Boris Jovanović

Iowa State University

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Djuradj Milošević

University of Nis

Dušan Palić

Ludwig-Maximilians-Universität München

Dimitrija Savić‐Zdravković

University of Nis

Jelena Stanković

University of Belgrade

Vladimir J. Cvetković

University of Nis

Tatjana Mitrović

University of Nis

Elizabeth M. Whitley

The University of Texas MD Anderson Cancer Center

Bojаn Zlаtković

University of Nis

Hatïce Duran

Kocaeli Üniversitesi

Tatjana Mihajilov‐Krstev

University of Nis

Cooperative Institutions

University of Nis

University of Belgrade

Middle East Technical University

Iowa State University

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University of Kragujevac

University of Zagreb

University of British Columbia

Institute for Biological Research “Siniša Stanković”

University of Montenegro

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Effects of titanium dioxide (TiO₂) nanoparticles on caribbean reef‐building coral (Montastraea faveolata)

Environmental Toxicology and Chemistry (2014)

Boris Jovanović Héctor M. Guzmán

Abstract Increased use of manufactured titanium dioxide nanoparticles (nano‐TiO 2 ) is causing a rise in their concentration in the aquatic environment, including coral reef ecosystems. Caribbean mountainous star coral ( Montastraea faveolata ) has frequently been used as a model species to study gene expression during stress and bleaching events. Specimens of M. faveolata were collected in Panama and exposed for 17 d to nano‐TiO 2 suspensions (0.1 mg L −1 and 10 mg L −1 ). Exposure to nano‐TiO 2 caused significant zooxanthellae expulsion in all the colonies, without mortality. Induction of the gene for heat‐shock protein 70 (HSP70) was observed during an early stage of exposure (day 2), indicating acute stress. However, there was no statistical difference in HSP70 expression on day 7 or 17, indicating possible coral acclimation and recovery from stress. No other genes were significantly upregulated. Inductively coupled plasma mass spectrometry analysis revealed that nano‐TiO 2 was predominantly trapped and stored within the posterior layer of the coral fragment (burrowing sponges, bacterial and fungal mats). The bioconcentration factor in the posterior layer was close to 600 after exposure to 10 mg L −1 of nano‐TiO 2 for 17 d. The transient increase in HSP70, expulsion of zooxanthellae, and bioaccumulation of nano‐TiO 2 in the microflora of the coral colony indicate the potential of such exposure to induce stress and possibly contribute to an overall decrease in coral populations. Environ Toxicol Chem 2014;33:1346–1353. © 2014 SETAC

Coral bleaching

Zooxanthellae

10.1002/etc.2560

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The effects of a human food additive, titanium dioxide nanoparticles E171, on Drosophila melanogaster - a 20 generation dietary exposure experiment

Scientific Reports (2018)

Boris Jovanović Nikola Jovanović Vladimir J. Cvetković Sanja Matić Snežana Stanić

In this study, fruit flies (Drosophila melanogaster) were exposed to an estimated daily human E171 consumption concentration for 20 generations. Exposure to E171 resulted in: a change in normal developmental and reproductive dynamics, reduced fecundity after repetitive breeding, increased genotoxicity, the appearance of aberrant phenotypes and morphologic changes to the adult fat body. Marks of adaptive evolution and directional selection were also exhibited. The larval stages were at a higher risk of sustaining damage from E171 as they had a slower elimination rate of TiO2 compared to the adults. This is particularly worrisome, since among the human population, children tend to consume higher daily concentrations of E171 than do adults. The genotoxic effect of E171 was statistically higher in each subsequent generation compared to the previous one. Aberrant phenotypes were likely caused by developmental defects induced by E171, and were not mutations, since the phenotypic features were not transferred to any progeny even after 5 generations of consecutive crossbreeding. Therefore, exposure to E171 during the early developmental period carries a higher risk of toxicity. The fact that the daily human consumption concentration of E171 interferes with and influences fruit fly physiological, ontogenetic, genotoxic, and adaptive processes certainly raises safety concerns.

