Socorro Rodrı́guez Holguı́n

Universidade de Santiago de Compostela

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Fernando Cadaveira

Universidade de Santiago de Compostela

Montserrat Corral

Universidade de Santiago de Compostela

Sonia Doallo

Universidade de Santiago de Compostela

Alberto Crego

University of Minho

Eduardo López‐Caneda

Doho University

Francisco Caamaño‐Isorna

Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública

Nayara Mota

University of California, San Francisco

María Parada

Universidade de Vigo

Fernando Maestú

Universidad Complutense de Madrid

Samuel Suárez‐Suárez

Universidad de Burgos

Cooperative Institutions

Universidade de Santiago de Compostela

Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública

Universidad Complutense de Madrid

UCLouvain

Instituto de Salud Carlos III

University of Minho

Université Libre de Bruxelles

Centre Hospitalier Universitaire Brugmann

Centro de Investigación Biomédica en Red de Salud Mental

Instituto de Investigación Sanitaria de Santiago

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Evolution of the binge drinking pattern in college students: Neurophysiological correlates

Alcohol (2014)

Eduardo López‐Caneda Socorro Rodrı́guez Holguı́n Montserrat Corral Sonia Doallo Fernando Cadaveira

Binge drinking

10.1016/j.alcohol.2014.01.009

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Citations (56)

Electrophysiological Anomalies in Face–Name Memory Encoding in Young Binge Drinkers

Frontiers in Psychiatry (2017)

Rocío Folgueira-Ares Fernando Cadaveira Socorro Rodrı́guez Holguı́n Eduardo López‐Caneda Alberto Crego

A growing body of evidence indicates that the intake of large amounts of alcohol during one session may have structural and functional effects on the still-maturing brains of young people. These effects are particularly pronounced in prefrontal and hippocampal regions, which appear to be especially sensitive to the neurotoxic effects of alcohol. However, to date, few studies have used the event-related potentials (ERPs) technique to analyze the relationship between binge drinking (BD) and associative memory. The objective of this study was to examine brain activity during memory encoding using the Subsequent memory paradigm in subjects who have followed a BD pattern of alcohol consumption for at least 2 years. A total of 50 undergraduate students (mean age = 20.6 years), i.e., 25 controls (12 females) and 25 binge drinkers (BDs; 11 females), with no personal or family history of alcoholism or psychopathological disorders, performed a visual face-name association memory task. The task used enables assessment of the Difference due to memory effect (Dm), a measure of memory encoding based on comparison of the neural activity associated with subsequent successful and unsuccessful retrieval. In ERP studies, study items that are subsequently remembered elicit larger positive amplitudes at midline parieto-frontal sites than those items that are subsequently forgotten. The Dm effect generally appears in the latency range of about 300-800 ms. The results showed a Dm effect in posterior regions in the 350-650 ms latency range in the Control group. However, in the BD group, no significant differences were observed in the electrophysiological brain activity between remembered and forgotten items during the encoding process. No differences between groups were found in behavioral performance. These findings show that young BDs display abnormal pattern of ERP brain activity during the encoding phase of a visual face-name association task, possibly suggesting a different neural signature of successful memory encoding.

10.3389/fpsyt.2017.00216

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Binge Drinking and Declarative Memory in University Students

Alcoholism Clinical and Experimental Research (2011)

María Parada Montserrat Corral Francisco Caamaño‐Isorna Nayara Mota Alberto Crego

Background: Binge drinking (BD), which is characterized by sporadic consumption of large quantities of alcohol in short periods, is prevalent among university students. Animal studies have shown that BD is associated with damage to the hippocampus, a region of the brain that plays a key role in learning and memory. The temporal cortex undergoes structural and functional changes during adolescence. The aim of the present study was to examine the association between BD and declarative memory in male and female university students. Methods: The participants were 122 students (between 18 and 20 years of age): 62 BD (30 women) and 60 non-BD (29 women). The neuropsychological assessment included the Rey Auditory Verbal Learning Test (RAVLT) and Weschler Memory Scale-3rd ed. (WMS-III) Logical Memory subtest, to evaluate verbal declarative memory, and the WMS-III Family Pictures subtest, to measure visual declarative memory. Results: The BD students remembered fewer words in the interference list and displayed greater proactive interference in the RAVLT; they performed worse in the Logical Memory subtest, both on immediate and delayed recall. There were no differences between the groups in performance of the Family Pictures subtest. No significant interactions were observed between BD and sex. Conclusions: Binge drinking is associated with poorer verbal declarative memory, regardless of sex. The findings are consistent with the vulnerability of the adolescent hippocampus to the neurotoxic effects of alcohol. Longitudinal studies will help determine the nature of this relationship, the neurodevelopmental trajectories for each sex, and the repercussions on academic performance.

