Djénéba Dabitao

Université des Sciences, des Techniques et des Technologies de Bamako

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i-10 index

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Co-Authors

Seydou Doumbia

Université des Sciences, des Techniques et des Technologies de Bamako

Mahamadou Diakité

Université des Sciences, des Techniques et des Technologies de Bamako

Bassirou Diarra

Université des Sciences, des Techniques et des Technologies de Bamako

Bocar Baya

University of Bamako

Bourahima Kone

Université des Sciences, des Techniques et des Technologies de Bamako

M. Sanogo

Université des Sciences, des Techniques et des Technologies de Bamako

Yéya dit Sadio Sarro

Université des Sciences, des Techniques et des Technologies de Bamako

Souleymane Diallo

Université Nangui Abrogoua

Jay H. Bream

Johns Hopkins University

Ibrahim Sanogo

Université des Sciences, des Techniques et des Technologies de Bamako

Cooperative Institutions

Université des Sciences, des Techniques et des Technologies de Bamako

160

Inserm

126

National Institutes of Health

125

National Institute of Allergy and Infectious Diseases

121

University of Bamako

104

London School of Hygiene & Tropical Medicine

Mali-Folkecenter

Johns Hopkins University

Bordeaux Population Health

Leidos (United States)

Author Statistics

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Supplementary Table 1 from A Peripheral Circulating T<sub>H</sub>1 Cytokine Profile Is Inversely Associated with Prostate Cancer Risk in CLUE II

Nrupen A. Bhavsar Jay H. Bream Alan K. Meeker Charles G. Drake Sarah B. Peskoe

<p>Risk of prostate cancer excluding cases diagnosed within 2 and 5 years comparing highest quartilea of cytokine concentration with lowest quartile_a of concentration, CLUE II.</p>

Table (database)

10.1158/1055-9965.22435270.v1

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Clinical risk factors associated with multidrug-resistant tuberculosis (MDR-TB) in Mali

International Journal of Infectious Diseases (2019)

Bocar Baya Chad J. Achenbach Bourahima Kone Y. Toloba Djénéba Dabitao

MDR-TB is a major threat to global TB control. In 2015, 580,000 were treated for MDR-TB worldwide. The worldwide roll-out of GeneXpert MTB/RIF® has improved diagnosis of MDR-TB; however, in many countries laboratories are unable to assess drug resistance and clinical predictors of MDR-TB could help target suspected patients. In this study, we aimed to determine the clinical factors associated with MDR-TB in Bamako, Mali.We performed a cross-sectional study of 214 patients with presumed MDR-TB admitted to University of Bamako Teaching Hospital, Point-G between 2007 and 2016. We calculated crude and adjusted odds ratios for MDR-TB disease diagnosis using SPSS.We found that age ≤40years (OR=2.56. 95% CI: 1.44-4.55), two courses of prior TB treatment (OR=3.25, 95% CI: 1.44-7.30), TB treatment failure (OR=3.82, 95% CI 1.82-7.79), sputum microscopy with 3+ bacilli load (OR=1.98, 95% CI: 1.13-3.48) and a history of contact with a TB patient (OR=2.48, 95% CI: 1.11-5.50) were significantly associated with confirmation of MDR-TB disease. HIV was not a risk factor for MDR-TB (aOR=0.88, 95% CI: 0.34-1.94).We identified several risk factors that could be used to identify MDR-TB suspects and prioritize them for laboratory confirmation. Prospective studies are needed to understand factors associated with TB incidence and clinical outcomes of TB treatment and disease.

GeneXpert MTB/RIF

10.1016/j.ijid.2019.02.004

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Citations (68)

Short Communication: Genetic Variation in Human IL10 Proximal Promoter and Susceptibility to HIV-1 Infection in Mali, West Africa

AIDS Research and Human Retroviruses (2020)

Djénéba Dabitao Mamadou Dembélé Michael E. Urbanowski Bourahima Kone Mamadou Wague

It is now recognized that to fully understand the role of host genetic variation on susceptibility to HIV-1 infection, investigations must be extended to African populations. We sought to determine if genetic variation in IL10 are associated with HIV-1 infection in a West African cohort in Mali. HIV-infected and -uninfected individuals were genotyped for three common single nucleotide polymorphisms (SNPs) located at positions -592 (C/A), -819 (C/T), and -1082 (G/A) of the IL10 promoter. We found that the ATA haplotype, which has been previously associated with low IL-10 expression, was the most represented in the cohort. Although we observed a trend toward an increased frequency of ATA/ATA carriage in HIV-infected compared with -uninfected individuals, the difference was not statistically significant. Similarly, individual IL10 SNPs were not significantly enriched in the HIV-infected group, suggesting that IL10 genetic variants are not associated with HIV-1 in this West African cohort from Mali.