10.1038/s41598-018-36174-w

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In situ effects of titanium dioxide nanoparticles on community structure of freshwater benthic macroinvertebrates

Environmental Pollution (2016)

Boris Jovanović Djuradj Milošević Milica Stojković Piperac Ana Savić

Titanium Dioxide

10.1016/j.envpol.2016.02.024

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Antimicrobial, Antioxidative, and Insect Repellent Effects of Artemisia absinthium Essential Oil

Planta Medica (2014)

Tatjana Mihajilov‐Krstev Boris Jovanović Jovana Jović Budimir S. Ilić Dragoljub L. Miladinović

In this paper, the chemical composition and biological activity of the essential oil of Artemisia absinthium was studied. The aim of this study was to investigate the potential of ethnopharmacological uses of this plant species in the treatment of gastrointestinal diseases and wounds, and as an insect repellent. The aerial part of the plant was hydrodistilled, and the chemical composition of the essential oil was analyzed by gas chromatography and gas chromatography/mass spectrometry. Forty-seven compounds, corresponding to 94.65 % of the total oil, were identified, with the main constituents being sabinene (24.49 %), sabinyl acetate (13.64 %), and α-phellandrene (10.29 %). The oil yield was 0.23 % (v/w). The antimicrobial activity of the oil was investigated against ten bacterial isolates (from patients wounds and stools) and seven American Type Culture Collection strains using a microwell dilution assay. The minimal inhibitory/bactericidal concentration of the oil ranged from < 0.08 to 2.43 mg/mL and from 0.08 to 38.80 mg/mL, respectively. The antioxidant activity of the essential oil was evaluated using 2,2-diphenyl-1-picrylhydrazil and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) radical-scavenging methods and assessed as significant. Skin irritation potential and acute toxicity of the oil were also investigated. Results of the skin irritant reaction showed that none of the 30 volunteers developed a positive skin irritant reaction to undiluted A. absinthium essential oil. Acute oral exposure to the essential oil did not cause mortality in the treated mice, but it did cause neurological, muscle, and gastrointestinal problems. A subchronic toxicity test on Drosophila melanogaster showed that the essential oil of A. absinthium is toxic for developing insect larvae. Starting with the concentration of 0.38 % of essential oil in medium, significant mortality of larvae exposed to the oil was noted when compared to the control. Probit analysis revealed that the LC₅₀ value of A. absinthium essential oil for D. melanogaster larvae after 15 days of exposure was 6.31 % (49 mg/mL). The essential oil also affected the development of D. melanogaster larvae and significantly delayed achievement of the pupa stadium.

Sabinene

Insect repellent

10.1055/s-0034-1383182

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Citations (62)

Immunotoxicology of titanium dioxide and hydroxylated fullerenes engineered nanoparticles in fish models

Boris Jovanović

Immunotoxicology

Titanium Dioxide

Nanotoxicology

10.31274/etd-180810-963

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Citations (3)

Toxicity of dimethyl sulfoxide against Drosophila melanogaster

DOAJ (DOAJ: Directory of Open Access Journals) (2015)

Vladimir J. Cvetković Tatjana Mitrović Boris Jovanović Slaviša S. Stamenković Miljana Todorović

Dimethyl sulfoxide (DMSO) is commonly used as a solvent for organic compounds but its toxic properties can affect both in vitro and in vivo studies. Thus, evaluation of DMSO toxicity must be performed on the model organism before its application as a solvent in the target studies. Present study aimed to determine the lethal concentration required to kill 50% of the population in a given period of time (LC 50 ), no observed effect concentration (NOEC), and lowest observed effect concentration (LOEC) values for DMSO on Drosophila melanogaster which is frequently used as a model for toxicity studies . Twelve different concentrations of DMSO were tested on three-day old D. melanogaster larvae for 12 days. At the end of the life cycle, number of live hatched adults and un-hatched pupae were counted. Based on probit analysis 12 days LOEC was 0.04% v/v, 12 days NOEC was ˂ 0.04% v/v and 12 days LC 50 was 0.42% v/v. The results indicate that DMSO may be more toxic to D. melanogaster than it was initially considered.

