and 5 to 10 m/min), respectively. After familiarization, 3 maximum exercise tests were carried out on a 48 h-interval to assess the average maximum distance and speed reached (MSR). The test consisted of 5-min warm up at 6 m/min followed by incremental speed stages of 2 m/min every 2 min, at 25° inclination. Tests were considered maximum when mice were unable to, or refused to run even with mechanical stimulation. After basal CRF evaluation, mice were separated into exercise (EG–9 fem/7 mal) and control groups (CG-5 fem/9 mal). The EG trained for 4 weeks, starting with a warm-up at 5 m/min and a subsequent IT of 10 bouts of 4 min running at moderate intensity (55–65% MSR), interspersed by 2 min active rest (5 m/min), always at 25°. After training, CRF was assessed as in the pre-training period. Groups were compared before and after training protocol. RESULTS: The IT significantly increased CRF (p < 0.01) in EG. Remarkably, females showed a higher CRF increase (56.3%) than males (43.1%) (p < 0.01). CRF remained unchanged in CGs of both sexes (p > 0.05). CONCLUSION: The 4-week of IT was effective to improve CRF in both sexes but females had a significantly higher improvement compared to males. Our findings suggest that sex differences must be taken into account in animal studies once sex hormonal and/or behavioral differences may significantly impact the training responses in mice. Supported by Fundação de Apoio à Pesquisa do Distrito Federal - FAP DF:0193.001571/2017; KAB is a PIBIC student – FAP DF: 00193.001467/2016.

Treadmill

Interval training

Basal (medicine)

Endurance Training

10.1249/01.mss.0000763540.62769.95

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GSTM1 polymorphism in patients with primary open-angle glaucoma

Genetics and Molecular Research (2012)

A.M. Barbosa A.B. Frare N. Costa R.E. Silva K.K.V.O. Moura

GSTM1 polymorphism in primary

Gene polymorphism

10.4238/2012.september.12.8

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Citations (9)

Gemcitabine and cisplatin in metastatic breast cancer

Journal of Clinical Oncology (2007)

G. L. Moura Ricardo Pasqüini A.B. Frare Karina Vianna Leomar Albini

1084 Background: Gemcitabine plus cisplatin have synergistic activity and have been tested in several schedules and doses in metastatic breast cancer. Our objectives were to assesss the efficacy and toxicity of gemcitabine and cisplatin in pretreated patients. Methods: Measurable disease and at least two prior anthracycline and /or taxane-containing regimen in either metastatic or adjuvant setting was required. Treatment consisted of gemcitabine 700mg/m(2) IV infusion over 30 min plus cisplatin 30mg(2) given on day1 and 8 every 3 weeks. Results: Seventy four patients with median age of 48 years (range 26- 73) were recruited. A median of six cycles of the study treatment was delivered. The overal response rate was 30% (95% confidence interval, 12–53%). Median time to progreesion was 30.6 weeks (95%CI, 12.6–44 weeks). Median survival was 73.2 weeks (95% CI, 47.1–93.2 weeks). Toxicities included grade 3 and 4 leukopenia in 27(36.4%), anemia in 19 (25.6%) and oral mucositis in 4 (5.4%). No grade 3 or 4 peripheral neurophaty, hepatic or renal dysfunction was observed. No treatment-related death ocurred. Conclusions: Gemcitabine plus cisplatin is a well tollerated and active treatment in heavily pretreated patients with metastatic breast cancer. No significant financial relationships to disclose.

