Steven C. Plaxe

Research Field

Uterine cancer

10.1016/j.ygyno.2012.04.013

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Citations (237)

Impact of therapeutic modalities on disease-specific survival in older adults with glioblastoma: A single-institution retrospective cohort study

Journal of Oncology Pharmacy Practice (2019)

Andrew Iskandar Wesley T. Kerr Andrew Hwang Stephanie Farrell Steven C. Plaxe

The standard first-line therapy for glioblastoma consists of maximal surgical resection, followed by concurrent chemoradiotherapy. Optimal management for older glioblastoma patients is unknown as they have not been extensively studied in clinical trials. We report data from a series of 156 consecutive glioblastoma patients treated at our institution from 2007 to 2017. Compared to glioblastoma patients aged 70 or less, the patients older than 70 were less likely to undergo surgical resection (34% vs. 64%; p = 0.0003), be treated with adjuvant chemotherapy (37% vs. 59%; p = 0.01) or radiation therapy (36% vs. 56%; p = 0.03). Disease-specific survival was significantly shorter in this age group (4.7 vs. 15.3 months; p = 0.002). Nonetheless, when older patients did undergo surgery or chemotherapy, the proportional improvement in cancer-specific survival was similar to the one recorded in younger patients, which is concordant with the findings of other published reports. A multidisciplinary input from neurosurgeons, medical and radiation oncologists, oncology pharmacists and geriatricians remain paramount for the optimal management of glioblastoma in patients older than 70.

Chemoradiotherapy

10.1177/1078155219857792

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Citations (1)

P20 Superficial myometrial invasion and chemotherapy are associated with improved outcomes in patients with stage 1 uterine carcinosarcoma

Gynecologic Oncology (2023)

Marianne S. Hom Katherine Coakley Ioana Bondre Breana Hill Michael McHale

Carcinosarcoma

10.1016/j.ygyno.2023.05.047

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Citations (0)

Recent advances in endometrial cancer: a review of key clinical trials from 2015 to 2019

F1000Research (2019)

Lindsey M. Charo Steven C. Plaxe

In the past few years, we have seen several important advances in understanding of and therapy for endometrial cancer. This review highlights key recent abstracts and publications in endometrial cancer from 2015 to 2019. We focus on clinical trials in surgical staging and the utility of sentinel lymph node mapping, adjuvant treatment for high-risk disease and HER2/neu-positive serous tumors, combination therapy for recurrent disease, molecular biology, and immunotherapy.

Adjuvant Therapy

Open peer review

10.12688/f1000research.17408.1

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Citations (56)

Patient and physician factors associated with participation in Gynecologic Oncology Group (GOG) trials in cervical and uterine cancer

Gynecologic Oncology (2014)

Sandra E. Brooks R.L. Carter Steven C. Plaxe Karen Basen‐Engquist Michael Rodriguez

Gynecologic oncology

Gynecologic cancer

Uterine cancer

10.1016/j.ygyno.2014.03.116

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Citations (1)

Clinical features of advanced ovarian mixed mesodermal tumors and treatment with doxorubicin- and cis-platinum-based chemotherapy

Gynecologic Oncology (1990)

Steven C. Plaxe Peter R. Dottino Howard M. Goodman L Deligdisch M. Idelson

10.1016/0090-8258(90)90341-h

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Citations (59)

Novel Intrauterine Brachytherapy Device Allows Precise Targeting of Tissues at Risk While Simultaneously Minimizing Normal Tissue Dose

Brachytherapy (2011)

Daniel J. Scanderbeg Cheryl Saenz Steven C. Plaxe Edwin Alvarez Michael McHale

Uterine cavity

10.1016/j.brachy.2011.02.212

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Citations (1)

Women with Gynecologic Malignancies Have a Greater Incidence of Suicide than Women with Other Cancer Types

Suicide and Life-Threatening Behavior (2012)

Kristy Ward Angelica M. Roncancio Steven C. Plaxe

To evaluate risk of suicide of women with invasive gynecologic malignancies, the N ational C ancer I nstitute's S urveillance, E pidemiology, and E nd R esults P rogram (1973–2007) was queried. S uicide per 100,000 women with gynecologic malignancies was compared with that of women with other malignancies; suicide was 30% more likely in those with gynecologic malignancies. Most suicides occurred within 4 years of diagnosis. Better understanding of the descriptive epidemiology of suicide among women with gynecologic malignancies could lead to improved risk assessment, screening, and prevention of this potentially avoidable cause of death.

Gynecologic cancer

10.1111/sltb.12002

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Citations (26)

Primary squamous carcinoma of the ovary likely arising from a monodermal cystic mucinous teratoma

Annals of Diagnostic Pathology (2010)

Mariah R. Baughn Steven C. Plaxe Noel Weidner

Mature Cystic Teratoma

Mucinous cystadenoma

Mucinous carcinoma

Squamous carcinoma

10.1016/j.anndiagpath.2010.06.005