Samaneh Abbasi

Sharif University of Technology

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Saber Soltani

Tehran University of Medical Sciences

Milad Zandi

Ministry of Health and Medical Education

Manoochehr Makvandi

Ahvaz Jundishapur University of Medical Sciences

Mona Fani

North Khorasan University of Medical Sciences

Saeedeh Ebrahimi

Kerman University of Medical Sciences

Pierre J. Carreau

Polytechnique Montréal

A. Derdouri

Constantine 1 University

Ali Teimoori

Hamedan University of Medical Sciences

Niloofar Neisi

Ahvaz Jundishapur University of Medical Sciences

Saeed Shahrokhian

Sharif University of Technology

Cooperative Institutions

Ahvaz Jundishapur University of Medical Sciences

Tehran University of Medical Sciences

Hamedan University of Medical Sciences

Shiraz University of Medical Sciences

Kerman University of Medical Sciences

Tarbiat Modares University

Iran University of Medical Sciences

University of Tehran

Isfahan University of Medical Sciences

Qom University of Medical Science and Health Services

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In silico functional and structural characterization of hepatitis B virus PreS/S-gene in Iranian patients infected with chronic hepatitis B virus genotype D

Heliyon (2020)

Nastaran Khodadad Seyed Saeed Seyedian Afagh Moattari Somayeh Biparva Haghighi Roya Pirmoradi

Chronic hepatitis B (CHB) virus infection is the most prevalent chronic liver disease and has become a serious threat to human health. In this study, we attempted to specify and predict several properties including physicochemical, mutation sites, B-cell epitopes, phosphorylation sites, N-link, O-link glycosylation sites, and protein structures of S protein isolated from Ahvaz.Initially, hepatitis B virus DNA (HBV DNA) was extracted from five sera samples of untreated chronic hepatitis B patients. The full-length HBV genomes were amplified and then cloned in pTZ57 R/T vector. The full sequences of HBV were registered in the GenBank with accessions numbers (MK355500), (MK355501) and (MK693107-9). PROTSCALE, Expasy's ProtParam, immuneepitope, ABCpred, BcePred, Bepipred, Algpred, VaxiJen, SCRATCH, DiANNA, plus a number of online analytical processing tools were used to analyse and predict the preS/S gene of genotype D sequences. The present study is the first analytical research on samples obtained from Ahvaz.We found major hydrophilic region (MHR) mutations at "a" determining region that included K122R, N131T, F134Y, P142L, and T126N mutations. Moreover, Ahvaz sequences revealed four sites (4, 112, 166, and 309) in the preS/S gene for N-glycosylation that could possibly be a potential target for anti-HBV therapy.In the present study, mutations were identified at positions T113S and N131T within the MHR region of S protein; these mutations can potentially decrease the effect of hepatitis B vaccination in vaccine recipients.

Hepatitis B

10.1016/j.heliyon.2020.e04332

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Citations (19)

Another Novel Missense Mutation in ARSB Gene in Iran.

DOAJ (DOAJ: Directory of Open Access Journals) (2017)

Samaneh Abbasi Mehrdad Noruzinia Oranous Bashti Mohammad Ahmadvand Ahmad Reza Salehi Chaleshtori

Mucopolysaccharidosis VI (MPS-VI) is an infrequent autosomal recessive disorder caused by mutations in ARSB gene and deficiency in lysosomal enzyyme ARSB activities subsequently. This enzyme is essential for the breaking of glycosaminoglycans (GAGs) such as dermatan sulfate and chondroitin sulfate. ARSB dysfunction results in imperfect breakdown of GAGs and their accumulation in urine. Mutations in ARSB gene are the main players in MPS-VI disease and its clinical consequences. Most reported mutations are point mutations but there are some other examples in literature. Here we report a novel missense mutation in ARSB gene that is inherited as an autosomal recessive mode and probably explain the clinical status of the proband. This mutation replaces the threonine 92 by proline and alters ARSB structure. This is the most feasible scenario for clinical condition we described here. This novel mutation should be remarked for PND and PGD to improve the health and management of such families.

Dermatan sulfate

Proband

Hereditary multiple exostoses

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Association between gastrointestinal cancers and fingerprint patterns in the Iranian population

Genetics and Molecular Research (2017)

Samaneh Abbasi Mahboobeh Rasouli

Gastrointestinal cancers are malignant diseases with high mortality rate. Early diagnosis of patients could improve the results of treatment. Many studies used dermatoglyphics as a biomarker to predict the incidence of genetic diseases and cancers. This study assessed the association between gastrointestinal cancers and particular fingerprint patterns, which could be useful in early diagnosis of these malignancies. The study was conducted on 153 histopathologically confirmed gastrointestinal cancer patients and 299 healthy individuals. The fingerprints were taken by a specific method of rolling the subject's fingers or thumbs in ink. The data were analyzed for the significance using the chi-square test and the t-test. Odds ratio with 95% confidence intervals were calculated. Dermatoglyphic analysis showed that whorl and loop patterns significantly changed in the case group as compared to control. However, the odds ratio suggested that whorl pattern in 6 or more fingers might be a risk factor for developing gastrointestinal cancers. Our results showed that there is an association between fingerprint patterns and gastrointestinal cancers, and so, the dermatoglyphic analysis may aid in the early diagnosis of these cancers.