Mucositis

Regimen

Leukopenia

Taxane

10.1200/jco.2007.25.18_suppl.1084

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Citations (4)

Castration Did Not Affect Muscle Mass In Male Mice Submitted To Treadmill Interval Training

Medicine & Science in Sports & Exercise (2021)

A.B. Frare Ana Beatriz da Silva Sousa Daniel Saint-Marti Saint-Marti Guilherme Vieira Kevin Alves Barreto

Testosterone (T) is responsible for the morphological adaptations resulting from systematic physical training and T deficiency is related to worsen the components of physical fitness with a marked effect on muscle mass. However, is still unkwon whether physical exercise can be an factor for maintaining muscle mass in T deficiency. PURPOSE: Evaluate whether Treadmill Interval Training (TIT) is efficient in maintaining muscle mass in castrated mice. METHODS: 14 adult (3-4 months) Swiss mice were separated in two groups, Sham (n = 6) and gonadectomized (GDX, n = 8). The GDX underwent bilateral orchiectomy while the Sham underwent a surgical trauma. After recovery mice were subjected to a 10-day treadmill familiarization step within 2 weeks, 5 days/wk, 25° inclination, having both session duration and speed progressively increased from 5 to 15 min and 5 to 10 m/min, respectively. Next a maximum exercise tests were carried out with an interval of 48 h to assess the average maximum distance and speed reached (MSR). The test consisted of 5 min warm-up at 6 m/min followed by incremental speed stages of 2 m/min every 2 min. Test were considered maximum when the mice were unable to, or refused to run even with mechanical stimulation. Then, the animals were submitted to a 4 weeks of an TIT, consisting of an initial warm-up at 5 m/min during 5 min, then 10 bouts of 4 min with interspersed with 2 min of active rest 5 m/min. The training starts with an intensity of 55-65% MSR, with an increase of 10% each week reaching the intensity range of 85-95%. After the training mice were euthanized and the soleus and gastrocnemius muscles were collected and weighed. We compared muscle weight between groups using One-way ANOVA/Tukey (p ≤ 0.05). Data are presented as mean ± SEM. RESULTS: No difference was observed in the soleus and gastrocnemius mass between Sham and GDX groups. CONCLUSION: Our finds showed that the T deficiency did not change soleus and gastrocnemius mass of male mice submitted to TIT. Supported by FAP-DF.

Treadmill

Interval training

Orchiectomy

Affect

Adult male

10.1249/01.mss.0000763556.55081.57

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Association between CYP1A1m1 gene polymorphism and primary open-angle glaucoma

Genetics and Molecular Research (2014)

N. Costa C.T.X. Silva A.B. Frare R.E. Silva K.K.V.O. Moura

The CYP1A1 gene is related to the generation of secondary metabolites that are capable of inducing DNA damage.The CYP1A1m1 polymorphism has been examined in many studies, and is located in a region near loci that have been linked to glaucoma, including the locus GLC1I.As a result, this polymorphism has been related to several diseases that are influenced by exposure to xenobiotic as well as primary open-angle glaucoma.We compared the prevalence of the CYP1A1m1 polymorphism in 152 Brazilian patients, 100 patients with primary open-angle glaucoma, and 52 normal controls using restriction fragment length polymorphism analysis.The frequency of the homozygous wild-type (w1/w1) CYP1A1 gene among patients with primary open-angle glaucoma (N = 100) was 16%, for genotype w1/m1, the frequency was 77%, and for m1/m1 it was 7%.Among the control group (N = 52), the frequency of the homozygous wild-type (w1/w1) CYP1A1 gene was 54%, the frequency of w1/m1 was 46%, and the frequency of m1/m1 was 0%.The presence of the CYP1A1m1 polymorphism may interfere with xenobiotic metabolism and exacerbate direct or indirect damage to the optic nerve.These CYP1A1m1 10383

Gene polymorphism

Genotype frequency

10.4238/2014.december.4.33

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Estudo do Polimorfismo de Presença/Ausência dos Genes GSTN1 e GSTT1 em Pacientes com Endometriose

Revista EVS - Revista de Ciências Ambientais e Saúde (2012)

A.B. Frare Kátita Karina V. O. Moura

Resumo: endometriose e a presenca funcional das glândulas estromais do endometrio fora da cavidade uterina. O resultado do teste do x2, foi significativo (p=0,0049), encontrando maior ausencia dos genes GSTM1 e GSTT1 no grupo sem endometriose comprovada. Palavras-chave: Endometriose. Infertilidade. GSTM1. GSTT1.

10.18224/est.v39i2.2596

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