Mohammed Asif Ahmed

King Saud University

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Khizar Hayat

Alabama Agricultural and Mechanical University

Ahmad Mohammad Salamatullah

King Saud University

Shaista Arzoo

King Saud University

Fohad Mabood Husain

King Saud University

Hassan A. Al‐Kahtani

King Saud University

Abdulhakeem Alzahrani

King Saud University

Mohammed Saeed Alkaltham

King Saud University

Hamza M. Abu‐Tarboush

King Saud University

Mohammed Bourhia

Université Ibn Zohr

Ghedeir M. Alshammari

King Saud University

Cooperative Institutions

King Saud University

Aligarh Muslim University

International Islamic University Malaysia

Technical University of Munich

The King's College

King Abdulaziz University

Riyadh Elm University

Alexandria University

Ministry of Health

Ain Shams University

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Cross-sectional study of the prevalence of inter-arm blood pressure difference in offspring of normotensive and hypertensive parents among students of tertiary care teaching hospital, Hyderabad

Asian Journal of Medical Sciences (2024)

Mohammed Asif Ahmed Santa Kumari A Abdul Raoof Omer Siddiqui Mudassir Mirza

Background: Hypertension (HTN) incidence and progression are monitored by regular blood pressure (BP) measurement; one of the most ignored components of regular check-up is the measurement of inter-arm difference (IAD) in BP. Aims and Objectives: The objective of this study was to estimate the prevalence of IAD in BP among offspring of hypertensive parents compared to normotensive parents. Materials and Methods: This cross-sectional study was conducted on 100 male students at Osmania Medical College, Hyderabad, Telangana for a period of 6 months. After IEC clearance, the subjects were divided into two groups, 50 students in each group: Group I had offspring with hypertensive parents and Group II had offspring with normotensive parents. Age, height, weight, and body mass index (BMI) were recorded. IAD was calculated as the difference between BP (Systolic BP [SBP] and diastolic BP [DBP]) in the right arm and left arm. Subjects with a history of structural, functional cardiovascular disease disorders, endocrine disorders, Diabetes mellitus, and addictions such as smoking and alcohol were excluded from the study. Data were statistically analyzed using Microsoft Excel software. Results: Among 100 subjects, Group I and II IAD in SBP was 8.68±6.02 and 5.00±3.24 (P<0.0002), respectively, and Group I and II IAD in DBP was 5.12±4.48 4.79±3.56 (P<0.7117), respectively. BMI of the two groups is almost within the similar range (23.44±4.04, 22.098±3.15, respectively) and not statistically significant (P=0.0694), a positive correlation of 0.12, 011 was found between BMI, systolic IAD,and diastolic IAD, respectively. Conclusion: The above results show a significant association between IAD in systolic BP and family history of HTN.

Tertiary care

Cross-sectional study

Tertiary level

10.3126/ajms.v15i6.63345

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Quantification of Chlorogenic Acid and Vanillin from Coffee Peel Extract and its Effect on α-Amylase Activity, Immunoregulation, Mitochondrial Oxidative Stress, and Tumor Suppressor Gene Expression Levels in H2O2-Induced Human Mesenchymal Stem Cells

Frontiers in Pharmacology (2021)

Heba Khalil Alyahya Pandurangan Subash‐Babu Ahmad Mohammad Salamatullah Khizar Hayat Nawal Albader

Background: Polyphenols and flavonoid-rich foods help in arresting reactive oxygen species development and protecting DNA from oxidative damage. Coffee peel (CP) preparations are consumed as beverages, and their total polyphenol or flavonoid content and their effect on oxidative stress-induced human mesenchymal stem cells (hMSCs) are poorly understood. Method: We prepared hot water extracts of CP (CPE) and quantified the amount of total polyphenol and flavonoid using HPLC analysis. In addition, CPE have been studied for their α-amylase inhibitory effect and beneficial effects in oxidative stress-induced hMSCs. Results: The obtained results show that the availability of chlorogenic acid, vanillin, and salicylic acid levels in CPE is more favorable for enhancing cell growth, nuclear integrity, and mitochondrial efficiency which is confirmed by propidium iodide staining and JC-1 staining. CPE treatment to hMSCs for 48 h reduced oxidative stress by decreasing mRNA expression levels of LPO and NOX-4 and in increasing antioxidant CYP1A, GSH, GSK-3β, and GPX mRNA expressions. Decreased pro-inflammatory (TNF-α, NF-κβ, IL-1β, TLR-4) and increased tumor suppressor genes (except Bcl-2) such as Cdkn2A, p53 expressions have been observed. Conclusions: The availability of CGA in CPs effectively reduced mitochondrial oxidative stress, reduced pro-inflammatory cytokines, and increased tumor suppressor genes.