Declarative memory

Binge drinking

10.1111/j.1530-0277.2011.01484.x

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Citations (73)

Addiction Biology (2022)

Javier Blanco‐Ramos Luis Fernando Antón‐Toro Fernando Cadaveira Sonia Doallo Samuel Suárez‐Suárez

Abstract Binge drinking is a pattern of intermittent excessive alcohol consumption that is highly prevalent in young people. Neurocognitive dual‐process models have described substance abuse and adolescence risk behaviours as the result of an imbalance between an overactivated affective‐automatic system (related to motivational processing) and damaged and/or immature reflective system (related to cognitive control abilities). Previous studies have evaluated the reflective system of binge drinkers (BDs) through neutral response inhibition tasks and have reported anomalies in theta (4–8 Hz) and beta (12–30 Hz) bands. The present study aimed to investigate the influence of the motivational value of alcohol‐related stimuli on brain functional networks devoted to response inhibition in young BDs. Sixty eight BDs and 78 control participants performed a beverage Go/NoGo task while undergoing electrophysiological recording. Whole cortical brain functional connectivity (FC) was evaluated during successful response inhibition trials (NoGo). BDs exhibited fast‐beta and theta hyperconnectivity in regions related to cognitive control. These responses were modulated differently depending on the motivational content of the stimuli. The increased salience of alcohol‐related stimuli may lead to overactivation of the affective‐automatic system in BDs, and compensatory neural resources of the reflective system will thus be required during response inhibition. In BDs, inhibition of the response to alcohol stimuli may require higher theta FC to facilitate integration of information related to the task goal (withholding a response), while during inhibition of the response to no‐alcoholic stimuli, higher fast‐beta FC would allow to apply top‐down inhibitory control of the information related to the prepotent response.

Neurocognitive

Response inhibition

Binge drinking

Salience (neuroscience)

Go/no go

Inhibitory control

10.1111/adb.13141

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Citations (10)

Exploratory Analysis of Power Spectrum and Functional Connectivity During Resting State in Young Binge Drinkers: A MEG Study

International Journal of Neural Systems (2015)

Ángeles Correas Socorro Rodrı́guez Holguı́n Pablo Cuesta Eduardo López‐Caneda Luis Miguel García‐Moreno

Binge Drinking (BD) is a pattern of intermittent intensive alcohol intake which has spread among young adults over the last decades. Adolescence constitutes a critical neuromaturation period in which the brain is particularly sensitive to the effects of alcohol. However, little is known about how BD affects the brain activity. This study aimed to characterize the brain's functional organization in BD and non-BD young population by means of analyzing functional connectivity (FC) and relative power spectra (PS) profiles measured with magnetoencephalography (MEG) during eyes-closed resting state. Our sample composed 73 first-year university students (35 BDs and 38 controls). Results showed that the BD subjects displayed a decreased alpha FC in frontal-parietal regions, and conversely, an enhanced FC in the delta, theta and beta bands in fronto-temporal networks. Besides the FC differences, the BD group showed a decreased PS within alpha range and an increased PS within theta range in the brain's occipital region. These differences in FC and PS measurements provide new evidence of the neurophysiological alterations related to the alcohol neurotoxicity and could represent an initial sign of an anomalous neural activity caused by a BD pattern of alcohol consumption during youth.