10.1089/aid.2020.0140

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Relationship between patient sex and anatomical sites of extrapulmonary tuberculosis in Mali

Journal of Clinical Tuberculosis and Other Mycobacterial Diseases (2023)

Bocar Baya Ibrahim Sanogo Mahamadou Koné D. Soumaré K Ouattara

Contribution of host factors in mediating susceptibility to extrapulmonary tuberculosis is not well understood.

Extrapulmonary tuberculosis

Abdominal Tuberculosis

10.1016/j.jctube.2023.100389

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Sex Differences in Active Pulmonary Tuberculosis Outcomes in Mali, West Africa

American Journal of Tropical Medicine and Hygiene (2022)

Djénéba Dabitao Anou M. Somboro Ibrahim Sanogo Bassirou Diarra Chad J. Achenbach

Men and women often respond differently to infectious diseases and their treatments. Tuberculosis (TB) is a life-threatening communicable disease that affects more men than women globally. Whether male sex is an independent risk factor for unfavorable TB outcomes, however, has not been rigorously investigated in an African context, where individuals are likely exposed to different microbial and environmental factors. We analyzed data collected from a cohort study in Mali by focusing on newly diagnosed active pulmonary TB individuals who were treatment naive. We gathered baseline demographic, clinical, and microbiologic characteristics before treatment initiation and also at three time points during treatment. More males than females were affected with TB, as evidenced by a male-to-female ratio of 2.4:1. In addition, at baseline, males had a significantly higher bacterial count and shorter time to culture positivity as compared with females. Male sex was associated with lower smear negativity rate after 2 months of treatment also known as the intensive phase of treatment, but not at later time points. There was no relationship between patients' sex and mortality from any cause during treatment. This study suggests that sex-based differences in TB outcomes exist, with sex-specific effects on disease outcomes being more pronounced before treatment initiation and during the intensive phase of treatment rather than at later phases of treatment.

Female sex

10.4269/ajtmh.21-1141

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Diagnostic Performances of Three Rapid Diagnostic Tests for Detecting HIV Infections in Mali.

PubMed (2019)

Bourahima Kone Yéya dit Sadio Sarro Bocar Baya Djénéba Dabitao Nadie Coulibaly

Diagnosis of HIV infections in resource-limited countries like Mali is based on Rapid Diagnostic Tests (RDTs). The RDTs are diagnostic assays designed for use at the Point-Of-Care (POC), which is quick, cost-effective and easy to perform. However, in these countries, the tests are commonly used without any initial evaluation or monitoring of their performance despite high levels of HIV strain diversity and rapid evolution of the virus. In this study, the reliability and accuracy of HIV RDTs (Determine™, Multispot™, SD Bioline™) used in Mali, where HIV-1 and HIV-2 co-exist, were evaluated from August 2004 to November 2017. A total of 1303 samples from new HIV-suspect patients in Bamako were tested for HIV-1 and HIV-2 using the RDT Determine™, followed by ELISA and Western Blot (WB). The Determine™ test showed a robust diagnostic sensitivity of 98.7% [CI 95: 97.59-99.37] and a diagnostic specificity of 99.2% [CI 95: 98.22-99.67]. The Multispot™ assay showed a diagnostic sensitivity of 98.77% [CI 95: 97.59-99.37] and a diagnostic specificity of 99.2% [CI 95: 98.22-99.67]. The diagnostic sensitivity and specificity of SD Bioline™ HIV-1/2 were 100% [CI 95:72.25-100] and 88.89% [CI 95: 56.50- 98.71], respectively. These data indicate excellent performance for HIV RDTs in Mali and we recommend the use of Determine™ HIV-1/2 for HIV screening and Multispot™ for discriminating HIV-2 from HIV-1 infections.

HIV diagnosis

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Investigating immune amnesia after measles virus infection in two West African countries: A study protocol

medRxiv (Cold Spring Harbor Laboratory) (2024)

Karine Fouth Tchos Renée Ridzon Mory Cherif Haidara Djénéba Dabitao Esther Akpa

“Investigation of Immune Amnesia Following Measles Infection in Select African Regions” (ClinicalTrials.gov Identifier: NCT06153979 ) is a prospective, observational, longitudinal study being conducted in two West African countries, Guinea, and Mali. The overall goal is to investigate the impact of measles virus (MeV) infection on pre-existing immunity, vaccine response, and susceptibility to subsequent illness. A total of 256 children aged 1 to 15 years are being enrolled into one of two study arms: those with acute MeV infection (cases) and without (controls). Acute MeV is confirmed by RT-PCR testing on upper respiratory specimens or IgM detection on blood samples at screening. Blood samples are collected at multiple time points at screening (Day 0), at an optional visit to repeat IgM serology for inconclusive or negative Day 0 results (Day 7-10), and during follow-up visits on Day 14, Week 13, and Week 52. These blood samples will be tested to evaluate both humoral and cellular immune responses to endemic pathogens to measure variations in antibody diversity and antibody secreting cells (ASCs). To explore how recent MeV infection may affect the child’s ability to respond to a controlled immune stimulus, all participants will receive rabies vaccine pre-exposure prophylaxis (PrEP) using Verorab inactivated rabies vaccine. Three doses of 0.5 ml of VERORAB vaccine are administered on Days 0, 7, and 28. Biological samples will be collected after vaccination to assess if the rabies vaccine response differs: 1) between cases and controls, and 2) based on the timing of the rabies vaccination after acute measles infection. In addition, the study team will collect information on healthcare encounters during the year-long follow-up will be collected to determine if there is a difference in the number of encounters by study group. The findings of this study will further the understanding of the MeV immune amnesia phenotype.

