Nore Somers

ZNA Middelheim Hospital

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Sebastiaan Engelborghs

University of Antwerp

Peter Paul De Deyn

ZNA Middelheim Hospital

Peter Mariën

ZNA Middelheim Hospital

Ellen Vloeberghs

University of Antwerp

J. Saerens

ZNA Middelheim Hospital

Johan Goeman

ZNA Middelheim Hospital

Stefan Van der Mussele

University of Antwerp

Karen Maertens

University of Antwerp

Peter Mariën

Ziekenhuisnetwerk Antwerpen Stuivenberg

Guy Nagels

Vrije Universiteit Brussel

Cooperative Institutions

University of Antwerp

ZNA Middelheim Hospital

VIB-UAntwerp Center for Molecular Neurology

KU Leuven

Antwerp University Hospital

Ziekenhuisnetwerk Antwerpen Stuivenberg

Ghent University Hospital

Bunge & Born Foundation

University Medical Center Groningen

Vrije Universiteit Brussel

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

A prospective, longitudinal Belgian study on behavioral and psychological signs and symptoms of dementia (BPSD)

European Journal of Neurology (2004)

Sebastiaan Engelborghs Karen Maertens Ellen Vloeberghs Peter Mariën A. Symons

Longitudinal Study

Source

Cite

Citations (0)

P3‐154: BEHAVIORAL SYMPTOMS ASSOCIATED WITH PROGRESSION FROM MILD COGNITIVE IMPAIRMENT TO ALZHEIMER'S DISEASE: A LONGITUDINAL STUDY

Alzheimer s & Dementia (2014)

Stefan Van der Mussele Erik Fransén Peter Mariën J. Saerens Nore Somers

This study would like to contribute to the understanding of the prognostic role of behavioral symptoms in mild cognitive impairment (MCI) for the progression to dementia due to Alzheimer's disease (AD). Data were generated through an ongoing prospective longitudinal study on behavioral symptoms in MCI and dementia. Behavioral assessment was performed by means of the MFS, Behave-AD, CMAI, CSDD and Geriatric Depression Scale 30-questions (GDS-30). Cox proportional hazard models were used to test the hypothesis that behavioral symptoms in MCI increase the risk for developing AD. The study population consisted of 183 MCI patients at baseline. At follow-up, 74 patients were stable and 109 patients progressed to AD. The presence of significant depressive symptoms in MCI as measured by the CSDD (HR: 2.06; 95% CI: 1.23 - 3.44; p=0.011) and the GDS-30 (HR: 1.77; 95% CI: 1.10 - 2.85; p=0.025) were associated with an increased the risk of progression to AD. The severity of depressive symptoms as measured by the GDS-30 was a predictor for progression too (HR: 1.06; 95% CI: 1.01 - 1.11; p=0.020). Furthermore, also the severity of agitated behavior, especially verbal agitation, and the presence of purposeless activity were associated risk factors for progression, whereas diurnal rhythm disturbances in our study was associated with a decreased risk of progression.

Geriatric Depression Scale

Depression

Longitudinal Study

10.1016/j.jalz.2014.05.1244

Cite

Citations (0)

P3‐105: Prognostic value of frontal lobe symptoms in mild cognitive impairment for conversion to Alzheimer's disease

Alzheimer s & Dementia (2011)

Stefan Van der Mussele Nathalie Le Bastard Yannick Vermeiren J. Saerens Nore Somers

