Si-Xuan Liu

Harbin Medical University

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i-10 index

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Yong‐Fu Lu

Harbin Medical University

Chang Li

Harbin Medical University

Yue‐Hu Pei

Harbin Medical University

Yihui Yang

Harbin Medical University

Yue‐Hu Pei

Harbin Medical University

Si‐Yang Dai

Harbin Medical University

Chunyue Liu

Harbin Medical University

Chunlin Guo

Harbin Medical University

Nan Ma

Jinan University

Fu-Hua Deng

Harbin Medical University

Cooperative Institutions

Harbin Medical University

Chinese Academy of Sciences

Shenyang Pharmaceutical University

Chinese Academy of Medical Sciences & Peking Union Medical College

Nanjing Medical University

University of Hong Kong

University of Chinese Academy of Sciences

Jinan University

Hohai University

Jiangnan University

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Meroterpenoids from Rhododendron racemosum and their anti-inflammatory activities

Journal of Asian Natural Products Research (2024)

Si-Xuan Liu Si‐Yang Dai Yong‐Fu Lu Chunlin Guo Chang Li

Three meroterpenoids, including one new compound, ranhuadujuanine E (

10.1080/10286020.2024.2431813

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A review of the fernane-type triterpenoids as anti-fungal drugs

Frontiers in Pharmacology (2024)

Chunyue Liu Lu Zhang Si-Xuan Liu Yong‐Fu Lu Chang Li

Human fungal pathogens could cause a broad plethora of infections in both the immunocompetent and immunocompromised host. Fungal infections have become important causes of morbidity and mortality in recent years, the current arsenal of anti-fungal therapies was restricted. Ibrexafungerp was a novel, highly bioavailable glucan synthase inhibitor formulated for both intravenous and oral administration being developed by Scynexis; it was also the first novel anti-fungal drug class approved in more than 20 years. Ibrexafungerp was one semi-synthetic derivative of enfumafungin, a natural product isolated from fungi. This review reported the discovery of enfumafungin and ibrexafungerp, their anti-fungal mechanism, summed up 63 fernane-type triterpenoids from natural products, including 49 from plants, 9 from fungi and 5 from lichen. In addition, the review summarized the progress of enzymes responsible for the biosynthesis of type II fernane triterpenoid (enfumafungin skeleton) and type I fernane triterpenoid (polytolypin skeleton). The good example kept our confidence up for searching for new leading compounds and discovering drugs from fungi.

Natural product

10.3389/fphar.2024.1447450

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Recent advances on cyclodepsipeptides: biologically active compounds for drug research

Frontiers in Microbiology (2023)

Si-Xuan Liu Si-Yi Ou-Yang Yong‐Fu Lu Guo Chun-lin Si‐Yang Dai

Cyclodepsipeptides are a large family of peptide-related natural products consisting of hydroxy and amino acids linked by amide and ester bonds. A number of cyclodepsipeptides have been isolated and characterized from fungi and bacteria. Most of them showed antitumor, antifungal, antiviral, antimalarial, and antitrypanosomal properties. Herein, this review summarizes the recent literatures (2010-2022) on the progress of cyclodepsipeptides from fungi and bacteria except for those of marine origin, in order to enrich our knowledge about their structural features and biological sources.

10.3389/fmicb.2023.1276928

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Lignan Glycosides from Fritillaria Verticillata Willd. And Their Anti-Inflammatory Activities

Chang Li Nan Ma Si-Xuan Liu Yongfu Li Fu-Hua Deng

Three undescribed lignan glycosides echiunines E-G (1-3), as well as eight known compounds (4-11) were isolated from Fritillaria verticillata Willd. Among them, compounds 1-3 were a series of lignan glycosides reported for the first time from genus Fritillaria. Their structures were elucidated by analyses of extensive spectroscopic data and comparison of the NMR data with those reported previously, the absolute configuration of compounds were further confirmed by calculated ECD method. The NO release inhibitory effects of compounds were evaluated in LPS-activated RAW264.7 macrophages. Compounds 7-8 showed inhibitory acitivities in a dose-dependent manner.

10.2139/ssrn.4411389

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Aristolochic alkaloids from Piper macropodum and their anti-inflammatory activities

Phytochemistry Letters (2023)

Chunyue Liu Yong‐Fu Lu Si-Xuan Liu Yongfu Li Yan Dong

Aristolochic Acid

Piperaceae

Anti-inflammatory

10.1016/j.phytol.2023.08.012

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