Mary‐Margaret Chren

Vanderbilt University Medical Center

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Eleni Linos

Stanford University

C. Seth Landefeld

University of Alabama at Birmingham

Mackenzie R. Wehner

The University of Texas MD Anderson Cancer Center

Eleni Linos

Stanford University

W. John Boscardin

University of California, San Francisco

Maryam M. Asgari

Institute of Cardiology

Martin A. Weinstock

Providence College

Sarah Stuart

Louisiana State University Health Sciences Center New Orleans

Daniel Bertenthal

San Francisco VA Health Care System

Sarah T. Arron

University of California, San Francisco

Cooperative Institutions

University of California, San Francisco

135

Stanford University

Pfizer (United Kingdom)

Sanofi (Mexico)

Regeneron (United States)

Estée Lauder (United States)

Harvard University

Bristol-Myers Squibb (Germany)

Janssen (Belgium)

San Francisco VA Medical Center

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Understanding Research about Quality of Life and other Health Outcomes

Journal of Cutaneous Medicine and Surgery (1999)

Mary‐Margaret Chren

Background: Papers reporting studies of health outcomes, particularly patients' perceptions, are becoming more common. Understanding the characteristics of tools used to measure these health outcomes is important for interpreting these studies accurately and applying them to clinical care. Objective: The purpose of this article is to describe important features of the measurement of patient-perceived health outcomes, and to illustrate how a consideration of these features can help in applying study results to individual patients. Conclusion: Understanding the principles of measurement is particularly important for interpreting studies of dermatological care, in which patients' perceptions are a crucial outcome.

Patient-reported outcome

Outcomes research

10.1177/120347549900300608

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Citations (27)

Morbidity in Advanced Basal Cell Carcinoma (BCC) and BCC Nevus Syndrome (BCCNS) from the Patient (PT) and Physician Perspective: Development of a Patient-Reported Outcome (PRO) Questionnaire

Annals of Oncology (2012)

Susan D. Mathias Mary‐Margaret Chren Yeun Mi Yim Hilary H. Colwell Cano Reyes

10.1016/s0923-7534(20)34019-9

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Citations (0)

Functional Status Before Hospitalization in Acutely Ill Older Adults: Validity and Clinical Importance of Retrospective Reports

Journal of the American Geriatrics Society (2000)

Kenneth E. Covinsky Robert M. Palmer Steven R. Counsell Zachary M. Pine Louise C. Walter

OBJECTIVES: Retrospective reports of patients' functional status before hospital admission are often used in longitudinal studies and by clinicians caring for hospitalized patients. However, the validity of these reports has not been established. Our aim was to examine the validity of retrospective reports by testing hypotheses about the relationships these measures would have with other clinical measures if they were valid. DESIGN: A prospective cohort study. PARTICIPANTS AND SETTING: A total of 2877 older patients (mean age 81, 36% women) hospitalized on the general medical service at two hospitals. For 1953 of the subjects, the patient was the primary respondent, whereas for 924 subjects, a surrogate was the primary respondent. MEASUREMENTS: Shortly after hospital admission, patients or surrogates reported whether the patient was independent in each of five activities of daily living (ADLs) on admission and at baseline 2 weeks before admission. Outcome measures included reported independence in each ADL 3 months after the hospitalization and survival to 1 year. RESULTS: Patients' retrospective reports of their ADL function 2 weeks before admission had a clinically plausible relationship with ADL function at the time of admission, in that patients independent in an ADL on admission rarely reported they were dependent in that ADL 2 weeks before admission (range 2–6%). Surrogates were somewhat more likely than patients to report that patients independent on admission were dependent 2 weeks before admission (range 5–14%). Retrospective reports of prehospitalization ADL function demonstrated strong evidence of predictive validity for both patients' and surrogates' reports. For example, among patients dependent in bathing on admission, patients who were reported as independent 2 weeks before admission were much more likely than those reported as dependent 2 weeks before admission to be independent 3 months after hospitalization (68% vs 20%, P t .001 for patient respondents; 30% vs 5%, P < .001 for surrogate respondents). Similarly, among patients dependent in bathing on hospital admission, survival 1 year after hospitalization was much higher in patients who were independent in bathing 2 weeks before admission than patients who were dependent 2 weeks before admission (76% vs 59%, P < .001 for patient respondents; 60% vs 45%, P < .001 for surrogate respondents). Results were similar for each of the other four ADLs. In a logistic regression model controlling for the number of ADLs reported as dependent on admission, the number of ADLs reported as dependent 2 weeks before admission was significantly associated with 1‐year mortality among both patient (odds ratio (OR) = 1.39 per dependent ADL, 95% confidence interval (CI) = 1.26–1.54) and surrogate (OR = 1.14, 95% CI = 1.06–1.24) respondents. CONCLUSIONS: Hospitalized patients' assessments of their ability to perform ADLs before their hospitalization have evidence of face and predictive validity. These measures are strong predictors of important health outcomes such as functioning and survival. In particular, among patients dependent in ADL function on hospital admission, these results highlight the prognostic importance of inquiring about the patient's functional status before the onset of the acute illness. J Am Geriatr Soc 48: 164–169, 2000.