Binge drinking

Magnetoencephalography

10.1142/s0129065715500082

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Citations (28)

Anomalías neurocognitivas asociadas al consumo intensivo de alcohol (binge drinking) en jóvenes y adolescentes: Una revisión Neurocognitive anomalies associated with the binge drinking pattern of alcohol consumption in adolescents and young people: A review

Eduardo López‐Caneda Nayara Mota Alberto Crego Teresa Velasquez Montserrat Corral

Binge drinking (BD) is the most common problematic drinking pattern during adolescence and youth. At the same time, it is a period marked by profound structural and functional brain changes, which may be affected by heavy alcohol consumption. In recent years, a considerable number of studies that attempt to characterize the effects of BD on the brain has been published. However, to date there is not any critical review in Spanish language on neurostructural, neurophysiological and cognitive consequences that may result from the maintenance of a BD pattern of alcohol consumption during adolescence and youth. The purpose of this review is to critically summarize the main research results on the effects of BD on the brain. To this end, a literature search in databases Web of Knowledge, PubMed and PsycINFO for the period 2000-2013 was performed. In general, studies agree that BD is associated with 1) lower performance on tasks assessing cognitive processes such as attention, memory and executive functions, 2) structural changes (in white matter and gray matter) in different brain regions and 3) neurophysiological abnormalities (hyper/hypoactivation) linked to different cognitive processes. These results, although still need to be contrasted, warn about important consequences that could result from the persistence of BD on a young and still maturing brain.

Neurocognitive

Binge drinking

PsycINFO

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Risky alcohol use and heavy episodic drinking among Spanish University students: a two-year follow-up Consumo de riesgo y consumo intensivo de alcohol entre estudiantes universitarios: dos años de estudio

DOAJ (DOAJ: Directory of Open Access Journals) (2010)

Nayara Mota Rosa Álvarez-Gil Montserrat Corral Socorro Rodrı́guez Holguı́n María Parada

Alcohol intake

Heavy drinking

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The effects of stimulus intensity and age on visual‐evoked potentials (VEPs) in normal children

Psychophysiology (1999)

M. T. Carrillo‐de‐la‐Peña Socorro Rodrı́guez Holguı́n Montserrat Corral Fernando Cadaveira

In this study, we explored the effects of flash intensity and age on visual-evoked potentials (VEPs) in a sample of 85 children aged 8-15 years. Results of previous studies are discrepant regarding the extent to which children show an evoked potential augmenting tendency at vertex, which has been reported to be a characteristic of an immature inhibitory control system. In the present study, VEPs to light flashes of four different intensities were recorded at Cz. The results confirmed that P1N1 and N1P2 at Cz were positively related to increases in stimulus intensity, whereas N1 was not related reliably to intensity. This difference between peak-peak and baseline-peak amplitude findings at Cz relative to evoked potential augmenting and reducing may help to explain discrepant results among earlier studies. Developmental changes were found for our sample of children that were independent of stimulus intensity: N1 amplitude increased significantly with age, whereas N1 latency showed a small (nonsignificant) age-related decrease.

Stimulus (psychology)

Visual evoked potentials

Evoked potential

10.1111/1469-8986.3660693

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Citations (12)

Definición del concepto de consumo intensivo de alcohol adolescente (binge drinking)

Adicciones (2011)

María Parada Montserrat Corral Francisco Caamaño‐Isorna Nayara Mota Alberto Crego

Background: Review of the concept of adolescent binge drinking in order to propose an operational definition. Methods: We conducted a literature review in the databases MEDLINE and PSYCLIT for the period 1980 to 2009. Through the filter "(binge drinking OR heavy-episodic-drinking) AND (adolescence OR universitystudents OR college-students)" 80 articles were selected for review. Results: Epidemiological studies that have reported the prevalence of binge drinking show a lack of consensus regarding the operational definition. Alternative approaches have been proposed in relation to the number of standard drink units (SDUs) consumed per occasion, frequency of episodes and their duration. Conclusions: A proper definition of the pattern of intensive alcohol consumption should integrate the quantity and frequency variables, and also take into account the negative consequences associated with it. The criterion most widely accepted by the international scientific community is the consumption of 5 or more SDUs – 4 or more for women – on a single occasion at least once in the last two weeks. However, aspects such as differences in the grams of alcohol of SDUs hinder the establishment of an international definition of the term, making it necessary to adapt this approach to the country in which the study is being carried out.

Binge drinking

Consumption

10.20882/adicciones.167

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Citations (52)

OR3-7BINGE-DRINKING AND RISKY ALCOHOL CONSUMPTION AMONG UNIVERSITY STUDENTS

Alcohol and Alcoholism (2017)

Fátima Mori-Gamarra Lucía Rodríguez Carina Carbia Pérez García Sonia Doallo

Consumption

10.1093/alcalc/agx074.27

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Citations (0)