Rabies vaccine

10.1101/2024.11.19.24317598

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Ex-vivo Sensitivity of Plasmodium falciparum to Common Anti-malarial Drugs: The Case of Kéniéroba, a Malaria Endemic Village in Mali

Drugs in R&D (2020)

Karim Traoré Seidina A. S. Diakité Sékou Bah Drissa Konaté Djénéba Dabitao

In 2006, the National Malaria Control Program in Mali recommended artemisinin-based combination therapy as the first-line treatment for uncomplicated malaria. Since the introduction of artemisinin-based combination therapy, few reports are available on the level of resistance of Plasmodium falciparum to the most common anti-malarial drugs in Mali. From 2016 to 2017, we assessed the ex-vivo drug sensitivity of P. falciparum isolates in Kéniéroba, a village located in a rural area of southern Mali. We collected P. falciparum isolates from malaria-infected children living in Kéniéroba. The isolates were tested for ex-vivo sensitivity to commonly used anti-malarial drugs, namely chloroquine, quinine, amodiaquine, mefloquine, lumefantrine, dihydroartermisinin, and piperaquine. We used the 50% inhibitory concentration determination method, which is based on the incorporation of SYBR® Green into the parasite's genetic material. Plasmodium falciparum isolates were found to have a reduced ex-vivo sensitivity to quinine (25.7%), chloroquine (12.2%), amodiaquine (2.7%), and mefloquine (1.3%). In contrast, the isolates were 100% sensitive to lumefantrine, dihydroartermisinin, and piperaquine. A statistically significant correlation was found between 50% inhibitory concentration values of quinine and amodiaquine (r = 0.80; p < 0.0001). Plasmodium falciparum isolates were highly sensitive to dihydroartermisinin, lumefantrine, and piperaquine and less sensitive to amodiaquine (n = 2), mefloquine (n = 1), and quinine (n = 19). Therefore, our data support the previously reported increasing trend in chloroquine sensitivity in Mali.

Ex vivo

Anti malarial

10.1007/s40268-020-00313-4

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Citations (5)

Correction: Design of an observational multi-country cohort study to assess immunogenicity of multiple vaccine platforms (InVITE)

PLoS ONE (2024)

Irini Sereti Kathryn Shaw‐Saliba Lori E. Dodd Robin Dewar Sylvain Laverdure

[This corrects the article DOI: 10.1371/journal.pone.0273914.].

10.1371/journal.pone.0314048

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Establishment of a collaborative research ethics training program to prepare the next generation of ethics researchers in Mali

International Journal of Ethics Education (2023)

Seydou Doumbia Heather Rosen Nino Paichadze Housseini Dolo Djénéba Dabitao

Abstract Background: Despite an increase in health research conducted in Africa, there are still inadequate human resources with research ethics training and lack of local long-term training opportunities in research ethics. A research ethics training program named United States-Mali Research Ethics Training Program (US-Mali RETP) was established through a partnership between the George Washington University Milken Institute School of Public Health (GWSPH), USA and University of Sciences, Techniques & Technologies of Bamako (USTTB), to address the critical need for improved bioethics training, leadership, and policy in Mali. Methods: The aims of the capacity building programme are achieved by leveraging US and Africa-based expertise to strengthen research ethics education and capacity through: (1) intensive faculty development to design ethics training curricula; (2) development of a research ethics specialization within the existing Masters of Public Health program (MPH); and (3) establishing professional development courses through short-term training workshops and webinars to address research and professional needs in ethics. Results: The program will strengthen USTTB’s capacity of research ethics by training at least 15 MPH students over 5 years to prepare the next generation of ethics researchers. During the first two years of the program, a new ethics training curricula was developed, two cohorts of Master’s students were enrolled, and a series of webinars and workshops were conducted with participation of Malian and international researchers. Conclusions: US-Mali RETP will promote a sustainable bioethics enterprise at USTTB, and enable dissemination of research ethics training to increase health research capacity in Mali.

Bioethics

Research Ethics

Capacity Building

10.1007/s40889-023-00170-0

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Citations (1)