Objective. The aim of this study was to explore the potential biological mechanisms of coix seed in the treatment of colorectal cancer (CRC) based on network pharmacology analysis. Methods. The active components of coix seed and their potential action targets were retrieved from Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform(TCMSP). The disease targets related to CRC were obtained from the DisGeNET database. The intersection targets of the drug targets and disease targets were selected, and a component-target-disease network was built using Cytoscape 3.8.0 tool. A global network of the core target protein interactions was constructed using String database. Biological function analysis and pathway enrichment analysis of core targets were conducted to explore the potential. Results. A total of nine active components were obtained from the TCMSP database corresponding to 37 targets. Further analysis showed that 18 overlapping targets were associated with CRC. Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis was conducted based on the 18 targets and 11 significantly enriched signaling pathways implicated in CRC were identified. Conclusion. The multicomponent and multitarget characteristics of coix seed are preliminarily verified, and the potential biological mechanisms of coix seed in the treatment of CRC are predicted, which provides a theoretical basis for the experimental research.
Objective
To investigate the diagnosis and treatment of autoimmune pancreatitis (AIP).
Methods
The clinical data of 25 patients with AIP who were admitted to the Cancer Hospital of Tianjin Medical University between January 2009 and December 2013 were retrospectively analyzed. Patients received the test of serum γ-globulin and IgG4 and abdominal imaging examination. The revised HISORt or results of postoperative pathological examination were performed as diagnostic criteria. Patients who were unable to tolerate surgery were treated by oral prednisone. The focal masses were apparent in the pancreas by imaging examination, which cannot exclude the possibility of malignancy because of ambiguous pathologic characters of masses. Patients who received ineffective hormonal therapy and were able to tolerate surgery underwent surgery. All the patients were followed up by outpatient examination and telephone interview up to December 2014.
Results
Primary symptoms: jaundice was detected in 16 patients, obvious weight loss (weight loss >10% standard body mass) in 4 patients, chronic diarrhea (duration of diarrhea >2 months or 2 weeks
AMA Zhang Z, Yang H, Li P, et al. The consequences of laparoscopic fascial space priority approach to lateral lymph node dissection on urinary and sexual functionality. Videosurgery and Other Miniinvasive Techniques/Wideochirurgia i inne techniki małoinwazyjne. 2023. doi:10.5114/wiitm.2023.130532. APA Zhang, Z., Yang, H., Li, P., Zhou, Y., Zeng, Q., & Zhang, X. et al. (2023). The consequences of laparoscopic fascial space priority approach to lateral lymph node dissection on urinary and sexual functionality. Videosurgery and Other Miniinvasive Techniques/Wideochirurgia i inne techniki małoinwazyjne. https://doi.org/10.5114/wiitm.2023.130532 Chicago Zhang, Zhichun, Hongjie Yang, Peng Li, Yuanda Zhou, Qingsheng Zeng, Xipeng Zhang, and Yi Sun. 2023. "The consequences of laparoscopic fascial space priority approach to lateral lymph node dissection on urinary and sexual functionality". Videosurgery and Other Miniinvasive Techniques/Wideochirurgia i inne techniki małoinwazyjne. doi:10.5114/wiitm.2023.130532. Harvard Zhang, Z., Yang, H., Li, P., Zhou, Y., Zeng, Q., Zhang, X., and Sun, Y. (2023). The consequences of laparoscopic fascial space priority approach to lateral lymph node dissection on urinary and sexual functionality. Videosurgery and Other Miniinvasive Techniques/Wideochirurgia i inne techniki małoinwazyjne. https://doi.org/10.5114/wiitm.2023.130532 MLA Zhang, Zhichun et al. "The consequences of laparoscopic fascial space priority approach to lateral lymph node dissection on urinary and sexual functionality." Videosurgery and Other Miniinvasive Techniques/Wideochirurgia i inne techniki małoinwazyjne, 2023. doi:10.5114/wiitm.2023.130532. Vancouver Zhang Z, Yang H, Li P, Zhou Y, Zeng Q, Zhang X et al. The consequences of laparoscopic fascial space priority approach to lateral lymph node dissection on urinary and sexual functionality. Videosurgery and Other Miniinvasive Techniques/Wideochirurgia i inne techniki małoinwazyjne. 2023. doi:10.5114/wiitm.2023.130532.