Chlorogenic Acid

Propidium iodide

10.3389/fphar.2021.760242

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Degradation of the acaricides abamectin, flufenoxuron and amitraz on Saudi Arabian dates

Food Chemistry (2006)

Alaa Kamel Saleh Al-Dosary Samy Ibrahim Mohammed Asif Ahmed

Amitraz

Abamectin

10.1016/j.foodchem.2006.01.002

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Citations (49)

Average daily intake of artificially food color additives by school children in Saudi Arabia

Journal of King Saud University - Science (2023)

Mohammed Asif Ahmed Abdulrahman S. Al‐Khalifa Doha M. Al-Nouri Mohamed Ferkry Serag EL-DIN

Food safety is related to nutritional risk in children. This study is to determine the types of artificial food color additives (AFCAs) daily intake by school children aged 6 to 17 years for ten AFCAs. Sunset Yellow (E110), Tartrazine (E102), Carmoisine (E122), Brilliant Blue (E133), Allura Red (E129), Black PN (E151), Indigo Carmine (E132), and Fast Green (E143) were identified using 24 h food consumption questionnaire, including the two unapproved AFCAs, Red 2G (E128) and Erythrosine (E127) in 839 food products. These food products are distributed into nine categories, containing juices and drinks, ice cream, cakes, jelly, chocolates, candy, chips, biscuits, and chewing gum. Results showed that the artificial food colors, Carmoisine (32.3 %) and Sunset Yellow (30.1 %) were the most highly consumed AFCAs by school children, whereas Erythrosine (0.05 %) was consumed the least. Therefore, Sunset Yellow was highly consumed (30.1 %) and detected in high amounts by high performance liquid chromatography, (HPLC) 34.2 %. The average daily intake (ADI) of AFCAs decreased with age to varying degrees in both sexes. In comparison to the Food and Agriculture Organization and World Health Organization, acceptable daily intakes, most permitted colors exceeded their acceptable daily intakes (ADIs) in the 6–11 years of age groups, and most permitted colors were within the recommended ADIs in the 12–17 years of age group. The average daily intake of AFCAs by school children decreased with age. Therefore, further studies are required to gain information about the possible negative health effects of high intake of these AFCAs on the test population.

Tartrazine

Acceptable daily intake

Erythrosine

Food preparation

Reference Daily Intake

10.1016/j.jksus.2023.102596

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Citations (10)

Different drying techniques effect on the bioactive properties of rose petals

Journal of King Saud University - Science (2023)

Ahmad Mohammad Salamatullah Mohammed Asif Ahmed Khizar Hayat Fohad Mabood Husain Shaista Arzoo

This study explored the effect of different drying methods (sun, shade, oven) on the total polyphenol content (TPC) using the Folin–Ciocalteu (FC) procedure, total flavonoid content (TFC) using the AlCl3 colorimetric method, volatile organic compounds using GC/MS and the antioxidant properties of the rose petals using the protocol of DPPH assy. The results demonstrated that the drying methods had a significant impact and the highest TPC (34.24 mg gallic acid equivalent (GAE)/ g fresh weight (FW)) and TFC (5.56 mg catechin equivalent (CE)/g FW) were obtained for the oven-dried sample. While, the fresh sample exhibited the lowest TPC (15.6 mg GAE/g FW) and TFC (3.83 mg CE/g FW), respectively. Similarly, the oven-dried sample showed the highest DPPH scavenging activity (60.30 %) and reducing power (absorbance 1.138) among all the samples. Fresh rose sample GC-MS analysis revealed that the there are two major compounds heptacosane 64.56% and citronellyl propionate 28.35%. Pentadecyl 2-phenylethyl ester oxalic acid was the second dominant compound in sun and oven-dried rose samples, 18.5% and 14.79% respectively.

Absorbance

Oxalic Acid

Petal

10.1016/j.jksus.2023.103025

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Citations (4)

Amino acid and protein changes in tilapia and spanish mackerel after irradiation and storage

Radiation Physics and Chemistry (1998)

Hassan A. Al‐Kahtani Hamza M. Abu‐Tarboush Mohamed A. M. Atia Adnan S. Bajaber Mohammed Asif Ahmed

10.1016/s0969-806x(97)00076-5

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Citations (27)

METHOD DEVELOPMENT AND VALIDATION OF LENVATINIB DRUG BY RP-HPLC IN PHARMACEUTICAL DRUG DOSAGE FORM

Zenodo (CERN European Organization for Nuclear Research) (2016)

