P. Vijaya Babu

University of Hyderabad

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Manojit Pal

University of Hyderabad

Pushkar Kulkarni

Dr. Reddy's Laboratories (India)

K. Mukkanti

Jawaharlal Nehru Technological University, Hyderabad

Swapna Yellanki

University of Hyderabad

Rambabu Dandela

Indian Institute of Technology Bhubaneswar

Bagineni Prasad

Uppsala University

Arunasree M. Kalle

University of Hyderabad

P. Surendra Reddy

Indian Institute of Chemical Technology

Mohanreddy Pothireddy

Oil India (India)

Srinivasarao Yaragorla

University of Hyderabad

Cooperative Institutions

University of Hyderabad

Institute of Life Sciences

Central University of Rajasthan

Indian Institute of Chemical Technology

Dr. Reddy's Laboratories (India)

Acharya Nagarjuna University

Osmania University

Shenyang Agricultural University

JSS Academy of Higher Education and Research

Institute of Chemical Technology

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Mefenamic acid based novel indole analogues: Their synthesis and anti-proliferative effects

Arabian Journal of Chemistry (2015)

P. Vijaya Babu Mohd Ashraf Ashfaq K. Shiva Kumar K. Mukkanti Manojit Pal

Prompted by the literature report on anticancer properties of mefenamic acid, a series of mefenamic acid based indole derivatives were designed via a rational approach. Synthesis of this class of compounds was carried out via a 3-step method starting from the mefenamic acid and using the Pd/C–Cu mediated coupling-cyclization strategy as a key step. A focused library of related molecules was synthesized and evaluated for their anti-proliferative properties against normal (HEK293T) and oral (CAL 27) as well as breast (MCF-7) cancer cell lines when several compounds showed selective growth inhibition of oral cancer cells of which the compound 5g [i.e. N-(2-(((5-fluoro-1-(methylsulfonyl)-1H-indol-2-yl)methoxy)methyl)phenyl)-2,3-dimethylaniline] was found to be promising.

Mefenamic acid

10.1016/j.arabjc.2015.05.018

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Citations (4)

Aspartic acid tagged carbon nanotubols as a tool to deliver docetaxel to breast cancer cells: Reduced hemotoxicity with improved cytotoxicity

Toxicology in Vitro (2019)

Nagarani Thotakura Saurabh Sharma Rajneet Kaur Khurana P. Vijaya Babu Deepak Chitkara

Conjugate

Zeta potential

10.1016/j.tiv.2019.04.012

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Citations (20)

Synthesis, Fungicidal Activity, and Structure Activity Relationship of β-Acylaminocycloalkylsulfonamides against Botrytis cinerea

Scientific Reports (2017)

Chunhui Liu Xiaohong Chen Pei-Wen Qin Zhiqiu Qi Mingshan Ji

Abstract In order to discover new antifungal agrochemicals that could have highly active and novel motifs, thirty-six new 2-acylaminocycloalkylsulfonamides ( IV ) were synthesized. Their structures were characterized and confirmed by 1 H NMR, 13 C NMR, IR, MS, elemental analysis and X-ray single crystal diffraction. In vitro and in vivo activities against various Botrytis cinerea strains were evaluated. Bioassay results revealed that most of the title compounds exhibited excellent in vitro fungicidal activity, in which compound IV-26 showed the highest activity against sensitive, low-resistant, moderate-resistant and high-resistant strains of B. cinerea compared with the positive fungicide procymidone. Meanwhile in vivo fungicidal activity of compound IV-31 was better than the commercial fungicides procymidone and chesulfamide in greenhouse trial. The structure activity relationship (SAR) was also discussed and the results were of importance to the structural optimization and development of more potent sulfonamides antifungal agents.

Procymidone

Botrytis

Fungal growth

10.1038/srep42096

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Citations (13)

Zebrafish based strategy for the identification of a potential pharmacophore for apoptosis: a greener CuAAC approach for novel 1,2,3-triazoles derived from mefenamic acid

RSC Advances (2013)

P. Vijaya Babu Soumita Mukherjee Dhilli Rao Gorja Swapna Yellanki Raghavender Medisetti

Prompted by the potential of a screening strategy in zebrafish for the identification of valuable pharmacophores, a series of triazole substituted mefenamic acid derivatives were designed and synthesized via a CuAAC under green conditions. A variety of terminal alkynes were reacted with the azide obtained from mefenamic acid to give the expected products in good to excellent yields. When screened for apoptosis, teratogenicity and hepatotoxicity in zebrafish embryos, one of these compounds showed encouraging apoptotic properties and safety profiles and seemed to have medicinal value.