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Comparative study of the essential oils of four Pinus species: Chemical composition, antimicrobial and insect larvicidal activity

Industrial Crops and Products (2017)

Zorica S. Mitić Boris Jovanović Snežana Č. Jovanović Tatjana Mihajilov‐Krstev Zorica Stojanović‐Radić

Terpene

10.1016/j.indcrop.2017.10.004

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Citations (68)

Spatial morphometric plasticity of spirlin Alburnoides bipunctatus (Bloch, 1782) phenotype from the Nišava River, Serbia, Danube basin

DOAJ (DOAJ: Directory of Open Access Journals) (2011)

Dušan Živković Boris Jovanović

Živkovic, D., Jovanovic, B.: Spatial morphometric plasticity of spirlin Alburnoides bipunctatus (Bloch,1782) phenotype from the Nisava River, Serbia, Danube basin. Biologica Nyssana, 2 (1), September 2011:67-77. Variation of 22 morphometric and 4 meristic characters of the species Alburnoides bipuuctatus from NisavaRiver were analyzed. Specimens were collected from four sampling stations along the putative mesohabitatgradient of river influence and were grouped into the categories with similar total length. Morphometric charactersvaried immensely between different mesohabitats outlining morphometric plasticity. Among severalmorphometry features that were influenced by different mesohabitats the most observable differences werenoted for: postocular distance, anal fin height, minimal body height and preanal length. Regarding themeristic features, number of soft rays in the anal fin did varied significantly among sampling stations while fourthhard ray in the anal fin for this species was reported for the first time ever. Pharyngeal teeth formula of spirlin alsoshowed variability across different mesohabitats. In conclusion, it appears that spirlin express a bigmorphological plasticity in relation to spatial and mesohabitat distribution and there is a possibility that spirlin fromNisava River is a complex of neospecies in formation/morphotypes/ecotypes rather than a single population. Key words : Alburnoides bipunctatus , Cyprinidae, mesohabitat, phenotype plasti

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Toxic effects of a cyanobacterial strain on Chironomus riparius larvae in a multistress environment

Aquatic Toxicology (2022)

Nikola Stanković Boris Jovanović Ivana Kostić Milica Stojković Piperac Jelica Simeunović

Chironomus riparius

Cyanotoxin

10.1016/j.aquatox.2022.106321

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Citations (8)

Beneath the Surface: Decoding the Impact of Chironomus Riparius Bioturbation on Microplastic Dispersion in Sedimentary Matrix

Djuradj Milošević Khouloud Sebteoui Jelena Stanković В. И. Баранов Boris Jovanović

A detailed understanding of microplastics (MPs) behaviour in freshwater ecosystems is crucial for a proper ecological assessment. This includes the identification of significant transport pathways and net accumulation zones, considering their inherent, and already proven influence on aquatic ecosystems. Bioavailability of toxic agents is significantly influenced by macroinvertebrates’ behaviour, such as bioturbation and burrowing, and their prior exposure history. This study aims to investigate the effect of bioturbation activity of Chironomus riparius Meigen, 1804 on the vertical transfer of polyethylene MPs ex-situ in an experimental setup exposing larvae to a scenario of 10x the environmentally relevant high concentration of MPs (80g/m2). Bioturbation activity was estimated using sediment profile imaging with luminophore tracers. This study demonstrated that spherical MPs are vertically transferred in the sediment due to the bioturbation activity of C. riparius larvae and that their presence influences the intensity of the bioturbation activity over time. The present findings provide a noteworthy contribution to the understanding of the relationship between ecosystem engineers and the dispersion and accumulation of MPs within freshwater ecosystems.

Bioturbation

Chironomus riparius

Matrix (chemical analysis)

10.2139/ssrn.4594313

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