Chuanya Jiang

First Affiliated Hospital of Anhui Medical University

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Yehai Liu

First Affiliated Hospital of Anhui Medical University

Xiyue Cao

Qingdao University

Fangfang Yang

Sun Yat-sen University

Hongwu Li

Anhui Medical University

Jun Dong

South China Normal University

Dapeng Li

Anhui Medical University

Weiwei Liu

Huazhong University of Science and Technology

Qiong Wang

Helmholtz-Zentrum Berlin für Materialien und Energie

Fangzheng Yi

Anhui Medical University

Zhanfeng Li

Taiyuan University of Technology

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Anhui Medical University

First Affiliated Hospital of Anhui Medical University

Qingdao University

China Medical University

Chinese Academy of Sciences

Capital Medical University

Sichuan University

Chongqing University

Nanyang Normal University

Chinese Academy of Medical Sciences & Peking Union Medical College

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Pescadillo ribosomal biogenesis factor 1 reduction suppresses tumour growth and renders chemosensitivity of head and neck squamous cell carcinoma

Cancer Medicine (2022)

Dapeng Li Changyu Yao Zhao Ding Ping Liu Xue Chen

Abstract Background As one of the most devastating cancers, head and neck squamous cell carcinoma (HNSCC) has a short survival time and poor prognosis. Pescadillo ribosomal biogenesis factor 1 (PES1) plays a critical role in the progression of numerous cancers. However, its role and underlying mechanisms in HNSCC remain unclear. Methods A variety of bioinformatic approaches were used to identify the expressions, prognostic and diagnostic value of PES1 in HNSCC. qRT‐PCR, immunofluorescence (IF) assay, western blotting and immunohistochemical (IHC) were used to evaluate the expression of PES1 in HNSCC cell lines and clinical tissues. PES1 was knocked down in TU177 and FaDu cells which have high PES1 expression. The effects of PES1 on cell proliferation and tumour growth in HNSCC were elevated by colony formation, CCK8 assays and tumorigenicity assay in nude mice. The effects on cisplatin (CDDP) sensitivity upon silencing of PES1 were assessed using a patient‐derived xenograft (PDX) model. Results PES1 expression was an independent prognostic factor for HNSCC and negatively associated with the overall survival rate. Silencing of PES1 reduces HNSCC cell proliferation and tumour growth. Moreover, PES1 inhibition significantly sensitises HNSCC cells to cisplatin. Furthermore, we found a PES1 has a high correlation with c‐Myc and plays an essential role in the tumour immune microenvironment. Conclusion Our findings suggest that PES1 is associated with tumour growth and drug resistance and served as a potential cancer marker for diagnosis and a putative therapeutic target for HNSCC.

Proliferation Marker

10.1002/cam4.5315

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Citations (4)

Preparation of porous carbon@TiO2 composites for the adsorption/sonocatalytic degradation of organic dyes

Journal of Molecular Liquids (2022)

Jun Dong Fangfang Yang Qiong Wang Chuanya Jiang Huiqi Wang

Rhodamine B

Degradation

Carbon fibers

Specific surface area

10.1016/j.molliq.2022.120469

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Management of Parapharyngeal Space Tumors: Clinical Experience with a Large Sample and Review of the Literature

Current Oncology (2023)

Chuanya Jiang Wenqian Wang Shanwen Chen Yehai Liu

Parapharyngeal space (PPS) tumors are rare, and they account for 0.5–1.5% of all head and neck tumors. This study summarized the findings of large-sample clinical studies of PPS tumors and reported the clinical work-up and management of 177 cases of PPS tumors at our center. This retrospective study included patients treated for PPS tumors between 2005 and 2020 at our center. The basic characteristics, symptoms, surgical approach, complications, and recurrence rates were analyzed. A total of 99 male and 78 female patients, with a mean age of 48.3 ± 15.1 years, were enrolled in this study. The most common symptoms were external or intraoral masses (114 patients, 64%). Surgical management leveraging, a cervical approach, was used for 131 cases (74%). The tumors were benign for 92% (160 cases), with pleomorphic adenoma being the most common (88 cases, 50%). Surgical complications were reported for 31 cases (18%); facial and vocal cord paralyses were the most common. Three cases of recurrence were observed during the follow-up. PPS tumors are rare and present with atypical clinical manifestations. The current study, which involved cases in a large single center, demonstrates the importance of surgical interventions for PPS tumors. The use of endoscopic techniques has further expanded the scope of traditional surgical approaches and demonstrated its advantages in selected cases.

Parapharyngeal space

Work-up

10.3390/curroncol30010078

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Citations (9)