Sonja Smiljic

Euromedik

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Vojkan Nestorović

University of Prishtina

Z. Milanović

University of Prishtina

V. Ivetić

University of Novi Sad

Mirjana Dejanović

Institut Mihajlo Pupin

B. Biševac

University of Nis

A. Stevanovic

Euromedik

Aleksandar Pavlović

University of Belgrade

Radisav Mitić

University of Nis

Ljiljana Popović

Univerzitetski Klinički Centar Srbije

M. Mišolić

Czech Academy of Sciences, Institute of Physiology

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University of Prishtina

Czech Academy of Sciences, Institute of Physiology

University of Novi Sad

University of Belgrade

University of Nis

Klinički centar Niš

Euromedik

Centar za Promociju Nauke

Univerzitetski Klinički Centar Srbije

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CLINICAL, LABORATORY AND ECHOCARDIOGRAPHIC VARIABLES ASSOCIATED WITH UNCONTROLLED RESISTANT HYPERTENSION IN WOMEN

Journal of Hypertension (2024)

A. Stevanovic Milica Dwklwva Sonja Smiljic Biljana Pencic Popovic

Objective: High blood pressure is the most deadly risk factor for women worldwide. Resistant hypertension (RH) is defined as office and ambulatory blood pressure (BP) requiring 4 or more antihypertensive medications, whether controlled or uncontrolled. Women are at greater risk of developing resistant hypertension than men. Design and method: 1119 resistant hypertensive patients diagnosed by ambulatory BP monitoring as true RH patients were divided into two groups: controlled RH (CRH) group, n = 489 and uncontrolled RH (URH), n = 630. The body mass index (BMI) was calculated and all patients were evaluated for nonmodifiable risk faktors, which included age and sex, and modifiable risc factors and concomitant diseases, such as smoking, use of alcohol, Dyslipidemia, Obesity, Diabetes mellitus, Ischemic heart disease, Renal disease and Cerebrovascular disease. Laboratory evaluation included fasting glycemia, creatinine, uric acid, lipids, microalbuminuria. Conventional and TDI echocardiography were performed in all patients, included E/Em (ratio of diastolic velocities), left ventricular mass index (LVM) and left atrial volume index (LAVI) were calculated according to the recommendation (ASE/EACVI). Statistical analysis included bivariate logistic regression. Results: Patients with URH were older (72±9.8 vs 71±10.7;p=0,01), more obese (28.0±4.0 vs 27.6±3.3;p=0.036), they also had higher prevalence of Diabetes mellitus (241(38.3%) vs 141(28.8%);p=0,001) and significantly more often in menopause or postmenopause (402(63.8%) vs 287(58.7%); p=0.046). LAVI (43.7±17.7 vs 40.2±15.0;p=0,001), LVEDV (183.3±46.3 vs 177.3±48.7;p=0,038), LVESV (82.2±24.9 vs 78.2±24.8,;p=0,007)), LVMI (116.2±23.2 vs 111.2±22.9;p=0,0003), E/Em (15.0±3.7 vs 14.5±3.8;p=0.038) and uric acid (356.3±106.7 vs 340.1±103;.p=0,028) were significantly higher in this group. Uncontrolled RH associated with older age (0.987(0.975-0.999); p=0,032), obesity (0.968(0.936-1.000);p=0,049) and diabetes (1.467(1.132-1.901);p=0,004), but not with menopause. Having left ventricular hypertrophy (0.992(0.987-0,998);p=0,008), increased LAVI (0.991(0.984-0.999);p=0.023) and higher uric acid (1.001 (1.000-1.003), p =0.038) are also associated with URH. Conclusions: The prevalence of uncontrolled RH in women was high, despite optimal therapy. Hypetension remains uncontrolled in patients who are older, obese, with diabetes, left ventricular hypertrophy, and in menopause. Higher uric acid level also seems to have a negative influence on the control of the disease. High prevalence of poor blood pressure control motivates promotion of new therapeutic strategies and lifestyle changes.

