Mika Takahashi

RIKEN Center for Brain Science

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Akihiko Hirose

National Institute of Health Sciences

Mutsuko Hirata‐Koizumi

National Institute of Health Sciences

Eiichi Kamata

National Institute of Health Sciences

Atsushi Ono

Okayama University

Mariko Matsumoto

Eisai (Japan)

Noriaki Takeda

Tokushima University

Takaomi C. Saido

RIKEN Center for Brain Science

Naoki Toda

Okayama University

Hiromitsu Mimata

Oita University

Makoto Ema

Shimane University

Cooperative Institutions

Oita University

National Institute of Health Sciences

The University of Tokyo

Tokushima University

Osaka University

RIKEN Center for Brain Science

Kyoto University

National Institute of Health Sciences

Nagoya University

University College London

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Efficacy of prophylactic single-dose therapy using fluoroquinolone for prostate brachytherapy

Japanese Journal of Radiology (2012)

Takeo Nomura Kenichi Hirai Mutsushi Yamasaki Toru Inoue Mika Takahashi

Prostate brachytherapy

10.1007/s11604-012-0053-z

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Citations (3)

Effects of caffeine on glandular stomach carcinogenesis induced in rats by N-methyl-N′-nitro-N-nitrosoguanidine and sodium chloride

Food and Chemical Toxicology (1995)

Akiyoshi Nishikawa Fumio Furukawa Takayoshi Imazawa Shinichiro Ikezaki Tomohiko Hasegawa

10.1016/0278-6915(95)80243-6

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Citations (29)

Susceptibility of newborn rats to 3‐ethylphenol and 4‐ethylphenol compared with that of young rats

Congenital Anomalies (2006)

Mika Takahashi Mutsuko Hirata‐Koizumi Nobuo Nishimura Yoshihiko Ito Masao Sunaga

ABSTRACT Newborn rat studies were conducted with oral administration of 3‐ethylphenol (3EP) and 4‐ethylphenol (4EP) on postnatal days (PND) 4–21 to allow comparison of no observed adverse effect level (NOAEL) and unequivocally toxic level (UETL) with those from 28‐day studies of young rats starting at 5–6 weeks of age. In the newborn rat studies, slightly lowered body weight was observed after 3EP treatment, and deaths, hypoactivity, Straub tail, deep respiration and delayed righting reflex were clearly observed after 4EP treatment. In the young rat studies, salivation, staggering gait, changes in the liver including high values of liver weight and alanine aminotransferase or total cholesterol and the lesions in the forestomach were clearly observed after 3EP and 4EP treatments. NOAELs of 3EP and 4EP in the newborn rat studies appeared to be almost 3 times lower than those in the young rat studies. As a clear toxicity of 3EP was not observed in newborn rats, UETLs were not established for 3EP. Regarding 4EP, UETL of young rats was 4–5 times higher than that of newborn rats. In conclusion, newborn rats were 3–5 times more susceptible to 3EP and 4EP than young rats.

Hypoactivity

Righting reflex

No-observed-adverse-effect level

10.1111/j.1741-4520.2006.00098.x

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Citations (9)

Nitrate Levels in Health Foods

京都女子大学食物学会誌 (2014)

禎浩川添 Sadahiro Kawazoe 美佳高橋 Natsuki Monzen Mika Takahashi

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An isogenic panel of single App knock-in mouse models of Alzheimer’s disease confers differential profiles of β-secretase inhibition and endosomal abnormalities

bioRxiv (Cold Spring Harbor Laboratory) (2021)

Naoto Watamura Kaori Sato Gen Shiihashi Ayami Iwasaki Naoko Kamano

SUMMARY We previously developed single App knock-in mouse models of Alzheimer’s disease (AD) that harbor the Swedish and Beyreuther/Iberian mutations with or without the Arctic mutation ( App NL- G-F and App NL-F mice). These models showed the development of amyloid β peptide (Aβ) pathology, neuroinflammation and cognitive impairment with aging. We have now generated App knock-in mice devoid of the Swedish mutations ( App G-F mice) and some additional mutants to address the following two questions: [1] Do the Swedish mutations influence the mode of β-secretase inhibitor action in vivo ? [2] Does the quantity of C-terminal fragment of amyloid precursor protein (APP) generated by β-secretase (CTF-β) affect endosomal properties as previously reported as well as other pathological events? Aβ pathology was exhibited by App G-F mice from 6 to 8 months of age, and was accompanied by microglial and astrocyte activation. We found that a β-secretase inhibitor, verubecestat, inhibited Aβ production in App G-F mice, but not in App NL-G-F mice, indicating that the App G-F mice are more suitable for preclinical studies of β-secretase inhibition given that most AD patients do not carry Swedish mutations. We also found that the quantity of CTF-β generated by various App knock-in mutants failed to correlate with endosomal alterations or enlargement, implying that CTF-β, endosomal abnormalities, or both are unlikely to play a major role in AD pathogenesis. This is the first AD mouse model ever described that recapitulates amyloid pathology in the brain without the presence of Swedish mutations and without relying on the overexpression paradigm. Thus, experimental comparisons between different App knock-in mouse lines will potentially provide new insights into our understanding of the etiology of AD.

