Marine M. Desgeorges

Université Claude Bernard Lyon 1

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Anne Bonnieu

Université de Montpellier

Yann S. Gallot

Université Paris-Saclay

ÉL

Étienne Lefai

Université Clermont Auvergne

Didier Rémond

Unité de Nutrition Humaine

Georges Némoz

Inserm

Vanessa E. Jahnke

Eurofins (France)

Barbara Vernus

Université de Montpellier

Josiane Castells

Université Claude Bernard Lyon 1

Laurent Schaeffer

Hospices Civils de Lyon

Damien Freyssenet

Université Jean Monnet

Cooperative Institutions

Université Claude Bernard Lyon 1

Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement

Inserm

Centre National de la Recherche Scientifique

Laboratoire Interuniversitaire de Biologie de la Motricité

Institut National de la Recherche Agronomique

Université Savoie Mont Blanc

Université Jean Monnet

Université Clermont Auvergne

Centre de Recherche en Nutrition Humaine d'Auvergne

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Supplementary Figure S3 from Myostatin Gene Inactivation Prevents Skeletal Muscle Wasting in Cancer

Yann S. Gallot Anne‐Cécile Durieux Josiane Castells Marine M. Desgeorges Barbara Vernus

Wild-type and Mstn-/- tumor-bearing mice have similar caloric intakes, indicating that anorexia is not involved in the development of cancer cachexia.

Myostatin

Anorexia

Cancer Cachexia

Caloric theory

Caloric intake

10.1158/0008-5472.22404573.v1

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Supplementary Figure S4 from Myostatin Gene Inactivation Prevents Skeletal Muscle Wasting in Cancer

Yann S. Gallot Anne‐Cécile Durieux Josiane Castells Marine M. Desgeorges Barbara Vernus

Effect of human recombinant Mstn (hrMstn) on the proliferation of Lewis lung carcinoma (LLC) cells - Bcl-2 protein content in the tumor tissue.

Myostatin

10.1158/0008-5472.22404570

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Supplementary Figure Legend from Myostatin Gene Inactivation Prevents Skeletal Muscle Wasting in Cancer

Yann S. Gallot Anne‐Cécile Durieux Josiane Castells Marine M. Desgeorges Barbara Vernus

Legend for Supplementary Figures S1-S6.

Myostatin

Legend

10.1158/0008-5472.22404582

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Supplementary Figure S3 from Myostatin Gene Inactivation Prevents Skeletal Muscle Wasting in Cancer

Yann S. Gallot Anne‐Cécile Durieux Josiane Castells Marine M. Desgeorges Barbara Vernus

Wild-type and Mstn-/- tumor-bearing mice have similar caloric intakes, indicating that anorexia is not involved in the development of cancer cachexia.

Myostatin

10.1158/0008-5472.22404573

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Myostatin Gene Inactivation Prevents Skeletal Muscle Wasting in Cancer

Cancer Research (2014)

Yann S. Gallot Anne‐Cécile Durieux Josiane Castells Marine M. Desgeorges Barbara Vernus

Abstract Cachexia is a muscle-wasting syndrome that contributes significantly to morbidity and mortality of many patients with advanced cancers. However, little is understood about how the severe loss of skeletal muscle characterizing this condition occurs. In the current study, we tested the hypothesis that the muscle protein myostatin is involved in mediating the pathogenesis of cachexia-induced muscle wasting in tumor-bearing mice. Myostatin gene inactivation prevented the severe loss of skeletal muscle mass induced in mice engrafted with Lewis lung carcinoma (LLC) cells or in ApcMin/+ mice, an established model of colorectal cancer and cachexia. Mechanistically, myostatin loss attenuated the activation of muscle fiber proteolytic pathways by inhibiting the expression of atrophy-related genes, MuRF1 and MAFbx/Atrogin-1, along with autophagy-related genes. Notably, myostatin loss also impeded the growth of LLC tumors, the number and the size of intestinal polyps in ApcMin/+ mice, thus strongly increasing survival in both models. Gene expression analysis in the LLC model showed this phenotype to be associated with reduced expression of genes involved in tumor metabolism, activin signaling, and apoptosis. Taken together, our results reveal an essential role for myostatin in the pathogenesis of cancer cachexia and link this condition to tumor growth, with implications for furthering understanding of cancer as a systemic disease. Cancer Res; 74(24); 7344–56. ©2014 AACR.

Myostatin

Muscle Atrophy

Pathogenesis

10.1158/0008-5472.can-14-0057

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Citations (98)

Supplementary Figure S5 from Myostatin Gene Inactivation Prevents Skeletal Muscle Wasting in Cancer

Yann S. Gallot Anne‐Cécile Durieux Josiane Castells Marine M. Desgeorges Barbara Vernus

Lifespan of wild-type and Mstn-/- mice - Number of polyps.

Myostatin

10.1158/0008-5472.22402761

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