Mild Cognitive Impairment (MCI) is a clinical concept that categorizes subjects who are cognitively in an intermediate state between normal aging and dementia. As preliminary studies provided some evidence that behavioral disturbances might predict conversion to Alzheimer's disease (AD), we set up a study that aims to investigate the prognostic value of frontal lobe symptoms for the conversion of MCI to AD. This study is part of a prospective, longitudinal study on behavioral and psychological signs and symptoms of dementia and MCI. Behavioral assessment was performed at baseline and follow-up by means of Middelheim Frontality Score (MFS), Behave-AD, Cohen-Mansfield Agitation Inventory and Cornell Scale for Depression in Dementia. The MFS is a validated clinical and behavioral assessment scale that measures frontal lobe features. Stable MCI patients (no conversion to AD during follow-up) will be compared with progressive MCI patients (conversion to AD during follow-up). Data will be analyzed by means of survival analysis. We here present preliminary results of 100 patients as follow-up, data collection and data analyses are still running. The final dataset will be presented at the ICAD meeting in July 2011. Preliminary data analysis comprises 50 stable MCI patients and 50 progressive MCI patients. The mean follow-up period is respectively 18,7 (12,0) months and 25,6 (17,8) months. The two groups differed significantly in MFS total scores and the MFS item score ‘loss of insight and judgment’. Mean MFS total score was 1,98 for stable MCI and 2,70 for progressive MCI patients. Multivariate analysis showed an increased risk of 59% for developing AD by each raise of one point on the MFS total score. Also, age increase of 1 year was linked to an increased risk of 42% for developing AD. The presence of frontal lobe symptoms in MCI showed to have an impact on the risk of conversion to AD. Consequently, these symptoms may have a prognostic value. Likewise, other behavioral symptoms should be investigated on their potential prognostic value.

Frontal lobe

Depression

10.1016/j.jalz.2011.05.1545

Cite

Citations (0)

Behavioral Syndromes in Mild Cognitive Impairment and Alzheimer's Disease

Journal of Alzheimer s Disease (2013)

Stefan Van der Mussele Peter Mariën J. Saerens Nore Somers Johan Goeman

Background: Behavioral disturbances belong to the core symptoms of dementia and are also common in mild cognitive impairment (MCI). The identification of sets of symptoms is clinically interesting, as interventions targeting syndromes may be more eff

Depression

10.3233/jad-130596

Cite

Citations (30)

Reversal of head drop after discontinuation of olanzapine in a DLB patient

Movement Disorders (2008)

Marcel Aries Hans Debruyne Sebastiaan Engelborghs Nathalie Le Bastard Nore Somers

Abstract We present a 72‐year‐oldpatient with probable diffuse Lewy body disease and visual hallucinations, who developed subacute reversible “dropped head syndrome” and parkinsonian signs after the introduction of olanzapine at a total daily dose of 10 mg. One week after olanzapine was withdrawn, the patient's posture started to improve. Further improvement was achieved after dopaminergic substitution. Clinical and electrophysiological observations might indicate neck extensor myopathy due to axial rigidity or focal neck dystonia, induced by dopamine receptor blockade. © 2008 Movement Disorder Society

Discontinuation

10.1002/mds.22182

Cite

Citations (7)

P3-037 CSF dopac levels predict aggressive and agitated behavior in FTD patients

Neurobiology of Aging (2004)

Sebastiaan Engelborghs Karen Maertens Ellen Vloeberghs Peter Mariën A. Symons

10.1016/s0197-4580(04)81191-6

Cite

Citations (0)

Dose dependent effect of APOE ɛ4 on behavioral symptoms in frontal lobe dementia

Neurobiology of Aging (2005)

Sebastiaan Engelborghs Bart Dermaut Peter Mariën R. C. Andrew Symons Ellen Vloeberghs

Apolipoprotein E

Frontal lobe

10.1016/j.neurobiolaging.2005.02.005

Cite

Citations (60)

Neuropsychiatric symptoms of dementia: cross-sectional analysis from a prospective, longitudinal Belgian study

International Journal of Geriatric Psychiatry (2005)

