Murat Tulmaç

Sağlık Bilimleri Üniversitesi

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

VŞ

Vedat Şimşek

Kırıkkale University

Mehmet Doğru

Dicle University

Haksun Ebinç

Northwestern University

Hamza Sunman

Sağlık Bilimleri Üniversitesi

Fatih Poyraz

Sivas Cumhuriyet Üniversitesi

Yusuf Tavıl

Gazi University

Murat Turfan

Bezmiâlem Vakıf Üniversitesi

Adnan Abacı

Gazi University

Engin Algül

Sağlık Bilimleri Üniversitesi

TÇ

Tolga Çimen

University Hospital of Zurich

Cooperative Institutions

Gazi University

Kırıkkale University

Sağlık Bilimleri Üniversitesi

Ministry of Health

Dışkapı Yıldırım Beyazıt Eğitim ve Araştırma Hastanesi

University of Health Sciences

University of Health Science

Institute of Cardiology

Gazi Hastanesi

University of Health Sciences Antigua

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

The effect of ticagrelor and clopidogrel on angiographic parameters according to diabetic status in patients with ST elevation myocardial infarction

Russian Journal of Cardiology (2022)

Faruk Aydınyılmaz Hamza Sunman Engin Algül Ayşenur Özkaya İbiş Nail Burak Özbeyaz

Aim . We aimed to compare post-interventional angiographic outcomes of ticagrelor versus clopidogrel according to glycosylated hemoglobin (HbA1c) levels in patients with ST-elevation myocardial infarction. Material and methods . The study included a total of 532 patients, with 334 receiving ticagrelor (62,8%) and 198 clopidogrel (37,2%). Diabetic status of the patients was assessed with HbA1c. TIMI flow grade and TIMI frame count were calculated and compared between two groups. Results . TIMI flow grade 3 was higher and TFC was lower after percutaneous coronary intervention of the infarct-related artery in patients treated with ticagrelor compared to clopidogrel (89,2% vs. 73,7%; p< 0,001, 20 vs. 24; p< 0,001). There was a positive correlation between the increases in HbA1c and TFC levels in the whole group (r=0,225; p=0,004). In subgroup analysis, higher HbA1c levels did not affect TFC in patients using ticagrelor (r=-0,060; p=0,326 for patients with noreflow, r=-0,133; p=0,321 for patients with TIMI-3 flow). While level of HbA1c did not affect TFC in patients with TIMI-3 flow, the presence of post-procedural no-reflow caused worsening of TFC in patients using clopidogrel as HbA1c levels increased (r=0,374; p=0,005). Conclusion . Ticagrelor was found to be better in terms of angiographic parameters regardless of diabetes.

TIMI

10.15829/1560-4071-2022-5021

Cite

Citations (2)

Conservative treatment of femoral neuropathy following retroperitoneal hemorrhage

Blood Coagulation & Fibrinolysis (2014)

Aliye Tosun Elem İnal Işık Keleş Murat Tulmaç Özgür Tosun

Anticoagulant drugs are used to reduce the incidence of thromboembolic events in patients at risk. However, minor and major bleeding complications may occur during anticoagulation therapy. Femoral neuropathy secondary to retroperitoneal hematoma is a well known complication of anticoagulant drugs. However, treatment of these patients is still controversial, both conservative and surgical treatments have been advocated. Herein, we report a male patient receiving warfarin for 7 years who developed femoral neuropathy due to retroperitoneal hematoma and was successfully treated with conservative methods. We suggest that conservative treatment and appropriate rehabilitation program should be given to the patients who do not demonstrate any signs of a continued bleeding and any progressive neurological deficits.