Etoposide is a second-line chemotherapy agent widely used for metastatic colorectal cancer. However, we discovered that etoposide treatment induced greater motility potential in four colorectal cancer cell lines. Therefore, we used microarrays to test the mRNA of these cancer cell lines to investigate the mechanisms of etoposide promoting colorectal cancer metastasis. Differentially expressed genes (DEGs) were identified by comparing the gene expression profiles in samples from etoposide-treated cells and untreated cells in all four colorectal cancer cell lines. Next, these genes went through the Gene Set Enrichment Analysis (GSEA), Gene Ontology (GO) and the Kyoto Encyclopedia of Genes and Genomes (KEGG) Pathway analysis. Among the top 10 genes including the upregulated and downregulated, eight genes had close interaction according to the STRING database: FAS, HMMR, JUN, LMNB1, MLL3, PLK2, STAG1 and TBL1X. After etoposide treatment, the cell cycle, metabolism-related and senescence signaling pathways in the colorectal cancer cell lines were significantly downregulated, whereas necroptosis and oncogene pathways were significantly upregulated. We suggest that the differentially expressed genes LMNB1 and JUN are potential targets for predicting colorectal cancer metastasis. These results provide clinical guidance in chemotherapy, and offer direction for further research in the mechanism of colorectal cancer metastasis.
The aim of this study was to explore the clinical value of a radiomics prediction model based on T2-weighted imaging (T2WI) and clinical indexes in predicting lateral lymph node (LLN) metastasis in rectal cancer patients. This was a retrospective analysis of 106 rectal cancer patients who had undergone LLN dissection. The clinical risk factors for LLN metastasis were selected by multivariable logistic regression analysis of the clinical indicators of the patients. The LLN radiomics features were extracted from the pelvic T2WI of the patients. The least absolute shrinkage and selection operator algorithm and backward stepwise regression method were adopted for feature selection. Three LLN metastasis prediction models were established through logistic regression analysis based on the clinical risk factors and radiomics features. Model performance was assessed in terms of discriminability and decision curve analysis in the training, verification and test sets. The model based on the combined T2WI radiomics features and clinical risk factors demonstrated the highest accuracy, surpassing the models based solely on either T2WI radiomics features or clinical risk factors. Specifically, the model achieved an AUC value of 0.836 in the test set. Decision curve analysis revealed that this model had the greatest clinical utility for the vast majority of the threshold probability range from 0.4 to 1.0. Combining T2WI radiomics features with clinical risk factors holds promise for the noninvasive assessment of the biological characteristics of the LLNs in rectal cancer, potentially aiding in therapeutic decision-making and optimizing patient outcomes.
Abstract Purpose The aim of this study is to examine the pattern of lymph node metastasis (lateral vs. mesenteric lymph nodes) in low rectal cancer. Methods This retrospective analysis included all patients undergoing laparoscopic total mesorectal excision plus lateral lymph node dissection for advanced low rectal cancer (up to 8 cm from the anal verge) during a period from July 1, 2017, to August 31, 2019, at the Department of Colorectal Surgery, Tianjin Union Medical Center. The decision to conduct lateral lymph node dissection was based on positive findings in preoperative imaging assessments. Results A total of 42 patients were included in data analysis. Surgery was successfully completed as planned, without conversion to open surgery in any case. A minimum of 10 mesenteric lymph nodes and 1 lateral lymph node on each side were dissected in all patients. Pathologic examination of resected specimens showed no metastasis to either mesenteric or lateral lymph nodes in 7 (16.7%) case, metastasis to both mesenteric and lateral lymph nodes in 26 (61.9%) cases, metastasis to mesenteric but not lateral lymph nodes in 4 (9.5%) cases, and metastasis to lateral but not mesenteric lymph nodes in 5 (11.9%) cases ( n = 2 in the obturator region; n = 3 in the iliac artery region). Conclusion A clinically significant proportion of low rectal cancer patients have metastasis to lateral lymph nodes without involvement of mesenteric lymph nodes. More carefully planned prospective studies are needed to verify this preliminary finding.
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