Chansuda Bongsebandhu‐phubhakdi

King Chulalongkorn Memorial Hospital

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Therdpong Tempark

King Chulalongkorn Memorial Hospital

Orapa Suteerojntrakool

King Chulalongkorn Memorial Hospital

Jarujan Subchartanan

Chulalongkorn University

Nadvadee Aungkawattanapong

King Chulalongkorn Memorial Hospital

Vichit Supornsilchai

Chulalongkorn University

Suphab Aroonparkmongkol

Chulalongkorn University

Thitaporn Prownpuntu

King Chulalongkorn Memorial Hospital

Usa Thisyakorn

Chulalongkorn University

Chatchai Chulapornsiri

Ratchaburi Hospital

Suttipong Wacharasindhu

Chulalongkorn University

Cooperative Institutions

Chulalongkorn University

King Chulalongkorn Memorial Hospital

Thai Red Cross Society

Mahidol University

Siriraj Hospital

Ratchaburi Hospital

Pediatrics and Genetics

Ramathibodi Hospital

Baylor College of Medicine

Texas Children's Hospital

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Serum Cortisol as a Biomarker of Severe Dengue

Tropical Medicine and Infectious Disease (2023)

Chansuda Bongsebandhu‐phubhakdi Vichit Supornsilchai Suphab Aroonparkmongkol Umaporn Limothai Sasipha Tachaboon

Dengue infection presents a wide range of clinical symptoms. Serum cortisol is known as a severity predictor of serious infection but is not yet clearly understood in dengue infection. We aimed to investigate the pattern of cortisol response after dengue infection and evaluate the possibility of using serum cortisol as the biomarker to predict the severity of dengue infection. This prospective study was conducted in Thailand during 2018. Serum cortisol and other laboratory tests were collected at four time points: day 1 at hospital admission, day 3, day of defervescence (DFV) (4-7 days post-fever onset), and day of discharge (DC). The study recruited 265 patients (median age (IQR) 17 (13, 27.5)). Approximately 10% presented severe dengue infection. Serum cortisol levels were highest on the day of admission and day 3. The best cut-off value of serum cortisol level for predicting severe dengue was 18.2 mcg/dL with an AUC of 0.62 (95% CI, 0.51, 0.74). The sensitivity, specificity, PPV and NPV were 65.4, 62.3, 16 and 94%, respectively. When we combined serum cortisol with persistent vomiting and day of fever, the AUC increased to 0.76. In summary, serum cortisol at day of admission was likely to be associated with dengue severity. Further studies may focus on the possibility of using serum cortisol as one of the biomarkers for dengue severity.

10.3390/tropicalmed8030146

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Prevalence of skin diseases in school-age children

Family Practice (2021)

Therdpong Tempark Khwaunrat Whaidee Chansuda Bongsebandhu‐phubhakdi Orapa Suteerojntrakool

The prevalence of community-based skin diseases, especially among school-age children, depends on topography, climate, and age of population.We determined the prevalence of skin diseases among community-based primary school-age children and identified demographic characteristics in relation to particular skin conditions.This was a cross-sectional descriptive survey study of a subproject school cohort in children aged 5-14 years of 2 community-based primary schools. Demographic data and whole-body skin examination were collected. The association of individual skin conditions was analysed by using bivariate and multivariable binary logistic regression.A total of 556 children were enrolled in this study. Of these, 90.2% had at least 1 skin disease. The most common skin disease was postinflammatory hyperpigmentation (PIH) (58.3%), followed by nevus/mole (40.1%), insect bite reaction (28.0%), acanthosis nigricans (20.0%), acne (13.7%), and pityriasis alba (12.9%). There was an increase of body mass index (BMI) in PIH and acanthosis nigricans with the adjusted odds ratios of 2.01 (95% confidence interval [CI] 1.40-2.87, P < 0.001) and 1.93 (95% CI 1.49-2.49, P < 0.001), respectively. Insect bite reaction was related to PIH with the adjusted odds ratio of 5.66 (95% CI 3.15-10.17, P = 0.001).The most common skin disease in community-based primary school-age children is PIH which related to acanthosis nigricans and insect bite reaction. A decrease of BMI may lower the risk for PIH and acanthosis nigricans. Education on common skin diseases is recommended for both community-based schools and school-age children.