Sebastiaan Engelborghs Karen Maertens Guy Nagels Ellen Vloeberghs Peter Mariën

Objective Given the rather limited knowledge on profiles of neuropsychiatric symptoms (behavioural and psychological signs and symptoms of dementia, BPSD) in several degenerative dementias, we designed a prospective study of which we here present the baseline data. Methods Diagnosed according to strictly applied clinical diagnostic criteria, patients with probable Alzheimer's disease (AD) (n = 205), frontotemporal dementia (FTD) (n = 29), mixed dementia (MXD) (n = 39) and dementia with Lewy bodies (DLB) (n = 23) were included. All patients underwent a neuropsychological examination and behavioural assessment by means of a battery of scales (Middelheim Frontality Score (MFS), Behave-AD, Cohen-Mansfield Agitation Inventory, Cornell Scale for Depression in Dementia). Results In AD and MXD, activity disturbances and aggressiveness occurred in more than 80% of the patients. With a prevalence of 70%, apathy was very common whereas delusions and hallucinations were rare in FTD patients. Frequently used behavioural assessment scales like the Behave-AD systematically underestimated BPSD in FTD whereas the MFS displayed high sensitivity for frontal lobe symptoms. Hallucinations discriminated DLB patients from other dementias. A high prevalence of disinhibition (65%) in DLB pointed to frontal lobe involvement. Conclusions Behavioural assessment may help differentiating between different forms of dementia, further stressing the need for the development of new and more sensitive behavioural assessment scales. By means of the MFS, frontal lobe involvement was frequently observed in DLB. As 70% of FTD patients displayed apathy, prevalence was about two times higher compared to the other disease groups, meanwhile indicating that apathy is frequently observed in dementia, irrespective of its etiology. Copyright © 2005 John Wiley & Sons, Ltd.

Apathy

Disinhibition

Frontal lobe

Depression

Geriatric Depression Scale

Lewy body

10.1002/gps.1395

Cite

Citations (109)

Prevalence and associated behavioral symptoms of psychosis in mild cognitive impairment and dementia due to Alzheimer’s disease

Journal of Alzheimer s Disease (2014)

Stephan Van Der Mussele Peter Mariën J. Saerens Nore Somers Johan Goeman

Source

Cite

Citations (0)

Prevalence and associated behavioral symptoms of depression in mild cognitive impairment and dementia due to Alzheimer's disease

International Journal of Geriatric Psychiatry (2012)

Stefan Van der Mussele Kim Bekelaar Nathalie Le Bastard Yannick Vermeiren J. Saerens

Background Mild cognitive impairment (MCI) is a clinical concept that categorizes subjects who are in an intermediate cognitive state between normal aging and dementia. The aims of this study are to determine the prevalence of significant depressive symptoms in MCI and Alzheimer's disease (AD) patients and to characterize the behavior associated with significant depressive symptoms in MCI and AD patients. Methods A cross‐sectional analysis of baseline data from a prospective, longitudinal study on behavioral symptoms of dementia and MCI was performed. The study population consisted of 270 MCI and 402 AD patients. Behavioral assessment was performed by means of Middelheim Frontality Score, Behavioral Pathology in Alzheimer's Disease Rating Scale (Behave‐AD) and Cohen‐Mansfield Agitation Inventory. The presence of significant depressive symptoms was defined as a Cornell Scale for Depression in Dementia total score >7. Results The prevalence of significant depressive symptoms in AD patients (25%) was higher compared with MCI patients (16%) ( p = 0.005). Patients with significant depressive symptoms showed an increased severity of frontal lobe symptoms, behavioral symptoms and agitation (Middelheim Frontality Score, Behave‐AD and Cohen‐Mansfield Agitation Inventory total scores; p < 0.001). Also, most of the individual frontal lobe and behavioral symptoms were more prevalent and severe, resulting in higher Behave‐AD global scores. Mild cognitive impairment patients with depressive symptoms showed more severe behavioral symptoms and more severe verbally agitated behavior than AD patients without depressive symptoms ( p < 0.001). Conclusions Frontal lobe and behavioral symptoms are more prevalent and severe in MCI and AD patients with significant depressive symptoms as compared with patients without depressive symptoms. Copyright © 2012 John Wiley & Sons, Ltd.

Depression

Frontal lobe

Clinical Dementia Rating

Severe dementia

10.1002/gps.3909

Cite

Citations (70)