Mefenamic acid

10.1039/c3ra46185h

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Citations (19)

ChemInform Abstract: Ligand‐Free MCR for Linking Quinoxaline Framework with a Benzimidazole Nucleus: A New Strategy for the Identification of Novel Hybrid Molecules as Potential Inducers of Apoptosis.

ChemInform (2015)

Rajnikanth Sunke P. Vijaya Babu Swapna Yellanki Raghavender Medishetti Pushkar Kulkarni

Abstract Benzimidazole functionalized quinoxalines are prepared in a multi‐component‐reaction.

Quinoxaline

Benzimidazole

Identification

Inducer

10.1002/chin.201506209

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Aquacatalytic A³ Coupling with Silica-Supported CuCl

Synfacts (2007)

B. Sreedhar P. Surendra Reddy C. S. Vamsi Krishna P. Vijaya Babu

The three-component coupling of aldehydes, alkynes, and amines (the so-called A3 coupling) was performed in water with a silica gel supported copper catalyst to give the corresponding propargylamines. Thus, for example, butanal, phenylacetylene, and piperidine were coupled in water at 100 °C in the presence of 0.05 mol% Cu from silica-supported CuCl for 8 hours to give 98% yield of the propargylamine. 20 Examples of A3 combination were reported (60-98% yield) to exhibit the generality of the present catalytic system.

10.1055/s-2007-991454

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Ligand/PTC-free intramolecular Heck reaction: synthesis of pyrroloquinoxalines and their evaluation against PDE4/luciferase/oral cancer cell growth in vitro and zebrafish in vivo

Organic & Biomolecular Chemistry (2013)

P. Vijaya Babu Soumita Mukherjee Girdhar Singh Deora Keerthana Sarma Chennubhotla Raghavender Medisetti

A series of 1,3-disubstituted pyrrolo[2,3-b]quinoxalines has been designed for the potential inhibition of PDE4 without inhibiting luciferase. A ligand/PTC (phase transfer catalyst) free intramolecular Heck cyclization strategy was used to prepare these compounds, some of which showed significant inhibition of PDE4B (IC50 ≈ 5–14 μM) and growth inhibition of oral cancer cells (CAL 27) but not inhibition of luciferase in vitro. They also showed acceptable safety profiles but no apoptosis in zebrafish embryos.

Heck Reaction

10.1039/c3ob41504j

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Citations (28)

ChemInform Abstract: A Green Synthesis of Unsymmetrical 9‐Arylxanthenes in a One‐Pot Cascade Benzylation/Annulation/Dehydration Strategy.

ChemInform (2016)

Srinivasarao Yaragorla Pyare Lal Saini P. Vijaya Babu Abdulrahman I. Almansour Natarajan Arumugam

Annulation

10.1002/chin.201639156

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A green synthesis of unsymmetrical 9-arylxanthenes in a one-pot cascade benzylation/annulation/dehydration strategy

Tetrahedron Letters (2016)

Srinivasarao Yaragorla Pyare Lal Saini P. Vijaya Babu Abdulrahman I. Almansour Natarajan Arumugam

Annulation

10.1016/j.tetlet.2016.04.016

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Citations (18)

ChemInform Abstract: Zebrafish Based Strategy for the Identification of a Potential Pharmacophore for Apoptosis: A Greener CuAAC Approach for Novel 1,2,3‐Triazoles Derived from Mefenamic Acid.

ChemInform (2014)

P. Vijaya Babu Soumita Mukherjee Dhilli Rao Gorja Swapna Yellanki Raghavender Medisetti

Abstract A wide range of 1,2,3‐triazoles derived from benzylic azide (I) are synthesized and tested in a new zebrafish based assay for the identification of a new pharmacophore for apoptosis.

Mefenamic acid

Identification

10.1002/chin.201438136

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Citations (0)