Mohammed Asif Ahmed

Lenvatinib

Drug Development

Pharmaceutical drug

Pharmaceutical Sciences

10.5281/zenodo.162124

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Citations (8)

Effect of Microwave and Conventional Heat Treatment on Total Phenolic Compounds, HPLC Phenolic Profile, and Antioxidant Activity of Leptadenia pyrotechnica (Forssk.) Decne Stem

Applied Sciences (2023)

Mohammed Saeed Alkaltham Khizar Hayat Ahmad Mohammad Salamatullah Mohammed Asif Ahmed Amro B. Hassan

Leptadenia pyrotechnica is considered a wild herb used to enhance the palatability of food, particularly in the Gulf region. The effect of microwave (5, 8, and 10 min at 900 W) and hot-air heating (60, 120, and 180 min at 100 °C) on the phenolic compounds and antioxidants of L. pyrotechnica stems was investigated. The results showed that microwave heating gave high values of the total phenolic content (TPC), total flavonoid content (TFC), and antioxidant properties, while the control sample was inferior in all these attributes. Moreover, microwave heating, particularly for 8 min, produced the highest TPC, TFC, and DPPH values (significant at p < 0.05) and reduced power in the L. pyrotechnica stem. However, prolonging the heating time caused adverse effects on the bioactive potential of the samples. The HPLC analysis indicates that both processes caused a significant increment in the phenolic compounds of the sample. Tannic acid, vanillin, and acetyl salicylic acid were found to be higher in the microwaved-treated samples than in those heated with hot air. The tannic acid was found to be high after microwave heating for 8 min at 116.06 mg/100 g, while the higher value of acetylsalicylic acid 119.08 mg/100 g was observed after microwave heating for 5 min. The partial least regression (PLS) validation model revealed that microwave heating, particularly at an 8 min application time, offered better results, and owing to its short processing time, which might be adopted for heating the L. pyrotechnica stems in the food industry, and it can be useful for preparing functional foods.

Tannic acid

Microwave heating

10.3390/app132413222

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Citations (3)

Extraction and characterization of gelatin from camel skin (potential halal gelatin) and production of gelatin nanoparticles

Saudi Journal of Biological Sciences (2020)

Mohammed Asif Ahmed Hassan A. Al‐Kahtani Irwandi Jaswir Hamza M. Abu‐Tarboush Elsayed A. Ismail

Gelatin is used as an ingredient in both food and non-food industries as a gelling agent, stabilizer, thickener, emulsifier, and film former. Porcine skins, bovine hides, and cattle bones are the most common sources of gelatin. However, mammalian gelatins are rejected by some consumers due to social, cultural, religious, or health-related concerns. In the present study, gelatin was obtained from camel skin as an alternative source using a combination of processing steps. Central composite design combined with response surface methodology was used to achieve high gelatin yields under different extraction conditions: temperatures of 40, 60, and 80 °C; pH values of 1, 4, and 7; and extraction times of 0.5, 2.0, and 3.5 min. Maximum gelatin yield from camel skin (29.1%) was achieved at 71.87 °C and pH 5.26 after 2.58 min. The extracted gelatin samples were characterized for amino acid profile, foaming capacity, film formation, foam stability, and gel strength (Bloom value). Gelatin nanoparticles were produced, and their morphology and zeta potential were determined. Bloom value of the camel skin gelatin was 340 g. Amino acid analysis revealed that the extracted gelatin showed high glycine and proline contents. Analysis of camel skin gelatin nanoparticle and functional properties revealed high suitability for food and non-food applications, with potential use in the growing global halal food market.

Gelatin

Ingredient

Zeta potential

Functional food

10.1016/j.sjbs.2020.03.022

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Citations (67)

Chemical and proximate composition of (Zizyphus spina‐christi) nabag fruit

Nutrition & Food Science (2009)

Magdi A. Osman Mohammed Asif Ahmed

Purpose The purpose of this paper is to investigate the potential food and industrial values of a tropical and underutilized indigenous plant. Design/methodology/approach Specimens of a dry‐milled plant, namely: Zizyphus spina‐christi , were subjected to chemical analysis to determine their proximate, mineral, sugar, and amino acid compositions using standard procedures. Findings The fruit pulp was found to be a good source of energy, carbohydrates and rich in Mg, Ca, Fe and Zn, whereas the seeds are rich in crude fiber. Essential amino acids are 32.96 percent in fruit pulp and 25.22 percent in seeds, whereas non‐essential amino acids are 61.25 percent in fruit pulp and 73 percent in seeds. Originality/value The nutritional composition of the plant materials suggests that they may find use in food formulation operations and as industrial raw materials.

Proximate

10.1108/00346650910930842

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Citations (22)