Retroperitoneal Hemorrhage

Conservative Treatment

Femoral nerve

Retroperitoneal space

Anticoagulant Therapy

10.1097/mbc.0000000000000110

Cite

Citations (14)

Valency of cystatin C and creatinine on troponin values in chronic kidney disease patients with chest pain in emergency department

The American Journal of Emergency Medicine (2024)

Elif Hamzaçebioğlu Bedriye Müge Sönmez Gülin Feykan Yeğin Murat Tulmaç Süleyman Kayışoğlu

Valency

10.1016/j.ajem.2024.12.020

Cite

Citations (0)

Stress Hyperglycemia Ratio Is Associated With High Thrombus Burden in Patients With Acute Coronary Syndrome

Angiology (2023)

Engin Algül Nail Burak Özbeyaz Haluk Furkan Şahan Faruk Aydınyılmaz Hamza Sunman

The blood glucose level at admission indicates (with some limitations) poor prognosis and thrombus burden in patients with the acute coronary syndrome (ACS). Our study aimed to measure the predictive value of the stress hyperglycemia ratio (SHR), an indicator of stress hyperglycemia, showing increased thrombus burden in patients with ACS. Patients (n = 1222) with ACS were enrolled in this cross-sectional study. Coronary thrombus burden was classified as high and low. SHR was calculated by dividing the admission serum glucose by the estimated average glucose derived from HbA1c. Low thrombus burden was detected in 771 patients, while high thrombus burden (HTB) was detected in 451 patients. SHR was found to be significantly higher in patients with HTB (1.1 ± .3 vs 1.06 ± .4; P = .002). SHR was determined as a predictor of HTB (odds ratio (OR) 1.547 95% CI (1.139–2.100), P < .001) as a result of univariate analysis. According to multivariate analysis, SHR was determined as an independent risk factor for HTB (OR 1.328 CI (1.082–1.752), P = .001). We found that SHR predicted thrombus burden with higher sensitivity than admission glucose level in patients with ACS.

Univariate analysis

10.1177/00033197231167054

Cite

Citations (12)

Markers of Endothelial Dysfunction and Evaluation of Vascular Reactivity Tests in Behçet Disease

Angiology (2013)

Pınar Özuğuz Ayşe Anıl Karabulut Murat Tulmaç Üçler Kısa Mukadder Koçak

We assessed endothelial dysfunction (ED) in patients with Behcet disease (BD; n = 40) and healthy controls (n = 20). Serum lipid, homocysteine, asymmetric dimethylarginine (ADMA) and high-sensitivity C-reactive protein (hsCRP) levels, erythrocyte sedimentation rates (ESRs), and ultrasonographic flow-mediated dilatation (FMD) were measured. Mean hsCRP, ESR, homocysteine, and ADMA were significantly higher in the BD group ( P < .001 for all). Patients with active BD had higher serum levels of hsCRP, homocysteine, and ESR compared with those in remission ( P < .001, P < .001, and P = .005, respectively). Flow-mediated dilatation was significantly lower in patients with BD than in controls ( P = .001). Flow-mediated dilatation correlated negatively with BD duration and serum ADMA levels ( P < .001, r = −.745 and P < .001, r = −.682); a positive correlation was seen between serum ADMA levels and BD duration ( P < .001, r = .552). Only stepwise multivariate regression analysis revealed BD duration to have a significant effect on FMD. Flow-mediated dilatation, in conjunction with markers of inflammation, may evaluate ED in patients with BD.

Endothelial Dysfunction

Asymmetric dimethylarginine

Erythrocyte sedimentation rate

10.1177/0003319713512413

Cite

Citations (21)

Front & Back Matter

Cardiology (2011)

Victor L. Serebruany Paul M. Ridker Mori J. Krantz Jennifer L. Gaudiani Victor W. Johnson

10.1159/000337719

Cite

Citations (0)

<b>Early and Late Outcome of Stenting in a Consecutive Series of Patients With Coronary Lesions in Vessels Less Than 2.8 mm in Diameter</b>

Japanese Heart Journal (2003)

