Julia Merz

University of Würzburg

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Todd B. Marder

University of Würzburg

Alexandra Friedrich

University of Würzburg

Holger Braunschweig

University of Würzburg

Ivo Krummenacher

University of Würzburg

Christoph Lambert

University of Würzburg

Michael Moos

University of Würzburg

Hamad H. Al Mamari

Muscat College

Marco Holzapfel

University of Würzburg

Sabine Lorenzen

University of Würzburg

Aobha Hickey

Eli Lilly (Ireland)

Cooperative Institutions

University of Würzburg

Ludwig-Maximilians-Universität München

Institute of Inorganic Chemistry of the Slovak Academy of Sciences

Center for NanoScience

Centre National de la Recherche Scientifique

LMU Klinikum

Université de Rennes

Czech Academy of Sciences, Institute of Inorganic Chemistry

Institute of Organic Chemistry

Durham University

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

CCDC 2217536: Experimental Crystal Structure Determination

The Cambridge Structural Database (2023)

Hamad H. Al Mamari J.P. Borel Aobha Hickey Eimear Courtney Julia Merz

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

10.5517/ccdc.csd.cc2dfjft

Cite

Citations (0)

CCDC 2217535: Experimental Crystal Structure Determination

The Cambridge Structural Database (2023)

Hamad H. Al Mamari J.P. Borel Aobha Hickey Eimear Courtney Julia Merz

10.5517/ccdc.csd.cc2dfjds

Cite

Citations (0)

Three-dimensional positioning of genes in mouse cell nuclei

Chromosoma (2008)

Claudia Hepperger Alexander Mannes Julia Merz Jürgen Peters Steffen Dietzel

To understand the regulation of the genome, it is necessary to understand its three-dimensional organization in the nucleus. We investigated the positioning of eight gene loci on four different chromosomes, including the β-globin gene, in mouse embryonic stem cells and in in vitro differentiated macrophages by fluorescence in situ hybridization on structurally preserved nuclei, confocal microscopy, and 3D quantitative image analysis. We found that gene loci on the same chromosome can significantly differ from each other and from their chromosome territory in their average radial nuclear position. Radial distribution of a given gene locus can change significantly between cell types, excluding the possibility that positioning is determined solely by the DNA sequence. For the set of investigated gene loci, we found no relationship between radial distribution and local gene density, as it was described for human cell nuclei. We did find, however, correlation with other genomic properties such as GC content and certain repetitive elements such as long terminal repeats or long interspersed nuclear elements. Our results suggest that gene density itself is not a driving force in nuclear positioning. Instead, we propose that other genomic properties play a role in determining nuclear chromatin distribution.

Gene density

Chromosome conformation capture

Nuclear gene

Genomic Organization

10.1007/s00412-008-0168-2

Cite

Citations (45)

Iridium-Catalyzed Borylation of 6-Fluoroquinolines: Access to 6-Fluoroquinolones

The Journal of Organic Chemistry (2022)

Aobha Hickey Julia Merz Hamad H. Al Mamari Alexandra Friedrich Todd B. Marder

The Ir-catalyzed C–H borylation of fluoroquinolines has been realized. The quinoline boronic ester formed undergoes a range of important transformations of relevance to medicinal chemistry. Judicious choice of the substituent at C4 on the quinoline facilitated the unmasking of a fluoroquinolone─the core structure of many antibiotics.

Borylation

Quinoline

10.1021/acs.joc.2c00973

Cite

Citations (4)

CCDC 1881912: Experimental Crystal Structure Determination

The Cambridge Structural Database (2019)

Julia Merz Andreas Steffen Jörn Nitsch Julian Fink Claudia B. Schürger

10.5517/ccdc.csd.cc2158vc

Cite

Citations (0)

CCDC 1940947: Experimental Crystal Structure Determination