María C. Baamonde Calzada

Hospital Sierrallana

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ÁL

Álex Larruzea

Institut de Seguretat Pública de Catalunya

María Arnaldos Carrillo

Hospital Universitario Virgen de la Arrixaca

Elisa Nuez‐Zaragoza

Corporació Sanitària Parc Taulí

María C. Zamorano Andrés

Hospital de Hellín

Patricia Esteban Torrella

Hospital Reina Sofía de Murcia

Juan Adell Ruiz de León

Hospital Clínico Universitario Virgen de la Victoria

Iria Cebreiros López

Hospital Universitario Virgen de la Arrixaca

Amaia Fernandez-Uriarte

Mount Sinai Hospital

Mercedes González Morales

Santa Lucía University General Hospital

María-Carmen Lorenzo-Lozano

Complejo Hospitalario Universitario de Toledo

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Sociedad Española de Medicina Interna

Spanish Society of Family and Community Medicine

Universitat Autònoma de Barcelona

Santa Lucía University General Hospital

Hospital Universitario Virgen de la Arrixaca

Hospital Rafael Méndez

Corporació Sanitària Parc Taulí

Institute of Research and Innovation Parc Tauli

Universitat de Barcelona

Marqués de Valdecilla University Hospital

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Characteristics and laboratory findings on admission to the emergency department among 2873 hospitalized patients with COVID-19: the impact of adjusted laboratory tests in multicenter studies. A multicenter study in Spain (BIOCOVID-Spain study)

Scandinavian Journal of Clinical and Laboratory Investigation (2021)

Luis García de Guadiana‐Romualdo Daniel Morell‐García Cristian Morales‐Indiano Josep Miquel Bauçà Maria José Alcaide Martín

Identification of predictors for severe disease progression is key for risk stratification in COVID-19 patients. We aimed to describe the main characteristics and identify the early predictors for severe outcomes among hospitalized patients with COVID-19 in Spain. This was an observational, retrospective cohort study (BIOCOVID-Spain study) including COVID-19 patients admitted to 32 Spanish hospitals. Demographics, comorbidities and laboratory tests were collected. Outcome was in-hospital mortality. For analysis, laboratory tests values were previously adjusted to assure the comparability of results among participants. Cox regression was performed to identify predictors. Study population included 2873 hospitalized COVID-19 patients. Nine variables were independent predictors for in-hospital mortality, including creatinine (Hazard ratio [HR]:1.327; 95% Confidence Interval [CI]: 1.040-1.695, p = .023), troponin (HR: 2.150; 95% CI: 1.155-4.001; p = .016), platelet count (HR: 0.994; 95% CI: 0.989-0.998; p = .004) and C-reactive protein (HR: 1.037; 95% CI: 1.006-1.068; p = .019). This is the first multicenter study in which an effort was carried out to adjust the results of laboratory tests measured with different methodologies to guarantee their comparability. We reported a comprehensive information about characteristics in a large cohort of hospitalized COVID-19 patients, focusing on the analytical features. Our findings may help to identify patients early at a higher risk for an adverse outcome.

10.1080/00365513.2021.1881997

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Citations (23)

Harmonized D-dimer levels upon admission for prognosis of COVID-19 severity: Results from a Spanish multicenter registry (BIOCOVID-Spain study)

Journal of Thrombosis and Thrombolysis (2021)

Luis García de Guadiana‐Romualdo Daniel Morell‐García Emmanuel J. Favaloro Juan A. Vílchez Josep Miquel Bauçà

D-dimer

Clinical endpoint

10.1007/s11239-021-02527-y

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Citations (24)