Dermatoglyphics

Whorl (mollusc)

Gastrointestinal cancer

10.4238/gmr16039762

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Detection of Common Respiratory Viruses in Patients with Acute Respiratory Infections Using Multiplex Real-Time RT-PCR

Jundishapur Journal of Microbiology (2019)

Niloofar Neisi Samaneh Abbasi Manoochehr Makvandi Shokrollah Salmanzadeh Somayeh Biparva

Background: Acute respiratory infection (ARI) is caused by human metapneumovirus (HMPV), respiratory syncytial virus type A and B (RSV-A, RSV-B), human parainfluenza viruses 1, 2, and 3 (HPIV-1, HPIV-2, and HPIV-3), influenza viruses A and B (IfV-A, IfV-B), and human coronaviruses (OC43/HKU1, NL63, 229E) worldwide. Objectives: This study was conducted to assess the causative agents of viral ARI among hospitalized adults by real-time PCR. Methods: Clinical nasopharyngeal swabs of 112 patients including 55 (49.1%) males and 57 (50.89%) females with ARI were analyzed using multiplex real-time RT-PCR. Results: Out of 112 specimens, 61 (54.46%) were positive including 10 (8.9%) for influenza H3N2, one (0.89%) for influenza B, 28 (25%) for RSV-A, 18 (16.07%) for HMPV-A, two (1.78%) for HPIV-1, and three (2.67%) for HPIV-3. Two (1.78%) specimens were positive for two agents, RSV-A/HMPV-A and RSV-A/HPIV-3. The distribution of viral infections was 30 among males (26.78%) and 31 (27.67%) among females (P = 0.862). High frequency of RSV-A infection (25%) and the low frequency of influenza B virus infection (0.89%) were detected among patients. The remaining 51 (45.53%) samples were negative for RSV-B, HMPV-B, IfV-A, HPIV2-4A-4B, and HCoVs (OC43/HKU1, NL63, 229E). Conclusions: The role of other viruses such as human adenoviruses rhinovirus/enterovirus (RV/EV), human bocavirus (HBoV), and human parechovirus (HpeV) was not investigated. Multiplex PCR can be used as a rapid test for the diagnosis of viruses causing acute respiratory infection, which results in decreased length of hospitalization.

Rhinovirus

Human bocavirus

Metapneumovirus

Human Parainfluenza Virus

Multiplex

10.5812/jjm.96513

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STUDY OF DAIRY FARMERS' TECHNICAL KNOWLEDGE TOWARD IMPROVING THE QUALITY OF MILK: A CASE OF GOLPAYEGAN TOWNSHIP

S. Jannat M Chizari Samaneh Abbasi

Dairy Farming

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Dual redox electrolytes for improving the performance of asymmetric supercapacitors constructed from heteroatom-doped green carbon spheres

Journal of Alloys and Compounds (2023)

Samaneh Abbasi Farzaneh Hekmat Saeed Shahrokhian

Heteroatom

Carbon fibers

10.1016/j.jallcom.2023.170452

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Citations (10)

Rheology, Properties and Microstructure Development of Polymer/Carbon Nanotube Composites in Microinjection Molding Process

