Olga Pavlova

Ministry of Health of the Russian Federation

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Pavlov Ka

Federal Medical Research Centre for Psychiatry and Narcology

ОИ

О. И. Гурина

Federal Medical Research Centre for Psychiatry and Narcology

Yana Zorkina

Federal Medical Research Centre for Psychiatry and Narcology

АM

Аnna Morozova

Moscow Research and Clinical Center for Neuropsychiatry

Olga Abramova

Federal Medical Research Centre for Psychiatry and Narcology

ВП

В. П. Чехонин

Endocrinology Research Center

Valeria Ushakova

Federal Medical Research Centre for Psychiatry and Narcology

G. P. Kostyuk

Moscow Regional Psychiatry Hospital No.5

A. A. Murashko

Federal Medical Research Centre for Psychiatry and Narcology

Eugene Zubkov

Federal Medical Research Centre for Psychiatry and Narcology

Cooperative Institutions

Federal Medical Research Centre for Psychiatry and Narcology

Ministry of Health of the Russian Federation

Moscow Research and Clinical Center for Neuropsychiatry

Federal Medical-Biological Agency

Russian Academy of Sciences

Lomonosov Moscow State University

Pirogov Russian National Research Medical University

Mental Health Research Center of Russian Academy of Medical Sciences

Center for Strategic Research

City Clinical Hospital

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Genes (2022)

Olga Abramova Kristina Soloveva Yana Zorkina Dmitry Gryadunov A. Yu. Ikonnikova

Dementia has enormous implications for patients and the health care system. Genetic markers are promising for detecting the risk of cognitive impairment. We hypothesized that genetic variants associated with suicide risk might significantly increase the risk of cognitive decline because suicide in older adults is often a consequence of cognitive impairment. We investigated several single-nucleotide polymorphisms that were initially associated with suicide risk in dementia older adults and identified the APOE gene alleles. The study was performed with subjects over the age of 65: 112 patients with dementia and 146 healthy volunteers. The MMSE score was used to assess cognitive functions. Study participants were genotyped using real-time PCR (APOE: rs429358, rs7412; genes associated with suicide: rs9475195, rs7982251, rs2834789, rs358592, rs4918918, rs3781878, rs10903034, rs165774, rs16841143, rs11833579 rs10898553, rs7296262, rs3806263, and rs2462021). Genotype analysis revealed the significance of APOEε4, APOEε2, and rs4918918 (SORBS1) when comparing dementia and healthy control groups. The association of APOEε4, APOEε2, and rs10903034 (IFNLR1) with the overall MMSE score was indicated. The study found an association with dementia of rs4918918 (SORBS1) and rs10903034 (IFNLR1) previously associated with suicide and confirmed the association of APOEε4 and APOEε2 with dementia.

Apolipoprotein E

Cognitive Decline

10.3390/genes13112174

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Citations (2)

NMDA receptors, anti-nmda receptor antibodies and their role in psychiatric and neuroinflammatory disorders

Molekulyarnaya Meditsina (Molecular medicine) (2021)

Olga Pavlova Pavlov Ka A. A. Murashko О. И. Гурина А.Б. Шмуклер

10.29296/24999490-2021-01-01

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Citations (2)

Association of rs4680 COMT, rs6280 DRD3, and rs7322347 5HT2A With Clinical Features of Youth-Onset Schizophrenia

Frontiers in Psychiatry (2019)

Аnna Morozova Yana Zorkina Pavlov Ka Olga Pavlova З. И. Сторожева

We investigated the associations of rs4680 COMT, rs6280 DRD3 and rs7322347 5HT2A with youth-onset schizophrenia in the Russian population in a case-control study, and the role of the genotype in the severity of clinical features. The association between rs7322347 and schizophrenia (p = 0.0001) is described for the first time. Furthermore, we found a link with rs6280 and rs4680 in females (p = 0.001 and p = 0.02 respectively) and with rs7322347 in males (p = 0.002). Clinical symptoms were assessed on three scales: the Clinician-Rated Dimensions of Psychosis Symptom Severity scale, PANSS and FAB. Gender differences in clinical features are of particular interest. In our study we found gender differences in the severity of clinical features - higher scores for delusions (PANSS and DSM-V) in males and higher scores for depression, delusions, somatic concern, motor retardation, poor attention were found in females.

