Jila Majidi

Iran University of Medical Sciences

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Sanaz Alizadeh

Iran University of Medical Sciences

Mazaher Gholipourmalekabadi

Iran University of Medical Sciences

Ali Hashemi

Shahid Beheshti University of Medical Sciences

Hajar Nasiri

Iran University of Medical Sciences

Zahra Esmaeili

Tehran University of Medical Sciences

Zahra Aliakbar Ahovan

Shahid Beheshti University of Medical Sciences

Zeinab Nokhbedehghan

Iran University of Medical Sciences

Seyed-Hashem Daryabari

Baqiyatallah University of Medical Sciences

Mozhgan Jahani

Iran University of Medical Sciences

Amir Mellati

Mazandaran University of Medical Sciences

Cooperative Institutions

Iran University of Medical Sciences

John Wiley & Sons (United States)

Amgen (United States)

Bioprocess Control (Sweden)

Tehran University of Medical Sciences

University of Queensland

Bioengineering Center

National Center for Genetic Engineering and Biotechnology

The University of Tokyo

Soochow University

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Engineering of a decellularized bovine skin coated with antibiotics‐loaded electrospun fibers with synergistic antibacterial activity for the treatment of infectious wounds

Biotechnology and Bioengineering (2024)

Sanaz Alizadeh Jila Majidi Mozhgan Jahani Zahra Esmaeili Zeinab Nokhbedehghan

Abstract An ideal antibacterial wound dressing with strong antibacterial behavior versus highly drug‐resistant bacteria and great wound‐healing capacity is still being developed. There is a clinical requirement to progress the current clinical cares that fail to fully restore the skin structure due to post‐wound infections. Here, we aim to introduce a novel two‐layer wound dressing using decellularized bovine skin (DBS) tissue and antibacterial nanofibers to design a bioactive scaffold with bio‐mimicking the native extracellular matrix of both dermis and epidermis. For this purpose, polyvinyl alcohol (PVA)/chitosan (CS) solution was loaded with antibiotics (colistin and meropenem) and electrospun on the surface of the DBS scaffold to fabricate a two‐layer antibacterial wound dressing (DBS‐PVA/CS/Abs). In detail, the characterization of the fabricated scaffold was conducted using biomechanical, biological, and antibacterial assays. Based on the results, the fabricated scaffold revealed a homogenous three‐dimensional microstructure with a connected pore network, a high porosity and swelling ratio, and favorable mechanical properties. In addition, according to the cell culture result, our fabricated two‐layer scaffold surface had a good interaction with fibroblast cells and provided an excellent substrate for cell proliferation and attachment. The antibacterial assay revealed a strong antibacterial activity of DBS‐PVA/CS/Abs against both standard strain and multidrug‐resistant clinical isolates of Acinetobacter baumannii , Pseudomonas aeruginosa , and Escherichia coli . Our bilayer antibacterial wound dressing is strongly suggested as an admirable wound dressing for the management of infectious skin injuries and now promises to advance with preclinical and clinical research.

Decellularization

10.1002/bit.28659

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Citations (1)

Biotechnology and Bioengineering: Volume 121, Number 4, April 2024

Biotechnology and Bioengineering (2024)

Tia Utami Mathieu Danoy Rubina Rahaman Khadim Fumiya Tokito Hiroshi Arakawa

10.1002/bit.28708

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Heat-treated alginate-polycaprolactone core-shell nanofibers by emulsion electrospinning process for biomedical applications

International Journal of Biological Macromolecules (2024)

Nazanin Negahdari Sanaz Alizadeh Jila Majidi Mahdi Saeed Tayyeb Ghadimi

Polycaprolactone

Electrospinning

10.1016/j.ijbiomac.2024.133709

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Mechanism of Anosmia Caused by Symptoms of COVID-19 and Emerging Treatments

ACS Chemical Neuroscience (2021)