Samaneh Abbasi

RESUME Dans le cadre de cette these des concepts nouveaux pour l'alignement des nanotubes de carbone multi-couche (MWCNT) induit par le cisaillement, la caracterisation de MWCNT / polymeres nanocomposites et la fabrication par microinjection de pieces a base de nanocomposites optimises sont presentes. Les effets des microstructures et des morphologies developpees dans diverses conditions, de mise en oeuvre par le procede de micromoulage sur les proprietes rheologiques, electriques et mecaniques de nanocomposites a base de CNT sont etudies. Le developpement dans la technologie des microsystemes et la demande constante de dispositifs fonctionnels a des echelles de longueur de plus en plus petites a impose l'application du procede de moulage par microinjection comme une technologie cle dans ce domaine. Le moulage par microinjection est un procede relativement nouveau avec un grand potentiel de production en serie de microdispositifs comprenant des details d’un niveau de complexite eleve qu’il n’est pas possible de fabriquer par les techniques de moulage par injection classique. Il s'agit d'un nouveau domaine de recherche et on s'attend a une croissance continue au cours des dix prochaines annees, etant donne la tendance croissante a la miniaturisation des composants et l'augmentation de la demande de microdispositifs. Les nanotubes de carbone sont des materiaux de grande utilite dans ce contexte avec des conductivites electrique et thermique superieures et des proprietes mecaniques extremement importantes, essentiellement dues a leur structure et a leur facteur de forme eleve. Par consequent, les nanocomposites a base de CNT dans une matrice de polymere sont des materiaux prometteurs pour la fabrication de micropieces multifonctionnelles ayant des proprietes uniques pour une large gamme d'applications. L’etude des proprietes rheologiques des materiaux composites, notamment leur comportement viscoelastique a non seulement une importance pratique, liee a leur mise en oeuvre, mais a aussi un interet scientifique, car elle peut etre utilisee comme une sonde de la microstructure des composites investigues. Par consequent, une recherche fondamentale est necessaire pour etablir la relation entre le comportement rheologique, les conditions de mise en oeuvre et les proprietes finales des pieces en composites a base de nanotubes de carbone / polymere par le procede de microinjection.----------Carbon nanotubes (CNTs) are great materials with superior electrical and thermal conductivity, mechanical properties and high aspect ratio. Consequently, CNT/polymer nanocomposites are promising materials for making multifunctional microscale components with unique properties and a wide range of applications. If considerable research has been conducted regarding the physical properties of carbon nanotube filled nanocomposites, including mechanical properties, electrical conductivity and rheological properties, only a few investigations have focused on the practical applications of nanocomposites in various industrial fields. In this dissertation, we intended to create a predictive understanding of the coupling of microinjection molding process to the development of the performance properties of carbon nanotube/polymer composites, focusing on the rheology, microstructure and properties of microparts. To explore the CNTs feature and to enable their processing, the nanocomposite preparation was optimized through a set of rheological measurements and microstructure characterization. We first examined the rheological behavior of polycarbonate (PC)/ MWCNT nanocomposites in light of interactions between CNTs and polymer chains or between CNTs themselves. To understand the percolated structure, the nanocomposites were characterized via a set of rheological, electrical and thermal conductivity measurements. The rheological measurements revealed that the structure and properties were temperature dependent; the percolation threshold was significantly lower at higher temperature suggesting stronger nanotube interactions. However, when the measurement temperature was high enough the percolation threshold tend to reach a plateau (0.3 wt%) The nanotube networks were also sensitive to the steady shear deformation particularly at high temperature. Following preshearing, the elastic modulus decreased markedly indicating that the nanotubes were aligned in the flow direction. Consequently, they interconnected minimally leading to a remarkable increase in the percolation threshold. The effect is more pronounced at higher temperature suggesting that nanotubes became more rigid. As expected, it was found that the rheological threshold (0.3-0.8 wt%) was smaller than the thermal (1-2 wt%) and electrical threshold (2-3 wt%).

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INVESTIGATION OF EFFECTIVE PARAMETERS ON QUALITY BLACK CURRANT RAISIN

Mahdiyeh Gholami Maria Rashidi Iraj Ranjbar Samaneh Abbasi

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Severe acute respiratory syndrome coronavirus 2 and respiratory syncytial virus coinfection in children

Osong Public Health and Research Perspectives (2021)

Milad Zandi Saber Soltani Mona Fani Samaneh Abbasi Saeedeh Ebrahimi

Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which has infected many people around the world. Children are considered an important target group for SARS-CoV-2, as well as other viral infections such as respiratory syncytial virus infection. Both SARS-CoV-2 and respiratory syncytial virus can affect the respiratory tract. Coinfection of SARS-CoV-2 and respiratory syncytial virus can pose significant challenges in terms of diagnosis and treatment in children. This review compares the symptoms, diagnostic methods, and treatment of COVID-19 and respiratory syncytial virus infection in children.

Coronavirus

Respiratory tract

10.24171/j.phrp.2021.0140

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Properties of microinjection molding of polymer multiwalled carbon nanotube conducting composites

Polymer Engineering and Science (2011)

Samaneh Abbasi A. Derdouri Pierre J. Carreau

Abstract The effects of processing conditions on the microstructure and properties of polypropylene/multiwalled carbon nanotube (PP/MWCNT) and polycarbonate/multiwalled carbon nanotube (PC/MWCNT) composites were studied. Samples of various MWCNT loadings were prepared by diluting commercial masterbatches. Different processing conditions were then used to systematically change the degree of nanotube alignment, from random to highly aligned. The crystallinity of the PP/MWCNT nanocomposites was found to go through a maximum as a function of nanotube content while the overall rate of crystallization increased. For the highly sheared microinjected PP/MWCNT samples well oriented crystals were formed. Electrical conductivity of the nanocomposites was improved by the presence of the crystalline structure; however, the high degree of nanotube alignment in the microparts resulted in a significant increase in the electrical percolation threshold. The PP nanocomposites exhibited mechanical properties significantly enhanced by nanotube loading; this effect was small in the case of the PC nanocomposites. POLYM. ENG. SCI., 2011. © 2011 Society of Plastics Engineers

Polypropylene

Polycarbonate

Molding (decorative)

Percolation (cognitive psychology)

10.1002/pen.21904

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Citations (56)