rs4680

Association (psychology)

Depression

10.3389/fpsyt.2019.00830

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Citations (17)

BDNF, DRD4, and HTR2A Gene Allele Frequency Distribution and Association with Mental Illnesses in the European Part of Russia

Genes (2024)

Аnna Morozova Valeria Ushakova Olga Pavlova Sakeena Bairamova Nika Andryshenko

The prevalence of mental disorders and how they are diagnosed represent some of the major problems in psychiatry. Modern genetic tools offer the potential to reduce the complications concerning diagnosis. However, the vast genetic diversity in the world population requires a closer investigation of any selected populations. In the current research, four polymorphisms, namely rs6265 in BDNF, rs10835210 in BDNF, rs6313 in HTR2A, and rs1800955 in DRD4, were analyzed in a case–control study of 2393 individuals (1639 patients with mental disorders (F20-F29, F30-F48) and 754 controls) from the European part of Russia using the TaqMan SNP genotyping method. Significant associations between rs6265 BDNF and rs1800955 DRD4 and mental impairments were detected when comparing the general group of patients with mental disorders (without separation into diagnoses) to the control group. Associations of rs6265 in BDNF, rs1800955 in DRD4, and rs6313 in HTR2A with schizophrenia in patients from the schizophrenia group separately compared to the control group were also found. The obtained results can extend the concept of a genetic basis for mental disorders in the Russian population and provide a basis for the future improvement in psychiatric diagnostics.

rs6265

10.3390/genes15020240

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P.0486 N-methyl-D-aspartate receptor antibodies in first episode psychosis: preliminary results

European Neuropsychopharmacology (2021)

A. A. Murashko Pavlov Ka Olga Pavlova О. И. Гурина А.Б. Шмуклер

Autoimmune encephalitis

Opsoclonus

10.1016/j.euroneuro.2021.10.458

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Genetic determinants of serum brain-derived neurotrophic factor (BDNF) after alcohol withdrawal

Deleted Journal (2024)

Д. И. Перегуд A.I. Korolkov Baronets VIu К Л Козлов Anna S. Lobacheva

Peripheral brain-derived neurotrophic factor (BDNF) levels increase during alcohol abstinence in dependent subjects. Meanwhile, the genetic determinants of circulating BDNF this context are poorly understood. Studies of associations between circulating BDNF and single nucleotide polymorphisms (SNPs) of the corresponding gene are mainly restricted by the most studied BDNF SNP rs6265. A recent genome-wide association study demonstrated that the BDNF-related SNP rs75945125 is associated with serum BDNF. However, it is unknown whether this SNP is associated with changes in peripheral BDNF levels in the context of alcohol abstinence. We aimed to assess the association of the BDNF-related SNPs rs75945125 and rs6265 with changes in serum BDNF levels after alcohol withdrawal and the corresponding clinical manifestations. A total of 132 inpatients diagnosed with alcohol withdrawal syndrome were enrolled in the study. Serum BDNF levels were assessed on 2nd, 7th, and 21st days after alcohol withdrawal. Alcohol withdrawal syndrome severity, craving severity, affective symptoms, and cognitive impairment were assessed on 7th and 21st days. BDNF SNPs rs75945125 and rs6265 were genotyped using real-time PCR. BDNF concentrations in the carriers of the rs75945125 C allele on 21st day were higher as compared with TT genotype carriers. BDNF SNP rs75945125 C allele carriers had a longer duration of problem drinking, consumed a lesser volume of alcohol in the last 3 months, and had lower severity of withdrawal syndrome on 7th day compared with TT genotype carriers. BDNF levels were moderated by rs75945125 and rs6265, as well as by the interaction of rs75945125 × rs6265, whereas only the interaction of rs75945125 × rs6265 had an effect on depression scores during abstinence. Thus, the trajectory of serum BDNF changes during alcohol abstinence is determined by both rs75945125 and rs6265. Moreover, BDNF gene-related SNPs are associated with the clinical parameters of alcohol dependence and withdrawal. The longitudinal design without a control group and the relatively small sample size are the limitations of this study. Future studies on the revealed interactions are warranted.