10.1097/01.hjh.0001022740.03975.85

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THE INFLUENCE OF DOMINANCE OF A HAND WHEN PERFORMING THE ODDBALL TASK ON EVENT-RELATED POTENTIAL P300

Praxis medica (2010)

B. Biševac V. Ivetić Z. Milovanović Vojkan Nestorović Sonja Smiljic

Event-related potential which represents a large positive wave which varies in amplitude and depends on subject's capability as well as on stimulus modality on which subject needs to react and appears around 300 ms after stimulation is called event related potential P300. In 1965. Sutton and the assistants were the first to suggest division of evocated potentials, according to the stimulus that provoke them, on "exogenous" (under the influence of exogenous stimulus) and "endogenous" or "cognitive" provoked by endogenous stimulus, which depends on the state of consciousness (vigilance), attention, concentration and especially, the type of the task a subject needs to perform during the recording. One of the most studied responses of the event-related potentials is so called "P300", the late positive wave complex which appears around 300 500ms after the stimulus. It is gained when the subjects' attention is focused on the signal which rarely appears, especially if the signal has some emotional or motivational meaning. The aim of this work was to determine whether there was a difference in latency and amplitude of the event related potential P300 when the button is pushed with dominant hand compared with nondominant hand in both males and females. The experiment included 30 subjects (15 males and 15 females). P300 potential was provoked with the auditive "oddball" paradigm. Event-related potencial P300 is recorded with 10-20 system. Cz electrode is set in the middle of nazion-inion line, while Fz electrode is set on the third of nazion-inion line above frontal lobe. In classical "oddball" paradigm, when a subject reacted on the signal by pushing the button with dominant hand, the value of Fz end Cz latency was significantly shorter in comparison to the values of Fz end Cz latency gained by pushing the button with non-dominant hand (left hand) in males, while such differences were not found in females.&nbsp;

Oddball paradigm

Dominance (genetics)

10.70949/pramed201002354b

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EFFECTS OF GLUCAGON ON HEMODINAMIC VARIABLES IN CONDITIONS ON BLOCADE BETA ADRENORECEPTORS

Praxis medica (2003)

Z. Milanović Aleksandar Pavlović P. Jovanović D. Radović Vojkan Nestorović

Scientific research of effects of glucagon on the cardiovascular system have shown that glucagon has some cardiostimulatory potential. The very interesting fact is that glucagon shows its cardiostimulatory effects by activating its own, higly specific glucagonic receptors. That is way we wanted to research not only the effects of glucagon on the C.V.S. but also its effects during the depression of the C.V.S. with high dosses of beta blocators (presolol) expecting a good hemodinamic response. The experiment has been performed on two groups of 6 dogs. The first group of animal was treated with i.v. bolus injections of glucagon and other group with presolol (15 mg/kg b.w.) i.v., and after that with i.v. bolus injection of glucagon. Hemodinamic variables (mean arterial pressure, central venal pressure and hearth frequency) were registred at the 1-st, 2-nd, 3-rd, 10-th, 20-th, 30-th and 40-th minute. The hearth frequency was registred by continous monitoring, mean arterial pressure was registred with cateter in the arterial femoralis, while the central venal pressure was registred over central venal cateter in v. femoralis. After the i.v. bolus injection glukagon shows higly positive effects, followed by short-term increase of the mean arterial pressure, while the c.v.p. considerably falls. During the administration of presolol the hearth frequency and mean arterial pressure fall considerably and progressively, while the c.v.p. rises considerably. Glucagon, in conditions of c.v.s. depresion by high doses of presolol (15 mg /kg b.w.) considerably increases hearth frequency and mean arterial pressure, while the c.v.p. falls considerably.

BETA (programming language)

10.70949/pramed200301036m

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the variability in P300 cognitive evoked potential amplitude in the auditory oddball paradigm

Praxis medica (2015)

B. Biševac Ljiljana Popović Z. Milanović Vojkan Nestorović Sonja Smiljic

One of the best-studied responses of cognitive evoked potentials is a so-called 'P300', the late positive wave complex that occurs about 300-500 ms after the stimulus. It is obtained when the subject's attention is focused on a signal that is rare, especially if the signal has a motivational or emotional meaning. In the study of P300 potential, we followed the variations of potential amplitude and latency, so the objective was to examine whether there is a difference in Fz and Cz amplitudes of auditory induced cognitive evoked P300 potential depending on the performance of oddball tasks, both in male and female subjects. The study included 60 subjects (30 female respondents and 30 male respondents). P300 potential is induced by the auditory 'oddball' paradigm with 80% of non-target and 20% of target stimuli that are presented to the patient through headphones. The target tones are high tones of 2000 Hz. The standard, 1000 Hz tones the respondent should ignore but when he hears the target tones the respondent should press the button on the special handle. The value of Fz and Cz amplitudes both in male and female subjects obtained in the classical 'oddball' paradigm when the subject reacted to the signal by pressing the key with the dominant (right) arm were statistically significantly lower (p>0,05) than the values of Fz and Cz amplitudes obtained when the key was pressed by the non-dominant hand. Based on this experiment it can be concluded that both in male and female subjects the performance of oddball tasks does not affect the amplitude of P300 cognitive evoked potentials.