Acanthosis Nigricans

10.1093/fampra/cmab164

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Hypothalamic-pituitary axis dysfunction and metabolic derangements in Thai childhood leukemia survivors

Indian Journal of Medical and Paediatric Oncology (2020)

Chansuda Bongsebandhu‐phubhakdi Suttipong Wacharasindhu

Abstract Aims: To determine the prevalence and severity of endocrine and metabolic derangements in childhood-onset alL survivors from Thailand and to describe the associated risk factors. Settings and Design: Paediatric department in medical school hospital, cross-sectional study. Methods: Insulin Tolerance Test (ITT), IGF-I and IGFBP-3 levels, Thyroid and gonadal function, serum sodium and metabolic profiles were investigated in 30 childhood onset alL survivors. (16 males, 14 females, mean age: 14.66 ± 7.16 years). Results: Endocrine abnormalities were displayed in 73.33 % of patients, 46.7% had two or more abnormalities. Grade3 of severity were present in 16.67%. Growth hormone deficiency (GHD) was detected in 10 patients (33%). Early onset of ALL was the potential risk factor of GHD. Adult height was more deteriorated in the female group. Twenty percent of patients were found with subnormal cortisol responses. Gonadal failure was evidenced in one case that experienced testicular irradiation. No diabetes insipidus was detected. Among 6 obese patients, 2 patients developed metabolic syndrome. Moreover, one patient was diagnosed with insulin-depleted diabetes mellitus. Conclusion: Our results highlighted various endocrine and metabolic sequelae occurring in childhood-onset alL survivors after completion of their therapy. The prevalence of GHD was higher than the one previously described in Japan population. Subclinical hormonal abnormalities may affect health outcomes. Biochemical and hormonal abnormalities should be carefully monitored for immediate treatment.

Subclinical infection

10.4103/ijmpo.ijmpo_238_19

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Thai teens’ privacy-related practices on Facebook

Journal of Children and Media (2021)

Pimchanok Laohabutr Jarujan Subchartanan Orapa Suteerojntrakool Therdpong Tempark Chansuda Bongsebandhu‐phubhakdi

Adolescents of today are at risk of online disclosure due to sharing personal information online without privacy settings. Facebook has the most users on social network site. This study aimed to 1)investigate the type of personal information that adolescents frequently display online 2)identify how adolescents manage their privacy settings on Facebook and 3)examine parents' intervention on adolescents' online lives.A self-administered questionnaire was used to survey participants aged 13to18 years old from 6 high schools across Thailand. The study recruited 1,242 adolescents (mean15.7 years,SD = 1.6). Most of adolescents allowed everyone to access their profiles. They shared information including real name (78.7%), phone number (22.7%), birthdate (82.5%), city of residence (62.2%), photo (64.5%), national ID number (2.3%), and credit card number (1%). The older group had more reputation management than the younger group. Parental control and guidance were significantly found in the older group than in the younger group.Different from studies in western countries, most Thai adolescents display their personal information on Facebook. Most adolescents reported that their parents have discussed online privacy and safety with them. However, they still choose to disclose a lot of information. Appropriate parental guidance and control might improve Thai adolescents' privacy practices.Impact SummaryPrior state of knowledgeAdolescents are at risk of oversharing and disclosing their personal information online. In western countries, adolescents discuss with their parents how to be safe on the internet. Approximately 60% of teen Facebook users in US keep their profiles private.Novel contributionsThe majority of Thai adolescents Facebook users shared of their profile publicly. This oversharing behavior may be resulted from cultures norms that Asian people may feel more comfortable than those in the West when mentioning private topics.Practical implicationsAppropriate parental guidance about teens' online privacy issues should be emphasized in Thailand. Moreover, national recommendation regarding adolescents' online safety should be considered.

Social network (sociolinguistics)

10.1080/17482798.2021.1993288

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Adherence to Screening for Anemia in 9-Month-Old Full-Term Infants in Bangkok, Thailand

Journal of Tropical Pediatrics (2020)

Kwanchanok Chienwittayakun Orapa Suteerojntrakool Piti Techavichit Chansuda Bongsebandhu‐phubhakdi Jarujan Subchartanan

To determine adherence to the screening for anemia in 9-month-old full-term infants and factors associated with non-adherence to the screening for anemia.A descriptive cross-sectional study was conducted in 9-month-old full-term healthy infants who visited the General Pediatric and Well Child Care Clinic, King Chulalongkorn Memorial Hospital, Bangkok, Thailand. Demographic data, adherence to the screening, and factors associated with non-adherence to the screening were analyzed using percentage, χ2 test, and bivariate logistic regression.A total of 234 full-term infants, aged 9 months, were included in the study between January and December 2019. The prevalence of adherence to the screening for anemia was 76.1% (95% CI 0.70-0.81). The most common cause of non-adherence to the screening was the waiting time for laboratory results (39.3%). Factors associated with non-adherence to the screening were low education of caregiver (AOR 2.684; 95% CI 1.451-4.966), low socio-economic status (AOR 2.26; 95% CI 1.568-3.258), and inadequate complementary food (AOR 1.961; 95% CI 1.107-3.473).The most common cause of non-adherence to the screening for anemia is the waiting time for laboratory results. Pediatricians and general practitioners should ensure the importance of anemia screening in infants and plan on anemia screening with parents.