Factor (programming language)

10.1007/s44337-024-00144-1

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Neurobiological Highlights of Cognitive Impairment in Psychiatric Disorders

International Journal of Molecular Sciences (2022)

Аnna Morozova Yana Zorkina Olga Abramova Olga Pavlova Pavlov Ka

This review is focused on several psychiatric disorders in which cognitive impairment is a major component of the disease, influencing life quality. There are plenty of data proving that cognitive impairment accompanies and even underlies some psychiatric disorders. In addition, sources provide information on the biological background of cognitive problems associated with mental illness. This scientific review aims to summarize the current knowledge about neurobiological mechanisms of cognitive impairment in people with schizophrenia, depression, mild cognitive impairment and dementia (including Alzheimer’s disease).The review provides data about the prevalence of cognitive impairment in people with mental illness and associated biological markers.

10.3390/ijms23031217

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Citations (61)

Protein Misfolding and Aggregation in the Brain: Common Pathogenetic Pathways in Neurodegenerative and Mental Disorders

International Journal of Molecular Sciences (2022)

Aleksandra Ochneva Yana Zorkina Olga Abramova Olga Pavlova Valeria Ushakova

Mental disorders represent common brain diseases characterized by substantial impairments of social and cognitive functions. The neurobiological causes and mechanisms of psychopathologies still have not been definitively determined. Various forms of brain proteinopathies, which include a disruption of protein conformations and the formation of protein aggregates in brain tissues, may be a possible cause behind the development of psychiatric disorders. Proteinopathies are known to be the main cause of neurodegeneration, but much less attention is given to the role of protein impairments in psychiatric disorders' pathogenesis, such as depression and schizophrenia. For this reason, the aim of this review was to discuss the potential contribution of protein illnesses in the development of psychopathologies. The first part of the review describes the possible mechanisms of disruption to protein folding and aggregation in the cell: endoplasmic reticulum stress, dysfunction of chaperone proteins, altered mitochondrial function, and impaired autophagy processes. The second part of the review addresses the known proteins whose aggregation in brain tissue has been observed in psychiatric disorders (amyloid, tau protein, α-synuclein, DISC-1, disbindin-1, CRMP1, SNAP25, TRIOBP, NPAS3, GluA1, FABP, and ankyrin-G).

Ankyrin

Chaperone (clinical)

10.3390/ijms232214498

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Citations (36)

EXPERIENCE OF THE EFFICIENT USING OF METHOTREXATE FOR SUBCUTANEOUS ADMINISTRATION IN PATIENT WITH POLYARTICULAR JUVENILE IDIOPATHIC ARTHRITIS

Вопросы современной педиатрии (2014)

S. A. Ushakova Olga Pavlova O. Yu. Khalidullina Valentina Lukyanova

The article describes successful case of the methotrexate monotherapy through subcutaneous administration (15 mg/m2 of body surface per week) for treatment of the polyarticular juvenile idiopathic arthritis in the girl in the age of 4. After 6 and 12 months of the methotrexate therapy the significant reduction of the clinical and laboratory disease activity indices and increase in functional activity of the child according to the pediatric ACR criteria for 50 and 90% respectively were observed. No adverse experience during the monotherapy was recorded. Development of inactive disease phase after 15 months of treatment allows predicting the development of pharmacological remission in patient in the prospective. Timely (immediately after the disease was diagnosed) administration of methotrexate allowed preventing the disablement of the child and improving the life quality of both the patient and her family.

Juvenile rheumatoid arthritis

10.15690/vsp.v13i4.1101

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P.0167 Genetic markers for schizophrenia spectrum disorders

European Neuropsychopharmacology (2021)

Kristina Soloveva Elena B. Khobta P. E. Alekseeva Yana Zorkina Pavlov Ka

Progression-free survival

10.1016/j.euroneuro.2021.10.162

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