Oddball paradigm

P3a

Evoked potential

Stimulus (psychology)

Psychoacoustics

Headphones

10.5937/pramed1502093b

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The importance of functional hemispheric asymmetry in the assessment of cognitive evoked potentials and reaction time

Praxis medica (2016)

Mirjana Dejanović V. Ivetić Vojkan Nestorović Z. Milanović Dragica Parlic

The aim of this study was to determine whether there is a correlation of latency and amplitude of P300 cognitive potential and the degree of lateralization of brain hemispheres. The study included 60 subjects whose age was between 45 and 56 years. Bioelectric brain activity was recorded using argentum chloride (AgCl) electrodes that were placed at central line of the scalp (over Fz and Cz regions) according to the international 10-20 standard. P300 was generated using 'oddball' paradigm with randomized stimuli: A frequent 1000 Hz tone with an occurrence of 80 % and a 2000 Hz tone (target) with a 20 % occurrence. The measurement is done with the right hand (first recording) and left hand (second recording). All subjects in this study were tested for usage lateralization and showed that they are right-handed. Based on the results of gestural lateralization subjects are divided in three groups. In the group with high degree of lateralization latencies of P300 were significantly lower when dominant hand was used in comparison to non-dominant hand, on Fz electrode (t = 4,162, p<0,01) and Cz electrode (t = 5,302, p<0,01 (p<0.01) and amplitudes of P300 were significantly higher, on Fz electrode (t=-2,725, p<0,05), on Cz electrode (t=2,527, p<0,05). However, there were no statistically significant differences (p>0.05) for latencies and amplitudes of P300 between dominant and non-dominant hand for the group of subjects with weak and average degree of lateralization. In both subject groups, significantly faster RT was measured when dominant hand was used. The P300 cognitive potential and reaction time can contribute to the study of indicators of the functional hemispheric asymmetry of the brain.

Evoked potential

Oddball paradigm

Degree (music)

10.5937/pramed1602077d

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ASSOCIATION BETWEEN HYPERHOMOCYSTEINEMIA AND VITAMIN D DEFICIENCY AND THE RISK OF HYPERTENSION

Journal of Hypertension (2024)

Sonja Smiljic Aleksandra Ilić A. Stevanovic Vojkan Nestorović Srna Sapic

Objective: Cardiovascular risk factors simultaneously affect the premature onset of hypertension. The aim of our study was to indicate the frequency of cardiovascular risk factors and coherency of dyslipidemia, elevated values of homocysteine and vitamin D deficiency with the arterial hypertension. Design and method: In a prospective study, we have included 230 respondents, of which 199 are being treated for hypertension, and 31 had normal blood pressure. All patients were divided into three groups, patients between 22-39 years old, 40-49 years old and 50-59 years old. We have processed socio-epidemiological data, clinical exam, and biochemical analyses. Results: In the group of patients between 22 and 39 years of age were significantly less female respondents, and younger patients significantly less had HTA (p >0.05). Compared to people with normal blood pressure, patients treated for HTA are physically inactive (p >0.17), smokers (0.002) and have BMI above 25 kg/m2 (p>0.02). Total cholesterol and triglycerides were elevated at patients with hypertension, and the value of HDL cholesterol was significantly higher in patients with normal blood pressure (P>0.05). Vitamin D deficiency and hyperhomocisteinemia were more common in people with hypertension and between 50-59 years of age (p<0.001). Conclusions: Patients with arterial hypertension have association of more cardiovascular risk factors at the same time. Association of arterial hypertension, dyslipidemia, hyperhomocisteinemia and vitamin D deficiency, speeds up the process of atherosclerosis, leads to coronary heart disease and premature death. Prevention has an important place in the early diagnosis of hypertension and prevention of complications.

Hyperhomocysteinemia

Association (psychology)

10.1097/01.hjh.0001022296.70886.d8

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