Raziyeh Najafloo Jila Majidi Alimohamad Asghari Mina Aleemardani Seyed Kamran Kamrava

The occurrence of anosmia, the loss or change in sense of smell, is one of the most common symptoms of COVID-19 experienced by almost 53% of those affected. Several hypotheses explain the mechanism of anosmia in patients suffering from COVID-19. This study aims to review the related mechanisms and answer the questions regarding COVID-19-related anosmia as well as propose a new strategy for treatment of long-term anosmia as a result of COVID-19 infection. This paper covers all of the studies investigating olfactory disorders following COVID-19 infection and explains the possible reasons for the correlated anosmia, including olfactory cleft syndrome, local inflammation in the nasal epithelium, early apoptosis of olfactory cells, changes in olfactory cilia and odor transmission, damage to microglial cells, effect on olfactory bulbs, epithelial olfactory injury, and impairment of olfactory neurons and stem cells. The key questions that arise in this field have been discussed, such as why prevalent anosmia is varied among the age categories and among sexes and the correlation of anosmia with mild or severe COVID-19 infection. The angiotensin-converting enzyme 2 receptor is a significant player in the mechanism of anosmia in COVID-19 patients. Based on current studies, a novel approach to treat long-COVID-19 with ongoing anosmia has been proposed. The fields of smart drug delivery, tissue engineering, and cell therapy provide a hypothesized strategy that can minimize the side effects of current treatments and support efficient recovery of the olfactory system.

Anosmia

Olfactory Receptor Cell

10.1021/acschemneuro.1c00477

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Citations (85)

Silk biomaterials for corneal tissue engineering: From research approaches to therapeutic potentials; A review

International Journal of Biological Macromolecules (2025)

Tahereh Manoochehrabadi Amin Solouki Jila Majidi Sadjad Khosravimelal El Mostapha Lotfi

10.1016/j.ijbiomac.2025.141039

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Biomimetic amniotic/silicone-based bilayer membrane for corneal tissue engineering

Materials & Design (2023)

Zahra Esmaeili Zeinab Nokhbedehghan Sanaz Alizadeh Jila Majidi Hadi Chahsetareh

Amniotic membrane (AM) is an effective and widely used dressing in ocular injuries to reconstruct the cornea. Due to its low mechanical strength, high biodegradation rate, and difficult handling, its usage in medical interventions remains challenging. In this study, decellularized AM was covered with an ultrathin layer of Polydimethylsiloxane (PDMS) through a spinning method, which in turn resulted in an ultrathin (less than 80 µm in thickness) bilayer corneal wound dressing membrane with improved mechanical behavior and transparency. The biomechanical, biological, and antibacterial properties of the bilayer membranes were measured both in vitro and in vivo. The optimized microsized membrane was applied on a corneal defect wound created in a rabbit model to evaluate the corneal healing. The results demonstrated a significant decrease in degradation rate, improved mechanical properties, and AM/PDMS transparency compared with AM. The corneal transparency improved until 21 days post-surgery in AM/PDMS group. Histological evaluations revealed that AM/PDMS had better epithelial delaminated cell morphology. The results of the RT-PCR showed a significant increase in MMP9, a significant decrease in Col1A1, TGF-β1, TNF-α and IL-6 in both AM and AM/PDMS compared with control wounds. This study suggessts AM/PDMS membrane as an excellent corneal wound dressing.

Polydimethylsiloxane

Decellularization

Amnion

10.1016/j.matdes.2023.112614

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Citations (3)

Engineering of a bilayer antibacterial wound dressing from bovine pericardium and electrospun chitosan/PVA/antibiotics for infectious skin wounds management: An in vitro and in vivo study

International Journal of Biological Macromolecules (2024)

Sanaz Alizadeh Mohammadreza Nassiri Navid Farahmandian Paniz Farshi Zahra Aliakbar Ahovan

Wound dressing

10.1016/j.ijbiomac.2024.137055

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