Hospital admission

Interquartile range

10.1111/j.1532-5415.2000.tb03907.x

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Citations (172)

Quality of life issues in pediatric dermatology

Current Problems in Dermatology (2000)

Sarah L. Chamlin Mary‐Margaret Chren

10.1016/s1040-0486(00)90034-6

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Citations (3)

A real-world, community-based cohort study comparing the effectiveness of topical fluorouracil versus topical imiquimod for the treatment of actinic keratosis

Journal of the American Academy of Dermatology (2017)

Romain Neugebauer Katherine A. Levandoski Zheng Zhu Monica Sokil Mary‐Margaret Chren

Imiquimod

Actinic keratosis

Cumulative incidence

Keratosis

10.1016/j.jaad.2017.12.042

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Citations (15)

Tumor recurrence of keratinocyte carcinomas judged appropriate for Mohs micrographic surgery using Appropriate Use Criteria

Journal of the American Academy of Dermatology (2017)

Sarah Stuart Patrick Schoen Chengshi Jin Rupa Parvataneni Sarah T. Arron

Mohs surgery

10.1016/j.jaad.2016.12.045

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Citations (14)

Drug Samples in Dermatology

JAMA Dermatology (2014)

Kenneth A. Katz Erika E. Reid Mary‐Margaret Chren

Is drug sampling—when physicians give samples of prescription medicines provided by pharmaceutical companies to their patients—good or bad? Is the answer different for dermatologists than it is for other physicians?

10.1001/jamadermatol.2013.9711

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Citations (8)

Sun protective behaviors and vitamin D levels in the US population: NHANES 2003–2006

Cancer Causes & Control (2011)

Eleni Linos Elizabeth Keiser Matthew Kanzler Kristin L. Sainani Wayne Lee

Sun Exposure

Cross-sectional study

Sunlight

10.1007/s10552-011-9862-0

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Citations (106)

Recurrence After Treatment of Nonmelanoma Skin Cancer

Archives of Dermatology (2011)

Mary‐Margaret Chren Jeanette S. Torres Sarah Stuart Daniel Bertenthal Remedios J. Labrador

Objective: To determine long-term tumor recurrence rates after treatment of primary nonmelanoma skin cancer (NMSC).Data are currently insufficient to permit evidence-based choices among treatments for NMSC.Design: Prospective study of an inception cohort observed for a median of 6.6 years after treatment.Setting: Dermatology clinic at a Veterans Affairs hospital.Care was provided by dermatology resident or attending physicians.Patients: Consecutive sample of all 495 patients with 616 primary NMSCs diagnosed in 1999 and 2000 and treated with electrodessication and curettage (ED&C), excision, or Mohs surgery.Follow-up was available for 608 tumors (99%).Main Outcome Measure: Tumor recurrence, deter-mined by medical record review, with validation by clinical examination. Results:The mean age at diagnosis was 71 years; 97% were men.Overall, 127 tumors were treated with ED&C (20.9%); 309 with excision (50.8%); and 172 with Mohs surgery (28.3%).Over the course of the study, 21 tumors recurred (3.5% [95% confidence interval (CI), 2.2%-5.2%]): 2 after ED&C (1.6% [95% CI, 0.2%-5.6%]),13 after excision (4.2% [95% CI, 2.2%-7.1%]),and 6 after Mohs surgery (3.5% [95% CI, 1.3%-7.4%]).Conclusions: Recurrence of primary NMSC after treatment occurred in less than 5% of tumors.The recurrence rate after ED&C was lower than expected, and the recurrence rate after Mohs surgery was higher than expected.These findings may be related to the risk for recurrence in the treatment groups.

Mohs surgery

Curettage

Veterans Affairs

Medical record

10.1001/archdermatol.2011.109

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Citations (89)

186 Acne Core Outcomes Research Network (ACORN): Standardizing outcome measures in acne trials

Journal of Investigative Dermatology (2016)

Diane Thiboutot Jerry Tan Marc P. Frey Mary‐Margaret Chren E. Anne Eady

10.1016/j.jid.2016.02.214

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Citations (1)