Gene knockin

Knockout mouse

P3 peptide

10.1101/2021.08.22.457278

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Citations (1)

Summary information of human health hazard assessment of existing chemical substances (I).

PubMed (2015)

Mariko Matsumoto Katsumi Kobayashi Mika Takahashi Mutsuko Hirata‐Koizumi Atsushi Ono

Under the Chemical Substances Control Law (CSCL) in Japan, initial hazard information tor existing chemical substances has been collected by the Ministry of Health, Labour and Welfare, Japan (MHLW) to assess potential initial risks to human health. We have reviewed all collected toxicity information pertaining to acute toxicity, repeated dose toxicity, genotoxicity, and/or reproductive/developmental toxicity and performed hazard assessments. Approximately 150 substances are currently undergoing review and assessment. For clarification and evaluation of each toxicity study, we have created a dossier (a collection of study data containing a detailed summary of the methods, results, and conclusions of each study) in English using the International Uniform Chemical Information Database (IUCLID) version 5. The IUCLID dossier format is widely used and has been accepted as one of the most beneficial formats for providing summarized chemical substance toxicity assessments. In this report, as a contribution to our ongoing hazard assessment activity, we present summary hazard information related to the potential human health effects of the following 5 chemical substances: 4-chlorobenzoyl chloride (CAS: 122-01-0); benzenesulfonic acid, 4-hydroxy-, tin (2+) salt (CAS: 70974- 33-3); chlorocyclohexane (CAS: 542-18-7); 1,3-cyclohexanedimethanamine (CAS: 2579-20-6); and 1,3,5-triazine-2,4,6 (1H,3H,5H) -trithione (CAS: 638-16-4). The IUCLID dossiers created for these 5 chemical substances will be made available via the Japan Existing Chemical Data Base (JECDB) at . Additional human health hazard information on existing chemical substances will be provided using the same methodology and website when it is available.

Christian ministry

Chemical toxicity

Developmental toxicity

Health hazard

Reproductive toxicity

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Citations (3)

A quinol glucoside from Abeliophyllum distichum

Phytochemistry (1993)

Hiroshi Kuwajima Mika Takahashi Mami Ito Wu Hua-Xin Kiyokazu Takaishi

Glucoside

10.1016/0031-9422(93)85409-k

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Citations (24)

[Progress on OECD Chemicals Programme (13)--SIAM 22 in Paris, 2006].

PubMed (2007)

Mika Takahashi Mariko Matsumoto Kazumi Kawahara Seiichirou Kanno Yoshio Sugaya

The 22nd Screening Information Data Set (SIDS) Initial Assessment Meeting (SIAM 22) was held at the Organisation for Economic Co-operation and Development (OECD) headquarters in Paris, France. The initial assessment documents of five substances (CAS numbers: 75-59-2, 80-51-3, 101-83-7, 103-24-2, 27813-02-1) sponsored by Japan were all agreed at the meeting. In this report, the documents of these substances are introduced.

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Citations (1)

[Progress on OECD chemicals programme].

PubMed (2004)

Mika Takahashi Mutsuko Hirata Mariko Matsumoto Akihiko Hirose Eiichi Kamata

The twelfth SIDS, the Screening Information Data Set, Initial Assessment Meeting (SIAM 12) was held at the Organisation for Economic Co-operation and Development (OECD) headquarters in Paris, France and SIAM 13 was held in Bern, Switzerland, hosted by the European Commission. Two substances at SIAM 12 (CAS No:91-15-6, 123-77-3) and 4 substances at SIAM 13 (CAS No:91-76-9, 112-85-6, 868-77-9, 1477-55-0) were submitted by the Japanese Government and/or International Council of Chemical Associations (ICCA). These substances were agreed at the meetings. In this report, the human health effects of 6 substances above-mentioned are introduced.

European commission

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Citations (0)

Higher susceptibility of newborn rats to 2-tert-butylphenol and 2,4-di-tert-butylphenol toxicity as compared with young rats

Toxicology Letters (2007)

Ryuichi Hasegawa Mutsuko Hirata‐Koizumi Masao Hamamura Hiromi Furukawa N. Fukuda

10.1016/j.toxlet.2007.05.530

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Citations (3)