Duncan J. Webster

Institute for Biomedical Engineering

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Ralph Müller

ETH Zurich

Gisela Kuhn

ETH Zurich

Friederike A. Schulte

Institute for Biomedical Engineering

Floor M. Lambers

ETH Zurich

Davide Ruffoni

University of Liège

Andreas J. Trüssel

ETH Zurich

Elad Wasserman

Weizmann Institute of Science

Harry van Lenthe

KU Leuven

Itai Bab

Hebrew University of Jerusalem

A.M. Levchuk

Institute for Biomedical Engineering

Cooperative Institutions

ETH Zurich

Institute for Biomedical Engineering

University of Zurich

École Polytechnique Fédérale de Lausanne

Biomechanics Institute of Valencia

Eindhoven University of Technology

Swiss Integrative Center for Human Health

KU Leuven

Board of the Swiss Federal Institutes of Technology

Hebrew University of Jerusalem

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Prompt response to rituximab of severe hemolytic anemia with both cold and warm autoantibodies

American Journal of Hematology (2004)

Duncan J. Webster Bruce Ritchie Michael J. Mant

Abstract A 71‐year‐old male with severe autoimmune hemolysis with both cold agglutinins and warm antibodies was intolerant of prednisone and cyclophosphamide. Rituximab was given during a 60‐day period when he required 41 units of packed cells to maintain hemoglobin above 75 g/l. Two weeks later hemoglobin stabilized at 95 g/l, and further transfusions were not required. A second course of rituximab was given 4 months later for continued hemolysis. A satisfactory hemoglobin was maintained for 9 months from initial treatment, when hemoglobin again fell to 65 g/L. A prompt response to a third course of rituximab was obtained. This is the second patient with both cold agglutinins and warm antibodies with severe hemolytic anemia who has had a prompt response to rituximab. This treatment should be considered when a rapid response is needed or when a patient has failed to respond to more standard therapies. Am. J. Hematol. 75:258–259, 2004. © 2004 Wiley‐Liss, Inc.

Cold Agglutinin

Haptoglobin

10.1002/ajh.20034

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Citations (15)

STRAIN ENERGY DENSITY GRADIENTS IN BONE MARROW PREDICT OSTEOBLAST AND OSTEOCLAST ACTIVITY

Journal of Biomechanics (2012)

Duncan J. Webster Friederike A. Schulte Floor M. Lambers Gisela Kuhn Ralph Müller

Strain (injury)

10.1016/s0021-9290(12)70105-7

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Citations (1)

Strain energy density gradients in bone marrow predict osteoblast and osteoclast activity: A finite element study

Journal of Biomechanics (2015)

Duncan J. Webster Friederike A. Schulte Floor M. Lambers Gisela Kuhn Ralph Müller

Mechanical load

X-ray microtomography

Strain (injury)

sed

Bone remodeling

10.1016/j.jbiomech.2014.12.009

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Citations (44)

Compartmental Bone Morphometry in the Mouse Femur: Reproducibility and Resolution Dependence of Microtomographic Measurements

Calcified Tissue International (2005)

Thomas Köhler Manuel Beyeler Duncan J. Webster Ralph Müller

Diaphysis

Coefficient of variation

Compartment (ship)

10.1007/s00223-005-0039-2

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Citations (74)

A combined experimental and computational model for genetic control of micro structural bone adaptation

Duncan J. Webster

10.3929/ethz-a-005780136

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Citations (1)

Mechanostat theory is not suspended at the local level despite estrogen depletion in murine trabecular bone

Bone (2010)

Friederike A. Schulte Floor M. Lambers Duncan J. Webster Gisela Kuhn Ralph Müller

10.1016/j.bone.2010.04.133

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Citations (0)

In Silico Medicine Approach to Predict Changes in Human Vertebrae Due to Osteoporosis and Treatment

Biomedical Engineering / Biomedizinische Technik (2013)

A.M. Levchuk Sandro D. Badilatti Duncan J. Webster van B Bert Rietbergen Javad Hazrati

It is generally accepted that trabecular architecture plays a pivotal role in the mechanical behaviour of bone.With age, bone undergoes structural changes, which can result in osteoporosis, leading to lifethreatening fractures, and inevitable decrease in the quality of life.While mathematical laws governing bone remodelling are under continued investigation, the aim of this project was to apply a simple in silico model to simulate changes in the bone architecture due to age, as previously reported in clinical studies.In addition, the effects of the current recommended treatments were investigated.Using high-resolution three-dimensional µCT scans of whole human vertebrae, age-related bone loss and recovery simulation produced realistic simulations of structural change over 30 years.

10.1515/bmt-2013-4343

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Citations (9)

Strain-adaptive in silico modeling of bone adaptation — A computer simulation validated by in vivo micro-computed tomography data

Bone (2012)

Friederike A. Schulte Alexander Zwahlen Floor M. Lambers Gisela Kuhn Davide Ruffoni

Experimental data

Computational model

10.1016/j.bone.2012.09.008

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Citations (81)

In silico biology of bone modelling and remodelling: adaptation

Philosophical Transactions of the Royal Society A Mathematical Physical and Engineering Sciences (2009)

Friederike A. Gerhard Duncan J. Webster Harry van Lenthe Ralph Müller

Modelling and remodelling are the processes by which bone adapts its shape and internal structure to external influences. However, the cellular mechanisms triggering osteoclastic resorption and osteoblastic formation are still unknown. In order to investigate current biological theories, in silico models can be applied. In the past, most of these models were based on the continuum assumption, but some questions related to bone adaptation can be addressed better by models incorporating the trabecular microstructure. In this paper, existing simulation models are reviewed and one of the microstructural models is extended to test the hypothesis that bone adaptation can be simulated without particular knowledge of the local strain distribution in the bone. Validation using an experimental murine loading model showed that this is possible. Furthermore, the experimental model revealed that bone formation cannot be attributed only to an increase in trabecular thickness but also to structural reorganization including the growth of new trabeculae. How these new trabeculae arise is still an unresolved issue and might be better addressed by incorporating other levels of hierarchy, especially the cellular level. The cellular level sheds light on the activity and interplay between the different cell types, leading to the effective change in the whole bone. For this reason, hierarchical multi-scale simulations might help in the future to better understand the biomathematical laws behind bone adaptation.

Bone Formation

Bone remodeling

Cellular adaptation

10.1098/rsta.2008.0297

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Citations (60)

3D SPATIAL MAPPING OF OSTEOCYTES IN AN IN VIVO MODEL FOR BONE ADAPTATION

Journal of Biomechanics (2012)

Andreas J. Trüssel Duncan J. Webster Ralph Müller

Osteocyte

10.1016/s0021-9290(12)70109-4

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Citations (4)