Semi-supervised learning is a sound measure to relieve the strict demand of abundant annotated datasets, especially for challenging multi-organ segmentation . However, most existing SSL methods predict pixels in a single image independently, ignoring the relations among images and categories. In this paper, we propose a two-stage Dual Contrastive Learning Network for semi-supervised MoS, which utilizes global and local contrastive learning to strengthen the relations among images and classes. Concretely, in Stage 1, we develop a similarity-guided global contrastive learning to explore the implicit continuity and similarity among images and learn global context. Then, in Stage 2, we present an organ-aware local contrastive learning to further attract the class representations. To ease the computation burden, we introduce a mask center computation algorithm to compress the category representations for local contrastive learning. Experiments conducted on the public 2017 ACDC dataset and an in-house RC-OARs dataset has demonstrated the superior performance of our method.

Similarity (geometry)

10.1109/icassp48485.2024.10447495

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Citations (3)

Rathke's cleft cyst: clinicopathological and MRI findings in 22 patients

Clinical Radiology (2009)

Lu Wen Liu Hu Xiaoyuan Feng D. Gaurav Lan Zou

Contrast Enhancement

10.1016/j.crad.2009.09.010

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Citations (50)

The DNA methylation landscape of human early embryos

Nature (2014)

Hongshan Guo Ping Zhu Liying Yan Rong Li Boqiang Hu

Pronucleus

DNA demethylation

Epigenomics

Bisulfite sequencing

10.1038/nature13544

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Citations (829)

Diagnostic performance of Node-RADS score for mesorectal lymph node metastasis in rectal cancer

Abdominal Radiology (2024)

Yue Niu Sanqiang Yu Peng Chen Mengjie Tang Lu Wen

10.1007/s00261-024-04497-0

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Citations (3)

Supplementary Table 7 from Single-Cell Chromatin Accessibility Analysis Reveals the Epigenetic Basis and Signature Transcription Factors for the Molecular Subtypes of Colorectal Cancers

Zhenyu Liu Yuqiong Hu Haoling Xie Kexuan Chen Lu Wen

Supplementary Table 7. Specifically gained promoter peaks of CIMP-High subtype.

10.1158/2159-8290.25956942

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Citations (0)

Supplementary Figure 5 from Single-Cell Chromatin Accessibility Analysis Reveals the Epigenetic Basis and Signature Transcription Factors for the Molecular Subtypes of Colorectal Cancers

Zhenyu Liu Yuqiong Hu Haoling Xie Kexuan Chen Lu Wen

Supplementary Figure 5. NMF identification of two malignant subtypes consistent with iCMS classification.

Signature (topology)

Transcription

Basis (linear algebra)

10.1158/2159-8290.25956981

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Supplementary Figure 14 from Single-Cell Chromatin Accessibility Analysis Reveals the Epigenetic Basis and Signature Transcription Factors for the Molecular Subtypes of Colorectal Cancers

Zhenyu Liu Yuqiong Hu Haoling Xie Kexuan Chen Lu Wen

Supplementary Figure 14. Module-trait association identified key TFs for CRC heterogeneities.

Signature (topology)

Basis (linear algebra)

10.1158/2159-8290.25956993.v1

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Clinical Research of Systemic Inflammatory Response Syndrome in Treatment by Combining Continuous hemofiltration and Ulinastatin

The Journal of Medical Theory and Practice (2011)

Lu Wen

Objective:To evaluate the clinical efficacy and safety in treatment systemic inflammatory response syndrome by combining continuous blood filtration and ulinastatin.Methods:Eighty-four cases with SIRS patients were randomly divided into treatment group A(treated with ulinastatin and hemofiltration),treatment group B(treated with hemofiltration)and control group,28 cases of each group.The patients inflammatory parameters,respiratory and hemodynamic indices,and lab exams such as IL-6,TNF-α were detected before and after treatment,and record live ICU time,total length of hospital stay,mortality,etc.Results:The combination of continuous hemofiltration and ulinastatin can significantly improve SIRS patient's clinical symptoms and test indicators,and reduce IL-6 and TNF-α level,shorten the length of time,reduce mortality,the results were better than the control group(P0.05).Conclusion:Ulinastatin and continuous hemofiltration combination therapy can improve the clinical symptoms,improve the curative effect of SIRS,significantly reduce mortality.

Ulinastatin

Hemofiltration

Inflammatory response

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Neoadjuvant chemoradiotherapy plus sequential tislelizumab followed by surgery for esophageal carcinoma (CRISEC study): A single-arm, bicentric, phase 2 trial

Radiotherapy and Oncology (2025)

Jinsong Yang Cui Liu Zhigang Zuo Fengjun Cao Zhanjie Zhang

Chemoradiotherapy

10.1016/j.radonc.2025.110797

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