10.1093/tropej/fmaa054

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Risk factors influencing severity in pediatric dengue infection

Asian Biomedicine (2010)

Chansuda Bongsebandhu‐phubhakdi Marisa Hemungkorn Usa Thisyakorn Chule Thisyakorn

Background: Dengue disease encompasses a wide spectrum of clinical presentations. While the severity of dengue disease can vary from patient to patient, it is, however, still unclear as to what factors determine dengue disease severity. Objective: To analyze the potential risk factors such as: sex, age, nutritional status, dengue serotypes, D-dimer positivity, and serologic responses, and study their correlation with the severity of dengue virus infection. Methods: Dengue patients at King Chulalongkorn Memorial Hospital were enrolled for the study. Dengue serotype was determined by PCR and primary or secondary infection was determined based on serological criteria. D-dimer levels were also tested using a rapid semiquantitation system. Clinical data such as age, body weight, sex, and nutritional status were also collected. Results: Forty-six patients were confirmed for dengue fever (DF), and 52 patients were confirmed for Dengue hemorrhagic fever (DHF). 77.5% of patients had secondary dengue infection, 11.3% had primary infection, and 11.2% were of inconclusive status. Gender and age of patients did not correlate with dengue disease severity (p > 0.05). It was inconclusive as to whether nutritional status was a risk factor. Positivity of the D-dimer test was statistically significant for DHF (p=0.001). Early increasing D-dimer in the febrile stage could predict severity of dengue infection during the initial stage of the disease (positive predictive value=68.4 %). Conclusion: D-dimer is significantly correlated with dengue severity and it may be one of the prognostic factors for dengue infection in children.

10.5372/abm.v2i5.212

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Citations (11)

P03-45 GH retesting and lipid profile in childhood-onset GHD when reaching final adult height

Growth Hormone & IGF Research (2012)

Suttipong Wacharasindhu Suphab Aroonparkmongkol Taninee Sahakitrungrueng Vichit Supornsilchai Chansuda Bongsebandhu‐phubhakdi

10.1016/s1096-6374(12)60230-5

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Body size perception in Thai school-aged children

Deleted Journal (2017)

Chansuda Bongsebandhu‐phubhakdi

10.58837/chula.cmj.61.3.5

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Citations (3)

51. Exploring Eating Disorder Risk Among Thai Transgender Females: A Comparative Study With Cisgender Females

Journal of Adolescent Health (2024)

Chansuda Bongsebandhu‐phubhakdi

10.1016/j.jadohealth.2023.11.249

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Exposure to Bisphenol A and its analogs among Thai School-age Children

Nattakarn Numsriskulrat Thanawan Teeranathada Chansuda Bongsebandhu‐phubhakdi Suphab Aroonparkmongkol Kyungho Choi

Bisphenol F (BPF) and bisphenol S (BPS) are increasingly used as substitutes for bisphenol A (BPA) in the plastic industry, driven by concerns over the adverse effects of BPA. However, there is a lack of infor-mation on the extent of exposure to these chemicals in children. This study aims to assess the extent of BPA, BPF, and BPS exposure and determine factors that influence such exposure. A group of Thai children (age 6-13 years, n=358) were recruited between October 2019-2020. Two first morning void was collected one week apart. Demographic and exposure-related information was gathered. Urinary concentrations of bisphenols were analyzed by liquid-chromatography and tandem mass spectrometry. Correlation between bisphenol concentrations and various factors was determined using generalized estimating equations with linear model. BPA, BPF, and BPS were detected at 79.6%, 31.0%, and 16.8%, with geometric mean (GM) concentrations of 1.41, 0.013, and 0.014 ng/mL respectively. Younger children aged < 10 years exhibited 1.3-1.6 times higher GM levels of all bisphenols compared to older children. Exposure to food stored in plas-tic containers were associated with higher levels of BPF and BPS. In conclusion, BPA was the most fre-quently detected bisphenol in urine samples from Thai children, followed by BPF and BPS.

Bisphenol S

Benzhydryl compounds

10.20944/preprints202308.1924.v1

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Citations (1)