Murat Ouml zdemir Timur Timurkaynak Murat Tulmaç Mustafa Cemri B. Boyacı

In an attempt to determine the early and late outcomes of small vessel stenting, we retrospectively evaluated our database on 51 consecutive patients (41 males, mean age, 57.1 ± 10.1 years) who underwent stenting of at least one significant lesion in a coronary artery with a reference vessel diameter (RVD) < 2.8 mm between March 1999 and March 2001. Sixty balloon expandable tubular stents were implanted in 57 lesions (29 Type B2/C, mean RVD: 2.54 ± 0.16 mm) without intravascular ultrasound guidance under a heparin-aspirin-ticlopidine regimen. The mean diameter stenosis (DS) decreased from 75.8 ± 13.6% to 4.2 ± 1.9% (P < 0.0001) with stenting at a mean deployment pressure of 13.6 ± 1.7 atm and a final balloon to RVD ratio (FB/RVD) of 1.08 ± 0.03. All stents were deployed successfully. Acute stent thrombosis occurred in 3 patients (6%), one died, and 2 developed non-Q-wave myocardial infarction (procedural success 94%). Clinical follow-up, available in 48 patients, revealed a 29% target lesion revascularization rate, a 2% myocardial infarction rate, and a 71% event-free survival at a mean of 11.6 months. Angiographic follow-up, available in 40 patients, showed a DS of 48.8 ± 31.3% and a binary restenosis rate of 50% at a mean of 7.7 months. The FB/RVD ratio was significantly lower in the group with restenosis than in the group without (1.06 ± 0.02 vs 1.1 ± 0.05, P = 0.04). Subgroup analysis yielded a significantly greater rate of restenosis in diabetics with complex (Type B2/C) lesion morphology compared to nondiabetics with simple (Type A/B1) lesions (75% vs 21%, P < 0.05). In conclusion, stenting in vessels < 2.8 mm was found to be associated with a high rate of acute stent thrombosis and in-stent restenosis. Further analysis detected a subgroup of patients without diabetes or complex lesions who could be stented with an acceptable in-stent restenosis rate.

Target lesion

Intravascular Ultrasound

10.1536/jhj.44.163

Cite

Citations (4)

A rial elect c romech c anical coupling int n erv r al and P-wav a e dispersion in healt l hy h elderl r y l

Nesligül Yıldırım Murat Tulmaç Vedat Şimşek Mehmet Doğru Haksun Ebinç

Source

Cite

Citations (0)

Lack of Association Between Matrix Metalloproteinase-9 and Endothelial Nitric Oxide Synthase Gene Polymorphisms and Coronary Artery Disease in Turkish Population

DNA and Cell Biology (2009)

Ebru Alp Sevda Menevşe Murat Tulmaç Derya Kan Rıdvan Yalçin

Polymorphic variants of genes encoding proteins involved in vascular remodeling may genetically diverge among different populations and play a role in the susceptibility to the coronary artery disease (CAD). MMP-9-1562 C/T (rs3918242), eNOS T-786C (rs2070744), and Glu298Asp (rs1799983) are among the most studied of these polymorphisms. The aim of this study was to determine the relationship between CAD and these polymorphisms in the Turkish population. The analysis included 146 CAD+ and 122 CAD- individuals. Genomic DNA was isolated from whole blood and genotyping was performed by the PCR-RFLP method. No significant associations were found between -1562 C/T (p = 0.557), Glu298Asp (p = 0.432), and -786 T/C (p = 0.055) polymorphisms and CAD. The distribution of each haplotype also did not differ between CAD+ and the CAD- samples (p > 0.05). The present investigation is the first to study an association between -1562 C/T polymorphism and CAD in the Turkish population. In conclusion, no appreciable differences between CAD+ and CAD- samples were found in terms of polymorphisms mentioned above.

Turkish population

10.1089/dna.2009.0866

Cite

Citations (36)

Preoperative exercise heart rate recovery predicts intraoperative hypotension in patients undergoing noncardiac surgery

Journal of Clinical Anesthesia (2012)

Emine Arzu Köse Hasan Kutsi Kabul Vedat Yıldırım Murat Tulmaç

Mean arterial pressure

Elective surgery

10.1016/j.jclinane.2012.02.007

Cite

Citations (3)